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  1. 121
  2. 122

    Single-Cell RNA Transcriptomics and Multi-omics Analyses Reveal the Clinical Effects of Acupuncture on Methadone Reduction by Yiming Chen, Baochao Fan, Jingchun Zeng, Yutian Zou, Chenyang Tao, Chen Chen, Peiming Zhang, Jian Liang, Fangfang Qi, Hailin Tang, Liming Lu

    Published 2025-01-01
    “…Opioid use disorders (OUDs) pose a substantial global health burden, with methadone maintenance treatment (MMT) widely adopted as an intervention; however, MMT is associated with immunosuppression, metabolic disturbances, and dysbiosis of the gut microbiota. …”
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  5. 125

    Metabonomics Analysis of Myocardial Metabolic Dysfunction in Patients with Cardiac Natriuretic Peptide Resistance by Pan Chang, Shengping Lei, Xiaomeng Zhang, Jing Zhang, Xihui Wang, Juan Wu, Jianbang Wang, Jianping Geng, Baoying Chen, Jun Yu

    Published 2020-01-01
    “…Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis demonstrated that the differentially expressed metabolites are involved in signaling pathways that regulate cardiac functions. In HF patients, BNP resistance develops in association with a reduction in heart function and metabolic remodeling. …”
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  6. 126

    Histological and Metabolic State of Dams Suckling Small Litter or MSG-Treated Pups by Claudia Regina Capriglioni Cancian, Nayara Carvalho Leite, Elisangela Gueiber Montes, Stefani Valeria Fisher, Leticia Waselcoski, Emily Caroline Lopes Stal, Renata Zanardini Christoforo, Sabrina Grassiolli

    Published 2016-01-01
    “…Lactation is an important function that is dependent on changes in the maternal homeostasis and sustained by histological maternal adjustments. …”
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  7. 127

    Role of oral and gut microbiomes in enterosalivary nitrate metabolism and their effects on systemic disease by Zi Yang, Conglin Du, Zhichao Chang, Yang Yang, Liang Hu

    Published 2025-07-01
    “…Nitrate can modulate microbiota metabolism and has important pathophysiological functions in diseases such as cardiovascular diseases, gastrointestinal diseases, diabetes, metabolic diseases, and brain diseases via nitrate-reducing bacteria. …”
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  8. 128
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    Microbes with higher metabolic independence are enriched in human gut microbiomes under stress by Iva Veseli, Yiqun T Chen, Matthew S Schechter, Chiara Vanni, Emily C Fogarty, Andrea R Watson, Bana Jabri, Ran Blekhman, Amy D Willis, Michael K Yu, Antonio Fernàndez-Guerra, Jessika Füssel, A Murat Eren

    Published 2025-05-01
    “…Here, we tested this hypothesis on a large scale, by developing a software framework to quantify the enrichment of microbial metabolisms in complex metagenomes as a function of microbial diversity. …”
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  10. 130

    Metformin as a disease-modifying therapy in osteoarthritis: bridging metabolism and joint health by Iryna Halabitska, Pavlo Petakh, Oleksandr Kamyshnyi

    Published 2025-03-01
    “…Metformin also led to significant reductions in inflammatory markers and improvements in lipid profiles and metabolic health indicators. …”
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  11. 131

    Carbohydrate metabolism parameters in angina patients treated with metoprolol and its combination with trimetazidine by E. V. Bochkareva, O. V. Aleksandrovich, P. Yu. Bardybakhin, E. K. Butina, N. G. Kucheryavaya, I. N. Ozerova, V. A. Metelskaya

    Published 2012-08-01
    “…In total, 28 men aged 46-68 years, with Functional Class (FC) II-III stable angina, positive exercise stress test (EST), and no prior β-AB therapy were examined. …”
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  12. 132

    Kaposi's sarcoma herpesvirus microRNAs induce metabolic transformation of infected cells. by Ohad Yogev, Dimitris Lagos, Tariq Enver, Chris Boshoff

    Published 2014-09-01
    “…However, how and why KSHV alters host cell metabolism remains poorly understood. Here, we investigated the effect of KSHV infection on the metabolic profile of primary dermal microvascular lymphatic endothelial cells (LEC) and the functional relevance of this effect. …”
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  13. 133

    Vitamin C potentiates the killing of Mycobacterium tuberculosis by bedaquiline through metabolic disruption by Catherine Vilchèze, Saranathan Rajagopalan, Raja Sab Kalluru, Niaz Banaei, William R. Jacobs

    Published 2025-08-01
    “…Transcriptomic analysis revealed that the BDQ/vitamin C combination induces widespread metabolic disruption in Mtb, characterized by upregulation of stress response and metal ion homeostasis genes and downregulation of energy metabolism and cell wall biosynthesis genes. …”
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  14. 134

    INTERACTION BETWEEN SYMPATHO-ADRENAL ACTIVITY AND IMMUNE MEDIATORS IN PATIENTS WITH METABOLIC SYNDROME by N. R. Uzbekova, M. A. Khuzhamberdiev, I. M. Tashtemirova

    Published 2014-03-01
    “…To investigate the interactions between the functional status of sympatho­adrenal system and immune meditators in patients with metabolic syndrome (MS).Material and methods. …”
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  15. 135

    Association of Cholesterol Efflux Capacity With Clinical Features of Metabolic Syndrome: Relevance to Atherosclerosis by Julie Gall, Eric Frisdal, Randa Bittar, Wilfried Le Goff, Eric Bruckert, Philippe Lesnik, Maryse Guerin, Philippe Giral

    Published 2016-12-01
    “…Cholesterol efflux capacity was reduced progressively by 4% to 11% (P<0.0001) as a function of the increasing number of coexisting criteria for the metabolic syndrome from 1 to 5. …”
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  16. 136

    Endothelial function status in hypogonadal men by I. A. Khripun, S. V. Vorobyev

    Published 2022-01-01
    “…Reduction of the endothelial vasomotor function was detected in 32.4% of patients in the 2st group and in 55.3% of the 1nd group (χ2=6.1; p=0.01), which was associated with a decrease in EDVD by 29.8 % (p&lt;0.001) and an increase in the time of development of maximal BA vasodilation by 30 seconds in patients with hypogonadism (p&lt;0.001). …”
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  17. 137

    Advances in Functionalized Nanoparticles for Osteoporosis Treatment by Cai R, Jiang Y, Sun H, Du F, Zhu L, Tao J, Xiao L, Wang Z, Shi H

    Published 2025-06-01
    “…This review examines the various types and architectures of functionalized nanoparticles, emphasizing their unique capabilities in targeting bone tissue and modulating bone metabolism. …”
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  18. 138

    Contribution and regulation of Ustilago maydis in carbohydrate metabolism during maize silage fermentation by Luo Chongyu, Ni Chengcheng, Dong Quanmin, Yang Fuyu

    Published 2025-06-01
    “…Furthermore, it revealed the potential interference of this infection with microbial community structure and functional metabolic pathways through metagenomic sequencing. …”
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  19. 139

    Prebiotic potential and metabolic benefits of Acorus gramineus rhizome-derived polysaccharides in a high-fat diet-induced obesity model by Miri Park, Yu-Rim Chae, Hye-Bin Lee, Jang-Eun Lee, Jang-Eun Lee, Yu Ra Lee, Jinyoung Hur, Ho-Young Park, Ho-Young Park

    Published 2025-06-01
    “…Importantly, mice fed a high-fat diet supplemented with AGRP showed significant improvements in metabolic disease markers, including reductions in body fat and white adipose tissue mass, compared to those in controls. …”
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  20. 140

    EFFECT OF FLUOXETINE ON SLEEP ARCHITECTURE IN PATIENTS WITH METABOLIC SYNDROME AND OBSTRUCTIVE SLEEP APNEA SYNDROME by O. V. Lyubshina, A. L. Vertkin, M. Yu. Maksimova

    Published 2016-01-01
    “…It improved adaptive function of the sleep and contributed to reduction in sleep disorders.…”
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