By-Products Valorization: Peptide Fractions from Milk Permeate Exert Antioxidant Activity in Cellular and In Vivo Models by Valeria Scalcon, Federico Fiorese, Marica Albanesi, Alessandra Folda, Gianfranco Betti, Marco Bellamio, Emiliano Feller, Claudia Lodovichi, Giorgio Arrigoni, Oriano Marin, Maria Pia Rigobello

“…Recovery strategies can lead to a reduction of waste and result in new applications. …”
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Reducing crude protein content in the diet of lactating dairy cows improved nitrogen-use-efficiency and reduced N excretion in urine, whilst having no obvious effects on the rumen... by Agalu W. Zeleke, Nicholas J. Dimonaco, Katie Lawther, Anna Lavery, Conrad Ferris, Jon Moorby, Sharon A. Huws

“…Additionally, propanoate metabolism, cysteine and methionine metabolism and amino acid biosynthesis pathways were more abundant in HE cows, whilst the methane (CH4) metabolism pathway was upregulated in LE cows. …”
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Anti-Obesity Potential of Barley Sprouts in Dog Diets and Their Impact on the Gut Microbiota by Hyun-Woo Cho, Kangmin Seo, Min Young Lee, Sang-Yeob Lee, Kyoung-Min So, Seung-Yeob Song, Woo-Duck Seo, Ju Lan Chun, Ki Hyun Kim

“…Additionally, the abundance of the <i>Ruminococcus gnavus</i> group was high in the experimental group. Functional predictions indicated an enhancement in carbohydrate, amino acid, and cofactor and vitamin metabolism. …”
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Influence of programmed death ligand 1 (PD-L1) knockout on gut microbiota in experimental autoimmune uveitis by Junxiang Gu, Junxiang Gu, Junxiang Gu, Yixian Ma, Yixian Ma, Yixian Ma, Qing Chang, Qing Chang, Qing Chang, Ling Chen, Ling Chen, Ling Chen

“…EAU was associated with declining microbial tryptophan metabolism and up-regulated functions related to lipid and carbohydrate metabolism; PD-L1 knockout in EAU further increased the metabolism of glycan and biosynthesis of 3-deoxy-α-D-manno-2-octulosonate (Kdo), a key component of bacterial lipopolysaccharide (LPS).ConclusionBoth EAU and PD-L1 knockout modulate gut microbiota, affecting microbial composition - particularly Akkermansia, CAG-485, Bacteroidaceae, Lachnospiraceae and Ruminococcaceae - and microbial functions such as lipid, carbohydrate and glycan metabolism.…”
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A comprehensive prognostic and immunological analysis of hexokinase domain containing protein-1 (HKDC1) in pan-cancer by Zhi Liang, Tianhao Zhang, Jiajia Huang, Zhixin Huang, Zeyu Zhao, Shirong Cai, Jinping Ma

“…Background Currently, research on the role of hexokinase domain-containing protein-1 (HKDC1) in neoplasm metabolism remains sparse. This study seeks to conduct a thorough investigation of HKDC1’s potential functions across thirty-three different tumor types, utilizing data obtained from The Cancer Genome Atlas (TCGA). …”
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Antibacterial and Antibiofilm Potential of Chlorophyllin Against <i>Streptococcus mutans</i> In Vitro and In Silico by Seemrose Khan, Ihtisham Ul Haq, Imran Ali, Abdul Rehman, Mazen Almehmadi, Meshari A. Alsuwat, Tariq Zaman, Muhammad Qasim

“…The antibiofilm potential of Chlorophyllin was measured by a reduction in the number of functional groups observed in the Fourier Transform Infrared Spectrometer (FTIR) spectra of the extracellular polymeric substance (EPS) samples. …”
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Effects of <i>Lactiplantibacillus-plantarum</i>-ZG7-Fermented Feed on Laying-Hen Productivity and Intestinal Health by Zhaolong Li, Wenjing Liu, Huini Wu, Song Peng, Mengshi Zhao, Fengqiang Lin, Lu Zhao

“…Non-targeted metabolomics revealed that ZG7-FF drives the suppression of key metabolites, including 3-hydroxybutyric acid, ethylnitronate, 6-chlorocoumarin-3-carboxylic acid, lotaustralin, and oleoylcarnitine, while enriching pathways related to amino acid metabolism. The downregulated metabolites were functionally linked to ABC transporters and neuroactive ligand–receptor interactions. …”
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Multimodal versus non-contrast computed tomography for assessment of acute ischaemic stroke: the PRACTISE RCT by Keith W Muir, Salwa El Tawil, Alex McConnachie, Alicia Murray, Ian Ford, Grant Mair, Joanna Wardlaw

“…Contrary to our initial hypothesis that multimodal CT might increase low treatment rates (estimated at 25%) by positively identifying significant brain ischaemia, we observed a much high baseline treatment rate (68%) that was significantly reduced in the multimodal imaging group (an absolute reduction of 18.5% in the use of rtPA). Workflow times, most notably time to treatment, and day 90 functional outcomes, were not significantly different between groups. …”
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Evaluating the safety and efficacy of Lacticaseibacillus paracasei TISTR 2593 as a therapeutic probiotic for obesity prevention by Jaruwan Sitdhipol, Kanidta Niwasabutra, Neungnut Chaiyawan, Kamonsri Nuankham, Thanaphol Thanagornyothin, Somboon Tanasupawat, Wasaporn Preteseille Chanput, Pongsathon Phapugrangkul, Chaivarakun Chaipanya, Sukanya Phuengjayaem, Saranporn Poothong, Engkarat Kingkaew

“…Several recent studies have reported the potential of probiotics in reducing body weight and fat mass and improving glucose and lipid metabolism. Therefore, probiotic administration is considered an alternative approach for treating obesity. …”
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The Polybrominated Diphenyl Ether Bromoxib Disrupts Nuclear Import and Export by Affecting Nucleoporins of the Nuclear Pore Complex by Karina S. Krings, Anastasia Ritchie, Laura Schmitt, Judith Hatzfeld, Gudrun Totzke, Thomas Lenz, María José Mendiburo, Björn Stork, Nicole Teusch, Peter Proksch, Kai Stühler, Lisa Müller, Sebastian Wesselborg

“…We have previously shown that the polybrominated diphenyl ether bromoxib (4,5,6-tribromo-2-(2′,4′-dibromophenoxy) phenol), isolated from the marine sponge <i>Dysidea</i> species, exhibits a strong cytotoxic potential in leukemia and lymphoma cells by targeting mitochondrial metabolism. Here, using a mass spectrometric thermal proteome profiling (TPP) approach, we observed that bromoxib induces a rapid reduction in the levels of 19 nucleoporins (NUPs) that are part of the nuclear pore complex (NPC). …”
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Integrated analysis of transcriptome and proteome provides novel insights into the response mechanisms of maca (Lepidium meyenii Walp.) to UV-B radiation by Zaihang Yu, Xueting Zhong, Li Xiao, Yuxi Cai, Ke Shen, Yu Luo, Xinxin Li, Hong Xu, Zihan Chen, Xiaomei Wang, Yi Wu, Yajun Wang, Wei Fan, Zhanqi Wang

“…Glutathione content measurement and inhibition assays demonstrated that disruption of the “glutathione metabolism” pathway led to a significant reduction in UV-B-induced total glutathione, reduced glutathione, and oxidized glutathione levels. …”
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Exploring the Potential of a New Nickel(II):Phenanthroline Complex with L-isoleucine as an Antitumor Agent: Design, Crystal Structure, Spectroscopic Characterization, and Theoretic... by Jayson C. dos Santos, João G. de Oliveira Neto, Ana B. N. Moreira, Luzeli M. da Silva, Alejandro P. Ayala, Mateus R. Lage, Rossano Lang, Francisco F. de Sousa, Fernando Mendes, Adenilson O. dos Santos

“…Supporting the experimental data, we performed computational modeling to examine the pharmacokinetic profile, with particular focus on the absorption, distribution, metabolism, and excretion properties and drug-likeness potential.…”
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Identification and whole genome sequencing analysis of Bacillus subtilis K35-1, a highly efficient cellulose in forage degrading bacterium by Dan Wu, Jing Feng, Dongxu Wen, Hongzhuang Wang, Sijia Lu, Kun Li, Rizwana Sultan, Bin Li

“…., Mol Genet Genomics 298:361–74, 2023), explaining its enhanced degradation efficiency (53.2% cellulose reduction vs. 7.3% in conventional treatments). Functional annotation revealed: 275 carbohydrate metabolism genes (KEGG), 228 cell wall/membrane biogenesis genes (COG) and 53.91% reduced-virulence mutations (PHI database). …”
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A Fungi-Driven Sustainable Circular Model Restores Saline Coastal Soils and Boosts Farm Returns by Fei Bian, Yonghui Wang, Haixia Ren, Luzhang Wan, Huidong Guo, Yuxue Jia, Xia Liu, Fanhua Ning, Guojun Shi, Pengfei Ren

“…Metagenomic analysis showed the enrichment of beneficial decomposer bacteria (<i>Hyphomicrobiales</i>, <i>Burkholderiales</i>, and <i>Streptomyces</i>) and functional genes involved in glyoxylate metabolism, nitrogen cycling, and lignocellulose degradation. …”
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Assessing the developmental effects of fentanyl and impacts on lipidomic profiling using neural stem cell models by Cheng Wang, Jinchun Sun, Rohini Donakonda, Richard Beger, Leah E. Latham, Leihong Wu, Shuliang Liu, Joseph P. Hanig, Fang Liu

“…However, a lipidomic analysis indicated that fentanyl may affect immature neural cell functions through modifying lipid composition and lipid metabolism. …”
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Structural Characterization and Hypolipidemic Activity of Highland Barley Polysaccharide-Polyphenol Complexes by Zibin GUO, Yang YANG, Bei FAN, Litao TONG, Yatao HUANG, Lili WANG, Ting ZHANG, Liya LIU, Peipei SUN, Jing SUN, Fengzhong WANG

“…The structural characteristics and potential to regulate lipid metabolism of HVP provide new insights into its application in functional foods.…”
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THE RISK FACTORS AND SPECIFIC FEATURES OF OSTEOPENIC SYNDROME IN PATIENTS WITH CHRONIC NON-INFECTIOUS DISEASES by N. G. Platitsyna, T. V. Bolotnova

“…The long-term uncontrolled course of disease, the degree of organ and functional disorders in the patients with CNID, and concomitant use of glucocorticoid therapy contribute to a reduction in BMD. …”
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Temporal dynamics of medium and micronutrient requirements in Epimedium pubescens: key elements regulating growth and Icariin-Flavonoids biosynthesis by Xiaojing An, Yanting Wang, Shangnian Liu, Ying Wang, Xianen Li, Baolin Guo, Haiying Wang, Caixia Chen

“…Nutrient deficiency experiments confirmed Mg, Fe, and Zn functioned as core elements governing growth, with deficiency causing chlorophyll loss and biomass reduction. …”
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Characterization of the salivary microbiome in healthy individuals under fatigue status by Xianhui Peng, Na Han, Yanan Gong, Lihua He, Yanli Xu, Di Xiao, Tingting Zhang, Yujun Qiang, Xiuwen Li, Wen Zhang, Jianzhong Zhang

“…Functional pathway analysis (PICRUSt2) revealed an enrichment of pathways such as "Neuroactive ligand-receptor interaction" in the FTG group, whereas pathways pertinent to energy metabolism (e.g., Citrate cycle (TCA cycle), Oxidative phosphorylation) and amino acid metabolism (e.g., Phenylalanine metabolism, Histidine metabolism) were significantly enriched in the ENG group.ConclusionThis study provides novel evidence that physiological fatigue induces significant structural and functional alterations in the salivary microbiome of healthy individuals. …”
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Organic material mulching regulated core microbial groups to promote soil carbon and nitrogen cycling and improve faba bean productivity under a triple-cropping system in purple so... by Ke Ren, Wenfeng Song, Zehui Wei, Lixia Song, Ming Liu, Yuling Zhou, Yuzhuo Zhen, Xinyao Wu, Kaiyuan Gu, Khanom Simarani, Longchang Wang

“…OMM promoted the establishment of key microbial communities dominated by Actinobacteria, Bacteroidetes, Ascomycota, and Basidiomycota. Predicted functional profiles based on PICRUSt and FUNGuild analyses suggest possible upregulation of up-regulated genetic information processing, metabolism, and organismal systems functional pathways. …”
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