Genome-based reclassification of the family Stappiaceae and assessment of environmental forcing with the report of two novel taxa, Flexibacterium corallicola gen. nov., sp. nov., a... by Mi-Jeong Park, Jinnam Kim, Yun Jae Kim, Jihyun Yu, Hyein Jin, Seonok Woo, Young-Gun Zo, Kae Kyoung Kwon

“…Canonical Correspondence Analysis attributed 64% of genomic variation to phylogenetic forcing and 36% to environmental forcing. Functional adaptations included pectin and aromatic compound degradation in sediment strains, nitrogen reduction in flatworm strains, and sulfur metabolism in coral strains. …”
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Up-regulation of microRNA-190b plays a role for decreased IGF-1 that induces insulin resistance in human hepatocellular carcinoma. by Tzu-Min Hung, Cheng-Maw Ho, Yen-Chun Liu, Jia-Ling Lee, Yow-Rong Liao, Yao-Ming Wu, Ming-Chih Ho, Chien-Hung Chen, Hong-Shiee Lai, Po-Huang Lee

“…<h4>Background & aims</h4>Insulin-like growth factor, (IGF)-1, is produced mainly by the liver and plays important roles in promoting growth and regulating metabolism. Previous study reported that development of hepatocellular carcinoma (HCC) was accompanied by a significant reduction in serum IGF-1 levels. …”
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Inflammation-Induced Klotho Deficiency: A Possible Key Driver of Chronic Kidney Disease Progression by Liang Y, Zhang Q, Qian JR, Li SS, Liu QF

“…However, the mechanism regarding their relationship is still unclear. The reduction in Klotho due to inflammation may be attributed to epigenetic mechanisms, such as DNA methylation, histone deacetylation, transcription factor, microRNA (miRNA) regulation and long non-coding RNA (lncRNA) regulation or non-epigenetic factors, such as endoplasmic reticulum (ER) stress and ER-associated degradation (ERAD), which affect Klotho protein metabolism. …”
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Cardioprotective effects of CoQ10 in pediatric patients with lysosomal storage disorders by Yasmine Abuzaid, Ghada Abdul Moemn Suliman, Osama Abd Rab El Rasool Toulba, Ahmed Abd El Basset Abo Elezz, Alshimaa Badraldeen, Heba Dawoud

“…CoQ10 resulted in significant beneficial reduction of serum MDA (15%) &NT-proBNP (30%) in the group of patients who received CoQ10, P-value < 0.001 and improvement of cardiac functional parameters in patients with LSDs. …”
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Crosstalk between neuroendocrinology and follicular dynamism: the mare experimental model for reproductive “aging” in women by Esterina Fazio

“…Follicular dynamism is characterised by three functional moments whose endocrine mechanisms dictate their physiological sequence of events: Recruitment, selection and dominance. …”
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Molecular Docking, Dynamics, and Preclinical Studies Reveal Morin Hydrate as a Potent PPARγ and Nrf2 Agonist That Mitigates Colon Inflammation by Aya A. Touny, Balaji Venkataraman, Saeeda Almarzooqi, Rajesh B. Patil, Bhoomendra A. Bhongade, Miroslav Harjaček, Tahir A. Rizvi, Shreesh Ojha, Shamanth Neralagundi Harihar Gowdru, Sandeep B. Subramanya

“…ABSTRACT Peroxisome proliferator‐activated receptors (PPARs), functioning as nuclear receptors, regulate the expression of genes associated with inflammation, lipid metabolism, and glucose metabolism. …”
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Transcriptome Analysis of Apple Leaves with Apple Necrotic Mosaic Virus-Associated Mosaic Symptoms by Dehang Gao, Fei Xing, Qin Yan, Zhixiang Zhang, Binhui Zhan, Meiguang Lu, Yunlong Ma, Hongqing Wang, Shifang Li, Jipeng Xie

“…A total of 815 differentially expressed genes (DEGs) were identified in mosaic leaves compared to healthy controls, while 1050 DEGs were found between symptomless leaves (infected with ApNMV) and mosaic leaves. Functional enrichment analysis revealed that these DEGs were predominantly involved in carbohydrate metabolism, oxidation-reduction processes, secondary metabolite biosynthesis, and plant hormone signal transduction. …”
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Roles of Response Regulators in the Two-Component System in the Formation of Stress Tolerance, Motility and Biofilm in <i>Salmonella</i> Enteritidis by Mengjun Hu, Zhuoan Zhou, Chenqi Liu, Zeqiang Zhan, Yan Cui, Shoukui He, Xianming Shi

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16S rRNA Sequencing and Metabolomics to Analyze Correlation Between Fecal Flora and Metabolites of Squabs and Parent Pigeons by Xiaobin Li, Shengchen Zheng, Haiying Li, Jiajia Liu, Fan Yang, Xiaoyu Zhao, Yafei Liang

“…At the family level, 10 distinct families were identified, with 9 at the genus level and 4 at the species level. (3) A LEfSe analysis identified 16 significantly different bacterial species in the parent pigeons and 7 in the squabs. Functional gene abundance was highest in the metabolism, genetic information processing, and environmental information processing pathways. (4) An LC-MS/MS analysis in cationic mode identified 218 metabolites, with 139 upregulated and 79 downregulated in the squabs relative to the parents. …”
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Analysis and validation of characteristic genes in RNA sequencing datasets from heart failure patients based on multiple algorithms by Yuxuan Li, Ying Bai, Wujiao Wang, Zhaotian Ma, Peng Li, Dong Li, Sinai Li, Jialin Jin, Jialin Jin, Qian Lin

“…Functional enrichment analyses (GO, KEGG, GSEA) revealed associated functional alterations. …”
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Gallic acid prevents obesity in mice on a high-fat diet via the gut microbiota-adipose tissue axis by Shiyan Jian, Xiaoying Jian, Lan Ye, Kang Yang, Limeng Zhang, Yixuan Xie, Jinping Deng, Yulong Yin, Baichuan Deng

“…Here, we found that high-fat diet (HFD) promoted lipid deposition and gut microbiota dysbiosis in mice, whereas GA slowed down lipid deposition and restored gut microbiota dysbiosis and its functional profile, as evidenced by the reduction of the obesity-causing bacterium Desulfovibrio and the enrichment of the beneficial bacterium Lachnospiraceae_NK4A136_group, Clostridiales_unclassified, Oscillospira and Adlercreutzia. …”
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Molecular mechanisms underlying TXNIP’s anti-tumor role in breast cancer, including interaction with a novel, pro-tumor partner: CAST by Jasvinder Singh, Bindeshwar Sah, Yibin Deng, Robert Clarke, Liang Liu

“…Abstract Thioredoxin-interacting protein (TXNIP) plays a pivotal role in glucose metabolism and redox signaling. Its emerging function as a potent suppressor of cell proliferation in various cancer contexts underscores its importance in cancer development. …”
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Combined effects of Yupingfeng and metformin on blood glucose levels and intestinal tissue in high-fat diet-induced type 2 diabetic rats by Hui Liu, Hui Liu, Yuan Guan, Like Xu, Ji Hu, Ji Hu

“…Lipid metabolism indicators, including triglycerides (TG), total cholesterol (TCHO), high-density lipoprotein cholesterol (HDL-c), and low-density lipoprotein cholesterol (LDL-c), showed significant reductions in the treatment groups (p&lt; 0.01). …”
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Single-cell transcriptomic dynamics of scallop heart reveals the heterogeneous response to heat stress by Danyang Wang, Na Liu, Xiangfu Kong, Xinghai Zhu, Yangfan Wang, Jingjie Hu, Zhenmin Bao

“…Results Here, we conducted a comprehensive investigation of the morphology, metabolism and scRNA-seq of the heart in a molluscan model, Argopecten irradians, under heat stress. …”
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Stem cell-derived exosome delivery systems for treating atherosclerosis: The new frontier of stem cell therapy by Hassan Tariq, Syeda Zunaira Bukhari, Ruibing An, Jian Dong, Ayesha Ihsan, Muhammad Rizwan Younis

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Investigating the bacterial community of gray mangroves (Avicennia marina) in coastal areas of Tabuk region by Hanaa Ghabban, Doha A. Albalawi, Amenah S. Al-otaibi, Dikhnah Alshehri, Asma Massad Alenzi, Marfat Alatawy, Hanan Ali Alatawi, Dalia Kamal Alnagar, Ahmad Bahieldin

“…The most dominant genera in rhizosphere sample of Al-Wajh were Geminicoccus and Thermodesulfovibrio while the same habitat of the Umluj site was dominated by Propionibacterium, Corynebacterium and Staphylococcus. Bacterial functional potential prediction analyses showed that bacteria from two locations have almost similar patterns of functional genes including amino acids and carbohydrates metabolisms, sulfate reduction and C-1 compound metabolism and xenobiotics biodegradation. …”
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Proteomic profiling of cotton fiber developmental transition from cell elongation to secondary wall deposition by Zhou Xiaoyun, Hu Wenran, Li Bo, Yang Yang, Zhang Yong, Thow Kieran, Fan Ling, Qu Yanying

“…During the transition, upregulated proteins are mainly involved in carbohydrate/energy metabolism, oxidation–reduction, cytoskeleton, protein turnover, Ca²⁺ signaling, etc., whereas important downregulated proteins are mostly involved in phenylpropanoid and flavonoid secondary metabolism pathways. …”
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Telomere attrition alters extracellular vesicles conferring adverse impacts on neuronal viability and inflammatory response by Yi Gong, Yunong Wang, Francheska Delgado-Peraza, Carlos Nogueras-Ortiz, Nicole Noren Hooten, Deborah L. Croteau, Mithlesh Temre, Abigail E. Molnar, Monica Bodogai, Ainslee Zou, Kotb Abdelmohsen, Wei Zhu, Yongqing Zhang, Myriam Gorospe, Nan-Ping Weng, Michele K. Evans, Dimitrios Kapogiannis, Yie Liu

“…Proteomic analysis revealed altered protein levels related to inflammation and lipid metabolism in plasma- and tissue-derived EVs. Functionally, EVs from G3 Tert−/−mice stimulated a pro-inflammatory response in bone marrow-derived macrophages and exhibited neurotoxic effects on primary cultured neurons. …”
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CK1δ/ε-mediated TDP-43 phosphorylation contributes to early motor neuron disease toxicity in amyotrophic lateral sclerosis by Vivian I. Ko, Kailee Ong, Deborah Y. Kwon, Xueying Li, Alicia Pietrasiewicz, James S. Harvey, Mukesh Lulla, Guruharsha Bhat, Don W. Cleveland, John M. Ravits

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Impact of Sleeve Gastrectomy on Body Weight and Food Intake Regulation in Diet-Induced Obese Mice by Sandra Lucinei Balbo, Gabriela Moreira Soares, Joseane Morari, Antonio Machado Felisberto, Jean Franciesco Vettorazzi, Gabriela Alves Bronczek, Maria Lúcia Bonfleur, Everardo Magalhães Carneiro, Antonio Carlos Boschero, Lício Augusto Velloso

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