Nebivolol effects on myocardial remodelling, inflammation markers and endothelial dysfunction in chronic heart failure patients with or without Type 2 diabetes mellitus by Yu. N. Belenkov, E. V. Privalova, I. S. Chekneva, L. V. Knyazeva, N. S. Suleymanova, I. V. Vasilyeva

“…Additional beneficial effects of nebivolol, such as endogenous NO synthesis modulation and immune inflammation reduction, could explain its clinical effectiveness and prognosis improvement in patients with CHF and DM-2, as well as in CHF patients with normal carbohydrate metabolism.Conclusion. …”
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The meaning of sport and physical activity from a youth perspective by Rizqie Windiyarto Rizqie, Fajar Ari Widiyatmoko, Osa Maliki

“…Results: The results showed that physiological needs are still the main needs to maintain health, increase metabolism, and optimise body functions. Conclusion: This research shows differences with previous studies that emphasise security and social needs, but this research reveals more that physiological needs remain the main motivation. …”
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Analysis of the SUMO2 Proteome during HSV-1 Infection. by Elizabeth Sloan, Michael H Tatham, Marine Groslambert, Mandy Glass, Anne Orr, Ronald T Hay, Roger D Everett

“…Covalent linkage to members of the small ubiquitin-like (SUMO) family of proteins is an important mechanism by which the functions of many cellular proteins are regulated. …”
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Lactate Dehydrogenase-B Oxidation and Inhibition by Singlet Oxygen and Hypochlorous Acid by Lisa M. Landino, Emily E. Lessard

“…Alterations in cellular energy metabolism are a hallmark of cancer and lactate dehydrogenase (LDH) enzymes are overexpressed in many cancers regardless of sufficient oxygen and functional mitochondria. …”
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Fatty acid composition of total lipids and phospholipids of muscular tissue and brain of rats under the impact of vibration by N. M. Kostyshyn, M. R. Grzegotsky, J. F. Rivis

“…These changes indicate worsening of structural and functional organization of muscles and brain cell membranes of rats due to increased viscosity of lipids and changes in their intramembrane dynamics.…”
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Cannabinoids reduce markers of inflammation and fibrosis in pancreatic stellate cells. by Christoph W Michalski, Milena Maier, Mert Erkan, Danguole Sauliunaite, Frank Bergmann, Pal Pacher, Sandor Batkai, Nathalia A Giese, Thomas Giese, Helmut Friess, Jörg Kleeff

“…Concomitantly, cannabinoid receptor activation specifically decreased invasiveness of PSC, MMP-2 secretion and led to changes in PSC phenotype accompanied by a reduction of intracellular stress fibres.<h4>Conclusions/significance</h4>Augmentation of the endocannabinoid system via exogenously administered cannabinoid receptor agonists specifically induces a functionally and metabolically quiescent pancreatic stellate cell phenotype and may thus constitute an option to treat inflammation and fibrosis in chronic pancreatitis.…”
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Ferroptosis: New Strategies for Clinical Treatment of Rheumatoid Arthritis by Sun Y, Liu J, He M, Huang D, Wang Y

“…Yanqiu Sun, Jian Liu, Mingyu He, Dan Huang, Yuan Wang Department of Rheumatology and Immunology, First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, Anhui, 230038, People’s Republic of ChinaCorrespondence: Jian Liu, Department of Rheumatology and Immunology, First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, 117 Meishan Road, Hefei, Anhui, 230038, People’s Republic of China, Tel +8613955109537, Email liujianahzy@126.comAbstract: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that can lead to joint deformities, functional loss, and a significant reduction in patients’ quality of life. …”
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The nrfA-type microbial communities are widespread in hot springs of the Tibet-Yunnan geothermal zone by Xi Chen, Geng Wu, Zhicheng Yu, Fangming Li, Hongchen Jiang

“…Investigating the distribution of DNRA-functional bacteria is of great significance to understanding the source of biological nitrogen production in geothermal environments. …”
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Chronic vs. Acute Interactions between Supraoptic Oxytocin Neurons and Astrocytes during Lactation: Role of Glial Fibrillary Acidic Protein Plasticity by Yu-Feng Wang, Kathryn A. Hamilton

“…These studies of the dynamic interactions that occur between astrocytes and OXT neurons mediated by GFAP extend our understanding of astrocyte functions within the central nervous system.…”
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Microbial diversity and composition in the gut microbiome of patients during systemic inflammatory response syndrome: can we use gut bacteria as potential biomarkers to characteriz... by Rafaela Ramalho Guerra, Rafaela Ramalho Guerra, Rafaela Ramalho Guerra, Patricia da Silva Fernandes, Otávio von Ameln Lovison, Otávio von Ameln Lovison, Giovanna de Ross Forni, Giovanna de Ross Forni, Gabriel Silva de Oliveira, Luana Cristina Viana, Dariane Castro Pereira, William Latosinski Matos, William Latosinski Matos, Miriane Melo Silveira Moretti, Fabiana Zempulski Volpato, Luciana Giordani, Luciana Giordani, Patricia Orlandi Barth, Patricia Orlandi Barth, Tarsila Vieceli, Diego Rodrigues Falci, Márcio Manozzo Boniatti, Afonso Luís Barth, Afonso Luís Barth, Afonso Luís Barth, Andreza Francisco Martins, Andreza Francisco Martins, Andreza Francisco Martins, Andreza Francisco Martins

“…In sepsis, the loss of taxa involved in key metabolic functions, as short-chain fatty acid production, reflects dysbiosis and may contribute to worse outcomes. …”
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The effect of tiotropium/olodaterol versus fluticasone propionate/salmeterol on left ventricular filling and lung hyperinflation in patients with COPD by Henrik Watz, Felix Herth, Jens M Hohlfeld, Johannes Haas, Alberto de la Hoz, Xidong Jin, Karl-Friedrich Kreitner, Claus Vogelmeier, Jens Vogel-Claussen

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Computer-tomography features of hemodynamics in hepatocellular carcinoma foci depend on the stage of histological differentiation by U. N. Tumanova, N. I. Yashina, Ye. A. Dubova, G. G. Karmazanovsky, A. I. Schegolev

“…The poorly differentiated tumor was characterized by decrease in both total number of blood vessels, and the quantity of neovasculatures that underlies transition of cells to anaerobic way of metabolism.Conclusion. Decrease in histological differentiation grade and concomitant gain of malignant potential of neoplasm is associated to reduction of the total area ofbarterial blood vessels. …”
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Specific Conditions for Resveratrol Neuroprotection against Ethanol-Induced Toxicity by Brigitte Gonthier, Nathalie Allibe, Cécile Cottet-Rousselle, Frédéric Lamarche, Laurence Nuiry, Luc Barret

“…Aims. 3,5,4′-Trihydroxy-trans-stilbene, a natural polyphenolic compound present in wine and grapes and better known as resveratrol, has free radical scavenging properties and is a potent protector against oxidative stress induced by alcohol metabolism. Today, the mechanism by which ethanol exerts its toxicity is still not well understood, but it is generally considered that free radical generation plays an important role in the appearance of structural and functional alterations in cells. …”
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COMBINED MONITORING OF DIURESIS AND BLOOD PRESSURE IN PATIENTS WITH ARTERIAL HYPERTENSION AND HEART FAILURE by M. P. Savenkov, A. V. Kirichenko, S. N. Ivanov, M. V. Borshchevskaya, L. A. Solomonova, A. M. Savenkova

“…DTR assessment could be recommended for diagnostics of fluid metabolism disturbances and the choice of the optimal diuretic therapy regimen.…”
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Putrescine Depletion in <i>Leishmania donovani</i> Parasites Causes Immediate Proliferation Arrest Followed by an Apoptosis-like Cell Death by Julia Johnston, Jonathan Taylor, Surbhi Nahata, Angelica Gatica-Gomez, Yvette L. Anderson, Sophia Kiger, Thong Pham, Kayhan Karimi, Jasmin-Faith Lacar, Nicola S. Carter, Sigrid C. Roberts

“…Starved ∆<i>odc</i> parasites also exhibited a marked reduction in metabolism, which was not observed in the starved ∆<i>spdsyn</i> cells. …”
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α/β-hydrolase domain containing protein 15 (ABHD15)--an adipogenic protein protecting from apoptosis. by Evelyn Walenta, Ariane R Pessentheiner, Helmut J Pelzmann, Alexander Deutsch, Madeleine Goeritzer, Dagmar Kratky, Hubert Hackl, Da Young Oh, Andreas Prokesch, Juliane G Bogner-Strauss

“…Our knowledge about adipocyte metabolism and development is steadily growing, yet many players are still undefined. …”
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Genome Sequencing Reveals the Adaptation of Chickens to High Altitudes in Different Regions by Yizhou Hu, Xing Li, Qixin Guo, Lan Huang, Hao Bai, Guobin Chang

“…Functional annotation of the genes showed that they are primarily involved in energy metabolism, ion channel activity, and blood pressure regulation. …”
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Chemoproteomic analysis of the pharmacological properties of vitamin В12 derivatives by I. Yu. Torshin, O. A. Gromova, I. A. Dereven’kov, L. A. Maiorova

“…A more detailed analysis of the chemoproteomic profiles of the studied compounds using the GO (Gene Ontology) nomenclature of biological functions of proteins made it possible to identify functional GO categories indicating differences in the biological effects of the studied compounds: neuroprotective regulation of neurotransmitter activity (serotonin receptor activity, cholinergic synapses, regulation of dopamine secretion, receptor thyroid hormones), reduction of inflammation (inhibition of cytokine biosynthesis, including tumor necrosis factor alpha and interleukin 1 beta, I-kappa-B kinases / nuclear factor kappa В, leukocyte migration), etc.Conclusion. …”
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Selective loss of ATP carriers in favour of SLC25A43 orthologues in metamonad mitochondria adapted to anaerobiosis by Natalia Janowicz, Vít Dohnálek, Justyna Zítek, Priscila Peña-Diaz, Eva Pyrihová, Martin S. King, Michaela Husová, Vojtěch Žárský, Edmund Kunji, Alena Zikova, Vladimír Hampl, Pavel Dolezal

“…Our bioinformatic analyses revealed remarkable reduction of MCP repertoire in Metamonada with striking loss of the major ADP/ATP carrier (AAC). …”
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Mavacamten for Obstructive Hypertrophic Cardiomyopathy: Rationale for Clinically Guided Dose Titration to Optimize Individual Response by Anjali T. Owens, Milind Desai, Matthew T. Wheeler, Anna Rodonski, Samira Merali, Amy J. Sehnert, Sara Saberi

“…This dosing approach allows for the identification of the lowest individualized mavacamten dose and exposure required to provide improvements in LV outflow tract obstruction, functional capacity, and symptoms. Mavacamten is primarily metabolized by CYP2C19 (cytochrome P450 2C19), and CYP2C19 metabolizer phenotype has an effect on mavacamten exposure. …”
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