Redox Regulation of PPARγ in Polarized Macrophages by Verena Trümper, Ilka Wittig, Juliana Heidler, Florian Richter, Bernhard Brüne, Andreas von Knethen

“…Cysteine residues located in the zinc finger regions (amino acid fragments AA 90-115, AA 116-130, and AA 160-167) of PPARγ were highly oxidized, accompanied by phosphorylation of serine 82 in response to LPS/IFNγ, whereas IL4-stimulation provoked minor serine 82 phosphorylation and less cysteine oxidation, favoring a reductive milieu. Mutating these cysteines to alanine to mimic a redox modification decreased PPARγ-dependent reporter gene transactivation supporting a functional shift of PPARγ associated with the MΦ phenotype. …”
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The 16SrXII-P Phytoplasma GOE Is Separated from Other Stolbur Phytoplasmas by Key Genomic Features by Rafael Toth, Bruno Huettel, Mark Varrelmann, Michael Kube

“…Phylogenetic position was revised, genome organization was compared, and functional reconstructions of metabolic and virulence factors were performed. …”
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基于无监督学习识别吲哚布芬治疗急性中重度缺血性卒中的应答患者 Unsupervised Learning-Based Identification of Responders to Indobufen Treatment in Acute Moderate-to-Severe Ischemic Stroke... by 蒲善宇，潘岳松，王拥军 (PU Shanyu, PAN Yuesong, WANG Yongjun )

“…The proportions of females, intracranial atherosclerotic stenosis, and metabolic disorders in responders were higher than those in non-responders. …”
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Genome-wide association study reveals the QTLs and candidate genes associated with seed longevity in soybean (Glycine max (L.) Merrill) by Naflath Thenveettil, R. L. Ravikumar, S. Rajendra Prasad

“…Seed longevity related traits such as seed germination, seedling vigor index-I (SVI-I), seedling vigor index-II (RVI-II), reduction in vigor index-I (RVI-I), and reduction in vigor index-II (RVI-II) were recorded after 12 and 14 months after natural ageing and accelerated ageing during the year 2019 and 2021. …”
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Gpbar1-mediated SIRT1-PGC-1α axis maintains mitochondrial homeostasis and mitigates renal injury in obstructive jaundice by Mingchen Li, Kai Luo, Xu Sun, Yuting Zhao, Haiyang Chen, Courtney Quan, Caiming Xu, Guixin Zhang

“…Mitochondrial structural disorder occurred in the kidneys, with significant reductions in SOD, GSH, and ATP levels, while MDA levels were significantly increased, indicating impaired antioxidant capacity and energy metabolism dysfunction. …”
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Integral Hematological Indices and Immunological Parameters in Acute Poisoning in Children by L. A. Kovalenko, G. N. Sukhodolova

“…The absorbing capacity of neutrophils remained unchanged and oxygen-dependent cellular metabolism was enhanced. Conclusion. Immunological findings and integral hematological indices point to immune system functional changes forming in children via a systemic response to acute chemical poisoning. …”
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Interventions to enhance mental health outcomes of persons with schizophrenia during the COVID-19 pandemic: A systematic review by Sudaporn Stithyudhakarn, Penpaktr Uthis, Trieu Van Nhat

“…These interventions were associated with reported improvements in physical activity, cognitive and social functioning, quality of life, and health behaviors, along with reductions in illness severity, self-stigma, and metabolic risk. …”
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Spotlight on the Mechanism of Action of Semaglutide by Ilias Papakonstantinou, Konstantinos Tsioufis, Vasiliki Katsi

“…Integrating the latest clinical trials, semaglutide in patients with or without diabetes presents significant therapeutic efficacy in ameliorating cardiometabolic risk factors and physical functioning, independent of body weight reduction. Semaglutide may modulate adipose tissue browning, which enhances human metabolism and exhibits possible benefits in skeletal muscle degeneration, accelerated by obesity and ageing. …”
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Altered O-Glycans in stimulated whole saliva from patients with primary Sjögren’s syndrome and non-pSS sicca by Sarah Kamounah, Kristina A. Thomsson, Christiane Elisabeth Sørensen, Eric Paul Bennett, Niclas G. Karlsson, Anne Marie Lynge Pedersen

“…Abstract To investigate if salivary O-linked glycans are altered in primary Sjögren’s syndrome (pSS), and thus contributing to explain symptoms of oral dryness, and an impaired oral mucosal barrier function leading to changes in microbial metabolism and colonization by both pathogenic and commensal microorganisms and increased prevalence of oral diseases. …”
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Is L‐Arginine an Appropriate Alternative for Conventional Anti‐Atherosclerotic Therapy?: A Comprehensive Review by Ali Mortezaei, Mohammad Ghorbani, Bardia Hajikarimloo, Omar Sameer, Toba Kazemi, Ebrahim Salavati, Mohsen Hamidpour, Mohammad Esmail Gheydari

“…Results L‐Arg supplementation has shown promising effects on NO production, improving endothelial function and reducing oxidative stress in preclinical models. …”
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Chlamydia species-dependent differences in the growth requirement for lysosomes. by Scot P Ouellette, Frank C Dorsey, Simon Moshiach, John L Cleveland, Rey A Carabeo

“…Thus, chlamydiae co-opt the functions of lysosomes to acquire essential amino acids.…”
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Genetic modification of the shikimate pathway to reduce lignin content in switchgrass (Panicum virgatum L.) significantly impacts plant microbiomes by Shuang Liu, Ming-Yi Chou, Gian Maria Niccolò Benucci, Aymerick Eudes, Gregory Bonito

“…Our results show unexpected reductions in mycorrhizas and actinobacteria in belowground tissues, raising questions on the resilience and function of genetically engineered plants in agricultural systems.…”
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Personalized allele-specific antisense oligonucleotides for GNAO1-neurodevelopmental disorder by Inna Shomer, Nofar Mor, Shaul Raviv, Noga Budick-Harmelin, Tanya Matchevich, Sharon Avkin-Nachum, Yoach Rais, Rebecca Haffner-Krausz, Ariela Haimovich, Aviv Ziv, Reut Fluss, Bruria Ben-Ze’ev, Gali Heimer, Denis N. Silachev, Vladimir L. Katanaev, Dan Dominissini

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Light Influences the Growth, Pigment Synthesis, Photosynthesis Capacity, and Antioxidant Activities in Scenedesmus falcatus by Rattanaporn Songserm, Yoshitaka Nishiyama, Nuttha Sanevas

“…However, noteworthy reductions in the maximum quantum yield (Fv/Fm) and actual quantum yield (Y(II)) were observed under 1000 μmol photons m−2·s−1, reflecting a decline in algal photosynthetic efficiency. …”
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Molecular Mechanisms of Druze Formation in the Retina in Age-Related Macular Degeneration by E. F. Barinov

“…Analysis of literature allowed to identify several promising areas of development of targeted therapy for lipid metabolism disorders in  retina. They include the reactivation of lipid carriers in RPE cells, ligand-receptor mechanisms that provide a reduction pH in lysosomes and maintaining functional activity of macrophages.…”
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In Vivo distribution dynamics of Gold Nanoparticles: A quantitative analysis by Angélica Barbezan, Wilmmer Alexander Rosero, Luis Fernando Almeida, Maria Eduarda Rigo, Fabio Fernando Silva, Maria Elisa Rostelato

“…The results showed predominant accumulation of GA-AuNPs in the liver, spleen, and gallbladder, suggesting hepatobiliary excretion as the primary clearance route. A reduction in liver uptake after 24 hours indicates potential nanoparticle metabolism or elimination. …”
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Tanshinone regulated gut microbiota and TMAO to improve high-fat diet induced atherosclerosis in APOE−/− mice by Aiming Zhou, Nian Peng, Lin Yang, Siyuan Yang, Jiawen Wang

“…Conversely, in the model group, lactobacillus levels diminished, whereas proteobacteria and lachnospiraceae levels increased. The primary functional enrichment of species in both groups was closely associated with lipid metabolism, with a more pronounced enhancement of lipid metabolism noted in the tanshinone group. …”
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Pathogenic effects of plasma thiols in patients with psoriasis on background of arterial hypertension by G. I. Makurina

“…Objective: to study the features of metabolism of nitric oxide and thiol-disulfide balance parameters in patients with psoriasis combined with essential hypertension. …”
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Erythrocyte nicotinamide adenine dinucleotide concentration is enhanced by systematic sports participation by Barbara Pospieszna, Krzysztof Kusy, Ewa Maria Slominska, Jacek Zieliński, Monika Ciekot-Sołtysiak

“…Abstract Background Nicotinamide adenine dinucleotide (NAD+), nicotinamide adenine dinucleotide phosphate (NADP+), and their reduced forms (NADH and NADPH) are the vital cofactors for most cellular oxidation/reduction reactions and therefore influence most critical pathways in cellular metabolism. …”
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The role of intravenous glutamine administration in critical care patients with acute kidney injury: a narrative review by Jonny Jonny, Astrid Devina Larasati, Bunga Pinandhita Ramadhani, Bhimo Aji Hernowo, Taufiq Fredrik Pasiak

“…The kidneys are complex organs responsible for waste removal and various regulatory functions. Critically ill patients often experience acute kidney injury (AKI). …”
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