Strawberry dietary intervention influences diversity and increases abundances of SCFA-producing bacteria in healthy elderly people by Franziska Meiners, Bernd Kreikemeyer, Patrick Newels, Ingmar Zude, Michael Walter, Alexander Hartmann, Daniel Palmer, Georg Fuellen, Israel Barrantes

“…Other findings included a significant reduction of CAG-352, Preveotellaceae_NK3B31-group, and Eubacterium coprostanoligenes (group 2), and a trend of lowered Firmicutes-to-Bacteroidetes ratio (P = 0.067) and a reduction in Ruminococcaceae (group 3). …”
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Integrated meta-analysis and network pharmacology analysis: evaluation of Zhigancao decoction as treatment for diabetic cardiomyopathy by Kangshou Ji, Kangshou Ji, Meizi Han, Mingqian Yang, Qian Xu, Yan Zhang, Yan Zhang

“…ZGCD not only significantly reduces blood pressure, but also enhances cardiac function while producing fewer adverse effects. The therapeutic effects of ZGCD on DCM can likely be ascribed to its capacity to modulate the AGEs-RAGE signaling pathway, as well as its efficacy in enhancing lipid metabolism and mitigating atherosclerosis.Systematic Review Registrationidentifier (INPLASY202430133).…”
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Niemann - Pick C2 regulates steroid hormone secretion and lipid deposition in chicken follicular granulosa cells by Ruihao Yu, Shuo Wei, Felix Kwame Amevor, Liuting Wu, Dan Xu, Zheliang Liu, Kunlong Qi, Yingjie Wang, Gang Shu, Xiaoling Zhao

“…The results showed that silencing NPC2 significantly increased the expression of SREBP1, SREBP2, LPL, SCD1, CPT1 and DGAT2 genes involved in lipid synthesis (P < 0.01), and also increased the synthesis of Triglyceride (TG) and Cholesterol (TC) in granulosa cells (P < 0.05), whereas NPC2 overexpression led to a marked reduction in the expression of these indicators of lipid metabolism (P < 0.01). …”
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Exacerbated ischemic brain damage in type 2 diabetes via methylglyoxal-mediated miR-148a-3p decline by Zhenguo Yang, Cheng Huang, Wenhui Huang, Chao Yan, Xueyi Wen, Di Hu, Hesong Xie, Kejing He, Chi Kwan Tsang, Keshen Li

“…This miR-148a-3p downregulation intensified the severity of BBB damage, infarct size, and neurological function impairment caused by stroke. Notably, the reduction in miR-148a-3p levels was primarily triggered by methylglyoxal, a toxic byproduct of glucose metabolism commonly associated with T2D. …”
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Sirtuin 1 expression in elderly patients with type 2 diabetes mellitus by Mohamed M. M. Hassaan, Imam M. Esmayel, Mayada M. Mousa, Samia Hussein, Ahmed K. Y. Alkolaly, Batoul A. Hegazy, Rodalia M. Makhlouf

“…SIRT3 is a mitochondrial enzyme that regulates mitochondrial functions, including ATP synthesis, reactive oxygen species production, fatty acid oxidation, ketone metabolism, and cellular death. …”
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Fusion of a bacterial cysteine desulfurase to redox-sensitive green fluorescent protein produces a highly sensitive cysteine biosensor for monitoring changes in intracellular cyste... by Damien Caubrière, Arthur de Butler, Anna Moseler, Pauline Leverrier, Jean-François Collet, Andreas J. Meyer, Nicolas Rouhier, Jérémy Couturier

“…The specificity, sensitivity, and the oxidation-reduction dynamics of CyReB were first investigated in vitro before its in vivo functionality was confirmed by expressing CyReB in Escherichia coli and Saccharomyces cerevisiae cells. …”
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KLF1 Promotes Cardiomyocyte Proliferation and Heart Regeneration Through Regulation of Wnt/β‐Catenin Signaling Pathway by Yanglin Hao, Xi Zhang, Shuan Ran, Yuan Li, Weicong Ye, Song Wang, Xiaohan Li, Zilong Luo, Jiulu Zhao, Junjie Zong, Kexiao Zheng, Ran Li, Han Zhang, Longyong Lai, Pinyan Huang, Zifeng Zou, Wang Zhan, Zhang Yue, Jie Wu, Jiahong Xia

“…Mechanistically, through RNA sequencing (RNA‐seq) and ATAC sequencing (ATAC‐seq) analyses, it is revealed that the promotion of cardiomyocyte proliferation by KLF1 is associated with the Wnt/β‐catenin signaling pathway, mitochondrial function, and fatty acid metabolism. These findings highlight the important role of KLF1 in cardiomyocyte proliferation and heart regeneration, which provides novel insights into therapeutic targets for heart failure.…”
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Biomarkers and subclinical left ventricular dysfunction in patients with type 2 diabetes without clinical manifestations of cardiovascular diseases by T. G. Utina, D. U. Akasheva, D. V. Korsunsky, O. N. Dzhioeva, O. M. Drapkina

“…GLS in the groups of patients with carbohydrate metabolism disorders was lower than in the control group (p=0,001). …”
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Rhizosphere Bacteria, Rather Than Benthic Bivalve Symbionts, May Facilitate Seagrasses by Yizhou Sun, Yang Liu, Xing-Xing Cai, Mark D. Bertness, Qiang He

“…We found no significant differences in the community structure of clam gill bacteria between seagrass beds and mudflats, with Spirochetes being the predominant bacterial taxa, most of which did not have known functions related to sulfur metabolism and nutrient regulation. …”
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Fluoride induces hepatointestinal damage and vitamin B2 mitigation by regulating IL-17A and Bifidobacterium in ileum by Chen Liang, Cuicui Zhuang, Chenkai Cheng, Jian Bai, Yue Wu, Xiang Li, Jie Yang, Bohui Li, Weixiang Fu, Qianlong Zhu, Jiawei Lv, Yanjia Tan, Ram Kumar Manthari, Yangfei Zhao, Jundong Wang, Jianhai Zhang

“…Methods: Fluoride and/or vitamin B2-treated IL-17A knockout and wild-type mouse models were established, the morphological and functional changes of liver and gut, total bile acid biosynthesis, metabolism, transport, and regulation of FXR-FGF15 signaling pathways were evaluated, the ileal microbiome was further analyzed by 16S rDNA sequence. …”
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The Effect of Iron Deficiency Stress on the Relative Expression of ZIP3, ZIP6, and ZIP7 Genes in Bread Wheat (Triticum aestivum L.) Cultivars by Saeed Rezaei Musa Dargh, Babak Abdollahi Mandoulakani, Raheleh Ghasemzadeh

“…Micronutrients regulate food metabolism in humans, and their deficiency endangers human health. …”
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Soil organic carbon mineralization is controlled by the application dose of exogenous organic matter by O. Mendoza, S. De Neve, H. Deroo, H. Li, A. Françoys, A. Françoys, S. Sleutel

“…Likewise, the formation of microbial biomass carbon was proportional to EOM dose, suggesting no reduction in microbial growth efficiency at a higher C concentration. …”
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Impact of aging on gene expression in human oocytes: a comparative analysis of young and older patients by Raoul Orvieto, Omri Nayshool, Louisa Cohen, Yuval Yung, Adva Aizer, Efrat Glick Saar, Dan Dominissini

“…Abstract Background Aging affects gene expression in pathways essential for energy metabolism, DNA repair, cell cycle regulation, and antioxidant defenses, directly affecting oocyte quality and viability. …”
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Direct Cardiac Mechanisms of the Sodium Glucose Co-Transporter 2 Inhibitor Class by Steven Hopkins M.D., Faiz Baqai M.D., Saivaroon Gajagowni M.D., Gavin Hickey M.D.

“…The search focused on studies examining the direct impact of SGLT2 inhibitors on cardiac function, remodeling, metabolism, and intracellular signaling pathways. …”
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The impact of pituitary adenomas on cognitive performance: a systematic review by Ting-Chia Young, Kai-Yen Lin, Wan-Cheng Li, Chi-Ning Huang, Wen-Hsuan Tsai

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METTL5 regulates SEPHS2-mediated selenoprotein synthesis to promote multiple myeloma survival and progression by Junyao Jiang, Fangmin Zhong, Zuomiao Xiao, Fangyi Yao, Jing Liu, Meiyong Li, Huan Zeng, Yuxiang Qiu, Jing Zhang, Haibin Zhang, Shuqi Li, Ting huang, Wenli Feng, Zhenglan Huang, Bo Huang, Xiaozhong Wang

“…Our data indicate METTL5’s function is to influence the overall translation efficiency and reprogram selenium metabolism to inhibit apoptosis. …”
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SFXN2 contributes mitochondrial dysfunction-induced apoptosis as a substrate of Parkin by Shishi Luo, Shishi Luo, Shishi Luo, Yechuan He, Yechuan He, Yaohui He, Yaohui He, Yaohui He, Danling Wang, Danling Wang, Danling Wang

“…SFXN2, a recently identified member of the mitochondrial transporter family, is localized to the outer mitochondrial membrane and regulates several critical mitochondrial functions, including iron metabolism, heme biosynthesis, bioenergetics, and redox homeostasis. …”
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INDICATION OF THE BIOCHEMICAL TARGETS OF RARE EARTH ELEMENTS IN BIVALVE MOLLUSCS UNDER MULTIPLE EXPOSURE by V. Khoma, K. Yunko, V. Martyniuk, M.Zarian, V. Havryshkiv

“…REEs in low concentrations cause adaptive metabolic responses in the mussels. The changes in the Zn distribution within the cells and Zn-dependent functions were indicated, confirming the impact of REEs on the functionality of the essential metal. …”
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Ceria nanoparticles alleviate myocardial ischemia-reperfusion injury by inhibiting cardiomyocyte apoptosis via alleviating ROS mediated excessive mitochondrial fission by Ying Sun, Jiabao Xu, Ling Zou, Yan Tan, Jie Li, Haoran Xin, Yanli Guo, Weikai Kong, Dingyuan Tian, Xinyu Bao, Xiaoqin Wan, Xiaoxu Li, Zhihui Zhang, Xiaochao Yang, Fang Deng

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Arterial hypertension treatment effectiveness in elderly patients by M. E. Statsenko, T. G. Shcherbakova, O. E. Sporova, S. V. Belenkova, Yu. V. Kalashnikova

“…Indapamide did not affect carbohydrate, purine, and electrolyte metabolism. In elderly patients with AH, six-month indapamide therapy was linked to significant improvement in quality of life and cognitive and mnestic functioning…”
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