Elevated ambient temperature reduces fat storage through the FoxO-mediated insulin signaling pathway. by Tucker Hopkins, Cole Ragsdale, Jin Seo

“…Temperature profoundly impacts all living organisms, influencing development, growth, longevity, and metabolism. Specifically, when adult flies are exposed to high temperatures, there is a notable reduction in their body fat content. …”
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The molecular determinants regulating redox signaling in diabetic endothelial cells by Swayam Prakash Srivastava, Swayam Prakash Srivastava, Swayam Prakash Srivastava, Olivia Kopasz-Gemmen, Aaron Thurman, Barani Kumar Rajendran, M. Masilamani Selvam, Sandeep Kumar, Rohit Srivastava, M. Xavier Suresh, Reena Kumari, Julie E. Goodwin, Julie E. Goodwin, Ken Inoki, Ken Inoki, Ken Inoki

“…Oxidation and reduction are vital for keeping life through several prime mechanisms, including respiration, metabolism, and other energy supplies. …”
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About atypical dyslipidemia variants in myocardial infarction and unstable angina by B. M. Lipovetsky

“…All primary DLP are hereditary, but typically they are linked to polygenic defects — i.e., are dependent on functionally important nucleotide polymorphisms in genes regulating lipid metabolism.…”
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Thyroid, neurodevelopmental, and kidney toxicities of common organic UV filters in embryo-larval zebrafish (Danio rerio), and their potential links by Ba Reum Kwon, Ah-Reum Jo, Inae Lee, Gowoon Lee, Young Joo Park, Jung Pyo Lee, Na-Youn Park, Younglim Kho, Sungkyoon Kim, Kyunghee Ji, Kyungho Choi

“…Moreover, the OUVFs exposure caused increased proteinuria in the fish, along with transcriptional changes of wt1, nephrin, podocin, and cdh17 genes, which could explain the observed reduction in kidney functions. Principal component analysis (PCA) implied the potential interplay of THs with neurogenesis, or podocyte differentiation of the larval fish. …”
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Intravenous Levosimendan versus Milrinone: Coronary Sinus Lactate and PA Catheter Derived Parameters in Patients with Pulmonary Hypertension Undergoing Elective Mitral Valve Replac... by Sanjula Virmani, Sukhdev Garg, Indira Malik, Abhas Chandra Dash, Sayyed Ehtesham Hussain Naqvi, Rachna Wadhwa, Harpreet Singh

“…Levosimendan and milrinone are increasingly being used as inodilators to treat PH and improve RV function to varying degrees, but their effect on myocardial metabolism awaits precise validation. …”
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The influence of the NRG1/ERBB4 signaling pathway on pulmonary artery endothelial cells by Jin‐Bo Huang, Qin Shen, Zhi‐Qi Wang, Song‐Shi Ni, Fei Sun, Yun Hua, Jian‐An Huang

“…Abstract This study aimed to examine the influence of the Neuregulin‐1 (NRG1)/ERBB4 signaling pathway on the function of human pulmonary artery endothelial cells (HPAECs) and investigate the underlying mechanisms. …”
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The regulatory effects of epigallocatechin gallate on growth performance, systemic antioxidant status, immune response, and gut microbiota structure in geese by Mengyu Liu, Yansong Ge, Enshuang Xu, Tingting Zhu, Hongri Ruan, Jiasan Zheng

“…Intestinal morphology demonstrated increased villus height–to–crypt depth ratios in the duodenum and ileum (P < 0.05). 16S rRNA sequencing indicated that EGCG increased the relative abundance of Akkermansia and Verrucomicrobiota (P < 0.05) in the cecal content and enriched microbial functions related to inorganic ion transport and metabolism. …”
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Cellular Cholesterol Loss Impairs Synaptic Vesicle Mobility via the CAMK2/Synapsin-1 Signaling Pathway by Atikam Qurban, Mengqi Zhang, Hengbing Zu, Kai Yao

“…Intact synaptic vesicle (SV) mobility is crucial for normal synaptic function, whereas disrupted SV mobility can trigger the synaptopathy associated with AD. …”
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Comparison of Efficacy and Safety Outcomes of Different Doses Schedules of Thalidomide for Treating Moderate-to-Severe &beta;-Thalassemia Patients by Yang WJ, Shi LD, Liang Y, Liang LM, Zhang H, Wang L, Zhou Q

“…Liver and kidney function impact was measured through tests for alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, and creatinine. …”
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Dialysis Disequilibrium: Is Acidosis More Important than Urea? by Akshay Athavale, Kate R Wyburn, Paul L Snelling, Steven J Chadban

“…Disturbance in cognition and neurologic functioning occurred six hours after the completion of initiation of intermittent haemodialysis. …”
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Bile acids in follicular fluid: potential new therapeutic targets and predictive markers for women with diminished ovarian reserve by Shu Ding, Wenyan Li, Xianglei Xiong, Manfei Si, Chuyu Yun, Yuqian Wang, Lixuan Huang, Sen Yan, Xiumei Zhen, Jie Qiao, Xinyu Qi

“…Additionally, we performed a functional enrichment analysis on differentially expressed genes (DEGs) in GCs from both DOR and NOR patients. …”
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Liuweizhiji Gegen-Sangshen beverage protects against alcoholic liver disease in mice through the gut microbiota mediated SCFAs/GPR43/GLP-1 pathway by Mingyun Tang, Mingyun Tang, Long Zhao, Long Zhao, Fuchun Huang, Fuchun Huang, Tiangang Wang, Tiangang Wang, Xu Wu, Shanshan Chen, Shanshan Chen, Juan Fu, Juan Fu, Chaoli Jiang, Chaoli Jiang, Shulin Wei, Shulin Wei, Xuseng Zeng, Xuseng Zeng, Xiaoling Zhang, Xiaoling Zhang, Xin Zhou, Xin Zhou, Mei Wei, Zhi Li, Zhi Li, Zhi Li, Guohui Xiao, Guohui Xiao

“…The Liuweizhiji Gegen-Sangshen beverage (LGS), as a functional beverage in China, is derived from a traditional Chinese herbal formula and has been clinically applied for ALD treatment, demonstrating significant efficacy. …”
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Impaired membrane lipids in ischemic stroke: a key player in inflammation and thrombosis by Qian Wang, Dandan Wang, Yan Gao, Jie Jiang, Minghui Li, Shuhui Li, Xiaowen Hu, Jinfeng Wang, Tianqi Wang, Juan Zhang, Lei Feng, Chao Quan, Ping Zhang, Lan Zheng, Chunling Wan

“…Abstract Background Membrane lipids play a crucial role in brain function and cell signalling, and they serve as key biological substrates in inflammatory responses, thrombosis, and energy metabolism. …”
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Immunological and physiological changes of exercise-released lactate on tumors: an important and new research window by Amir Hossein Ahmadi Hekmatikar, Arsham Entesari, Hossein Shirvani

“…Additionally, it has been discovered that lactate metabolism is essential for the function of anti-tumor immune cells (Ahmadi Hekmatikar et al., 2023; Heuser et al., 2023). …”
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Effects of the efficacy of the Yi Shen Tiao Gan formula on aromatase inhibitor associated musculoskeletal syndrome: a randomized controlled trial by Yan Zhang, Meiling Chu, Meina Ye, Yiqin Cheng, Hui Cong, Yulian Yin, Hongfeng Chen

“…The study observed and compared the following indicators between the two groups: the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores, Traditional Chinese Medicine symptom and sign scores, bone mineral density, bone metabolism biochemical indicators, bone metabolism-related hormones and safety assessments.ResultsIn total, 108 participants were included in the analysis. …”
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Dietary supplementation of compound probiotics to improve performance, egg quality, biochemical parameters and intestinal morphology of laying hens by Yan Wang, Yan Wang, Chaosheng Zhang, Xing Chen, Aijuan Zheng, Guohua Liu, Ying Ren, Zhimin Chen

“…In conclusion, the supplementation of compound probiotics can regulate the body metabolism and improve the intestinal morphology, thus enhancing the antioxidant capacity and immune function of the body, which in turn improves the performance and egg quality of laying hens.…”
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Schizophrenia, Nutrition and Choices in Kilojoules (SNaCK): protocol for a feasibility and acceptability randomised controlled trial of two dietary interventions by Donni Johnston, Urska Arnautovska, Andrea Baker, Ingrid J. Hickman, Hannah L. Mayr, Nicole Korman, Wolfgang Marx, Eryn Murray, Nicola Warren, Sarah Weighell, Veronica De Monte, Gemma McKeon, Dan Siskind, Scott B. Teasdale

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Content of Some Endothotelium-Dependent Vasoactive Substances in the Blood of Patients, Depending on the Liver Cirrhosis Severity and the Organism’s Redox System State by Abrahamovych M., Abrahamovych O., Fayura O., Tolopko S., Ferko M.

“…It leads to the impaired functioning of the endothelial cells that are one of the most sensitive to the reactive oxygen species cells. …”
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A putative ABC transporter gene, CcT1, is involved in beauvericin synthesis, conidiation, and oxidative stress resistance in Cordyceps chanhua by Zhimin Liu, Jiahua Zhu, Ruixue Gong, Zhiyuan Wen, Yanwen Liu, Yulong Wang, Zengzhi Li, Bo Huang, Fan Peng

“…The findings in this study enrich the understanding of the function of ABC transporter in fungal metabolism and growth and development.…”
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CHANGES IN MORPHODENSITOMETRIC PARAMETERS OF THE PARAVENTRICULAR NUCLEUS OF THE HYPOTHALAMUS IN RATS UNDER STRESS OF DIFFERENT DURATIONS by І. Федоряк, Р. Булик

“… Paraventricular nuclei of the hypothalamus play the important role in both endocrine regulation of the tropic function of the adenohypophysis and the organism's neuroendocrine response to stress of various origins, particularly sustained photoperiod disturbances. …”
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