Long term exposure to multiple environmental stressors induces mitochondrial dynamics imbalance in testis: Insights from metabolomics and transcriptomics by Shiqin Jiang, Tianli Nong, Ting Yu, Zhiyan Qin, Junyuan Huang, Zhaokun Yin, Shiqi Luo, Yating Lai, Jing Jin

“…Comprehensive multi-omics analysis revealed that long-term exposure to environmental stressors disrupted the BTB and testes, which was associated with mitochondrial metabolism disorders, including oxidative phosphorylation and fatty acid beta-oxidation, as well as glutathione and lipid metabolism alterations. …”
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Gut microbiota alterations in golden snub-nosed monkeys during food shortage and parturition-nursing periods by Guanwei Lan, Guanwei Lan, Rui Ma, Yanshan Zhou, Zhantao Lu, Zhantao Lu, Biqing Zhu, Juan Liu, Wei Wu, Yue Zhang, Jiabin Liu, Jiabin Liu, Haijun Gu, Jie Lin, Wei Wei, Dunwu Qi

“…Meanwhile, there was a notable reduction in 12 metabolism-related pathways, including those related to carbohydrates, amino acids, and lipid. …”
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Transcriptomic analysis of melatonin-mediated drought stress response genes in alfalfa during germination period by Xiaoxia Zhang, Wenxuan Zhu, Zirui Liu, Xiangling Ren, Yingao Li, Guomin Li, Jingzhuo Wang, Xiaoyan Zhu, Yinghua Shi, Chengzhang Wang, Defeng Li, Hao Sun

“…Conclusions Through the application of GO functional annotation and KEGG pathway enrichment analysis, we discovered that DEGs were predominantly enriched in pathways related to flavonoid and isoflavone biosynthesis, plant hormone biosynthesis and signal transduction, glutathione metabolism, and MAPK signaling, and the ABC transporter signaling. …”
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Impact of Plant-Based Diets on Hepatosomatic Index, Circulating Globulins and Growth in Rainbow Trout (<i>Oncorhynchus mykiss</i>) by Alejandro Villasante, Elías Figueroa, Karina Godoy, Patricio Dantagnan, Johana López-Polo, Rafael Opazo, Jaime Romero

“…Studying the effects of plant-based diets on these proteins is crucial to understanding their impact on fish health and immune function. Methods: This study was conducted in a recirculation system, with rainbow trout distributed across nine tanks and fed three diets: fishmeal (control), medium plant meal (MPM; 40% of fishmeal replacement), and high plant meal (HPM; 80% of fishmeal replacement). …”
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Dietary non-enzymatic antioxidant capacity and risk of breast cancer: the Swedish National March Cohort by Daniela Mariosa, Marta Ponzano, Alessandra Grotta, Ylva Trolle Lagerros, Essi Hantikainen, Hans-Olov Adami, Mauro Serafini, Rino Bellocco, Weimin Ye

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Novel and Highly Potent Therapeutic Agent, Trametes Robiniophila Murr (Huaier), Mitigates Pulmonary Vascular Remodeling in Rodents by Huangshu Ye, Yue Zhang, Li Hu, Yuxin Feng, Tianfan Zhu, Qi Meng, Xiaoxuan Sun, Miaojia Zhang, Zhengsheng Mao, Feng Chen, Yanfang Yu, Qiang Wang, Jie Wang

“…Methods Huaier treatment effectively mitigated hypoxia‐ and monocrotaline‐induced PH in rodent models, as evidenced by reductions in pulmonary artery pressure, right ventricular hypertrophy, and vascular remodeling. …”
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Hybrid 2-[18F] FDG PET/MRI in premanifest Huntington's disease gene-expansion carriers: The significance of partial volume correction. by Marie N N Hellem, Tua Vinther-Jensen, Lasse Anderberg, Esben Budtz-Jørgensen, Lena E Hjermind, Vibeke Andrée Larsen, Jørgen E Nielsen, Ian Law

“…Striatal atrophy and hypometabolism has been described in HD as far as 15 years before clinical onset and therefore structural and functional imaging biomarkers are the most applied biomarker modalities which call for these to be exact; however, most studies are not considering the partial volume effect and thereby tend to overestimate metabolic reductions, which may bias imaging outcome measures of interventions.…”
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Ti3C2Tx@Pt nanocomposite based colorimetric and electrochemical dual-mode platform for glucose detection by Xuming Sun, Mingyan Zhang, Jinlong Chang, Linyan Xie, Qiongqiong Ren, Wenshuai Jiang, Zhen Jin, Shiqi Pan, Xiuli Yang, Wu Ren

“…Glucose is the main source of energy in cellular metabolism and is essential for normal cellular function and growth. …”
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High temperature induces reproductive dysfunction in male zebrafish via DNA methylation-mediated tssk6 downregulation by Xuan Ma, Rongjian Liu, Zhongchang Ren, Yongmei Qi, Dongqiong Wei, Jiamin Shi, Samra., Cong Yuan, Dejun Huang

“…These findings establish an epigenetic mechanistic link between environmental HT and reproductive function in aquatic organisms.…”
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Physiological and molecular responses of juvenile silver crucian carp (Carassius gibelio) to long-term high alkaline stress: Growth performance, histopathology, and transcriptomic... by Kemeng Jiang, Wenqian Wang, Jianlin Li, Wenrong Feng, Ezra Martini Kamunga, Zhihua Zhang, Yongkai Tang

“…Genes related to carbohydrate metabolism were upregulated while those related to protein metabolism were downregulated, indicating that alkaline stress caused the organism to utilize carbohydrates rather than proteins as much as possible to meet enhanced metabolism. …”
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Dose-dependent effects of atorvastatin in the hospitalisation period of myocardial infarction by O. L. Barbarash, O. V. Gruzdeva, O. E. Akbasheva, T. S. Fedorova, A. A. Silonova, E. I. Palicheva, E. G. Uchasova, V. N. Karetnikova, V. V. Kashtalap

“…The increase in atorvastatin dose up to 40 mg was associated with a reduction in pancreatic insulin-producing function. …”
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Spatiotemporal composition and diversity of endophyte communities in Dracaena cambodiana on Hainan Island by Sipeng Li, Yang Liu, Xin Yang, Yun Yang, Junxiang Peng, Yanhong Xu, Jianhe Wei, Jianhe Wei

“…These changes indicated that metabolic pathways associated with resin metabolism, sucrose metabolism, signal transduction, and phenylalanine metabolism were likely involved in resin formation. …”
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Effect of the Several Herbal Medicines Mixture on BMI and Lipid Profile -The Animal Study by Mozhgan Mohammadzadeh, Ali Shamsizadeh, Mohammad Reza Memarzadeh, Jalal Hassanshahi, Ayat Kaeidi, Morteza Khademalhosseini, Mohammad-Reza Shafiepour

“…Furthermore, GUTAC enhanced renal function markers (BUN and creatinine) and mitigated hepatic steatosis, as evidenced by histological analysis. …”
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Docking and Molecular Dynamics Identify Leads against 5 Alpha Reductase 2 for Benign Prostate Hyperplasia Treatment by Selina A. Saah, Patrick O. Sakyi, David Adu-Poku, Nathaniel O. Boadi, Gideon Djan, Desmond Amponsah, Robert N. O. A. Devine, Kojo Ayittey

“…Steroid 5 alpha-reductase 2 (5αR-2) is a membrane-embedded protein that together with other isoforms plays a key role in the metabolism of steroids. This enzyme catalyzes the reduction of testosterone to the more potent ligand, dihydrotestosterone (DHT) in the prostate. …”
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Chronic antidiabetic sulfonylureas in vivo: reversible effects on mouse pancreatic beta-cells. by Maria Sara Remedi, Colin G Nichols

“…<h4>Background</h4>Pancreatic beta-cell ATP-sensitive potassium (K ATP) channels are critical links between nutrient metabolism and insulin secretion. In humans, reduced or absent beta-cell K ATP channel activity resulting from loss-of-function K ATP mutations induces insulin hypersecretion. …”
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First-phase insulin response (FPIR) to intravenous glucose tolerance test (IVGTT), insulin sensitivity and long-term follow-up in ?- transfusion-dependent thalassemia (TDT) normog... by Vincenzo De Sanctis

“…Objective: To  study the function of the endocrine pancreas in transfusion-dependent ?…”
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Evaluation of the antidyslipidemic and nephroprotective effect of methanolic seed extract of Lepidium sativum on male Swiss albino mice fed on deep fried palm oil by Ebsa Tofik Ahmed, Abebe Dukessa, Tigist Mateos, Welela Meka, Meskelu Seyoum Moti, Belay Zawdie

“…Increased consumption of energy dense foods are main cause of disorder on lipid metabolism and kidney function, which are primary risk factors for many chronic diseases. …”
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The role of intestinal homeostasis in sevoflurane-induced myelin development and cognitive impairment in neonatal mice by Chang Liu, Jinjie Li, Ruizhu Liu, Guoqing Zhao, Guoqing Zhao

“…There was a reduction in proteins associated with oligodendrocytes and myelin formation, which had a certain impact on memory and cognitive behavior. …”
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Dysfunctional immunity in the comorbidity of vitamin A deficiency and tuberculosis identifies therapeutic potential of vitamin A supplementation by Dr. Faye Lanni, Revanth Krishna, David Forrest Ackart, Victoria Mitcham, Sarah K Cooper, Connor King, Hadley Gary, Dr. Chuangqi Wang, Dr Brendan Podell

“…Conclusion: Collectively, these data indicate a potential compensatory role for CD8 cytotoxic T cell function in the absence of vitamin A and provides a link between dysfunctional CD4 T cells and neutrophil pulmonary pathology. …”
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Pathophysiological Significance of Urea in Glomerular Filtration Dysregulation in Hepatorenal Syndrome: An Integrative Review by Anatoliy Gozhenko, Walery Zukow, Olena Gozhenko, Olga Kvasnytska

“…Gozhenko’s Hypothesis on Urea Regulation   Professor Gozhenko fundamentally revises the traditional view of urea, proposing it as an active regulatory metabolite with critical homeostatic functions rather than a mere metabolic waste product. …”
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