Glymphatic system dysfunction in young adults hospitalized for an acute psychotic episode: a preliminary report from a pilot study by Tommaso Barlattani, Dalila De Luca, Sara Giambartolomei, Antony Bologna, Antonio Innocenzi, Federico Bruno, Valentina Socci, Maurizio Malavolta, Alessandro Rossi, Domenico de Berardis, Alessandra Splendiani, Francesca Pacitti

“…The study’s findings indicated significant reductions in the ALPS index among patients compared to controls, supporting the hypothesis of impaired glymphatic function during acute psychotic episodes. …”
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Changes in the intestinal microbiota induced by the postnatal environment and their association with hypertension by Patrizia Dardi, Camille Perella Coutinho, Sarah de Oliveira, Simone Aparecida Teixeira, Renaide Rodrigues Ferreira Gacek, Eduardo Purgatto, Marco Aurélio Ramirez Vinolo, Marcelo Nicolás Muscará, Luciana Venturini Rossoni

“…In this sense, the current study explored the influence of normotensive and hypertensive postnatal environments on the intestinal microbiota structure, composition, and functional capacity of SHR and Wistar rats. Our findings revealed significant differences in the microbiota's composition and its metabolic activity in young non-fostered SHR (SS) vs. …”
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Bioengineered platelet nanoplatform enables renal-targeted dexamethasone delivery for chronic nephritis therapy with dual anti-inflammatory/anti-fibrotic effects and minimized syst... by Lingling Zhang, Haifeng Gong, Xuelian Gong, Bing Zhou, Xijian Wang, Shengnan Fei, Donglin Xia, Chunyang Xu, Xinzhong Huang

“…This system integrates lipid nanoemulsion encapsulation with platelet-mediated hitchhiking delivery to achieve three key functionalities: (1) enhanced renal targeting demonstrated by 2.2-fold higher glomerular accumulation compared to free dexamethasone via In vivo imaging, (2) effective mitigation of glucocorticoid-induced metabolic toxicity evidenced by reduced fasting plasma glucose (5.2 ± 0.3 vs 8.3 ± 0.7 mmol/L in free DEX), suppression of hepatic gluconeogenic enzymes (PEPCK expression decreased by 43 %, G-6 Pase by 51 %, both p < 0.001), and suppressed body weight (−23.1 % versus free DEX group), and (3) dual-pathway therapeutic effects through IL-6/TNF-α suppression and p53-p21Cip1-mediated senescence delay. …”
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High-fat diet impairs microbial metabolite production and aggravates influenza A infection by Franziska Hornung, Harini K. SureshKumar, Laura Klement, Yasmina Reisser, Christoph Wernike, Vivien Nischang, Paul M. Jordan, Oliver Werz, Carsten Hoffmann, Bettina Löffler, Stefanie Deinhardt-Emmer

“…Microbial changes were analyzed via taxonomic and functional profiling and SCFA levels were measured from non-obese and obese serum donors. …”
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Dapagliflozin combined with methylcobalamin in the treatment of type 2 diabetes mellitus with peripheral neuropathy: a systematic review and meta-analysis by Xiao-Long Deng, Ren Wu, Xuan-Xia Lin, Jia-Jian Liang, Han-Wei Huang

“…BackgroundType 2 diabetes mellitus (T2DM) is a prevalent chronic metabolic disorder, with diabetic peripheral neuropathy (DPN) being one of its most common complications. …”
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Understanding HIV-Exposed Uninfected Children: A Narrative Review by Martina Salvi, Benedetta Fioretti, Maria Alberti, Irene Scarvaglieri, Stefania Arsuffi, Giorgio Tiecco, Francesco Castelli, Eugenia Quiros-Roldan

“…This narrative review explores the multisystem effects of ART exposure in HEU children, focusing on immune function, neurodevelopment, cardiovascular health, growth, and bone metabolism. …”
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The protective role of omentin-1 in IL-1β-induced chondrocyte senescence by Bin Chai, Zi-Hui Zheng, Xiang Liao, Kang-Yang Li, Jiang-Shan Liang, Yong-Xiang Huang, Chang-Jun Tong, Di-Jun Ou, Jun Lu

“…Omentin-1 is a newly identified anti-inflammatory adipokine involved in lipid metabolism. In this study, we examined the biological function of omentin-1 in cultured chondrocytes. …”
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Composite single-cell protein as a sustainable fishmeal substitute: Enhancing growth and health in largemouth bass (Micropterus salmoides) by Jian Chen, Jianqiang Huang, Ling Pan, Fuping Song, Yonghua Hu, Shuang Zhang, Yan Wang

“…Functional predictions indicated enhanced pathways in “Cell motility” and “Immune system,” with enrichment of the NOD-like receptor signaling pathway. …”
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Lysinibacillus sphaericus exposure impedes Anopheles dirus’s oviposition via downregulating vitellogenin by Shasha Yu, Zhilong Liu, Jing Wang, Hong Zheng, Shiqian Han, Feifei Zheng, Dan Zheng, Caizhi Zhao, Xin Li, Tingting Liu, Xuesen Yang, Ying Wang

“…Notably, L. sphaericus inhibit lysosomal function and lipid metabolism, which are critical for mosquito physiology. …”
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CRISPR-Cas9-mediated deletions of FvMYB46 in Fragaria vesca reveal its role in regulation of fruit set and phenylpropanoid biosynthesis by Arti Rai, Magne Nordang Skårn, Abdelhameed Elameen, Torstein Tengs, Mathias Rudolf Amundsen, Oskar S. Bjorå, Lisa K. Haugland, Igor A. Yakovlev, May Bente Brurberg, Tage Thorstensen

“…In the FvMYB46-mutant flowers, the flavanol and flavan-3-ol contents, especially epicatechin, quercetin-glucoside and kaempferol-3-coumaroylhexoside, were reduced, and we observed a local reduction in the lignin content in the anthers. Together, these results suggest that FvMYB46 controls fertility and efficient fruit set by regulating the cell wall structure, flavonoid biosynthesis, carbohydrate metabolism, and sugar and ROS signalling in flowers and early fruit development in F. vesca.…”
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Nucleoporin 153 deficiency in adult neural stem cells defines a pathological protein-network signature and defective neurogenesis in a mouse model of AD by Claudia Colussi, Alessia Bertozzi, Lucia Leone, Marco Rinaudo, Raimondo Sollazzo, Federica Conte, Elena Paccosi, Luca Nardella, Giuseppe Aceto, Domenica Donatella Li Puma, Cristian Ripoli, Maria Gabriella Vita, Camillo Marra, Marcello D’Ascenzo, Claudio Grassi

“…Abstract Background Reduction of adult hippocampal neurogenesis is an early critical event in Alzheimer’s disease (AD), contributing to progressive memory loss and cognitive decline. …”
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APOE Drives Glioma Progression by Modulating CCL5/CCR5 Signaling in the Tumor Microenvironment and Inducing M2 Macrophage Polarization by Wei Huang, Weimin Li, Xingyu Chen, Chengwei Xiang, Ke Luo

“…Immunofluorescence analysis revealed that the reduction of M2 macrophages was dependent on APOE and CCL5. …”
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Unveiling Therapeutic Potential of Yoga Mitigating Oxidative Stress and Mitochondrial Dysfunction in PCOS: A Randomized Controlled Trial by Deepika Kumari, Manoj Kumar, Ashish Datt Upadhyay, Neena Malhotra, Reeta Mahey, Vatsala Dadhwal, Tushar Sehgal, Richa Mishra, Rima Dada

“…Mitochondria is pivotal for ovarian cell functioning for instance steroidogenesis, ovarian follicle development, and energy metabolism. …”
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Renal protective role of active vitamin D3 supplement in oatients with type 2 diabetes:a meta-analysis by HE Lei, YI Xin, LIN Mei, ZHAO Tian-ya, LI Meng-si, GAO Ping

“…Objective To systematically evaluate the efficacy,safety and the renoprotective effect of active vitamin D3 treatment in patients with type 2 diabetes mellitus(T2DM).Methods Literature searches were performed with PubMed,EMBase,Google scholar,CNKI,VIP,Wanfang Date and CBM from inception to December 2014.Publications of the randomized controlled trials on the treatment of T2 DM with active vitamin D3 were included.The methodology quality of the included studies was assessed and the pooled analysis on therapeutic effect index was performed by two reviewers independently according to the criteria of the Cochrane handbook Results A total of 10 eligible RCT were included.The fixed-effect model was used to analyze urinary albumin creatinine ratio(UACR),and the pooled SMD was- 0.34(95%CI:- 0.55,- 0.12),P = 0.002,which indicated that active vitamin D3-treated group had a statistically significant reduction in UACR.The randomeffect model was used to analyze serum creatinine,and the pooled SMD was-1.27(95%CI:- 3.66,1.12),P = 0.30,which indicated that there was no statistically significant difference between experimental group and control group.In addition,active vitamin D3-treated group was more obvious than control group in terms of lowering insulin resistance,serum cholesterol,triglycerides,systolic pressure,and increasing high-density lipoprotein cholesterol(HDL-C) in patients with T2DM(P<0.05)[SMD or WMD(95%CI) was-2.69(-3.42,-1.97);-0.37(-0.63,-0.11),-0.30(- 0.56,- 0.05);- 5.94(- 9.08,- 2.80);0.33(0.03,0.63),respectively].However,there was no statistically significant difference in hemoglobin A1c(HbAlc) and diastolic pressure between experimental group and control group(P>0.05)[WMD(95%CI) was 0.06(-0.08,0.19);- 1.77(- 3.65,- 0.12),respectively].Conclusions Currently available evidence shows that active vitamin D3 is effective in improving glucose metabolism,and reducing blood lipids and blood pressure in T2 DM patients.It can also reduce proteinuria,and protect renal function to some extent…”
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Effect of exercise on postprandial lipaemia in children with sickle cell disease by Mahfoodha Al Kitani

“…These findings suggest that a single bout of exercise prior to a high-fat meal reduces postprandial TAG concentrations in children with SCD, consistent with previous studies in healthy populations. The reduction in postprandial TAG may have implications for improving endothelial function and reducing the risk of cardiovascular and vaso-occlusive events in individuals with SCD. …”
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The role of mesenchymal stem cells in peripheral nerve regeneration by N. M. Nevmerzhytska, L. M. Yaremenko, O. M. Grabovyi

“…The ability of MSCs to produce various immunoregulatory factors is also known, which leads to the reduction of an inadequate inflammatory response after nerve damage. …”
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Genome-wide association mapping identifies a new arsenate reductase enzyme critical for limiting arsenic accumulation in plants. by Dai-Yin Chao, Yi Chen, Jiugeng Chen, Shulin Shi, Ziru Chen, Chengcheng Wang, John M Danku, Fang-Jie Zhao, David E Salt

“…Complementation verified the identity of HAC1, and expression in Escherichia coli lacking a functional arsenate reductase confirmed the arsenate reductase activity of HAC1. …”
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Changes in the Brain-Derived Neurotrophic Factor Are Associated with Improvements in Diabetes Risk Factors after Exercise Training in Adolescents with Obesity: The HEARTY Randomize... by Jeremy J. Walsh, Amedeo D’Angiulli, Jameason D. Cameron, Ronald J. Sigal, Glen P. Kenny, Martin Holcik, Steve Doucette, Angela S. Alberga, Denis Prud’homme, Stasia Hadjiyannakis, Katie Gunnell, Gary S. Goldfield

“…In conclusion, exercise-induced reductions in some diabetes risk factors were associated with increases in BDNF in adolescents with obesity, suggesting that exercise training may be an effective strategy to promote metabolic health and increases in BDNF, a protein favoring neuroplasticity. …”
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Development of an in vitro model to study muscle maladaptation to overtraining by Giuseppe Sirago, Clément Lanfranchi, Justin Carrard, Vincent Gremeaux, Nadège Zanou, Nicolas Place

“…It has been reported that regeneration of skeletal muscle fibres is impaired, probably through a change in energy metabolism (Grobler et al., 2004). For instance, altered mitochondrial structure and function have been suggested (Grobler et al., 2004). …”
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Integration of single-cell sequencing and drug sensitivity profiling reveals an 11-gene prognostic model for liver cancer by Qunfang Zhou, Jingqiang Wu, Jiaxin Bei, Zixuan Zhai, Xiuzhen Chen, Wei Liang, Jing Meng, Mingyu Liu

“…An 11-gene prognostic model was constructed, effectively stratifying patient prognosis (p < 0.05) and achieving an AUC above 0.6 for 5 year survival prediction in multiple cohorts. Functional analysis revealed that upregulated genes in high-risk groups were enriched in cell adhesion pathways, while downregulated genes were enriched in metabolic pathways. …”
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