Extending Investigations of miR‐126‐5p on the Regulation of CYP2A6, the Major Nicotine‐Inactivating Enzyme by Weilong Gu, Alec W. R. Langlois, Haidy Giratallah, Katrina G. Claw, Bhagwat Prasad, Kenneth E. Thummel, Rachel F. Tyndale

“…A published molecular study of microRNA‐126‐5p, the microRNA‐126 functional arm, showed it decreased CYP2A6 expression post‐transcriptionally; it also showed that higher CYP2A7 mRNA competed for microRNA‐126‐5p binding, mitigating the CYP2A6 reduction. …”
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Gold(III) Complexes with 2-(1-Ethylbenzyl)pyridine as Promising Antimicrobial and Antitumor Agents by Antonio Zucca, Bruna Canu, Maria I. Pilo, Sergio Stoccoro, Giacomo Senzacqua, Sara Fais, Giuseppina Pichiri, Alessandra Scano

“…A preliminary study was conducted to assess the anti-cancer activity of the compounds, and treatments with the gold compounds also resulted in a significant reduction in the metabolic activity of HT29 colon cancer cells.…”
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Thermophilic microbial agents promote the fermentation progression of spent mushroom compost and pig manure by Hongbo Du, Chongchong Lu, Muhanmad Zunair Latif, Jianfeng Du, Yong Liu, Hongxin Li, Xinhua Ding

“…Overall, the application of thermophilic microbial agents not only extended the high temperature phase of composting by over 30% and shortened the composting cycle by 50%, but more importantly, it achieved comprehensive improvement in compost quality by selectively enriching functional microbial communities such as Pseudomonas. …”
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Impact of SGLT2 inhibitors on myocardial fibrosis in diabetic HFpEF: a longitudinal study by Arif Albulushi, Kimia M. Askari, Ammar M. Al-Abedi, Malak A. Al-Kulaibi, Murtadha S. Hasan, Zahra Hosseini, Mezon T. Al-Rahman, Desmond B. Tanoh, Amjad S. Hasan, Yaseen Al-Helli, Ahmed Basouni

“…Additional benefits included greater reductions in LVMI (− 8.2 g/m2 vs. − 2.1 g/m2; p = 0.002), improved glycemic control (HbA1c: − 1.2% vs. − 0.4%; p = 0.01), and enhanced functional capacity (+ 45 m vs. + 10 m in 6MWT; p = 0.01). …”
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Adaptive Resistance of <i>Staphylococcus aureus</i> to Cefquinome Sulfate in an In Vitro Pharmacokinetic Model with Transcriptomic Insights by Yue Hu, Hao Zhu, Xingbo Zhang, Yuhui Wu, Jingtao Li, Nan Li, Zhanbo Cai, Yuhui Yang

“…Transcriptome Gene Ontology (GO) analysis revealed that differentially expressed genes were involved in cellular respiration, energy derivation by oxidation of organic compounds, and oxidation–reduction processes. The differentially expressed genes identified functioned in the synthesis of cell membranes, cytoplasm, and intracellular parts. …”
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Cadmium Increases the Sensitivity of Adolescent Female Mice to Nicotine-Related Behavioral Deficits by Philip Adeyemi Adeniyi, Babawale Peter Olatunji, Azeez Olakunle Ishola, Duyilemi Chris Ajonijebu, Olalekan Michael Ogundele

“…Nicotine and cadmium increased the metabolism and food intake in the female adolescent mice. …”
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Effect of Cortexin administration on Kisspeptin and Spexin expression after testicular torsion by Ahmet Turk, Busra Zencirci, Tuba Ozcan–Metin, Ibrahim Bozgeyik, Abdullah Karadag, Seda Koçak

“… Kisspeptin–1 (KISS–1) and Spexin (SPX) are neuropeptides that play crucial roles in metabolism and sexual function, with their expression levels in tissues potentially influenced by antioxidant treatments. …”
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The TOR Signaling Pathway Governs Fungal Development, Virulence and Ustiloxin Biosynthesis in <i>Ustilaginoidea virens</i> by Yuejiao Li, Shuqin Sun, Guangsheng Li, Zezhong Yang, Yuqi Xing, Ruixiang Wang, Yuanhu Xuan, Xiurong Yang

“…The target of rapamycin (TOR) signaling pathway acts as a master regular in regulating cell growth and secondary metabolism in fungi. However, little is known about the function of the TOR pathway in regulating fungal development, pathogenicity and mycotoxin biosynthesis in <i>U. virens</i>. …”
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Secondary stroke prevention beyond antiplatelets: The role of colchicine and GLP-1RA – an ounce of prevention is worth a pound of cure by Milija D. Mijajlović, Natan M. Bornstein, Vuk Aleksić

“…GLP-1RA drugs work by mimicking the effects of GLP-1, a peptide that regulates insulin release and glucose metabolism. They also exhibit anti-inflammatory properties, potentially reducing stroke risk through mechanisms such as improved endothelial function and reduced plaque formation. …”
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Organic cation transporter 3 on neuronal mitochondria mediates MPP+-induced mitochondrial dysfunction and neurotoxicity in a TIMM22-dependent manner by Ao Guan, Sida Han, Suzhen Liang, Weiwei Shen, Min Guo, Mei Cui

“…Abstract Background Mitochondria play crucial roles in cellular metabolism, and metabolite compartmentalization significantly impacts mitochondrial function and disease pathophysiology. …”
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CRABP proteins – relatives or homonyms? by E. M. Tchevkina, I. A. Favorskaya

“…The data pointing on either oncogenic or tumor-suppressive functions are given for each protein.…”
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Prediction of lesion-based response to PRRT using baseline somatostatin receptor PET by Anas Aouf, Tilman Speicher, Arne Blickle, Moritz B. Bastian, Caroline Burgard, Florian Rosar, Samer Ezziddin, Amir Sabet

“…SUVmax, SUVmean (automated segmentation with a 50% SUVmax threshold), and corresponding tumor-to-liver ratios (SUVmaxT/L and SUVmeanT/L) were calculated. Functional tumor response was assessed based on the relative change in metabolic tumor volume (%ΔTVPET). …”
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Case Report: Sympathetic nerve block treat chronic kidney disease-associated pruritus by Ying Li, Yaohua Chen, Jingyi Nie, Xiaoguang Huang, Weiwei Zhang

“…The results demonstrated significant reductions in pruritus intensity concurrent with measurable enhancements in sleep quality and daily functioning.…”
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RETRACTED ARTICLE: Effect of radiotherapy on head and neck cancer tissues in patients receiving radiotherapy: a bioinformatics analysis-based study by Zhenjie Guan, Jie Liu, Lian Zheng

“…A comparison of ssGSEA scores related to glucose and lipid metabolism between the two groups indicated a reduction in glycolysis, tricarboxylic acid cycle activity, and fat synthesis in tissues treated with radiotherapy, suggesting that radiotherapy can effectively inhibit tumour cell energy metabolism. …”
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Integrative Analysis of the Methylome, Transcriptome, and Proteome Reveals a New Mechanism of Rapeseed Under Freezing Stress by Guoqiang Zheng, Zigang Liu, Jinxiong Wang, Jiaping Wei, Xiaoyun Dong, Hui Li, Ying Wang, Haiyang Tian, Zefeng Wu, Junmei Cui

“…A total of 6776 unique differentially methylated genes (DMGs), 4285 unique differentially expressed genes (DEGs), and 269 unique differentially abundant proteins (DAPs) were identified between the two cultivars under T1 and T2 freezing stress. Function enrichment analysis revealed that these genes were involved in signal transduction, biosynthesis of unsaturated fatty acids, sugar metabolism, peroxidase, peroxisome, photosynthesis, and additional pathways. …”
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Identification, Characterization, and Ultrastructure Analysis of the Phenol-Degrading <i>Rhodococcus erythropolis</i> 7Ba and Its Viable but Nonculturable Forms by Valentina N. Polivtseva, Anton N. Zvonarev, Olesya I. Sazonova, Yanina A. Delegan, Yulia N. Kocharovskaya, Alexander G. Bogun, Nataliya E. Suzina

“…The following distinctive features were found: modifications (thickening) of cell membranes, cell size reduction, nucleoid condensation. Functional analysis of the genome showed the presence of genes for the degradation of alkanes, and two branches of the β-ketoadipate pathway for the degradation of aromatic compounds. …”
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Dynamic relationship between gut microbiota and post-necrotizing pancreatitis: insights from a multi-stage 16S rRNA sequencing study by Jiongdi Lu, Jiongdi Lu, Zhe Wang, Zhe Wang, Feng Cao, Feng Cao, Jia Li, Guofeng Ji, Guofeng Ji, Fei Li, Fei Li

“…Functional prediction suggested disruptions in cellular processes, including apoptosis and necroptosis, and links to pathways associated with inflammatory and metabolic diseases. …”
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Analysis of cognitive status in patients with type 2 diabetes by Irina V. Gatckikh, Marina M. Petrova, Olga F. Veselova, Tatyana P. Shalda, Artem N. Narkevich, Irina N. Brickman

“…In patients with type 2 diabetes prevailed violations fronto-subcortical type with a reduction in short-term memory function, attention and constructive praxis. …”
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Effects of m6A methylation of MAT2A mRNA regulated by METTL16 on learning and memory, hippocampal synaptic plasticity and Aβ1–42 in 5 × FAD mice by Huan Chen, Huan Chen, Fangzhen Guo, Fangzhen Guo, Yan Zhao, Yan Zhao, Wei Liu, Bingyu Chen, Bingyu Chen, Chang Wang, Chang Wang, Lining Huang, Lining Huang, Lining Huang, Sufang Jiang, Sufang Jiang, Sufang Jiang, Xiaowei Ma, Huiling Ren, Huiling Ren, Sha Li, Sha Li, Sha Li, Huixian Cui, Huixian Cui

“…However, the precise mechanisms underlying these associations remain elusive.MethodsThis study employed the overexpression of methyltransferase-like protein 16 (METTL16), or overexpression of methionine adenosyltransferase 2A (MAT2A), or a combination of METTL16 overexpression with MAT2A knockdown to explore the influence of METTL16 on the regulation of MAT2A in cognitive function, hippocampal synaptic plasticity, and amyloid-beta (Aβ1–42) metabolism in 5 × FAD mice.ResultsOur findings indicated a reduction in m6A methylation levels and the expression of METTL16 and MAT2A in the hippocampus of 5 × FAD mice. …”
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Investigation of the astringency-masking effect of ι-carrageenan on natural polyphenols and its differential mechanism at various concentrations by Qiang Yu, Yifan Zhang, Jun Liu, Xue Han, Mengqi Li, Junzhi Lin, Taigang Mo, Li Han, Haozhou Huang, Dingkun Zhang

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