Abnormal gut microbiota may cause PD-1 inhibitor-related cardiotoxicity via suppressing regulatory T cells by Huili Cao, Huwei Dai, Songshan Li, Zeeshan Afzal, Xinyan Wang, Zeyu Wen, Kaiyong Xiao, Yajing Zhao, Jin Li, Bin Yang

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Research Progress on Human Ovarian Aging Using Non-Human Primates as Laboratory Animals by XIAO Wenxian, LÜ Longbao

“…The ovary has two main functions: folliculogenesis and hormone secretion, both of which are closely related to female fertility. …”
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Molecular characterization of adipose tissue in the African elephant (Loxodonta africana). by Emeli M Nilsson, Hernan P Fainberg, Siew S Choong, Thomas C Giles, James Sells, Sean May, Fiona J Stansfield, William R Allen, Richard D Emes, Alison Mostyn, Nigel P Mongan, Lisa Yon

“…Adipose tissue (AT) is a dynamic and flexible organ with regulatory roles in physiological functions including metabolism, reproduction and inflammation; secreted adipokines, including leptin, and fatty acids facilitate many of these roles. …”
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Distinct roles for the thioredoxin and glutathione antioxidant systems in Nrf2-Mediated lung tumor initiation and progression by Amanda M. Sherwood, Basma A. Yasseen, Janine M. DeBlasi, Samantha Caldwell, Gina M. DeNicola

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MiR-147b-3p promotes osteogenesis by targeting NDUFA4 and PI3K/AKT pathway by Yuanyuan Guo, Kai Shen, Zhijie Li, Changchun Niu, Yang Luo

“…Therefore, further investigation is warranted to elucidate the function and underlying mechanism of miR-147b-3p in osteogenic differentiation. …”
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Congenital T-cell activation impairs transitional-to-follicular B-cell maturation in humans by Hugues Allard-Chamard, Kirsty Hillier, Michelle L. Ramseier, Alice Bertocchi, Naoki Kaneko, Katherine Premo, Grace Yuen, Marshall Karpel, Vinay S. Mahajan, Christina Tsekeri, Joseph S. Hong, Jean Vencic, Rory Crotty, Anish V. Sharda, Sara Barmettler, Emma Westermann-Clark, Jolan E. Walter, Musie Ghebremichael, Alex K. Shalek, Jocelyn R. Farmer, Shiv Pillai

“…We observed a marked reduction in transitional-to-follicular (FO) B-cell development in patients with CTLA4 deficiency, correlating with decreased CTLA4 function in regulatory T cells, increased CD40L levels in effector CD4+ T cells, and increased mammalian target of rapamycin complex 1 (mTORC1) signaling in transitional B cells (TrBs). …”
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EVALUATION OF THE EFFICACY AND SAFETY OF A GLYCOSAMINOGLYCAN-PEPTIDE COMPLEX IN THE TREATMENT OF KNEE OSTEOARTHRITIS IN PATIENTS WITH PREVIOUS INEFFICIENCY OF SLOW-RELEASE ORAL ANT... by A. E. Karateev, L. I. Alekseeva, A. M. Lila, S. A. Makarov, N. V. Chichasova, E. V. Zonova, N. G. Kashevarova, E. A. Taskina, E. P. Sharapova

“…At 8 and 12 weeks, VAS pain scores decreased by 30.1±18.3% and 36.9±16.9%, respectively; the reductions in WOMAC pain scores were 29.8±16.3 and 38.2±23.4%; WOMAC stiffness scores, 29.2±15.4 and 31.6±17.4%; WOMAC function scores, 27.7±14.7 and 30.6±18.4%; and total WOMAC scores, 27.2±13.5 and 33.6±18.0%. …”
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Development of a method for assessing the depth of penetration of ethosomes with methylene blue into the skin during application and photodynamic exposure by A. G. Loginova, I. S. Nikitenko, G. V. Tikhonovsky, A. S. Skobeltsin, A. V. Voitova, V. B. Loschenov

“…Among these advantages, the following are distinguished – minimal injury, reduction of side effects, and prevention of degradation or metabolism in the gastrointestinal tract or liver. …”
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Association between diaphragm excursion and whole-body muscle mass in older adults: an observational study by Shuji Ouchi, Toru Yamada, Takahiro Shinohara, Suguru Mabuchi, Kazuharu Nakagawa, Kanako Yoshimi, Ayane Horike, Tatsuya Mayama, Kenji Toyoshima, Yoshiaki Tamura, Atsushi Araki, Ryoichi Hanazawa, Akihiro Hirakawa, Hiroyuki Ichige, Takeshi Ishida, Takuma Kimura, Haruka Tohara, Masayoshi Hashimoto

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Proteomic analysis reveals the alleviation of follicular development defects in offspring mice under DEHP exposure by melatonin by Jing-Cai Liu, Yuan-Jing Zou, Kun-Huan Zhang, Yi-Ming Ji, Yue Wang, Shao-Chen Sun

“…Molecular docking results indicated that DEHP/MEHP/melatonin binds to HSD17B2 to form a stable conformation, which may explain the reduction in 17β-estradiol induced by DEHP. Moreover, melatonin restored granulosa cell proliferation, reduced oxidative stress and DNA damage-related apoptosis, enhanced mitochondrial function, and protected ovarian cells. …”
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Some aspects of morphogenesis of diabetic encephalopathy by V. A. Tumanskiy, Yu. N. Avramenko

“…Despite great number of works on complications of diabetes mellitus of types I and II, abnormalities of cognitive functions of central nervous system are less studied. …”
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Phenotypic screen of early-developing larvae of the blood fluke, schistosoma mansoni, using RNA interference. by M M Mourão, Nathalie Dinguirard, Glória R Franco, Timothy P Yoshino

“…., although application of this technology as a functional genomic profiling tool has yet to be explored. …”
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Protective Role of Tangshen Formula on the Progression of Renal Damage in db/db Mice by TRPC6/Talin1 Pathway in Podocytes by Qian Wang, Xuefei Tian, Wei’e Zhou, Yan Wang, Hailing Zhao, Jialin Li, Xuefeng Zhou, Haojun Zhang, Tingting Zhao, Ping Li

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Cell-free supernatant of Levilactobacillus brevis (RAMULAB51) from coconut inflorescence sap (Neera) enhances glucose uptake and PPAR-γ in 3T3-L1 adipocytes and inhibits α-glucosid... by Chandana Kumari V B, Ramith Ramu, Prithvi S. Shirahatti, Perwez Alam, Ling Shing Wong

“…By inhibiting these digestive enzymes, RAMULAB51 reduces the conversion of carbohydrates into glucose, thereby decreasing blood glucose levels. This reduction in circulating glucose subsequently influences adipocyte function, as evidenced by the enhanced glucose uptake (1000 µg/mL) and upregulation of PPAR-γ, C/EBPα, Adiponectin, and Glut-4, alongside the downregulation of FAS.ConclusionThe study highlights RAMULAB51’s potential for improving glucose and lipid metabolism. …”
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Liver-Targeting Nanoparticles GA-MSe@AR Treat NAFLD Through Dual Lipid-Lowering and Antioxidant Efficacy by Lei S, Wu Q, Zhang B, Lu M, Xia Y, Li N

“…Additionally, its effects on inflammation and pancreatic function were analyzed in vivo.Results: Network pharmacology analysis revealed AR may against NAFLD through regulating metabolism, inflammation, and oxidative stress. …”
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2 kDa Hyaluronic Acid Reduces Blemishes and Sagging in Human Facial Skin by Ito S, Kurihara H, Kuriyama K, Kimura M, Tokudome Y

“…Hyaluronic acid (HA) is involved in many biological processes, including collagen metabolism, wound healing, and skin barrier function. …”
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Evaluation of Packaging Effects on the Phenolic Profile and Sensory Characteristics of Extra Virgin Olive Oil During Storage Using Liquid Chromatography Coupled with Mass Spectrome... by Mohamed M. Abuhabib, Francesc M. Campins-Machado, Julián Lozano-Castellón, Antònia Ninot, Agustí Romero-Aroca, Rosa M. Lamuela-Raventós, Maria Pérez, Anna Vallverdú-Queralt

“…The health benefits of extra virgin olive oil (EVOO), including improved cardiovascular health and metabolic function, are linked to its phenolic content. …”
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Mendelian randomization reveals probucol’s preventive role in Behçet’s disease via circulating metabolites by Zhang Hongchen, Zhang Yijia, Xu Yubo, Zhong Jianguang, Sun Mouyuan, Li Jian, Li Jin

“…This disease often disrupts lipid metabolism, adversely affecting vascular endothelial function. …”
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Efficacy of a Soft Wearable Robot for Hip Assistance in Chronic Stroke Patients: A Randomized Crossover Trial by Seung-Hyeon Han, Sanguk Choi, Chanyoung Ko, Jong Weon Lee, Kyoungchul Kong, Dong-Wook Rha, Deog Young Kim

“…Notable outcomes include a 14.9% reduction in oxygen cost during SWR-assisted walking compared to unassisted walking, underscoring its metabolic benefits. …”
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Efficacy and safety of micro-fragmented adipose tissue combined with knee arthroscopy in the treatment of knee osteoarthritis: a systematic review by Xinyu Hu, Zhongyi Zhang, Wen Zhang, Ning Wang, Shuaijie Lv, Chentong Pan, Peijian Tong

“…All studies reported significant pain reduction (VAS score improvement: 44.4%-62.2%) and varying degrees of joint function improvement (WOMAC, KOOS, Lysholm scores). …”
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