Primary congenital hypothyroidism: a clinical review by Paolo Cavarzere, Valentina Mancioppi, Riccardo Battiston, Valentina Lupieri, Anita Morandi, Anita Morandi, Claudio Maffeis, Claudio Maffeis

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SLC44A2 negatively regulates mitochondrial fatty acid oxidation to suppress colorectal progression by blocking the MUL1-CPT2 interaction by Ying Yang, Longlong Zheng, Jiaxing He, Tao Wu, Haicheng Yang, Bo Zhang, Shuai Zhou, Yueyue Lu, Xianli He, Jibin Li, Nan Wang

“…However, the effects of SLC44A2 on malignant phenotypes and mitochondrial metabolism in human cancers remain unexplored. In the present investigation, we observed a significant reduction in SLC44A2 expression in colorectal cancer (CRC), and low SLC44A2 expression was closely associated with poorer survival of CRC patients. …”
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FEATURES OF FREE RADICAL OXIDATION AND ANTIOXIDANT PROTECTION IN CHILDREN WITH SUGAR DIABETES OF THE FIRST TYPE by I. M. Bykov, L. G. Ivchenko, D. A. Domenyuk, N. Yu. Kostyukova, A. P. Storozhuk, D. M. Ilijev

“…Reduction of reactive oxygen species production, reduced activation rate оxygendependent metabolism phagocytes incompleteness phagocytosis mechanisms, correlating with an increase in lesion area (destruction of insulin-producing β-cells) of the pancreas in children with decompensated type 1 diabetes, indicating the occurrence of the third step (debilitation) oxidative stress. …”
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JMJD3 deficiency disturbs dopamine biosynthesis in midbrain and aggravates chronic inflammatory pain by Xi-Biao He, Fang Guo, Wei Zhang, Jiacheng Fan, Weidong Le, Qi Chen, Yongjun Ma, Yong Zheng, Sang-Hun Lee, Hui-Jing Wang, Yi Wu, Qinming Zhou, Rui Yang

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Various endurance training intensities improve GFR and Up-regulate AQP2/GSK3β in lithium-induced nephropathic rats by Shadan Saberi, Mohammad Amin Rajizadeh, Mohammad Khaksari, Azadeh Saber, Mohammad Akhbari, Soheil Aminizadeh, Forouzan Rafie

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Bifidobacterium animalis subsp. Lactis BX-BC08 modulates gut microbiota and secretes alpha-Ketoglutaric acid to alleviate MC903-induced atopic dermatitis by Jiamin Zhao, Ling Kui, Jinqun Huang, Jie Deng, Lingjun Liu, Chenwei Zhu, Yanqiang Shi, Chengyi Li, Yue Xiao, Jinshi Yu, Qing Li, Bin Yang, Bingfeng Leng, Hung Chan

“…Functional validation in the murine AD model demonstrated that AKG strongly suppressed T helper 2 (Th2)-driven pro-inflammatory responses. …”
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Increased Insulin Secretion and Glucose Effectiveness in Obese Patients with Type 2 Diabetes following Bariatric Surgery by Roberto Visentin, Katrine Brodersen, Bjørn Richelsen, Niels Møller, Chiara Dalla Man, Andreas Kristian Pedersen, Jan Abrahamsen, Jens Juul Holst, Michael Festersen Nielsen

“…., sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB), are procedures both known to induce weight loss, increase insulin action, and enhance β-cell function, but hepatic insulin extraction and glucose effectiveness may also play a role. …”
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A Multicenter, Randomized, Open-Label Study to Compare the Effects of Gemigliptin Add-on or Escalation of Metformin Dose on Glycemic Control and Safety in Patients with Inadequatel... by Hae Jin Kim, Jung Hyun Noh, Min Kyong Moon, Sung Hee Choi, Seung-Hyun Ko, Eun-Jung Rhee, Kyu Yeon Hur, In-Kyung Jeong

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Mitochondria-targeted nanovesicles for ursodeoxycholic acid delivery to combat neurodegeneration by ameliorating mitochondrial dysfunction by Shizheng Zhang, Mengmeng Li, Yuan Li, Shike Yang, Jian Wang, Xiaoxiang Ren, Xiuhui Wang, Long Bai, Jianping Huang, Zhen Geng, Guosheng Han, Yibin Fang, Jiacan Su

“…Herein, artificial NVs are loaded with UDCA and then functionalized with triphenylphosphonium (TPP) molecules, denoted as UDCA-NVs-TPP. …”
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Injectable platelet-mimicking silk protein-peptide conjugate microspheres for hemostasis modulation and targeted treatment of internal bleeding by Yajun Shuai, Yu Qian, Meidan Zheng, Chi Yan, Jue Wang, Peng Wang, Jie Wang, Chuanbin Mao, Mingying Yang

“…Furthermore, these microspheres exhibit favorable metabolic kinetics, with 71% degradation occurring within one-day post-subcutaneous injection. …”
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EFFICACY OF COMBINED ANTIHYPERTENSIVE THERAPY IN ACHIEVEMENT OF TARGET BLOOD PRESSURE IN DIABETIC PATIENTS by O. A. Koshel'skaya, O. A. Zhuravleva, R. S. Karpov

“…Target BP was achieved in 86.7% of patients. Evenly reduction of day and night BP without reflex tachycardia and hypotension episodes was observed. …”
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Remodeling of adipose tissue at experimental diabetes mellitus by O. A. Konovalova, A. M. Kamyshnyi

“…The aim of research The aim of this study was to investigate the morphological and functional state of parapancreatic fibre adipocytes in male Wistar rats in experimental diabetes mellitus. …”
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Parenteral Nutrition with Oliclinomel N8-800 in Patients with Hypercatabolism during Extended Abdominal Surgery by V. A. Zyryanov, V. V. Stets, A. E. Shestopalov, G. M. Klimova, M. D. Lyubimov, N. G. Panova

“…The glucose-electrolyte solution and standard enteral formula were intraintestinally administered as the absorptive and digestive functions of the small bowel recovered. On postoperative days 7 and 8, the parenteral nutrition was stopped and completely switched to enteral feeding. …”
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Effectiveness of Digital Health Interventions on Sedentary Behavior Among Patients With Chronic Diseases: Systematic Review and Meta-Analysis by Yan Zhang, Fei Wan Ngai, Qingling Yang, Yao Jie Xie

“…The functions included facilitating self-monitoring of SB, reminding interruption of long undisturbed sitting, and promoting goal attainment. …”
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Mucosal microbiota signatures reveal diagnostic insights in chronic liver disease by Sadık Dinçer, Yakup Ülger, Anıl Delik

“…The intestinal microbiota acts as a bioreactor for autonomous metabolic and immunological functions in regulating the host’s response to external stimuli in the intestinal microbiota. …”
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Lactococcus lactis I7 isolated from traditional Italian cheese making: a biotechnological integrated platform by Alberto Alfano, Darshankumar Parecha, Alessandra Fusco, Vittoria Savio, Ida De Chiara, Lidia Muscariello, Giovanna Donnarumma, Chiara Schiraldi

“…In this study, a Lactococcus lactis strain identified and isolated from natural whey starter cultures of cow milk for the production of artisanal cheeses was cultivated in optimized vegan grade medium to assess its growing ability and metabolic fingerprint. In fact, traditionally fermented dairy products are considered nutritionally complete and possibly functional to human health with a number of benefits not only to the gastro-intestinal tract but also in a systemic manner. …”
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Effect of puerarin administration on serum NOD-like receptor protein 3 (NLRP3) inflammasome, C1Q/TNF-related protein 3 (CTRP3) and lipoprotein-associated phospholipase 2 (LP-PLA2)... by Wang Ge, Tang Qisheng, Wang Dan

“…Outcomes were assessed using electrocardiograms, laboratory tests, and cardiac function evaluations. Results: Relative to the controls, the study subjects had a reduction in the number of angina episodes and an increase in exercise tolerance. …”
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Characterization of the regulatory network and pathways in duodenum affecting chicken abdominal fat deposition by Zhijie Liu, Sibei Cheng, Xing Zhang, Miaomiao Yang, Jixiang Wei, Fei Ye, Zheng Ma, Huimin Kang, Zhengfen Zhang, Hua Li, Hai Xiang

“…A total of 36 DEmRNAs, 170 DElncRNAs, 92 DEcircRNAs and 88 DEmiRNAs were identified as differentially expressed between chickens with extremely high and low abdominal fat deposition. The functional enrichment analyses demonstrated that the differentially expressed RNA in the duodenum were involved in the regulation of chicken abdominal fat deposition by mediating a series of metabolic pathways, including the Wnt signaling pathway, the PPAR signaling pathway, the Hippo signaling pathway, the FoxO signaling pathway, the MAPK signaling pathway and other signaling pathways that are involved in fatty acid metabolism and degradation. …”
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The environmental adaptation of acidophilic archaea: promotion of horizontal gene transfer by genomic islands by Jingxuan Qiu, Huiling Tao, Hongyu Li, Xinyi Liu, Rui Liu, Muhammed Naveed Nawaz, Xingjie Wang, Liyuan Ma

“…In the majority of GIs, the GC content was lower than the average GC content of the strain genome, suggesting that GIs were typically looped out of the genomes with poor stability and transferred into those with higher stability. tRNAs with classical stem-loop secondary structures have been found at the ends of several GIs, suggesting that GIs frequently integrate near tRNAs. In contrast to functional genes directly involved in cellular life processes, GIs were more likely to carry genes related to genetic information and metabolism. …”
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The crystal structures of the tryparedoxin-tryparedoxin peroxidase couple unveil the structural determinants of Leishmania detoxification pathway. by Annarita Fiorillo, Gianni Colotti, Alberto Boffi, Paola Baiocco, Andrea Ilari

“…Structural analyses bring out key structural features to elucidate LmTXN and LmTXNPx function. LmTXN displays an unusual N-terminal α-helix which allows the formation of a stable domain-swapped dimer. …”
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