Discovery of a distinct type of methylenetetrahydrofolate reductase family that couples with tetrahydrofolate-dependent demethylases by HongYang Yu, Naofumi Kamimura, Ryo Kato, Michelle Jane Genoveso, Miki Senda, Eiji Masai, Toshiya Senda

“…Abstract Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in one-carbon (1C) metabolism, catalyzing the reduction of methylenetetrahydrofolate to methyltetrahydrofolate. …”
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Halymenia durvillei Extracts Exert Antiobesity Effects by Targeting hosl‐1‐Mediated Lipolysis in a Glucose‐Induced Caenorhabditis elegans Model by Kawita Chumphoochai, Sukrit Promtang, Pawanrat Chalorak, Preeyanuch Manohong, Nakorn Niamnont, Montakan Tamtin, Prasert Sobhon, Simon Tuck, Krai Meemon

“…Furthermore, transcriptomic analysis revealed diverse metabolic activities in glucose‐induced worms treated with HDEA, affecting fatty acid metabolism. …”
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Single-cell transcriptomic atlas of the chicken cecum reveals cellular responses and state shifts during Eimeria tenella infection by Jun-Hao Tu, Bo-Gong Liu, Bing-Jin Lin, Hui-Chao Liu, Song-Chang Guo, Qing-Yuan Ouyang, Ling-Zhao Fang, Xi He, Ze-He Song, Hai-Han Zhang

“…These findings highlight the substantial impact of E. tenella on epithelial integrity and immune responses, emphasizing the parasite’s role in disrupting nutrient absorption and energy metabolism. Our single-cell atlas serves as a critical resource for understanding the cellular architecture of the chicken cecum and provides a valuable framework for future investigations into cecal diseases and metabolic functions, with potential applications in enhancing poultry health and productivity.…”
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LONG-TERM THERAPY WITH INDAPAMIDE IN ELDERLY AND SENILE PATIENTS WITH HYPERTENSION: CARDIORENOPROTECTIVE EFFECTS AND INFLUENCE ON QUALITY OF LIFE by M. E. Statsenko, T. G. Sherbakova, S. V. Belenkova, O. E. Sporova

“…The indapamide reduced left ventricle mass, improved renal function, vessel resistance and quality of life. Negative influence of long-term therapy with indapamide on lipid, glucose, purine metabolism and serum potassium level was not observed.Conclusion. …”
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Research progress on the role of exercise-regulated reactive astrocytes in the prevention and treatment of Parkinson’s disease by Quan Yang, Chunyu Zhuang

“…Astrocytes generally perform protective roles, such as the release of neurotrophic factors, glutamate metabolism, transfer of healthy mitochondria to neurons, and maintenance of the blood-brain barrier. …”
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Genomic survey of the non-cultivatable opportunistic human pathogen, Enterocytozoon bieneusi. by Donna E Akiyoshi, Hilary G Morrison, Shi Lei, Xiaochuan Feng, Quanshun Zhang, Nicolas Corradi, Harriet Mayanja, James K Tumwine, Patrick J Keeling, Louis M Weiss, Saul Tzipori

“…Only one E. bieneusi protein with assigned function had no E. cuniculi homolog. The shared proteins were, in general, evenly distributed among the functional categories, with the exception of a dearth of genes encoding proteins associated with pathways for fatty acid and core carbon metabolism. …”
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Effect of Oregano Essential Oil on Growth and Composition of Gut Prokaryote Microbiota on Striped Bass (<i>Morone saxatilis</i>) by Dora Alejandra Trejo-Ramos, César Omar Rodríguez-Arana, Roberto Cruz-Flores, Mónica Hernández-Rodríguez

“…The predicted functions shifted from nutritional (OEO75) to replication, proliferation, and bacterial defense mechanisms (OEO100 and OEO125). …”
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Resolution of experimental malaria-associated acute respiratory distress syndrome is Alox12 independent and shows residual inflammation by Fran Prenen, Bram De Pauw, Sofie Knoops, Emilie Pollenus, Hendrik Possemiers, Johan Van Weyenbergh, Philippe E. Van den Steen

“…Further bioinformatic analysis of the Nanostring data revealed persistent T cell-driven inflammation, partial reduction in JAK/STAT signalling, altered chemokine expression and incomplete metabolic recovery during the resolution phase of MA-ARDS. …”
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Comparison of clinical and pharmacodynamic features of proton pump inhibitors efficacy in gastroesophageal reflux disease by O. A. Storonova, A. S. Trukhmanov

“…Intensity of acid-suppressive action of PPI depends on drug metabolic pathways and genetically determined features of cytochrome P450 system. …”
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Risk factors for sarcopenia in cirrhotic patients under evaluation for liver transplantation. by Karla E. Pérez-Reséndiz, Yvonne Tadeo-Jiménez, Aleida Bautista-Santos, Rosalba Moreno-Alcántar

“…Results: 63 patients with liver cirrhosis on a liver transplant protocol were included, with a predominance of female sex (74.6%), whose most frequent etiology was steatotic liver disease associated with metabolic dysfunction (MASLD) (27%), mostly Child- Pugh Functional Class. …”
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Physiologically based pharmacokinetic modeling to predict the effect of risperidone on aripiprazole pharmacokinetics in subjects with different CYP2D6 genotypes and individuals wit... by Fan Mou, Zhiwei Huang, Yu Cheng, Xue Zhao, Xiujia Sun, Huafang Li, Shunying Yu

“…However, in individuals with mild hepatic impairment and CYP2D6 normal metabolizer, a dose reduction of approximately 11% was advised when aripiprazole was combined with risperidone. …”
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In-vivo Hepatoprotective Evaluation of Sicyos edulis on Wistar Albino Rats by Karisma Borah, Devid Chutia, Manodeep Chakraborty, Ananya Bhattacharjee, Nihar Ranjan Bhuyan

“… The liver is known for synthesising enzymes, metabolism, and excretion of drugs and food. However, during biological processes, the abnormality occurs in the liver, which becomes a significant global health burden in humans, characterised by loss of synthetic function, breakdown of blood, irregular vitamin K, and localised, permanent changes to parenchymal cells. …”
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Transcriptomic analysis of the toxic effects and potential mechanisms of fenvalerate on the liver of Odontobutis potamophila by Guoxing Liu, Tian Zhu, Zihan Zhou, You Zheng, Yanhua Zhao, Chen Hao, Shuyan Ding, Xiuhui Tan, Qichen Jiang

“…Gene Ontology enrichment analysis showed significant DEGs enrichment in pathways such as DNA integration, obsolete oxidation-reduction process, regulation of DNA-templated transcription, etc. in C0.5, and in pathways such as obsolete oxidation-reduction process, translation, structural constituent of ribosome, etc. in C2. …”
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Breaking the Cycle: Enhancing Cardiovascular Health in the Elderly Through Group Exercise by Lovorka Bilajac, Mihaela Marinović Glavić, Zulle Kristijan, Bilobrk Matea, Denis Juraga, Ana Jelaković, Tomislav Rukavina, Vanja Vasiljev, Bojan Jelaković

“…Results revealed significant reductions in systolic blood pressure (mean −3.4 mmHg) and pulse pressure among hypertensive participants, highlighting improved cardiovascular function. …”
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Oligodendrocyte precursor cells facilitate neuronal lysosome release by Li-Pao Fang, Ching-Hsin Lin, Yasser Medlej, Renping Zhao, Hsin-Fang Chang, Qilin Guo, Zhonghao Wu, Yixun Su, Na Zhao, Davide Gobbo, Amanda Wyatt, Vanessa Wahl, Frederic Fiore, Szu-Min Tu, Ulrich Boehm, Wenhui Huang, Shan Bian, Amit Agarwal, Marcel A. Lauterbach, Chenju Yi, Jianqin Niu, Anja Scheller, Frank Kirchhoff, Xianshu Bai

“…These contacts facilitate exocytosis of neuronal lysosomes. A reduction in the number or branching of OPCs reduces these contacts, which is associated with lysosome accumulation and altered metabolism in neurons and more senescent neurons with age. …”
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Exploring the Potential of Ribes nigrum L., Aronia melanocarpa (Michx.) Elliott, and Sambucus nigra L. Fruit Polyphenol-Rich Composition and Metformin Synergy in Type 2 Diabetes Ma... by Katarzyna Zima, Barbara Khaidakov, Laura Banaszkiewicz, Krzysztof Lemke, Paulina Karolina Kowalczyk

“…Furthermore, hepatic analyses unveiled a modulation in cellular pathways, suggesting a potential influence on lipid metabolism, attenuation of inflammatory pathways, a decrease in cellular stress response, and antioxidant defense mechanisms, collectively implying a potential reduction in liver fat accumulation. …”
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Role of astrocytes and microglia in hepatic encephalopathy associated with advanced chronic liver disease: lessons from animal studies by Wouter Claeys, Anja Geerts, Lien Van Hoecke, Christophe Van Steenkiste, Roosmarijn E. Vandenbroucke

“…Its clinical impact is highlighted by a notable increase in patient mortality rates and a concomitant reduction in overall quality of life. Systemically, liver disease, liver function failure, portosystemic shunting, and associated multi-organ dysfunction result in the increase of disease-causing neurotoxins in the circulation, which impairs cerebral homeostasis. …”
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Cell differentiation controls iron assimilation in the choanoflagellate Salpingoeca rosetta by Fredrick Leon, Jesus M. Espinoza-Esparza, Vicki Deng, Maxwell C. Coyle, Sarah Espinoza, David S. Booth

“…Similar to their animal relatives, we found that the model choanoflagellate, S. rosetta, divides metabolic functions between distinct cell types. One cell type uses an iron reductase to acquire ferric colloids, a key source of iron in the ocean. …”
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An integrated physiology and proteomics analysis reveals the response of wheat grain to low temperature stress during booting by Anmin Zhang, Zihong Li, Qirui Zhou, Jiawen Zhao, Yan Zhao, Mengting Zhao, Shangyu Ma, Yonghui Fan, Zhenglai Huang, Wenjing Zhang

“…Moreover, the activities of sucrose synthase (SuS, EC 2.4.1.13) and ADP-glucose pyrophosphorylase (AGPase, EC 2.7.7.27) exhibited a significant reduction, leading to a significant reduction in the contents of amylose and amylopectin. …”
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The Roles of AMPK in Revascularization by Ming-Hong Chen, Qiong-Mei Fu

“…Usually, AMPK can be activated by ADP or AMP, upstream kinases or other cytokines, and pharmacological agents, and then it phosphorylates key molecules that are involved in energy metabolism, autophagy, anti-inflammation, oxidative stress, and aging process to keep cellular homeostasis and finally keeps cell normal activity and function. …”
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