Echocardiographic and biomarker characteristics in diabetes, coronary artery disease or both: insights from HOMAGE trial by Luca Monzo, Masatake Kobayashi, João Pedro Ferreira, Zohra Lamiral, Christian Delles, Andrew L. Clark, Frank Edelmann, Arantxa González, Stephane Heymans, Pierpaolo Pellicori, Johannes Petutschnigg, Job A. J. Verdonschot, Patrick Rossignol, John G. F. Cleland, Faiez Zannad, Nicolas Girerd, on behalf of the HOMAGE “Heart Omics in AGEing” Trial Committees and Investigators

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DYNAMICS OF DATA OF DIFFERENTIAL WHITE BLOOD CELL COUNT IN PATIENTS WITH GENERALIZED PERIODONTITIS WITH DIFFERENT BLOOD GROUPS by Y.L. Bandrivsky

“…Conclusions Thus, in patients with GP endogenous intoxication phenomena can be traced, which, according to the grading scale, corresponds to a slight degree of severity and is due to metabolic disorders, barrier functions of the membranes, regulatory systems, excessive presence of inflammatory mediators, and microbial toxins of immuno-foreign products. …”
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Temporal network analysis of gut microbiota unveils aging trajectories associated with colon cancer by Ziqi Chen, Zhipeng Zhang, Bei Ning Nie, Wei Huang, Ying Zhu, Long Zhang, Meng Xu, Mengfei Wang, Chenyue Yuan, Ningning Liu, Xinyi Wang, Jianhui Tian, Qian Ba, Ziliang Wang

“…Functionally, the CRC-associated microbiome showed an increase in pathways related to DNA repair, cell cycle regulation, and metabolic activities, such as the Citrate cycle and Galactose metabolism, underscoring distinct microbial alterations in CRC patients that could influence disease onset and progression. …”
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The role of immunity in comorbid pain and depression by Antonella Ciaramella, Giancarlo Carl

“…Various other mechanisms, including changes in the function of the glutamatergic, GABAergic, and serotonergic systems are also implicated, but inflammation-induced reduction of BDNF (brain-derived neurotrophic factor) appears to be the deciding factor. …”
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The Putative Role of the Antiageing Protein Klotho in Cardiovascular and Renal Disease by Giuseppe Maltese, Janaka Karalliedde

“…Ageing is a multifactorial process often characterized by a progressive decline in physiological function(s). Ageing can and is often associated with an increased incidence of cardiovascular and renal disease. …”
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Echinochrome pigment attenuates diabetic nephropathy in the models of type 1 and type 2 diabetes by Amel Mahmoud Soliman, Ayman Saber Mohamed, Mohamed-Assem Said Marie

“…Administration of echinochrome improves renal function and ameliorates renal histopathological changes possibly by improvement of glucose metabolism and inhibition of lipid peroxidation process.…”
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VERY LOW CALORIE DIETS AFFECT LONG TERM WEIGHT LOSS AND HEALTH OUTCOMES: A SYSTEMATIC REVIEW by Sheila Amara Putri, Shintia Yunita Arini, Dominikus Raditya Atmaka, S.Gz, MPH, Ardyanisa Raihan Kusuma, Anisah Firdaus Rahmawati, Mutiara Arsya Wijanarko, Norfezah Md Nor, Nadiatul Syima Mohd Shahid

“…VLCD benefits include improved insulin sensitivity, reduced fat, and better heart function, but it may have temporary negative effects on metabolism, aortic elasticity, constipation, sensitivity to cold, headache, and dizziness. …”
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Auricular Acupressure Versus an Intermittent Low-Carbohydrate Diet in Children With Overweight or Obesity With Gastric-Heat and Dampness-Obstruction Syndrome: Protocol for a Random... by Wen Sun, Jingwei He, Wenqin Wang, Chen Lu, Yating Lin, Yalan Dou, Weili Yan, Jian Yu

“…Secondary outcomes included body weight, waist circumference, waist-to-height ratio, BMI, blood pressure, body fat content, indexes of liver and renal function, indexes of glucose metabolism, gut microbiota, and TCM syndrome scores at the end of 1 month and 3 months, respectively. …”
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Spatial ecology of the Neisseriaceae family in the human oral cavity by Jonathan J. Giacomini, Julian Torres-Morales, Floyd E. Dewhirst, Gary G. Borisy, Jessica L. Mark Welch

“…Plaque specialists showed metabolic versatility, with adaptations in nitrogen metabolism, including nitrate reduction and denitrification, lysine degradation, and galactose metabolism. …”
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Serum creatine kinase elevation following tyrosine kinase inhibitor treatment in cancer patients: Symptoms, mechanism, and clinical management by Hang Zhang, Kenneth K. W. To

“…While the TKIs are mostly well tolerated, they were reported to increase serum levels of creatine kinase (CK) and cause muscle metabolism‐related toxicity. CK is an essential enzyme involved in cellular energy metabolism and muscle function. …”
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Comparative effectiveness of various combined interventions for type 2 diabetes and obesity: a systematic review and network meta-analysis by Li Cui, Donglei Lu, Sijie Tan, Liquan Cao

“…PMT improved lipid metabolism and insulin sensitivity by reducing stress hormone levels and modulating endocrine and nervous system functions. …”
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Effect of fiber-modified kombucha tea on gut microbiota in healthy population: A randomized controlled trial (RCT) by Beatriz Arce-López, Guadalupe X. Bazan, Susana Molina, Maria Carmen Crespo, María García-Beccaria, Silvia Cruz-Gil, Cristina M. Fernández-Díaz, Ana Ramírez de Molina, Ricardo Ramos-Ruiz, Maria Isabel Espinosa-Salinas

“…These findings suggest its promise as a functional beverage for improving metabolic and gut health in healthy individuals. …”
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Markers of intracellular energy supply under conditions of hypoxia in premature babies by O.S. Godovanets

“…The well-being of the intrauterine environment and birth, morphological and functional maturity at birth are the basis for the child’s postnatal adaptation. …”
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Integrative bulk RNA analysis unveils immune evasion mechanisms and predictive biomarkers of osimertinib resistance in non-small cell lung cancer by Ling Shi, Feng Qiu, Chao Shi, Guohua Zhang, Feng Yu

“…Functional enrichment analyses revealed critical pathways, including p53 signaling and metabolic reprogramming, underlying resistance mechanisms. …”
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Single cell transcriptomic analysis reveals transcriptome differences of different cells between eosinophilic chronic rhinosinusitis with nasal polyps and non-eosinophilic chronic... by Ying Jin, Yuanshan Liang, Zhijun Wang, Yiting Jiang, Fayang Yuan, Tian Zhang

“…Furthermore, there were notable discrepancies in the numbers and functionality of immune cells between eCRSwNP and neCRSwNP. …”
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Impact of rhizosphere quantitative microbiome and soil properties on alkaloid levels in Lycoris aurea herb by Guang-hua Liu, Jianglin Li, Long-Xia Yan, Hong-Ping Deng, Miao-Hua Quan, You-Wei Zuo

“…Linear discriminant analysis revealed distinct variations in bacterial and fungal taxa, with the high-alkaloid content group containing ten bacterial indicators, such as Kitasatospora and Acidimicrobiaceae, and ten fungal taxa, including Boletales, Vandijckomycella and Sclerodermataceae. Functional annotations of microbial taxa revealed differences in metabolic functions such as chitinolysis and nitrate reduction in the high alkaloid groups, respectively. …”
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Development of technology for obtaining and formulating high-protein potato food products with a low glycemic index by V. V. Shilov, V. V. Litvyak, A. A. Zhurnya, Yu. F. Roslyakov, T. V. Okulova, A. M. Mazur

“…The research takes into account the growing problems with insufficient protein intake in the diet, and focuses on the need to develop new functional foods that can meet the needs of the modern population.The methods. …”
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Cardiac specific knock-down of peroxisome proliferator activated receptor α prevents fasting-induced cardiac lipid accumulation and reduces perilipin 2. by Natasha Fillmore, Natasha Fillmore, Vincent Hou, Junhui Sun, Danielle Springer, Elizabeth Murphy

“…Interestingly, cPPAR-/- hearts also had reduced Plin2, a key protein involved in lipid accumulation and lipid droplet regulation, which may contribute to the reduction in cardiac lipid accumulation. Overall, this suggests that a decline in cardiac PPARα may blunt cardiac lipid accumulation by decreasing Plin2 and that independent of differences in systemic metabolism a decline in cardiac PPARα does not seem to drive pathological changes in the heart.…”
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Design and Evaluation of RNA Aptamer–Mediated Delivery of C/EBPβ siRNA for Oncological Therapy by D. Vasconcelos, M. H. Sodergren, V. Reebye, J. Vasara, M. S. Song, K. Holm, S. E. Khorsandi, J. Rossi, N. Habib, K. W. Huang

“…In murine models of metastatic PDAC and cirrhotic HCC, treatment with TfR-siCEBPB was associated with reduction in tumor burden and improvement in liver function biomarkers. …”
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Study on the Toxicological Impacts of Intraperitoneal Microcystin-LR Injection on GIFT Tilapia (<i>Oreochromis niloticus</i>) Through Multi-Omics Analysis by Haizheng Wu, Haojun Zhu, Quanjie Li, Jiancao Gao, Jinliang Du, Liping Cao, Yi Sun, Gangchun Xu

“…At the phylum level, the relative abundances of Firmicutes and Bacteroidota significantly decreased; at the genus level, several genera, including <i>Bacteroides</i> and <i>Pseudomonas</i>, also exhibited significant changes. Functional prediction indicated that the affected pathways were primarily related to metabolism and disease. …”
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