Transcriptomic Analysis Reveals the Biosynthesis Mechanism of Coixol Under Salicylic Acid Treatment by Yao Wang, Hanli Ye, Xuqin Luo, Ziwei Li, Chuanqi Zheng, Dali Sun

“…The bioaccumulation of coixol was mainly through benzoxazinoid biosynthetic metabolic pathway (ko00402). Conclusions: These findings not only pointed the way for increasing the content of coixol in cultivation but also provided a reference for further elucidation of the gene functions involved in the bioaccumulation of coixol.…”
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PIEZO1 activity promotes stemness in mesenchymal stem cells under shear stress and enhances protection of leukemia cells by Amit Sharma, Jina Bhattacharyya, Piruthivi Sukumar, Bithiah Grace Jaganathan

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Nb-FAR-1: A key developmental protein affects lipid droplet accumulation and cuticle formation in Nippostrongylus brasiliensis. by Wenmin Qi, Fei Shen, Chuyue Wang, Juan Wen, Xi Pan, Zhongying Zhao, Lihua Xiao, Yaoyu Feng, Dongjuan Yuan

“…The offspring L3s in Nb-far-1 RNAi group had a reduction in lipid droplets within the subcuticle and the swelling of the perioral epidermis, accompanied with down-regulated expression of enzymes in amino acid and glycerolipid metabolism and glycometabolism for growth by RNA-seq data. …”
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Dopaminergic changes in the subgenual cingulate cortex in dementia with lewy bodies associates with presence of depression by Lina Gliaudelytė, Steven P. Rushton, Rolando Berlinguer-Palmini, Alan J. Thomas, Christopher M. Morris

“…The subgenual anterior cingulate cortex (sgACC) is important in mood regulation and in the symptomatic expression of depression, displaying structural, functional and metabolic abnormalities in MDD. To assess dopaminergic and serotonergic synaptic changes in DLB, post mortem sgACC tissue from DLB donors with and without depression was investigated using high-resolution stimulated emission depletion (STED) microscopy, as well as Western and dot blotting techniques. …”
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Cell-autonomous light sensitivity via Opsin3 regulates fuel utilization in brown adipocytes. by Mari Sato, Tadataka Tsuji, Kunyan Yang, Xiaozhi Ren, Jonathan M Dreyfuss, Tian Lian Huang, Chih-Hao Wang, Farnaz Shamsi, Luiz O Leiria, Matthew D Lynes, King-Wai Yau, Yu-Hua Tseng

“…Interestingly, anatomical profiling of GPCRs reveals that Opn3 mRNA is highly expressed in adipose tissue. The photosensitive functions of Opn3 in mammals are poorly understood, and whether Opn3 has a role in fat is entirely unknown. …”
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Dysregulatory Changes in the Lymphocytic Antiradical Defense System in Severe Concomitant Brain Injury by T. F. Sokolova, V. T. Dolgikh, T. I. Dolgikh, Yu. V. Yemelyanov, N. Ye. Turok

“…The posttraumatic inactivation of the enzymes is associated with their baseline levels: the higher activity of an enzyme is seen in the lymphocytes of a healthy organism and accordingly its implication in the inactivation of excess products of free radicals, the more significant reduction is in its activity in injury. The abnormal changes in the metabolic resource of the lymphocytic antioxidative system, occurring in the early stages of traumatic disease, persisted within 3 weeks and they tended to normalize only by day 30. …”
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Sleep duration, sleep disturbances and skeletal muscle mass change over time: A population-based longitudinal analysis in Peru [version 4; peer review: 1 approved, 2 approved with... by Enrique S. Nuñez-del-Arco, Renzo A. Agurto-García, Rodrigo M. Carrillo-Larco, J. Jaime Miranda, Antonio Bernabe-Ortiz

“…Background The skeletal muscle has mainly a structural function and plays a role in human’s metabolism. Besides, the association between sleep quality and muscle mass, in the form of sarcopenia, has been reported. …”
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Multi-omics analysis reveals the efficacy of two probiotic strains in managing feline chronic kidney disease through gut microbiome and host metabolome by Hsiao-Wen Huang, Tzu-Chien Kuo, Tzu-Chien Kuo, Ya-Jane Lee, Ya-Jane Lee, Ming-Ju Chen, Ming-Ju Chen

“…Gut dysbiosis has been implicated in the progression of chronic kidney disease (CKD), yet the functional alterations of the microbiome and their links to host metabolism in feline CKD pathophysiology remain unclear. …”
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CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome by Marta Luna‐Sánchez, Agustín Hidalgo‐Gutiérrez, Tatjana M Hildebrandt, Julio Chaves‐Serrano, Eliana Barriocanal‐Casado, Ángela Santos‐Fandila, Miguel Romero, Ramy KA Sayed, Juan Duarte, Holger Prokisch, Markus Schuelke, Felix Distelmaier, Germaine Escames, Darío Acuña‐Castroviejo, Luis C López

“…Abstract Coenzyme Q (CoQ) is a key component of the mitochondrial respiratory chain, but it also has several other functions in the cellular metabolism. One of them is to function as an electron carrier in the reaction catalyzed by sulfide:quinone oxidoreductase (SQR), which catalyzes the first reaction in the hydrogen sulfide oxidation pathway. …”
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Butyric Acid Modulates Gut Microbiota to Alleviate Inflammation and Secondary Bone Loss in Ankylosing Spondylitis by Ke You, Lianjun Yang, Zhihai Su, Jun Shen, Xinyang Fan, Yuanqing Guo, Zhen Yuan, Hai Lu

“…Furthermore, BA was found to impact the intestinal barrier function positively. Notably, BA was associated with the downregulation of harmful inflammatory factors and the reversal of bone loss, suggesting its protective effects against AS. …”
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Efficacy and potential pharmacological mechanism of Astragalus-Salvia miltiorrhiza combination in diabetic nephropathy: integrating meta-analysis, network pharmacology, molecular d... by Huiyu Liang, Zedong Chen, Mingmin Zhu, Jingying Zhong, Shufan Lin, Jianfeng Chen, Jing Yuan, Pingping Jiang, Xiaoshan Zhao, Ya Xiao

“…Specifically, AS has been shown to enhance renal function, ameliorate renal fibrosis, and positively influence iron metabolism. …”
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Right-sided hemicolectomy in 90-year-old patient with cecum cancer by A. M. Sidorenko, T. A. Semenova, V. V. Varvarov

“…In 70 years the basal metabolic rate is 60% of normal, which means slowing down of metabolism and expression of anesthetics. …”
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Paroxetine alleviates dendritic cell and T lymphocyte activation via GRK2-mediated PI3K–AKT signaling in rheumatoid arthritis by Tingting Liu, Chao Jin, Jing Sun, Lina Zhu, Chun Wang, Feng Xiao, Xiaochang Liu, Liying Lv, Xiaoke Yang, Wenjing Zhou, Chao Tan, Xianli Wang, Wei Wei, Xiangxiang Pan

“…Additionally, paroxetine inhibited the PI3K–AKT–mTOR metabolic pathway in both DCs and T cells. This was associated with a reduction in mitochondrial membrane potential and changes in the utilization of glucose and lipids, particularly in DCs. …”
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PINK1 modulates Prdx2 to reduce lipotoxicity‐induced apoptosis and attenuate cardiac dysfunction in heart failure mice with a preserved ejection fraction by Hao Zhang, Tianyu Xu, Xiyuan Mei, Qiming Zhao, Qiling Yang, Xianghui Zeng, Zhuang Ma, Haobin Zhou, Qingchun Zeng, Dingli Xu, Hao Ren

“…Abstract Introduction Heart failure with preserved ejection fraction (HFpEF) is a complex condition characterized by metabolic dysfunction and myocardial lipotoxicity. …”
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The effect of an interval training course on nitric oxide levels, insulin resistance, and some blood lipid factors in type 2 diabetic male rats by Roohollah i Mohammadi Mirzae, Hamid Malekshahi, Halimeh Vahdatpoor

“…Conclusion: Six weeks of intermittent exercise improved glucose metabolism and vascular function in the diabetic rats by reducing insulin resistance and increasing NO levels, suggesting its potential as a non-pharmacological therapy for diabetes-related endothelial dysfunction.…”
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Effects of combined exposure to heavy metals on lower respiratory flora and its role of lung injury in rats by Ping Ding, Xiaoxia Wang, Nan Li, Shuxia Yu, Shuxia Yu, Yiwen Zhang, Junpu Yu, Tian Tian, Rentong Chen, Bin Luo, Li Ma, Rongxuan Zhang, Rongxuan Zhang

“…Microbial community structure and function were further analyzed using LEfSe, PICRUSt2, and ecological network analysis.ResultsCompared exposure to Ni, Cu, and As induced dose-dependent lung damage, including inflammation, alveolar deformation, and bronchial thickening, accompanied by significant declines in lung function, including a 21.2% reduction in tidal volume and a 34.5% increase in airway resistance in the high-dose group (P < 0.05). …”
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Metagenome association study of the gut microbiome revealed biomarkers linked to chemotherapy outcomes in locally advanced and advanced lung cancer by Zhe Zhao, Kailun Fei, Hua Bai, Zhijie Wang, Jianchun Duan, Jie Wang

“…The composition, diversity, function, and metabolic pathway analysis were compared among patients with different clinical outcomes. …”
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Efficacy of paleolithic diet in control of blood glucose level in type 2 DM patients by Nagy Nageh Abdo Sous, Manal El Sayed Ezz Eldeen, Mohammed Abbas El-Masry, Hany Ahmed Muhammed Khalil

“…Dietary strategies play a crucial role in the management of T2DM, and the Paleolithic Diet (PD), which emphasizes whole, unprocessed foods, has demonstrated potential in enhancing glycemic control and overall metabolic function. However, its comparative efficacy against standard treatments remains a subject of ongoing debate. …”
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Glufosinate constrains synchronous and metachronous metastasis by promoting anti‐tumor macrophages by Alessio Menga, Marina Serra, Simona Todisco, Carla Riera‐Domingo, Ummi Ammarah, Manuel Ehling, Erika M Palmieri, Maria Antonietta Di Noia, Rosanna Gissi, Maria Favia, Ciro L Pierri, Paolo E Porporato, Alessandra Castegna, Massimiliano Mazzone

“…These results identify GS as a druggable enzyme to rewire macrophage functions and highlight the potential of targeting metabolic checkpoints in macrophages to treat cancer metastasis.…”
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Differentially expressed whey proteins of donkey and bovine colostrum revealed with a label-free proteomics approach by Mohan Li, Qilong Li, Haikun Yu, Xiumin Zhang, Dehao Li, Wanying Song, Yan Zheng, Xiqing Yue

“…Gene Ontology analysis revealed that these DEWPs were mainly related to cellular components, such as extracellular exosome, plasma membrane, and mitochondrion; biological processes, such as oxidation-reduction process, cell-cell adhesion, and small guanosine triphosphate (GTP) ase-mediated signal transduction; and molecular functions, such as GTP binding, GTPase activity, and soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein receptor activity. …”
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