Prescribing Medications in Patients with Decompensated Liver Cirrhosis by Deepak N. Amarapurkar

“…Though there is no predictable test which can be used to determine drug dosage in patients with decompensated liver cirrhosis, drugs with first pass metabolism require reduction in oral dosages, for high clearance drugs both loading and maintenance dosages need adjustment, for low clearance drugs maintenance dose needs adjustment, whenever possible measuring drug level in the blood and monitoring of adverse events frequently should be done. …”
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Fungal-mediated synthesis of multimetallic nanoparticles: mechanisms, unique properties, and potential applications by Amanpreet K. Sidhu, Sanskruthi B. Agrawal, Naveen Verma, Priya Kaushal, Madhvi Sharma

“…In addition to highlighting the structural diversity of MMNPs, such as core-shell, alloy, and Janus configurations, this review investigates the mechanisms underpinning fungal-mediated synthesis, including enzymatic reduction and stabilisation pathways. Additionally covered are characterisation methods for examining functionality, morphology, and composition. …”
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Metformin and Diammonium Glycyrrhizinate Enteric-Coated Capsule versus Metformin Alone versus Diammonium Glycyrrhizinate Enteric-Coated Capsule Alone in Patients with Nonalcoholic... by Rong Zhang, Keran Cheng, Shizan Xu, Sainan Li, Yuqing Zhou, Shunfeng Zhou, Rui Kong, Linqiang Li, Jingjing Li, Jiao Feng, Liwei Wu, Tong Liu, Yujing Xia, Jie Lu, Chuanyong Guo, Yingqun Zhou

“…Anthropometric parameters, liver function, lipid profile, serum ferritin (SF), metabolic parameters, liver/spleen computed tomography (CT) ratio, and fibroscan value were evaluated at baseline and after 8, 16, and 24 weeks of treatment. …”
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Female pseudohermaphroditism due to classical 21-hydroxylase deficiency and insulin resistance in a girl with Turner syndrome by M Emre Atabek, Selim Kurtoğlu, Mehmet Keskin

“…We conclude that chronic hypersecretion of androgen precursors due to an inborn error of metabolism can induce a reduction in insulin sensitivity. …”
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Flavor compound geraniol induces inhibited nutrient utilization and developmental toxicity on embryonic–larval zebrafish by Yumin Luo, Run Han, Zhengyu Ren, Nana Ai, Shaowen Yu, Simon Ming‐Yuen Lee, Wei Ge, Ying Chen, Ying Zheng

“…Transcriptome analysis reveals that under geraniol treatment, 248 differentially expressed genes (DEGs) are downregulated, whereas 23 DEGs are upregulated, and 110 DEGs are related to metabolic process. Biological processes of lipid metabolism, carbohydrate metabolism, protein hydrolysis, and transmembrane transport, including their involved functional genes, are all downregulated. …”
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Lysophosphatidylethanolamine improves diastolic dysfunction by alleviating mitochondrial injury in the aging heart by Guiwen Xu, Wei Xiao, Pengqi Sun, Yuanjun Sun, Xinyu Yang, Xiaomeng Yin, Yang Liu

“…Studies also show that aberrant mitochondrial lipid metabolism impairs mitochondrial function in aging cardiomyocytes. …”
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Efficacy of Shenkang Injection combined with renin-angiotensin-aldosterone system blockers in diabetic nephropathy: a systematic review and meta-analysis of randomized controlled t... by Xinyue Zhang, Xuyuan Lao, Shengchun Liao, Chaoyang Ye, Chen Wang

“…No publication bias was detected for TER, SCr, BUN, 24h-UTP, TG, and adverse reactions, though UPER and TC showed potential bias.Conclusion SKI combined with RAAS blockers may enhance renal function and metabolic profiles in DN patients. Further high-quality RCTs are needed to validate these findings and assess long-term safety.…”
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Sulfur-rich deposits associated with the deep submarine volcano Fani Maoré support broad microbial sulfur cycling communities by Stéven Yvenou, Mélanie Le Moigne, Olivier Rouxel, Johanne Aubé, Blandine Trouche, Cécile Cathalot, Emmanuel Rinnert, Xavier Philippon, Sandrine Chéron, Audrey Boissier, Vivien Guyader, Yoan Germain, Anne Godfroy, Erwan G. Roussel, Karine Alain

“…Estimation of the cultivable microbial fraction revealed a diversity of microorganisms, with high growth rates for sulfur reduction, sulfate reduction with dihydrogen, and sulfur oxidation. …”
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The effects of elastic band resistance training on serum levels of growth differentiation factor 11, myostatin, and insulin resistance in overweight elderly women by Akbar Azamian Jazi, Elias Abdellah

“…Even though these two factors have similar structural and signaling pathways, they can have different functions, and the available information about their effects on the regeneration of degenerated muscles during old age is contradictory. …”
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The landscape of renal protein S-acylation in mice with lipid-induced nephrotoxicity by Fangrui Xiu, Zhibo Gai, Peter Gehrig, Witold E. Wolski, Museer A. Lone, Michele Visentin

“…Further in vitro experiments indicated that S-acylation inhibition results in a reduction of megalin protein level. We conclude that diet-induced derangement of fatty acid metabolism modifies the renal landscape of the S-acylated proteome during the early stages of the kidney injury, which might reduce the efficiency of protein reabsorption by the proximal tubule.…”
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Metabolomics and proteomics insights into hepatic responses of weaned piglets to dietary Spirulina inclusion and lysozyme supplementation by Cátia Falcão Martins, Manolis Matzapetakis, David M. Ribeiro, Josipa Kuleš, Anita Horvatić, Nicholas Guillemin, Peter David Eckersall, João P. B. Freire, André M. Almeida, José A. M. Prates

“…The addition of lysozyme further improved these benefits by reducing some of the negative impacts on growth and enhancing nutrient digestibility, tissue regeneration, and overall metabolic balance. Together, Spirulina and lysozyme demonstrate potential as functional dietary components, but further optimization is needed to fully realize their benefits without compromising growth performance.…”
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Disclosing the benefits of multi-strain compounds and their health impact mechanisms utilizing intestinal biomimetic technology by Jiahao Liao, Jiahao Liao, Jianyu Huang, Xiaoqiong Li, Jian Kuang, Jianqiang Li, Weiwei Wang, Weiwei Wang, Jinjun Li

“…Our findings revealed that 4P demonstrated excellent capabilities for producing short-chain fatty acids, modulating intestinal gas metabolism, and regulating oxidative-reduction potential. …”
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Effect of glycemic control on lymphocyte subsets in the dissemination of pulmonary tuberculosis: A retrospective analysis by Yujun Lin, Xiaohong Chen, Jiangwei Chen, Di Wu

“…Diabetes mellitus impairs immune function, worsening tuberculosis (TB) outcomes. Methods: This retrospective study investigates the effect of glycemic control on immune function and TB dissemination in 1,768 TB patients (2022–2024). …”
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Sleep duration, sleep disturbances and skeletal muscle mass change over time: A population-based longitudinal analysis in Peru [version 3; peer review: 1 approved, 2 approved with... by Enrique S. Nuñez-del-Arco, Renzo A. Agurto-García, Rodrigo M. Carrillo-Larco, J. Jaime Miranda, Antonio Bernabe-Ortiz

“…Background The skeletal muscle has mainly a structural function and plays a role in human’s metabolism. Besides, the association between sleep quality and muscle mass, in the form of sarcopenia, has been reported. …”
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Analysis of Amino Acid Profiles in Bone, Oil, and Muscle Tissue and Wound Healing Activity of Pangasius hypophthalmus Oil in Rattus norvegicus by Hidayaturrahmah Hidayaturrahmah, Agik Suprayogi, Novriyandi Hanif, Katrin Roosita, Huda Shalahudin Darusman, Lia Aprilyana

“… Patin (Pangasius hypophthalmus), a commercially important freshwater fish, is a rich source of protein containing both essential and non-essential amino acids, crucial for various biological functions. This study aimed to determine the amino acid composition of muscle tissue, oil, and bones of P. hypophthalmus and evaluate the wound healing potential of its oil extract in Rattus norvegicus. …”
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Transcriptomic response of marine dinoflagellate Prorocentrum cordatum to phosphorus deficiency by Vera Kalinina, Olga Palii, Pavel Safonov, Sergei Skarlato, Mariia Berdieva

“…Under phosphorus deficiency, dinoflagellates exhibit changes in their feeding regime, alterations in transporters functioning, a reduction in cell proliferation rate and, in some cases, a transition to sexual reproduction. …”
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Restoration of high-mountain lakes: effects on nutrient concentrations and biological communities by Silvena Boteva, Ivan Traykov, Boyanka Angelova, Anelia Kenarova

“…Changes in bacterial metabolism were characterised by a reduction in metabolic activity, a shift from preferential utilisation of carbohydrates and polymers to an increased use of carboxylic acids and a decrease in functional richness and diversity, followed by partial recovery. …”
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Astral-based DIA proteomics analysis reveals the effects of selenium on Pleurotus pulmonarius by Chengxuan Xu, Lijuan Qian, Qi Meng, Xiangru Meng, Yujun Sun

“…DEPs in PP-Se2 were predominantly involved in carbon metabolism, ribosomes, peroxisomes, and ABC transporters. …”
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ENPP1 affects insulin action and secretion: evidences from in vitro studies. by Rosa Di Paola, Nunzia Caporarello, Antonella Marucci, Claudia Dimatteo, Claudia Iadicicco, Silvia Del Guerra, Sabrina Prudente, Dora Sudano, Claudia Miele, Cristina Parrino, Salvatore Piro, Francesco Beguinot, Piero Marchetti, Vincenzo Trischitta, Lucia Frittitta

“…Our data clearly indicate that ENPP1, especially when the Q121 variant is operating, affects insulin signaling and glucose metabolism in skeletal muscle- and liver-cells and both function and survival of insulin secreting beta-cells, thus representing a strong pathogenic factor predisposing to insulin resistance, defective insulin secretion and glucose metabolism abnormalities.…”
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MdUGT88F4 involved in the synthesis of isosalipurposide positively regulates the salt stress response of apple plants by Ying Ye, Yanrong Hu, Yuan Liu, Cheng Yu, Kun Zhou, Fengwang Ma, Xiaoqing Gong

“…In order to verify whether it had biological function in apple plants, we generated transgenic apple plants overexpressed MdUGT88F4 and treated them with salt stress. …”
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