A Comparative Study of N-Acetyl Cysteine, Rosuvastatin, and Vitamin E in the Management of Patients with Non-Alcoholic Steatohepatitis: A Randomized Controlled Trial by Amr Y. Zakaria, Rehab Badawi, Hasnaa Osama, Mona A. Abdelrahman, Asmaa M. El-Kalaawy

“…<b>Results</b>: The analyzed groups demonstrated a significant reduction in steatosis and lipid peroxidation (<i>p</i> < 0.05). …”
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Integrative proteomic and lipidomic analysis of GNB1 and SCARB2 knockdown in human subcutaneous adipocytes. by Takuya Kitamoto, Aya Kitamoto

“…Our findings highlight the significant roles of GNB1 and SCARB2 in lipid metabolism and adipocyte function, providing insights that could inform therapeutic strategies targeting these regulatory genes in obesity.…”
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The results of correction of endothelial dysfunction in type 2 diabetes mellitus in patients with diabetic retinopathy and associated hypertension by L. K. Moshetova, I. V. Vorobieva, D. N. Gigineishvili, E. A. Neshkova, V. A. Metelskaya, N. G. Gumanova, V. I. Alekhnovich, G. V. Podguzov

“…Purpose:Studying the dynamics of clinical functional and morphological status of the retina against the metabolic and antiischemic therapy of retinopathy in type 2 diabetes associated with hypertension based on indicators in the tear fluid and serum nitric oxide metabolites.Methods: Following a standard ophthalmologic examination of 50 patients, among which are the two groups are similar in age andsex. …”
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Research advances in the molecular regulatory mechanisms of fruit coloration in fruit trees by MA Shurui, CHI Fumei, SONG Yang

“…In epigenetics, long-chain noncoding RNAs (lncRNAs) and microRNAs (miRNAs) play a significant role in the accumulation of anthocyanins by regulating transcription factors or chromatin remodeling to influence anthocyanin metabolism. Chlorophyll plays a core role in photosynthesis, and it also has antioxidant, anti-inflammatory, anti-cancer and anti-obesity medical and health care functions. …”
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Hypoglycaemia after Initiation of CFTR Modulator Therapy in a Cystic Fibrosis Patient without Diabetes by Marie Yskout, Joke Vliebergh, Hakan Bor, Lieven Dupont, Natalie Lorent, Pascal Van Bleyenbergh, Pieter Gillard, Bart Van der Schueren, Ann Mertens, Chantal Mathieu, Roman Vangoitsenhoven

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In Vitro CO-Releasing and Antioxidant Properties of Sulfonamide-Based CAI-CORMs in a H₂O₂-Stimulated Human Achilles Tendon-Derived Cell Model by Emanuela Berrino, Paolo Guglielmi, Fabrizio Carta, Simone Carradori, Cristina Campestre, Andrea Angeli, Francesca Arrighi, Virginia Pontecorvi, Paola Chimenti, Daniela Secci, Claudiu T. Supuran, Marialucia Gallorini

“…Tendon disorders are marked by a reduction in mechanical function, accompanied by pain and swelling. …”
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Correction of renal dysfunction under the influence of dietary management, exercises and lisinopril in patients with abdominal obesity and hypertension. by M. K. Rokutova

“…The effect of diet therapy, exercise and lisinopril on parameteres of renal function (glomerular filtration rate, urine protein, urine albumin, urine β2 microglobulin, urine albumin / creatinine ratio, β2- microglobulin  / urine creatinine ratio). …”
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A prospective, multicentre study evaluating safety and efficacy of a fixed dose combination of Remogliflozin etabonate, Vildagliptin, and Metformin in Indian patients with type 2 d... by Prabhat K Agarwal, Divendu Bhushan, Amit Bhate, Sunil Naik, Shailesh Adwani, J S Kushwaha, Sumit Bhushan, Abhishek Mane, Rujuta Gadkari, Sanjay Choudhari, Saiprasad Patil, Hanmant Barkate

“…The treatment led to significant improvements in glycemic control and other metabolic parameters over 24 weeks, without compromising renal function or causing serious adverse events. …”
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Peripheral blood transcriptomic differences predict depression status in individuals undergoing bariatric surgery by Rebecca Milton, Anna P. McLaughlin, Nicole Mariani, Melisa Kose, Zuzanna Zajkowska, Giulia Lombardo, Naghmeh Nikkheslat, Esperanza Perucha, Valeria Mondelli

“…More than one third of candidates for bariatric surgery suffer with clinical depression. Significant reduction in depression following bariatric surgery has been shown, but this is not consistent for all patients. …”
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Correction of renal dysfunction under the influence of dietary management, exercises and lisinopril in patients with abdominal obesity and hypertension by Rokutova М.К.

“…The effect of diet therapy, exercise and lisinopril on parameteres of renal function (glomerular filtration rate, urine protein, urine albumin, urine І2 microglobulin, urine albumin / creatinine ratio, І2- microglobulin / urine creatinine ratio). …”
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Association between triglyceride-glucose-body mass index and adverse prognosis in elderly patients with severe heart failure and type 2 diabetes: a retrospective study based on the... by Jing Cheng, Qi Cheng, Yingting Wu, Jiashun Yin, Fei He

“…Subgroup analyses demonstrated a consistent inverse TyG-BMI-mortality association across all strata (age, cardiac function, comorbidities), with pronounced risk reduction in HFrEF (LVEF ≤40%; all-timepoint HR >1, p<0.05) and patients without prior myocardial infarction (365-day aHR 0.69 vs. 0.81 with infarction). …”
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Tissue-specific responses to oxidative fuel source preference during heat stress in lactating dairy cows by M.D. Ellett, K.M. Daniels, M.D. Hanigan, B.A. Corl, G. Perez-Hernandez, C.L.M. Parsons, J.A. Melvin, D.W. Fausnacht, R.P. McMillan, L.H. Baumgard, R.P. Rhoads

“…No treatment differences were observed in skeletal muscle Mit enzyme activity indicating the decrease in Met Flex occurred independently of changes in Mit function. The reduction in Met Flex of skeletal muscle during HS may contribute to reduced milk yield and warrants further investigation.…”
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Gut cannabinoid receptor 1 regulates alcohol binge-induced intestinal permeability by Bin Gao, Luca Maccioni, George Kunos, Szabolcs Dvorácskó, Grzegorz Godlewski, Resat Cinar, Malliga R Iyer

“…Mechanistically, we found that alcohol activated intestinal epithelial CB1R-ERK1/2 pathway with subsequent downregulation of tight junction proteins and reduction in villi length. In addition, targeting intestinal CB1R and downstream ERK1/2 was able to reverse this process, with subsequent upregulation of tight junction proteins and increased villi length, thus improving gut barrier function. …”
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Angelica sinensis polysaccharide as potential protectants against recurrent spontaneous abortion: focus on autophagy regulation by Yeli Sun, Guohua Li, Mengwen Kong, Junyuan Li, Shuyun Wang, Yuan Tan

“…Functional assays revealed that ASP enhances trophoblast cell proliferation, migration, and invasion.ConclusionIn summary, our findings demonstrate diminished autophagy activity in RSA patients, while ASP appears to restore autophagy and regulate key metabolic pathways, including glycolysis/gluconeogenesis. …”
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Co-Inoculating <i>Burkholderia vietnamiensis</i> B418 and <i>Trichoderma harzianum</i> T11W Reduced <i>Meloidogyne incognita</i> Infestation of Tomato Plants by Yanqing Jiang, Wenzhe Li, Jishun Li, Jindong Hu, Yanli Wei, Yilian Wang, Hetong Yang, Yi Zhou, Yuanzheng Wu, Shanshan Zhang

“…Actinomycetota (46.42%) and Ascomycota (97.92%) were enriched in the co-inoculated rhizosphere, showing negative correlations with RKNs severity. Functional analysis indicates enriched metabolic pathways, including streptomycin and unsaturated fatty acid biosynthesis, enhancing microbial antagonism. …”
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Optical and Morphometric Parameters of Neutrophils in Rats Exposed to Copper-Zinc Pyrite Ore by Albina R. Nikitina, Klara R. Ziyakaeva, Aliya F. Kayumova, Valentina G. Shamratova

“…Considering this, morphometric and optical parameters can serve as markers of the functional and metabolic activity of neutrophilic leukocytes when exposed to adverse environmental factors. …”
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The effect of non-surgical periodontal therapy on glycemic control in Indian diabetics with periodontal disease – A systematic review and meta-analysis by Komal K. Ghadge, Sharath K. Shetty, Anita Kulloli, Santosh Martande, Vini Mehta, D. Gopalakrishnan, Ankita Mathur, Luca Fiorilla

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Diagnostic value of blood urea and bilirubin levels determination in patients with gastroduodenal zone diseases by I. B. Zhakun, O. O. Sorokopud, L. M. Strilchuk, Z. M. Kit, M. O. Kondratyuk

“…The study of relationships of urea and bilirubin blood levels in patients with Helicobacter pylori associated gastroduodenal pathology (HP-aGDP) has the considerable relevance for clinicians, since these indicators represent the status and function of the gastroduodenal zone. The aim of this study was to estimate changes of bilirubin and urea blood levels in patients with HP-aGDP before and after treatment. …”
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BIOLOGICAL EFFECTS OF TNF-BINDING VARIOLAVIRUS RECOMBINANT PROTEIN by I. A. Orlovskaya, D. D. Tsyrendorzhiev, L. B. Toporkova, V. V. Kurilin, Y. A. Lopatnikova, E. A. Vyazovaya, I. P. Gileva, S. N. Schelkunov, S. V. Sennikov

“…Its effects can be explained by its ability of neutralizing TNF-induced activation of oxidation-related metabolic, cytokine-producing and migratory functions of effector cells in therapy of pathological inflammatory processes.…”
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Igf2 pathway dependency of the Trp53 developmental and tumour phenotypes by Victoria L. Haley, David J. Barnes, Ionel Sandovici, Miguel Constancia, Christopher F. Graham, Francesco Pezzella, Claudia Bühnemann, Emma J. Carter, A. Bassim Hassan

“…Here, we tested whether loss of function of p53 leads to IGF2 ligand pathway dependency in vivo. …”
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