PRPS activity tunes redox homeostasis in Myc-driven lymphoma by Austin C. MacMillan, Bibek Karki, Juechen Yang, Karmela R. Gertz, Samantha Zumwalde, Jay G. Patel, Maria F. Czyzyk-Krzeska, Jarek Meller, John T. Cunningham

“…Myc hyperactivation coordinately regulates numerous metabolic processes to drive lymphomagenesis. Here, we elucidate the temporal and functional relationships between the medley of pathways, factors, and mechanisms that cooperate to control redox homeostasis in Myc-overexpressing B cell lymphomas. …”
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Cardiac energy metabolic disorder and gut microbiota imbalance: a study on the therapeutic potential of Shenfu Injection in rats with heart failure by Zhenyu Zhao, Zhixi Hu, Lin Li

“…The changes in gut microbiota structure were analyzed by 16S rRNA high-throughput sequencing, the content of short-chain fatty acids (SCFAs) was detected by targeted metabolomics technology, and cardiac function and energy metabolism-related indicators were evaluated.ResultsMyocardial energy metabolism in HF rats was disordered, characterized by reduced fatty acid oxidation, enhanced anaerobic glycolysis of glucose, mitochondrial damage, and decreased ATP content; The gut microbiota of HF rats was imbalanced, with a reduction in beneficial bacteria, an increase in conditional pathogenic bacteria, and impaired intestinal barrier function; Both Shenfu Injection and trimetazidine improved myocardial energy metabolism and cardiac function, but Shenfu Injection was more significant in regulating gut microbiota and improving intestinal health; The production of SCFAs from the gut microbiota of HF rats increased, which may be closely related to myocardial energy metabolism; SCFAs-producing bacteria Akkermansia and Blautia played a key role in the development of HF, and their abundance was positively correlated with SCFAs content.ConclusionShenfu Injection in treating HF may improve myocardial energy metabolism and intestinal health by regulating gut microbiota, especially the abundance of SCFAs-producing bacteria Akkermansia and Blautia, thereby exerting therapeutic effects. …”
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Comparative evaluation of pure non-Saccharomyces yeasts fermentation and Lactiplantibacillus plantarum co-fermentation in fig pulp: Achieving remarkable sugar reduction and flavor... by Kangxue Chen, Zijian Gong, Caiyun Wu, Wenbin Rong, Ting Zhang, Qiaomei Li, Hongjie Lei

“…This study investigates pure fermentations of Torulaspora delbrueckii, Metschnikowia pulcherrima, and Lachancea thermotolerans, as well as their mixed fermentations with Lactiplantibacillus plantarum in fig pulp, with a focus on sugar metabolism and flavor enhancement. T. delbrueckii and L. thermotolerans demonstrated remarkable sugar reduction, decreasing glucose levels from 12.43 mg/mL to 0.34 mg/mL or lower, and fructose levels from 13.64 mg/mL to 0.08 mg/mL or lower. …”
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Exercise interventions of ≥8 weeks improve body composition, physical function, metabolism, and inflammation in older adults with stage I sarcopenic obesity: a systematic review an... by Huiting Wei, Huiting Wei, Jiabao Zhang, Jiabao Zhang, Kaiyin Cui, Kaiyin Cui, Hao Su, Hao Su

“…Physical function improves with both RT and CE, and RT is better for muscle strength, while CE benefits metabolism and inflammation. …”
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Effects of Sodium-Glucose Cotransporter 2 Inhibition on Glucose Metabolism, Liver Function, Ascites, and Hemodynamics in a Mouse Model of Nonalcoholic Steatohepatitis and Type 2 Di... by Koichi Yabiku, Keiko Nakamoto, Maho Tsubakimoto

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Ecological effects of water and fertilizer addition on poplar-planting soil by Yimin You, Shitong Li, Xiao Li, Liran Wang, Hongxing Wang, Luping Jiang, Yanhui Peng, Zhongyi Pang, Xiyang Zhao

“…For sulfur (S) cycling, water-urea treatment favored thiosulfate oxidation genes, whereas water-compound fertilizer treatment increased assimilatory sulfate reduction genes. Multi-omics integration linked these microbial dynamics to metabolic reshaping—water-urea increased lipid and secondary metabolites in rhizosphere soils, while water-compound fertilizer additions elevated amino acid-associated metabolites in non-rhizosphere soils. …”
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Branched perfluorohexanesulfonic acid (PFHxS) and perfluoroheptanoic acid (PFHpA): ’Safer’ per- and polyfluoroalkyl substances (PFASs) alternatives for their effects on gut microbi... by Zhen Hong, Lizi Lin, Haoran Yu, Qinzhi Wei, Yunting Zhang, Wanting He, Xuemei Liao, Jin Jing, Guanghui Dong, Zheqing Zhang

“…This study examined the effects of branched perfluorohexanesulfonic acid (PFHxS) and perfluoroheptanoic acid (PFHpA), two alternatives to per- and polyfluoroalkyl substances (PFASs), on gut microbiota and metabolic function in Chinese children aged 6–9 years. …”
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Effects of replacing Laminaria japonica with mixed seaweed meal on growth performance, digestive and metabolic enzyme activities, and immune function of the sea cucumber Apostichop... by Bin Xia, Zhengyong Liu, Qingfei Li, Dongxue Xu, Ji Liu, Jinghua Chen

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COMPARISON OF THE INFLUENCE OF LONG-TERM TREATMENT BASED ON CARVEDILOL OR BISOPROLOL ON METABOLIC PARAMETERS AND ERECTILE FUNCTION IN HYPERTENSIVE PATIENTS WITH OVERWEIGHT OR OBESI... by S. Y. Martsevich, S. N. Tolpigina

“…To compare antihypertensive and metabolic effects as well as influence on erectile function (EF) of long-term treatment with carvedilol or bisoprolol in patients with arterial hypertension (HT) of 1-2 degree and overweight/obesity. …”
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Freeze-thaw carry-over effect promotes decomposition of recalcitrant carbon in peatlands by nitrogen limitation by Jiawen Yan, Lianxi Sheng, Xiaofei Yu, Shanshan Ding, Yongen Min, Hongyan Shen, Yuanchun Zou

“…Here, an in situ field experiment focusing on snowpack manipulation (presence and absence) was conducted within a northern peatland, China. The N functional groups and availability, bacterial community’s structure, succession and metabolic function, and carbohydrate-active enzymes (CAZymes) were determined at 0–30 cm (topsoil) and 30–60 cm (subsoil) employing synchrotron radiation X-ray absorption near-edge structure (XANES) and metagenomic sequencing technologies. …”
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Metabolic adaptation to acute metabolic stress via PFKFB3 upregulation in rodent beta cells by Koki Chiba, Hiroshi Nomoto, Hiroshi Nomoto, Rimi Izumihara, Xinxin Zhang, Hiraku Kameda, Akinobu Nakamura, Tatsuya Atsumi

“…MTT assay results showed a time-dependent reduction in metabolic activity following Pfkfb3 knockdown, suggesting compromised cell survival under acute metabolic stress.ConclusionPFKFB3 upregulation under acute metabolic stress may be an adaptive response that helps maintain beta cell function. …”
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Relieving Effect of <i>Artemisia ordosica Krasch</i> Extract on DSS-Induced Colitis by Regulating Immunity, Antioxidant Function, Gut Microbiota, and Bile Acid Metabolism in Mice by Min Jiang, Xuekai Zhang, Xiao Jin, Binlin Shi, Yuanqing Xu, Zheqi Wang

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CRISPR/Cas9 modified An. gambiae carrying kdr mutation L1014F functionally validate its contribution in insecticide resistance and combined effect with metabolic enzymes. by Linda Grigoraki, Ruth Cowlishaw, Tony Nolan, Martin Donnelly, Gareth Lycett, Hilary Ranson

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The effect of chitosan supplementation on liver function, hepatic steatosis predictors, and metabolic indicators in adults with non-alcoholic fatty liver disease: a randomized, dou... by Mohammad Ali Mohsenpoor, Karim Parastouei, Maryam Taghdir, Marzieh Akbarzadeh, Sepideh Abbaszadeh, Mohammad Ali Abyazi Heris, Mohammad Reza Mansouri Rad, Mohammad Amin Jafari, Ronak Borzooei

“…Thus, the present study aimed to investigate the effect of chitosan supplementation on liver function, hepatic steatosis predictors, and metabolic indices in adults with NAFLD. …”
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Reversing Decline in Aging Muscles: Expected Trends, Impacts and Remedies by Matthew Halma, Paul Marik, Joseph Varon, Jack Tuszynski

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Histidine metabolism drives liver cancer progression via immune microenvironment modulation through metabolic reprogramming by Pengcheng Liu, Fuxin Huang, Peixu Lin, Jiayao Liu, Pincheng Zhou, Jie Wang, Huanhuan Sun, Fan Xing, Haiqing Ma

“…Results The proportion of parenchymal cells exhibiting high histidine metabolism was significantly increased, accompanied by a general reduction in immune and stromal cell infiltration. …”
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Carotenoid and peptide supplementation from Caulerpa sp. (sea grapes) extract mitigate metabolic syndrome in cholesterol-enriched diet rats via modulation of gut microbiota by Rudy Kurniawan, Fahrul Nurkolis, Agussalim Bukhari, Andi Yasmin Syauki, Burhanudin Bahar, Andi Makbul Aman, Nurpudji Astuti Taslim

“…Results Supplementation with Caulerpa sp. extracts significantly improved metabolic markers, including reductions in body weight gain, triglycerides, total cholesterol, low-density lipoprotein (LDL), and blood glucose levels, while increasing high-density lipoprotein (HDL) (p < 0.05). …”
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Reduction of sphingomyelinase activity associated with progranulin deficiency and frontotemporal dementia by Nicholas R. Boyle, Stephanie N. Fox, Aniketh S. Tadepalli, Nicholas T. Seyfried, Thomas Kukar, Eliana M. Ramos, Alissa L. Nana, Salvatore Spina, Lea T. Grinberg, Bruce L. Miller, William W. Seeley, Andrew E. Arrant, Erik D. Roberson

“…Loss-of-function mutations affecting the lysosomal protein progranulin are a leading cause of frontotemporal dementia. …”
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Effect of treadmill walking on cardiometabolic risk factors and liver function markers in older adults with MASLD: a randomized controlled trial by Jiyoun Kim, Sungju Lee, Yong-Seok Jee

“…Therefore, this study aimed to investigate the effects of a 12-week walking intervention on metabolic syndrome risk factors, liver function indicators, and liver ultrasound findings in older adults with both metabolic syndrome and MASLD. …”
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TORC1 Regulates Thermotolerance via Modulating Metabolic Rate and Antioxidant Capacity in Scallop <i>Argopecten irradians irradians</i> by Longfei Chu, Ancheng Liu, Jiaxi Chang, Junhao Zhang, Xiujiang Hou, Xinghai Zhu, Qiang Xing, Zhenmin Bao

“…Collectively, this study elucidates the presence, structural features, evolutional relationships, expression profiles, and roles in antioxidant capacity and metabolism regulation of AiTORC1 in the bay scallop, providing a preliminary understanding of its versatile functions in response to high-temperature challenges in marine mollusks.…”
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