Peculiarities of children’s health status after acute respiratory viral infections: a look at the problem, ways to solve it by Yu.V. Marushko, T.V. Marushko, O.A. Dmytryshyn, O.A. Bovkun, T.V. Iovitsa, B.Ya. Dmytryshyn

“…This determines the urgency of finding appropriate methods of correction with etiopathogenetic (inhibition of oxidative stress, reduction of acidosis and hypoxia, restoration of liver function), immunoregulatory (improvement of the immune system), and symptomatic (improvement of appetite) effects. …”
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Lysyl oxidase promotes seminal vesicle atrophy and fibrosis in type-2 diabetes mellitus through TGF-β1 signaling by Yi Yu, Peng-Fei Liu, Ming-Wei Zhan, Yao-Qi Chen, Yu-Qi Lai, Lei Wang, Jun-Jie Wu, Fan Yao, Xue-Qin Chen, Xue-Jun Shang, Ke-Rong Wu

“…Abstract Type-2 diabetes mellitus (T2DM) is a complex metabolic disorder that adversely affects various physiological systems, particularly male reproductive health. …”
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Unveiling the immunological terrain of pancreatic ductal adenocarcinoma: strategies to prompt immunotherapy from Mendelian randomization by Peizan Ni, Lilin Li, KunPeng Du, Pengkhun Nov, Duanyu Wang, Changqian Wang, Qianzi Kou, Ying Li, Yangfeng Zhang, Chongyang Zheng, Wen Fu, Jiqiang Li

“…Additionally, the traits concerning Interleukin-12 subunit beta levels and T-cell surface glycoprotein CD5 levels further indicate their function of this complex interaction. Conclusions This study enhances our understanding of PDAC's resistance to immunotherapies and highlights the potential of personalized immunotherapy and metabolic pathway modulation in PDAC treatment. …”
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Alterations in the Morphology of the Testis and Epididymis Caused by the Consumption of Hyperlipidic Diets in Wistar Rats by Rosario Tarragó Castellanos, Maria Mendoza Delgado, Lorena Ruiz Valderrama, Isabel Arrieta Cruz, Edith Cortés Barberena, Adriana Morales Otal, Ernesto Rodríguez Tobón, Ahiezer Rodríguez Tobón, Javier Olvera Ramírez, Edith Arenas Ríos

“…Obesity is considered a metabolic disease, in which leptin is used as an indicator of energy in the body. …”
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Drug-induced cognitive impairment by O. D. Ostroumova, M. I. Kulikova, T. M. Ostroumova, M. S. Chernyaeva, A. I. Kochetkov, V. A. Parfenov

“…Drug-induced CI should be suspected if an association is established between a decline of cognitive functions and the start of drug intake. The treatment of this CI involves primarily dose withdrawal or reduction and the use of sustained-release dosage forms, if available. …”
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Limiting serine availability during tumor progression promotes muscle wasting in cancer cachexia by Erica Pranzini, Livio Muccillo, Ilaria Nesi, Alice Santi, Caterina Mancini, Giulia Lori, Massimo Genovese, Tiziano Lottini, Giuseppina Comito, Anna Caselli, Annarosa Arcangeli, Lina Sabatino, Vittorio Colantuoni, Maria Letizia Taddei, Paolo Cirri, Paolo Paoli

“…By investigating the metabolic crosstalk between colorectal cancer cells and muscle cells, we found that incubating myotubes with conditioned media from tumor cells relying on exogenous serine consumption triggers pronounced myotubes diameter reduction. …”
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Intravitreal bevacizumab injection alone or combined with macular photocoagulation compared to macular photocoagulation as primary treatment of diabetic macular edema by Jovanović Sandra, Čanadanović Vladimir, Sabo Ana, Grgić Zorka, Mitrović Milena, Rakić Dušan

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CYTOPROTECTOR MILDRONATE IN CORRECTING MYOCARDIAL DYSFUNCTION AMONG STABLE ANGINA PATIENTS AFTER CORONARY REVASCULARISATION by I. G. Gordeev, E. E. Luchinkina, S. V. Hegay

“…In total, 149 patients, aged 41–75 years, with Functional Class (FC) II-III stable angina, who underwent coronary artery bypass graft surgery (CABG) or percutaneous coronary intervention (PCI), were examined. …”
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Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma by Mingzhi Han, Shuai Wang, Ning Yang, Xu Wang, Wenbo Zhao, Halala Sdik Saed, Thomas Daubon, Bin Huang, Anjing Chen, Gang Li, Hrvoje Miletic, Frits Thorsen, Rolf Bjerkvig, Xingang Li, Jian Wang

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The Effect of Heavy Metal Treatments on Uptake of Nitrogen, Phosphorus and Potassium in Transgenic and Non-Transgenic Tobacco Plants by Hatice Dağhan

“…The first visual signs of toxicity for these heavy metals were chlorosis and the reduction in shoot and root biomass due to inhibition of metabolic functions. …”
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Reduced Cardiorespiratory Fitness after Stroke: Biological Consequences and Exercise-Induced Adaptations by Sandra A. Billinger, Eileen Coughenour, Marilyn J. MacKay-Lyons, Frederick M. Ivey

“…Evidence from several studies consistently shows decline in cardiorespiratory (CR) fitness and physical function after disabling stroke. The broader implications of such a decline to general health may be partially understood through negative poststroke physiologic adaptations such as unilateral muscle fiber type shifts, impaired hemodynamic function, and decrements in systemic metabolic status. …”
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Multicenter Long-Term Real World Data on Treatment With Lumasiran in Patients With Primary Hyperoxaluria Type 1 by Cristina Martin-Higueras, Lodovica Borghese, Armando Torres, Fátima Fraga-Bilbao, Raquel Santana-Estupiñán, Constantinos J. Stefanidis, Kálmán Tory, Adam Walli, Leire Gondra, Caroline Kempf, Michaela Gessner, Sandra Habbig, Lisa Eifler, Claus P. Schmitt, Benjamin Rüdel, Malte P. Bartram, Bodo B. Beck, Bernd Hoppe

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Analysis of molecular mechanisms of the development of experimental diabetes in Wistar rats under conditions of intermittent hypoxia by T. V. Ivanenko

“…Such interventions can potentially lead to improvements in insulin resistance, a reduction in glycemia, and an overall enhancement of cardiorespiratory function. …”
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Decreased brain-derived neurotrophic factor expression in chronic kidney disease: integrated clinical and experimental evidence by Juan Chen, Lili Fu, Mengjin Li, Kun Xie, Xinming Li, Xu-jie Zhou, Li Yang, Liming Zhang, Cheng Xue, Cheng Xue, Zhiguo Mao

“…BackgroundChronic kidney disease (CKD) is a progressive disorder characterized by declining renal function and systemic metabolic disturbances. Brain-derived neurotrophic factor (BDNF), a key member of the neurotrophic family, plays critical roles in neuronal function and muscular metabolism. …”
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<i>Thiocapsa</i>, <i>Lutimaribacter</i>, and <i>Delftia</i> Are Major Bacterial Taxa Facilitating the Coupling of Sulfur Oxidation and Nutrient Recycling in the Sulfide-Rich Isinuk... by Henry Joseph Oduor Ogola, Ramganesh Selvarajan, Somandla Ncube, Lawrence Madikizela

“…Using high-throughput Illumina 16S rRNA sequencing and PICRUSt-based functional inference, we analyzed bacterial diversity and metabolic potential in sediment and water samples. …”
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SPECIFIC FEATURES OF LIPID EXCHANGE IN PULMONARY TUBERCULOSIS PATIENTS WITH CONCURRENT DIABETES OF TYPE 1 AND 2 by G. O. Kaminskaya, R. Yu. Abdullaev, O. G. Komissarova

“…SIRS was related to reduction of cholesterol transporting function of HDLC which reduced anti-atherogenic blood potential. …”
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Polystyrene microplastics disrupt adrenal steroid synthesis in male mice via mitochondrial dysfunction by Ying Xiong, Zhe Chen, Hanmin Xiang, Yi Liu, Yanlin Wang

“…In this study, through both in vivo and in vitro models, we found that polystyrene microplastics (PS-MPs) impaired adrenal steroid synthesis, leading to a reduction in corticosterone levels. In vivo, we further observed that chronic exposure to PS-MPs (0.25, 0.5 and 1 mg/d for 4 weeks) could induce abnormal mitochondrial morphology and functional disruptions of adrenal glands in male mice, along with an imbalance in cellular oxidative stress, manifested as increased level of reactive oxygen species, diminished antioxidant activity (glutathione peroxidase and superoxide dismutase). …”
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Obesity drives depot-specific vascular remodeling in male white adipose tissue by Sana S. Hasan, David John, Martina Rudnicki, Ibrahim AlZaim, Daniel Eberhard, Iris Moll, Jacqueline Taylor, Christian Klein, Maximilian von Heesen, Lena-Christin Conradi, Ralf H. Adams, Eckhard Lammert, Joanna Kalucka, Christiana Ruhrberg, Stefanie Dimmeler, Andreas Fischer

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Losebig: An effective nutritional suplement to impove weight loss and mental health, by Dimitris Grigorakis, Konstantinos Voutsadakis, Georgia Kapoli, Maria Kazantzidi, Angelina Lorentzou

“…Additionally, cognitive function (MoCA scores) improved, while binge eating and emotional eating behaviors (BES and EES scores) decreased significantly in the Losebig group. …”
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Agrobacterium mediated manipulation of the expression of an polysaccharide biosynthetic phosphoglucose isomerase gene to improve polysaccharide production in Sanghuangporus vaninii by Zihao Li, Weihang Li, Yi Zhou, Congtao Xu, Jinlong Pan, Yajie Zou

“…To elucidate the potential role of PGI in S. vaninii polysaccharide metabolism, the interference transformation system of SvPgi was constructed to study the related functions. …”
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