To construct and validate a risk score model of angiogenesis-related genes to predict the prognosis of hepatocellular carcinoma by Duangui Gao, Yuan Lu, Tianpeng Jiang, Qinghong Duan, Zhi Huang

“…The GSVA analysis suggested that the predicted high-risk population showed higher activity in the purine, pyrimidine, and riboflavin metabolic pathways. Compared with the low-risk group, the tumor microenvironment in the high-risk group showed a reduction in the number of cells promoting anti-tumor immunity and an increase in the number of cells inhibiting anti-tumor immunity, as well as a reduction in overall immune infiltration and matrix components. …”
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Influence of <i>Astragalus extract</i> on Gut Microbiome Regulation and Ammonia Emission Mitigation in Laying Hens by Shasha Xiao, Kunxian Feng, Shikai Li, Miao Li, Xiliang Yan, Yinbao Wu, Jiandui Mi, Xindi Liao, Yan Wang

“…This study explored its effects through feeding experiments, with a focus on gut microbial metabolic pathways and NH₃ reduction mechanisms. …”
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Plant Dominant Low-Protein Diet, Nutritional Status (Phase Angle) and Progression of Renal Failure: Case-Report Study by Danijela Ristic-Medic, Snjezana Petrovic, Biljana Pokimica, Marija Paunovic, Vesna Vucic

“…Liver and thyroid function and ferritin and potassium levels were within normal limits. …”
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Differential effects of electroacupuncture and manual acupuncture on spontaneously hypertensive rats: insights from intestinal microbiota and metabolomics by Ji-Peng Liu, Long-Teng Tu, Ke-Zhen Yang, Yin-Yin Li, Yu Gong, Bing-Xuan Han, Chuan Liu, Tian-Qi Xia, Yu Liu, Xiao-Min Hao, Bing-Nan Yue, Jing Zhang, Bing-Hui Wang, Gui-Rong Luo, Qing-Guo Liu, Meng Xu

“…In terms of fecal metabolomics, both acupuncture techniques are implicated in primary bile acid biosynthesis, dopaminergic synapse function, and sphingolipid signaling pathways. Notably, EA exerts a more significant influence on the steroid hormone biosynthesis pathway, whereas MA impacts the tryptophan metabolic pathway.ConclusionBoth EA and MA demonstrate antihypertensive effects by modulating intestinal microbiota composition and metabolite profiles in SHRs, although the specific microbiota and metabolites affected differ between the two techniques, and EA treatment reversed more fecal and serum metabolites than did MA. …”
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Proton motive force and antibiotic tolerance in bacteria by Yingkun Wan, Jiaqi Zheng, Edward Wai‐Chi Chan, Sheng Chen

“…Previous works showed that bacterial antibiotic tolerance was attributed to the reduction in metabolic activities and activation of the stringent response, SOS response and the toxin–antitoxin system which down‐regulates transcription functions. …”
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Nutritional priorities to support GLP-1 therapy for obesity: A joint advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medic... by Dariush Mozaffarian, Monica Agarwal, Monica Aggarwal, Lydia Alexander, Caroline M. Apovian, Shagun Bindlish, Jonathan Bonnet, W. Scott Butsch, Sandra Christensen, Eugenia Gianos, Mahima Gulati, Alka Gupta, Debbie Horn, Ryan M. Kane, Jasdeep Saluja, Deepa Sannidhi, Fatima Cody Stanford, Emily A. Callahan

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Unlocking the Potential of <i>Lacticaseibacillus rhamnosus</i> 73 as a Ripening Agent in Semi-Hard Cheese After Freeze-Drying and a Six-Month Storage Period by Mara E. Batistela, Carina V. Bergamini, Elisa C. Ale, Guillermo H. Peralta

“…Dehydration and storage conditions used to preserve dairy cultures in the industry may negatively impact their viability and functionality. This study investigated the effects of freeze-drying and storage on the metabolic activity of <i>Lacticaseibacillus rhamnosus</i> 73 (L73). …”
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GCKIII kinases control hepatocellular lipid homeostasis via shared mode of action by Emmelie Cansby, Mara Caputo, Emma Andersson, Rasool Saghaleyni, Marcus Henricsson, Ying Xia, Bernice Asiedu, Matthias Blüher, L. Thomas Svensson, Andrew J. Hoy, Margit Mahlapuu

“…By comparing different combinations of the silencing of MST3, STK25, and/or MST4 in immortalized human hepatocytes, we found that their single knockdown results in a similar reduction in hepatocellular lipid content and metabolic stress, without any additive or synergistic effects observed when all three kinases are simultaneously depleted. …”
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Impact of Dietary Phytochemicals on Gut Microbiota and Intestinal Barrier Integrity – Nutritional Interventions and Their Role in Chronic Diseases Prevention by Klaudia Michalak, Kacper Janowski, Emilia Piotrowicz, Sandra Góras

“…The intestinal microbiota is a complex community of microbes involved in maintaining host homeostasis, and nutritional interventions affecting its functioning are the subject of many scientific studies. …”
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The Switching of the Type of a ROS Signal from Mitochondria: The Role of Respiratory Substrates and Permeability Transition by Alexey G. Kruglov, Anna B. Nikiforova

“…Flashes of superoxide anion (O₂⁻) in mitochondria are generated spontaneously or during the opening of the permeability transition pore (mPTP) and a sudden change in the metabolic state of a cell. Under certain conditions, O₂⁻ can leave the mitochondrial matrix and perform signaling functions beyond mitochondria. …”
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ENDOTHELIAL-TROPIC AND NEPHROPROTECTIVE EFFECTS OF COMBINED ANTIHYPERTENSIVE THERAPY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS by M. E. Statsenko, M. V. Derevyanchenko, M. N. Titarenko, O. R. Pastuchova

“…It has been shown that the prescription of a long-term antihypertensive therapy with dose-fixed combination (lisinopril plus amlodipine) is safe and effective for endothelial function improvement, including renal endothelium, with no negative effect on glucose and lipid metabolism in patients with HT and DM type 2.…”
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Mechanisms of beneficial effects of DPP-4 inhibitors as a promising perspective for the prevention/treatment of the disruption of cardio-cerebrovascular homeostasis by Katarina Tomović Pavlović, Marko Anderluh, Andrija Šmelcerović

“…These include improvements in endothelial function, reduction of oxidative stress and inflammatory responses, modulation of lipid and glucose metabolism, and regulation of blood pressure. …”
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The Application of Incretin-Based Pharmacotherapy in the Contemporary Management of Type 2 Diabetes: A Review of the Literature by Jakub Waszczyński, Wojciech Kulej, Wiktor Biesiada, Piotr Kulej, Justyna Woźniak, Justyna Weronika Kmieć, Anna Mariia Chernysh, Aleksandra Dusińska, Kamila Fuczyło, Karolina Stankević

“…These drugs also improved glycemic and metabolic parameters, though initial gastrointestinal side effects were common but temporary. …”
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Sleep Loss as a Factor to Induce Cellular and Molecular Inflammatory Variations by Gabriela Hurtado-Alvarado, Lenin Pavón, Stephanie Ariadne Castillo-García, María Eugenia Hernández, Emilio Domínguez-Salazar, Javier Velázquez-Moctezuma, Beatriz Gómez-González

“…A reduction in the amount of time spent sleeping occurs chronically in modern society. …”
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MoMkt1, a member of XPG/RAD2 nuclease family, regulates development and pathogenicity in Magnaporthe oryzae by Na Li, Junlian Xiao, Long Yan, Xiaoru Kang, Wenjuan Wang, Shen Chen, Weihuai Wu, Shulin Zhang

“…Transcriptome data revealed that MoMKT1 regulates metabolic pathways, cell wall, oxidation-reduction processes, and DNA repair. …”
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Dietary restriction and exercise for diabetic patients with chronic kidney disease: a systematic review. by Liesbeth Van Huffel, Charles R V Tomson, Johannes Ruige, Ionut Nistor, Wim Van Biesen, Davide Bolignano

“…<h4>Outcomes</h4>Death, cardiovascular events, glycaemic control, kidney function, metabolic parameters and body composition.…”
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Oxidative Stress and Keap1-Nrf2 Pathway Involvement in Bisphenol A-Induced Liver Damage in Rats by Juan Tang, Kai Wang, Dan Shen, Chunmei Li

“…These findings suggest that BPA may contribute to metabolic disorders of liver function and poses a hepatotoxicity risk. …”
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Postharvest Application of <i>Myo</i>-Inositol Extends the Shelf-Life of Banana Fruit by Delaying Ethylene Biosynthesis and Improving Antioxidant Activity by Lingyu Hu, Yi Li, Kun Zhou, Kaili Shi, Yi Niu, Feng Qu, Shenglin Zhang, Weidi He, Yuanli Wu

“…Moreover, physiological, metabolic, and gene expression analyses indicated that MI application improved MI metabolism and postponed ethylene biosynthesis and cell wall loosening. …”
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Effects of sotagliflozin on kidney and cardiac outcome in a hypertensive model of subtotal nephrectomy in male mice by Helen Goodluck, Alice Zemljic‐Harpf, Ony Araujo Galdino, Sadhana Kanoo, Natalia Lopez, Young Chul Kim, Volker Vallon

“…Sotagliflozin, however, did not improve markers of kidney injury, inflammation, fibrosis, albuminuria, and plasma FGF23, or signs of cardiac overload, fibrosis, or impaired function. Limited sotagliflozin responsiveness may relate to short treatment time, limited metabolic benefits in nondiabetic setting and/or the model's dominant angiotensin II‐driven effects/hypertension.…”
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Characterisation of patients who develop atrial fibrillation-induced cardiomyopathy by Guy Lloyd, Mehul Dhinoja, Richard J Schilling, Ross J Hunter, Nikhil Ahluwalia, Shohreh Honarbakhsh, Anthony W C Chow, Hakam Abbass

“…It is unclear why some patients develop AIC.Hypothesis Patients with AIC have a subtle cardiomyopathic process that precedes their AF-mediated LVEF reduction. Detailed assessment of cardiac function after successful catheter ablation will reveal this.Objective To evaluate the utility of measures to identify cardiomyopathic features that persist after LVEF normalisation in AIC.Methods Patients with rate-controlled persistent AF and LVEF&lt;50% undergoing catheter ablation (CA) were prospectively evaluated using echocardiography, cardio-pulmonary exercise testing and serum N-terminal pro b-type natriuretic peptide (NT-proBNP) at baseline and 6 months after CA. …”
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