IL-1β-Mediated Immunometabolic Adaptation in Corneal Epithelial Cells by Sanches JM, Ayilam Ramachandran R, Mussi N, Baniasadi HR, Robertson DM

“…While increased levels of IL-1β have been associated with corneal disease, the effects of IL-1β on mitochondrial function in corneal epithelial cells (CECs) is unknown.Methods: To investigate the effects of IL-1β on mitochondrial function, telomerase immortalized human CECs were cultured in either 50 ng/mL or 100 ng/mL IL-1β for short term (24 hours) or prolonged (72 hours) time periods. …”
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Safety, pharmacokinetics, and potential benefits of TSH-receptor-specific monoclonal autoantibody K1-70TM in Japanese Graves’ disease patients: results of a phase 1 trial by Jaeduk Yoshimura Noh, Natsuko Watanabe, Koichi Ito, Mika Tsuiki, Yuki Ishihara, Tetsuya Tagami, Ichiro Yamauchi, Ai Kozaki, Toshu Inoue, Bernard Rees Smith

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Hemoadhican-based self-leveling Janus patch for comprehensive prevention of postoperative adhesions by Rui Fang, Ning Yu, Simeng Chen, Xi Xu, Jianfa Zhang

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CARI Guideline: Evidence-Based Recommendations for Balanced Electrolyte Solutions to Improve Kidney Transplant Outcomes by Colm O’Reilly, David Tunnicliffe, Allan Blackley, Michael Collins, Emmy O’Neill, Siah Kim, Karthik Venkataraman, Emily See, Ross Francis

“…The use of i.v. fluids during kidney transplantation is required for hemodynamic stability; however, there are concerns that normal saline may contribute to increased delayed graft function and hyperchloremic metabolic acidosis. Balanced electrolyte solutions have been suggested as an alternative i.v. fluid that may decrease delayed graft function. …”
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Assessment of the effectiveness and safety of fixed-dose combination of alogliptin and pioglitazone in real clinical practice: results of the PROsperity study by M. V. Shestakova, M. I. Kharakhulakh, Y. A. Belolipetsky

“…Study design: Initially, after 3 and 6 months of incresync therapy, researchers recorded the target and current levels of HbA1c, fasting and post-prandial glycemic indices, as well as a wide range of cardiorenal-metabolic markers, including assessments of lipid profile, renal function, blood pressure, cardiovascular risk factors, concurrent medication, insulin resistance (HOMA-IR), and anthropometric measurements such as body weight and waist circumference, on the background of treatment. …”
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Heparin-Binding Hemagglutinin-Induced Trained Immunity in Macrophages: Implications for Antimycobacterial Defense by Yongqiang Li, Xiuping Jia, Jinhua Tang, Huilian Qiao, Jiani Zhou, Yueyun Ma

“…Functionally, HBHA-trained macrophages exhibited improved control of intracellular mycobacteria, as evidenced by a significant reduction in colony-forming units following BCG infection. …”
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The effects of rifaximin and lactulose on the gut-liver-brain axis in rats with minimal hepatic encephalopathy. by Xueyan Lin, Zhengchao Zhang, Yi Lin, Shiyun Lu, Rongrong Chen

“…Additional analyses included the detection of tight junction proteins in the intestinal mucosa as well as colon fecal 16S rRNA sequencing and metabolic pathway assessments.<h4>Results</h4>Both rifaximin and lactulose were effective in reducing ammonia concentrations in MHE rats and ameliorating cognitive deficits, although they exhibited a minimal impact on hepatic function. …”
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Knockdown of lncRNA XR_877193.1 suppresses ferroptosis and promotes osteogenic differentiation via the PI3K/AKT signaling pathway in SONFH by Yang Huixia, Ding Ning, Qing Shi, Hao Yinju, Zhao Cilin, Wu Kai, Li Guizhong, Zhang Huiping, Ma Shengchao, Bai Zhigang, Jiang Yideng

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Lupus nephritis serum induces changes in gene expression in human glomerular endothelial cells, which is modulated by L-sepiapterin: implications for redox-mediated endothelial dys... by Jim C Oates, Dayvia A Russell, Margaret Markiewicz, Justin P Van Beusecum, Sandra M Sanchez, Jeremy L Barth

“…Addition of L-Sep induced genes involved in promoting endothelial function and enriched for pathways of NO biosynthetic and metabolic processes, fatty acid and lipid biosynthesis, neurotransmitter biosynthesis, reactive oxygen biosynthesis, vascular endothelial growth factor production and regulation of smooth muscle contraction.Conclusions These results indicate that glomerular endothelial cells can mount an active inflammatory response in an LN serum environment. …”
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Inhibition of LINC00707/miR‐223‐3p/FKBP5 axis has a protective effect on diabetic kidney disease by Hongzhen Ye, Yiting Chen, Hong Xia, Lingbo Lv, Lijun Gao

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Evaluating the effect of chronic and continuous use of methadone on the glomerular filtration rate of patients receiving oral methadone (syrup) by Valiollah Goudarzvand Chegini, Amir Mohammad Kazemifar, Amir Ershad Tavakolian, Arian Ghannadi Karimi, Arsalan Jamali Pour Sofi, Darya Ipchian, Sahand Kamali, Mehran Ebrahimi Varkiani, Zohreh Yazdi

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Neuronal CD59 isoforms IRIS-1 and IRIS-2 as regulators of neurotransmitter release with implications for Alzheimer’s disease by Ewelina Golec, Robin Olsson, Emre Can Tuysuz, Maja Karlsson, Yasmin Serjieh, Ben C. King, Malin Wennström, Anna M. Blom

“…While investigating their expression across human tissues, we identified IRIS-1 and IRIS-2 mRNA in the human brain, though their protein expression and function remained unclear. This study shows the presence of both IRIS-1 and 2 proteins in the human brain, specifically in neurons and astrocytes. …”
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Diagnosis and treatment of obstructive sleep apnea by Natalia Myśliwiec, Michał Pniak, Paweł Miklis, Maciej Mawlichanów, Aleksandra Ciesielska, Aleksandra Sieradzka, Krzysztof Szerej, Alicja Kot, Marta Wojtczak, Adrian Różycki

“…Common in middle-aged and older adults, its pathogenesis is multifactorial, encompassing obesity, craniofacial abnormalities, altered upper airway muscle function, pharyngeal neuropathy, and fluid redistribution to the neck. …”
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Validation of an LC–HRMS Method for Quantifying Indoxyl Sulfate and <i>p</i>-Cresyl Sulfate in Human Serum by María Rodríguez-García, Irene Martínez, Irene Aliart, Jaime I. Sainz de Medrano, Nayra Rico, Víctor Joaquín Escudero-Saiz, Francisco Maduell, Manuel Morales-Ruiz, Gregori Casals

“…Serum levels of IndS and pCS correlated with decreased renal function. After hemodiafiltration, there was a significant reduction of IndS (50%) and pCS (43%). …”
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Effects of sodium-glucose cotransport-2 inhibitors treatment in patients with pulmonary hypertension by Mohammed Obeidat, Aravinthan Vignarajah, Rashid Abdel-Razeq, Ala’eddien Nathir, Nishanthi A. Vigneswaramoorthy, Adriano R. Tonelli

“…Preliminary data suggest that sodium-glucose cotransport-2 inhibitors (SGLT2-I), known for their benefits in chronic kidney disease, heart failure, and type-2 diabetes mellitus, may have therapeutic implications in PH through their metabolic effects, which include reducing aerobic glycolysis, improving mitochondrial function, and enhancing fatty acid oxidation. …”
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Overexpression of the transcription factor Yap1 modifies intracellular redox conditions and enhances recombinant protein secretion by Marizela Delic, Alexandra B. Graf, Gunda Koellensperger, Christina Haberhauer-Troyer, Stephan Hann, Diethard Mattanovich, Brigitte Gasser

“…Constitutive co-overexpression of PpYAP1 leads to increased levels of secreted recombinant protein, while a lowered Yap1 function leads to accumulation of ROS and strong flocculation. …”
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Geopolymerization threatens the persistence of organic carbon associated with iron in anoxic environments by Cheng Zhao, Yingxun Du, Hongwei Wang, Wenjie Zhou, Fan Xun, Shun Liu, Biao Li, Xiancai Lu, Qinglong L. Wu, Ke-Qing Xiao, Peng Xing

“…In this work, we report that synergistic interactions among metal (oxyhydr)oxides, such as iron (Fe), manganese (Mn), and aluminum (Al) drive the polymerization of simple organic molecules into macromolecular geopolymers, increasing their electron transfer capacity by 52–115%. These geopolymers function as electron shuttles, enhancing OC decomposition through microbial dissimilatory iron reduction. …”
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Raw and boiled ginger (Zingiber officinale Roscoe) inclusive diet improves fertility parameters in high cholesterol diet-induced obese rats by Akomolafe Seun Funmilola, Atoyebi David Ayodeji

“…Conclusion This study found that both raw and boiled ginger-supplemented diets improved sexual function in obese rats by modulating metabolic hormones, sperm parameters, steroidogenic enzymes, and reproductive hormones, with the boiled ginger treatment outperforming the raw ginger treatment. …”
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Use of Blemaren citrate formula in gout patients with nephrolithiasis by M S Eliseev, V G Barskova, M S Eliseyev, V G Barskova

“…The Blemaren citrate formula used in gout patients with nephrolithiasis causes a significant increase in the renal excretion of UA (p = 0,01), normalizes its metabolic parameters, and shows a high safety, without worsening hepatic and renal functions and electrolyte metabolism.…”
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Mucosal‐associated invariant T cells correlate with myocardial ischaemia and remodelling in coronary artery disease by Jiafu Wang, Song Li, Xianling Zhou, Hongxing Wu, Xiaolan Ouyang, Zhuoshan Huang, Long Peng, Qian Chen, Yuman Wu, Zhitong Li, Ziyi Peng, Yi Yang, Yan Lu, Xixiang Tang, Yue Li, Suhua Li

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