Intermittent fasting inhibits the development of colorectal cancer in APCMin/+ mice through gut microbiota and its related metabolites by Jia Chen, Rishun Su, Yulong He, Jiong Chen

“…Concurrently, western blotting was conducted to examine the expression levels of intestinal barrier function-related proteins. Finally, in vitro validation experiments, including colony formation assay and transwell invasion assay, were performed to investigate the effects of the key microbial metabolite isovaleric acid on the proliferative and invasive capacities of CRC cells.ResultsIntermittent fasting significantly reduced tumor incidence by approximately 50% compared to the control group (1.25 ± 0.38 vs 2.50 ± 0.38 tumors/mouse, P = 0.017) and markedly attenuated tumor progression. 16S rRNA sequencing analysis revealed significant enrichment of two key bacterial genera, Alistipes (P = 0.030) and Odoribacter (P = 0.030), along with a significant reduction in fecal isovaleric acid levels (P < 0.05) in the intermittent fasting group. …”
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HYPOANDROGEN CONDITION AND CARDIOVASCULAR DISEASES: ACTUAL QUESTIONS OF COMORBIDITY IN CLINICAL PRACTICE by G. G. Sharvadze, D. G. Kurbatov, E. A. Poddubskaya, M. N. Mamedov

“…Up to date data about changes of cardiovascular system related to androgen hormone levels reduction are presented. They should help in understanding of pathogenesis of many metabolic and clinical changes. …”
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Pregnancy in obese mice protects selectively against visceral adiposity and is associated with increased adipocyte estrogen signalling. by Silvia M A Pedroni, Sophie Turban, Tiina Kipari, Donald R Dunbar, Kerry McInnes, Philippa T K Saunders, Nicholas M Morton, Jane E Norman

“…Attenuation of adipose inflammation was functionally confirmed by a 45% reduction of CD11b+CD11c+ adipose tissue macrophages (expressed as a proportion of all stromal vascular fraction cells) in HF pregnant compared to HF non pregnant animals (P<0.001). …”
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Clinical study of 3D printing template in the treatment of pediatric distal tibial epiphyseal fracture by Taotao Hui, Jun Wang, Yinghao Yu, Li Qiang, Haojuan Dong, Weifeng Lin

“…Additionally, individuals with a follow-up duration of less than 12 months or incomplete medical records were excluded. The reduction effect was evaluated using radiographs, and the times of fluoroscopy, operation time, time to union, and complications (such as infection or loss of reduction) were documented. …”
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Immunometabolic changes in macrophages in response to house dust mite extract by T. R. Yurakova, E. A. Gorshkova, M. A. Nosenko, E. O. Gubernatorova, M. S. Drutskaya

“…One possible approach would be to influence the metabolism and immune functions of myeloid cells. This approach finds its application in the treatment of cancer and other diseases in the pathogenesis of which macrophages play an important role. …”
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Conceptual Development of Urban Super-blocks Model in Urban Planning Based on Content Analysis Method by Hafez Mahdnejad

“…Axial codes in six selected codes are classified including background conditions (superblock and mini-block environment), causal conditions (field of urban action, land use and urban morphology, urban function, urban complexity, biodiversity and urban green, metabolic efficiency , social unity, human-centered street, complete streets, healthy streets and sustainable streets), mediating conditions (good urban governance and mixed use), central category (biological and physiological needs, security needs, belonging needs, respect needs, cognitive needs, aesthetic needs and self-fulfillment needs), strategies (green space redesign, space reassignment and restrictions and active transportation) and consequences (environmental improvement, traffic reduction, air pollution reduction, social cohesion, health promotion, economic). …”
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Ablation of LAT2 Transporter Causes Intramuscular Glutamine Accumulation and Inhibition of Fasting‐Induced Proteolysis by Meritxell Espino‐Guarch, Susie Shih Yin Huang, Clara Vilches, Esther Prat, Rana El Nahas, Ghalia Missous, Susanna Bodoy, Abbirami Sathappan, Mohammad Ameen Al‐Aghbar, Clara Mayayo, Montse Olivé, Silvia Busquets‐Rius, David Sebastián, Antonio Zorzano, Manuel Palacin, Nicholas vanPanhuys, Virginia Nunes

“…Ex vivo incubation of LAT2KO muscle with rapamycin recovered proteolysis function, demonstrating a mTORC1‐dependent pathway. …”
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An anonymized, de-identified registry study protocol to determine the effectiveness and safety of weight loss with enavogliflozin in patients with type 2 diabetes mellitus. by Hyunji Sang, Sunyoung Kim, Jiyoung Hwang, Selin Woo, Jaewon Kim, Dong Keon Yon, Sang Youl Rhee

“…Sodium-glucose co-transporter 2 inhibitors, such as enavogliflozin, offer promising metabolic benefits for patients with type 2 diabetes (T2D), including glycemic control and improved cardiac function. …”
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Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques by Lis de Weerd, Selina Hummel, Stephan A. Müller, Iñaki Paris, Thomas Sandmann, Marie Eichholtz, Robin Gröger, Amelie L. Englert, Stephan Wagner, Connie Ha, Sonnet S. Davis, Valerie Warkins, Dan Xia, Brigitte Nuscher, Anna Berghofer, Marvin Reich, Astrid F. Feiten, Kai Schlepckow, Michael Willem, Stefan F. Lichtenthaler, Joseph W. Lewcock, Kathryn M. Monroe, Matthias Brendel, Christian Haass

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Effects of hyperhomocysteinemia on follicular development and oocytes quality by Lu Wang, Jinmei Gao, Jie Ma, Jing Sun, Yajie Wang, Jia Luo, Zhaoyang Wang, Hui Wang, Jialing Li, Danyu Yang, Jinfang Wang, Rong Hu

“…Therefore, it remains uncertain whether reproductive function is affected in patients without PCOS with hyperhomocysteinemia (HHcy). …”
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DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans. by Jennifer M A Tullet, Caroline Araiz, Matthew J Sanders, Catherine Au, Alexandre Benedetto, Irene Papatheodorou, Emily Clark, Kathrin Schmeisser, Daniel Jones, Eugene F Schuster, Janet M Thornton, David Gems

“…The DAF-16/FoxO transcription factor controls growth, metabolism and aging in Caenorhabditis elegans. The large number of genes that it regulates has been an obstacle to understanding its function. …”
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Does Pro12Ala Polymorphism Enhance the Physiological Role of PPARγ2? by A. C. Pereira, R. Oliveira, A. C. Castro, R. Fernandes

“…The peroxisome proliferator activated by gamma 2 (PPARγ2) plays an important role in the lipid metabolism. Since PPARγ2 is expressed mainly in adipose tissue, a moderate reduction of its activity influences the sensitivity to insulin, diabetes, and other metabolic parameters. …”
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Effects of Coadministration of Eryngium billardieri and Boswellia serrata Extracts on Insulin-Related Biomarkers, Lipid Profile, and Hepatic Enzymes in Patients with Type 2 Diabete... by Sorour Rajabalipour, Akram Ahangarpour, Mehrnoosh Zakerkish, Fatemeh bineshfar

“…Background: A multifactorial metabolic disorder, diabetes mellitus (DM) is characterized by chronic hyperglycemia. …”
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Diagnostical significance of dimethylarginine in the development of hepatorenal syndrome in patients with alcoholic liver cirrhosis by Ničković Vanja, Nikolić Jelenka, Đinđić Nataša, Ilić Мilena, Ničković Jovan, Mladenović Dragan, Krstić Nebojša

“…Chronic consumption of alcohol during a longer period of time leads to the development of cirrhosis with the reduction in metabolic liver function and disorders in arginine metabolism. …”
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The effects of annual cycle stages and life-history traits on feather abrasion by Yosef Kiat, Quentin Dupriez, Gina Pyo, Oliver J. L. Fox, Rafi Paz, Hans-Jürgen Eilts, Carlos Talabante, Nir Sapir

“…Abstract Tissue wear in animals occurs consistently and can impair their functionality. In birds, abrasion – which reduces the feathered surface area – is caused by various factors. …”
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Evaluating the Role of Coenzyme Q10 in Migraine Therapy—A Narrative Review by Anna Fajkiel-Madajczyk, Michał Wiciński, Zuzanna Kurant, Józef Sławatycki, Maciej Słupski

“…Furthermore, by improving mitochondrial function, CoQ10 can contribute to the energy supply to brain cells, which is particularly important in migraine. …”
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The effect of zinc and copper proteinate on the growth and development of crossbred pigs during fattening by V. S. Bomko, S. G. Karapysh, Yu. G. Kropyvka

“…These elements are crucial for various biological processes, including enzymatic activity, metabolic regulation, and immune system function. The use of organic trace elements, such as chelated complexes, enhances the absorption and bioavailability of these substances compared to inorganic salts like sulfates. …”
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Incidence, complications and therapeutic evaluation of clinical hypothyroidism in different breeds of dogs by Gehad E. Elgalfy, Mohamed M. Ghanem, Mahmoud A. Y. Helal, Heba M. El-khaiat

“…Results After ruling out other causes of alopecia and obesity, hypothyroidism was diagnosed in 28 dogs (14%) depending on the result of thyroid function test. Results of this study showed that the highest incidence of hypothyroidism was reported in Golden retriever (21.42%) followed by Griffon dogs (17.85%). …”
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Evening primrose oil ameliorates tissue architecture, apoptosis, and oxidative stress in the pancreas of diabetic rats: Possible role of miR-21 by Ali Louei Monfared, Ali Menatnia

“…Treatment with EPO resulted in a reduction of miR-21 and caspase-3 expression, as well as MDA levels, and an increase in insulin expression and SOD levels compared to the diabetic group. …”
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Oleic Acid and Succinic Acid: A Potent Nutritional Supplement in Improving Hepatic Glycaemic Control in Type 2 Diabetic Sprague–Dawley Rats by Kemmoy G. Lattibeaudiere, Ruby Lisa Alexander-Lindo

“…In particular, many supplements are being proposed to reduce the impacts of type 2 diabetes (T2D), a metabolic condition that has reached global epidemic proportions. …”
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