PRE-CONCEPTIONAL PREPARATION OF WOMEN AND ITS INFLUENCE TO THE FETUS AND CHILD HEALTH by L.L. Nisevich, A.A. Adieva, D.B. Medzhidova, I.G. Suleimanova, Z.S. Gadzhieva, V.M. Shishchenko, A.A. Kushch

“…They also found out that the metabolic therapy during the pre con ceptional preparation and pregnancy leads to a drastic drop of different complications during pregnancy, delivery and down lying period, improves placenta function and optimizes the fetus development conditions, sizably reduces any chances of the fetus and newborn intrauterine infection, enhances the newborn adaptation and leads to reductions in the perinatal and infant mortality. …”
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Evaluation of three mechanisms of action (SGLT2 inhibitors, GLP-1 receptor agonists, and sulfonylureas) in treating type 2 diabetes with heart failure: a systematic review and netw... by Huize Gao, Qian Wei, Anqi Zou, Keying Yu, Da Song, Jian Li, Huize Han, Aidong Liu

“…., heart failure biomarkers and cardiac function) and metabolic outcomes (e.g., glycemic control and body weight), aiming to determine whether the newer agents offer superior cardiometabolic benefits. …”
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mTOR inhibition triggers mitochondrial fragmentation in cardiomyocytes through proteosome-dependent prohibitin degradation and OPA-1 cleavage by Hugo E. Verdejo, Valentina Parra, Andrea del Campo, Cesar Vasquez-Trincado, Damian Gatica, Camila Lopez-Crisosto, Jovan Kuzmicic, Leslye Venegas-Zamora, Ursula Zuñiga-Cuevas, Mayarling F. Troncoso, Rodrigo Troncoso, Beverly A. Rothermel, Mario Chiong, E. Dale Abel, Sergio Lavandero

“…Abstract Introduction Cardiac mitochondrial function is intricately regulated by various processes, ultimately impacting metabolic performance. …”
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Therapeutic Potential of Ginger Ethanolic Extract, Ginger-Loaded Chitosan ‎Nanoparticles, and Chitosan Nanoparticles in Induced Type 2 Diabetes Mellitus in Dogss in Induced Type 2... by Rasema M Hameed, Alaa K Mahmood

“…Compared to the diabetic Positive Control, oral GEE, GEE-CNPs, and CNPs ‎treatments significantly (P<0.05) improved ‎fasting glucose levels, insulin sensitivity, lipid profiles (reduced total cholesterol, ‎triglycerides, and LDL-C), liver function markers, and antioxidant status, indicating ‎enhanced metabolic health and reduced oxidative stress. …”
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Cardioprotective mechanisms of sodium-glucose cotransporter 2 inhibitors by A. M. Mkrtumyan, T. N. Markova, N. K. Mishchenko

“…The metabolic effects of this medicine are accompanied by an increase the production of ketone bodies, followed by improving ATP production and myocardial energetics. …”
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Relationship between bmi and glomerular filtration rate in a large cohort initiating a weight loss program: differential contributions of fat mass, fat-free mass, and abdominal fat... by Alessandro Leone, Francesca Menichetti, Laila Vignati, Federica Sileo, Ramona De Amicis, Andrea Foppiani, Simona Bertoli, Alberto Battezzati

“…Results Among 9,704 subjects, 61.1% had a normal renal function, while 29.3% reported a reduction, from slightly to severely. …”
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Effect of Long-Term Moderate Physical Exercise on Irisin between Normal Weight and Obese Men by Farah A. Rashid, Hamid Jaddoa Abbas, Naser Ali Naser, Hana'a Addai Ali

“…Serum irisin levels, fasting blood glucose, serum insulin, homeostatic model assessment of the insulin resistance index (HOMA-IR), and β-cell function (HOMA-B2) were assessed. Results. Long-term moderate exercise induced elevation of the irisin level significantly (P<0.0001) with significant reduction of the BMI, WC, fasting blood glucose, insulin, HOMA-IR, and HOMA-B2 levels (P<0.0001) in comparison between obese and normal weight groups. …”
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Drug Prevention of Reperfusion Lesions during Thrombolytic Therapy for Myocardial Infarction by G. A. Boyarinov, A. A. Usanova, I. S. Kotlov, A. S. Saushev, A. P. Komkov

“…Administration of mexicor results in a more complete recovery of cardiovascular function, cardiac hemodynamics, and metabolism in patients after thrombolysis and favors a reduction in the number of disease complications in the hospital treatment stage. …”
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Escherichia coli is implicated in the development and manifestation of host susceptibility to the roundworm Trichostrongylus colubriformis infections in sheep by Fang Liu, Jody McNally, Damarius Flemming, Aaron B. Ingham, Peter William Hunt, Robert W. Li

“…Further, the resistant lambs displayed a significant reduction in worm establishment in response to a Trichostrongylus colubriformis challenge infection (P < 0.0001; N = 20 per group). …”
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Organelle symphony: Nuclear factor erythroid 2-related factor 2 and nuclear factor-kappa B in stroke pathobiology by Ziliang Hu, Mingyue Zhao, Hangyu Shen, Liangzhe Wei, Jie Sun, Xiang Gao, Yi Huang

“…It plays a significant role in post-stroke neuroprotection and repair by influencing mitochondrial function, endoplasmic reticulum stress, and lysosomal activity and regulating metabolic pathways and cytokine expression. …”
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NANOVESICLES IN THE GUT–BRAIN AXIS: INSIGHTS FROM PROBIOTIC SUPPLEMENTATION IN IRRITABLE BOWEL SYNDROME

“…Our findings suggest that probiotic-induced nanovesicles may influence CNS function through the gut–brain axis and help maintain gut homeostasis under stress. …”
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The Impact of GLP-1 Receptor Agonists on Women's Reproductive Health: A Review by Marta Wolszczak, Hanna Wołodkiewicz, Jakub Szmit

“…However, they quickly proved to be effective in weight reduction and became an option for obesity therapy. …”
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The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis by Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He

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Cardiometabolic Modulation by Semaglutide Contributes to Cardioprotection in Rats with Myocardial Infarction by Yan H, Yao W, Li Y, Li T, Song K, Yan P, Dang Y

“…Its mechanism involves modulating glucose metabolism, lipid metabolism, and organic acid metabolism. …”
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Introducing a Novel Personalized Microbiome-Based Treatment for Inflammatory Bowel Disease: Results from NostraBiome’s Internal Validation Study by Adrian Goldiș, Radu Dragomir, Marina Adriana Mercioni, Christian Goldiș, Diana Sirca, Ileana Enatescu, Oana Belei

“…Primary outcomes included stool frequency and consistency as well as inflammatory markers (C-reactive protein and fecal calprotectin), while secondary outcomes assessed nutritional status, metabolic function, and quality of life. Statistical analyses included paired t-tests and repeated measures ANOVA to determine significant changes over time. …”
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Nitrite-driven anaerobic ethane oxidation by Cheng-Cheng Dang, Yin-Zhu Jin, Xin Tan, Wen-Bo Nie, Yang Lu, Bing-Feng Liu, De-Feng Xing, Nan-Qi Ren, Guo-Jun Xie

“…Batch tests demonstrated that ethane is essential for nitrite removal in this microbial culture. Metabolic function analysis revealed that a species affiliated with a novel genus within the family Rhodocyclaceae, designated as 'Candidatus Alkanivoras nitrosoreducens', may perform the nitrite-driven anaerobic ethane oxidation. …”
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Research progress on brain network imaging biomarkers of subjective cognitive decline by Han Yingmei, Wang Chaojie, Zhang Yi, Li Yijie, Zhang Heng, Feng Ze, Li Weiqing, Chu Bingyuan, Wang Feng

“…PurposeSubjective cognitive decline (SCD) is an early manifestation of the Alzheimer’s disease (AD) continuum, and accurately diagnosing SCD to differentiate it from neurotypical aging in older adults is a common challenge for researchers.MethodsThis review examines and summarizes relevant studies regarding the neuroimaging of the AD continuum, and comprehensively summarizes and outlines the SCD clinical features characterizing along with the corresponding neuroimaging changes involving structural, functional, and metabolic networks.ResultsThe clinical characteristics of SCD include a subjective decline in self-perceived cognitive function, and there are significant imaging changes, such as reductions in gray matter volume in certain brain regions, abnormalities in the integrity of white matter tracts and diffusion metrics, alterations in functional connectivity between different sub-networks or within networks, as well as abnormalities in brain metabolic networks and cerebral blood flow perfusion.ConclusionThe 147 referenced studies in this paper indicate that exploring the structural, functional, and metabolic network changes in the brain related to SCD through neuroimaging aims to enhance the goals and mission of brain science development programs: “Understanding the Brain,” “Protecting the Brain,” and “Creating the Brain,” thereby strengthening researchers’ investigation into the mechanisms of brain function. …”
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Translational interdisciplinary research on human chorionic gonadotropin’s enhancement of neuroendocrine crosstalk: a novel medical hypothesis for systemic adjunctive treatment of... by João Francisco Pollo Gaspary, João Francisco Pollo Gaspary, Luis Felipe Dias Lopes, Antonio Geraldo Camara

“…HHT also increases IGF-1 availability, promoting neuroprotection, cognitive improvements, and reduced mitochondrial dysfunction, restoring cellular function critical for brain health.Implications for Clinical PracticeThe findings underscore the significance of enhancing endocrine and metabolic functions as a viable strategy for improving psychiatric care, aligning with trends that advocate holistic treatment strategies. …”
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BIOCHEMICAL SUBSTANTIATION OF COMBINED THERAPY APPLICATION IN THE ACUTE PHASE OF EXPERIMENTAL HELMINTHIASIS OF ANIMALS by E. A. Grishina, A. A. Erovichenkov

“…The above-mentioned complex of metabolic changes clearly reveals a disturbance in hepatocyte metabolism that leads to the decrease in detoxifying function of the liver. …”
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The dynamic distribution of the rectal microbiota in Holstein dairy calves provides a framework for understanding early-life gut health by Qi Huang, Fengtao Ma, Yuhang Jin, Duo Gao, Meinan Chang, Peng Sun

“…The fermentation pattern and metabolic function changed from propionate fermentation dominated by Shigella to lactic acid fermentation dominated by Lactobacillus, Blautia, and Oscillospira. …”
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