Development and Evaluation of a Powered Artificial Gastrocnemius for Transtibial Amputee Gait by Michael F. Eilenberg, Jiun-Yih Kuan, Hugh Herr

“…The data do not support our hypothesis that metabolism decreases for all participants, but some participants demonstrate large metabolic reductions with the biarticular condition. …”
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Insulin secretion deficits in a Prader-Willi syndrome β-cell model are associated with a concerted downregulation of multiple endoplasmic reticulum chaperones. by Erik A Koppes, Marie A Johnson, James J Moresco, Patrizia Luppi, Dale W Lewis, Donna B Stolz, Jolene K Diedrich, John R Yates, Ronald C Wek, Simon C Watkins, Susanne M Gollin, Hyun Jung Park, Peter Drain, Robert D Nicholls

“…Prader-Willi syndrome (PWS) is a multisystem disorder with neurobehavioral, metabolic, and hormonal phenotypes, caused by loss of expression of a paternally-expressed imprinted gene cluster. …”
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To Assess the Respiratory Muscle Strength in Patients with Chronic Kidney Disease Undergoing Hemodialysis: Cross-sectional Study by Manjula Murugan, S Sridevi

“…To maintain homeostasis of metabolic function in end-stage renal disease (ESRD), renal replacement therapy (RRT) is required, with hemodialysis (HD) being the most common method. …”
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Human induced pluripotent stem cell-derived myotubes to model inclusion body myositis by Judith Cantó-Santos, Laura Valls-Roca, Ester Tobías, Francesc Josep García-García, Mariona Guitart-Mampel, Félix Andújar-Sánchez, Adrià Vilaseca-Capel, Anna Esteve-Codina, Beatriz Martín-Mur, Joan Padrosa, Emma Peruga, Irene Madrigal, Paula Segalés, Carmen García-Ruiz, José Carlos Fernández-Checa, Pedro J. Moreno-Lozano, Albert Selva O’Callaghan, Ana Sevilla, José César Milisenda, Glòria Garrabou

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What change in body mass index is associated with improvement in percentage body fat in childhood obesity? A meta-regression by Rachel Perry, Julian PH Shield, Laura Birch, Linda P Hunt, Rhys Matson, Amanda Chong, Rhona Beynon

“…Interventions of <2 weeks duration and those that involved surgical and/or pharmacological components (eg, bariatric surgery, drug therapy) were excluded.Primary and secondary outcome measures To be included in the review, studies had to report baseline and post-intervention BMI-SDS or change measurements (primary outcome measures) plus one or more of the following markers of metabolic health (secondary outcome measures): adiposity measures other than BMI; blood pressure; glucose; inflammation; insulin sensitivity/resistance; lipid profile; liver function. …”
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Gut microbiome and metabolome interactions in Crohn’s disease: mechanistic insights into exclusive enteral nutrition-induced remission by Weiwei Zheng, Weiwei Zheng, Weiwei Zheng, Weiwei Zheng, Quan Zhou, Quan Zhou, Mengli Xue, Mengli Xue, Mengli Xue, Mengli Xue, Xing Yu, Xing Yu, Xing Yu, Xing Yu, Xue’e Chen, Xue’e Chen, Xue’e Chen, Xue’e Chen, Jintong Chen, Jintong Chen, Jintong Chen, Jintong Chen, Chengdang Wang, Chengdang Wang, Chengdang Wang, Chengdang Wang

“…Functional analyses indicated the activation of energy metabolism pathways and the suppression of pro-inflammatory metabolic pathways. …”
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Systematic Review and Meta-Analysis of Chicory Inulin-Type Fructans Supplementation on Weight Management Aspects by Yoghatama Cindya Zanzer, Stephan Theis

“…Maintaining and reducing weight are considered as important features in reducing mortality and morbidity caused by metabolic-associated diseases. Increasing evidence from in vivo mechanistic and clinical studies has shown that the gut microbiota is interacting with the host's physiological function in regulating energy intake and body weight. …”
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The Effects of Disease-Modifying Antirheumatic Drugs on Cardiovascular Risk in Inflammatory Joint Diseases: Current Evidence and Uncertainties by Garmish O, Smiyan S, Hladkykh F, Koshak B, Komorovsky R

“…Karazin National University, Kharkiv, UkraineCorrespondence: Roman Komorovsky, Ivan Horbachevsky Ternopil National Medical University, 1, Maidan Voli, Ternopil, 46001, Ukraine, Email komorovsky@tdmu.edu.uaAbstract: Patients with inflammatory joint diseases, including rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis, have an elevated risk of cardiovascular complications due to systemic inflammation, immune-mediated endothelial dysfunction, and associated metabolic changes. Disease-modifying antirheumatic drugs (DMARDs) influence cardiovascular risk through their effects on inflammation, lipid metabolism, and endothelial function. …”
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Light-dark dependent changes in chloroplast and mitochondrial activity in Chlamydomonas reinhardtii by Gunjan Dhawan, Gunjan Dhawan, Basuthkar Jagadeeshwar Rao, Basuthkar Jagadeeshwar Rao

“…Mitochondrial activity, measured using Seahorse flux analyzer, showed basal oxygen consumption rate in continuous light and a marked reduction in continuous dark condition, resulting in dynamic changes observed in light-dark cycle, indicating a coordination in the organellar function. …”
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The treatment of primary CoQ deficiency requires the targeting of multiple pathogenic mechanisms by Pilar González-García, Laura Jiménez-Sánchez, Julia Corral-Sarasa, Sergio López-Herrador, Sara Torres-Rusillo, María Elena Díaz-Casado, Luis C. López

“…Mechanistically, this enhanced therapeutic efficacy results from the complementary actions of both compounds, i.e., CoQ10 increases quinone pools in peripheral tissues and modulates one-carbon metabolism, particularly in the liver, while VA reduces DMQ accumulation in the kidney and liver and exhibits potent anti-neuroinflammatory properties, leading to a reduction in gliosis. …”
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Dietary pattern index and sleep disturbances: findings from the 2011–2014 National Health and Nutrition Examination Survey (NHANES) by Yao Xiao, Yuehong Wu, Can Wang, Jianmin Dong, Ximing Zhang, Zhiyou Peng, Yunfei Cao

“…Healthy dietary patterns characterized by increased fiber intake, reduced sodium, and lower fat content were associated with improved sleep quality, potentially through mechanisms involving enhanced metabolic function. Conclusions The findings suggest that dietary interventions aimed at improving dietary quality—specifically through the reduction of fat and salt intake, and the enhancement of fiber and vegetable consumption—may alleviate sleep disturbances. …”
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Bistable dynamics underlying excitability of ion homeostasis in neuron models. by Niklas Hübel, Eckehard Schöll, Markus A Dahlem

“…This is interpreted as a threshold reduction of a new fundamental mechanism of ionic excitability that causes a long-lasting but transient FES as observed in pathological states. …”
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Innovative strategies in combating intervertebral disc degeneration: pathological mechanisms and biomaterial advancements by Long Ma, Jizhou Pan, Jiankang Zhang, Fashun Liu

“…The onset of IVDD is associated with various factors such as age, lifestyle, and genetics, and its pathological mechanisms involve multidimensional interactions, including oxidative stress, inflammation, and extracellular matrix (ECM) metabolic disorders. During degeneration, there is a reduction in the number of nucleus pulposus cells (NPCs), resulting in an imbalance between the synthesis and degradation of the ECM, leading to changes in the disc’s morphology and biomechanical function, ultimately causing pain and mobility issues. …”
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MORPHOLOGICAL CHARACTERISTICS OF TISSUE MICROREGION OF THE THYROID GLAND AT EXPERIMENTAL HYPOTHYROIDISM by O. V. Gorchakova, V. N. Gorchakov, G. A. Demchenko, S. N. Abdreshov

“…It testifies to decrease of thyroid function and the creation of hypothyroidism adequate model.…”
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Fermented Dairy Products as Precision Modulators of Gut Microbiota and Host Health: Mechanistic Insights, Clinical Evidence, and Future Directions by Yuan Gao, Yanyan Liu, Tingting Ma, Qimeng Liang, Junqi Sun, Xiaomeng Wu, Yinglong Song, Hui Nie, Jun Huang, Guangqing Mu

“…Clinical evidence supports significant improvements in metabolic parameters (fasting glucose, lipid profiles, blood pressure) and reductions in systemic inflammation across metabolic syndrome, hypertension, and IBS cohorts. …”
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Hemodynamics and Gas Exchange in Hemorrhagic Shock and Hyperbaric Oxygenation (Experimental Study) by Yu. M. Tumanovsky

“…HBO used in anemic animals promotes the recovery of hemodynamic homeostasis due to the activation of oxygen-dependent myocardial metabolic processes and the reduction of tissue hypoxic manifestations.…”
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Metformin for knee osteoarthritis with obesity: study protocol for a randomised, double-blind, placebo-controlled trial by Yuanyuan Wang, Flavia M Cicuttini, Stephane Heritier, Mahnuma Mahfuz Estee, Anita E Wluka, Yuan Z Lim, Donna M. Urquhart

“…The primary outcome is reduction of knee pain [assessed by 100 mm Visual Analogue Scale (VAS)] at 6 months. …”
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Optimized heat-moisture treatment decreases the starch digestibility of polished maize flour from predominant varieties consumed in Uganda by Finagnon Toyi Kevin Fassinou, Solomon Olum, Lawrence Okidi, Duncan Ongeng

“…It is largely consumed in polished form characterized by high digestibility, rapidly releasing glucose into the bloodstream, making it unsuitable for metabolic health. This calls for the reduction of maize flour digestibility through increasing its slowly-digestible (SDS) and resistant-starch (RS) contents, typical function of Heat-moisture Treatment (HMT). …”
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Carbonic anhydrase 2 mediates anti-obesity effects of black tea as thermogenic activator by Peng Ma, Jie Xiao, Biyu Hou, Ping He, Xinyu Yang, Yisa Wang, Zijing Wang, Tianshu Xu, Xiuying Yang, Xuan Zhu, Shasha Xiang, Song Li, Guanhua Du, Jian Ying, Guifen Qiang

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Reduced Levels of Neurosteroids in Cerebrospinal Fluid of Amyotrophic Lateral Sclerosis Patients by Chiara Lucchi, Cecilia Simonini, Cecilia Rustichelli, Rossella Avallone, Elisabetta Zucchi, Ilaria Martinelli, Giuseppe Biagini, Jessica Mandrioli

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