Liver Disease and Central Nervous System Dysfunction: Linking the Two - A Narrative Review by Maciej Tenderenda, Bartosz Buczkowski, Piotr Oleksy, Agnieszka Klecza, Aleksandra Broniak, Magdalena Reclik, Karol Zieliński, Aarushi Chourasia, Krzysztof Nowakowski, Martyna Chraścina

“…The gut-liver-brain axis, involving gut microbiota's role in CNS functioning, presents promising avenues for adjunctive treatment. …”
Get full text

Renal replacement therapy in the treatment and prevention of contrastinduced nephropathy after cardiovascular surgery by E. A. Tabakyan, A. E. Komlev, A. A. Margolina, R. S. Akchurin

“…In patients with CIN and ARF after CM use during angioplasty and hybrid cardiac surgery, RRT effectively reduces life-threatening metabolic complications of ARF. Among individuals with a very high ARF risk, RRT immediately after CM-using cardiovascular surgery can prevent a significant GFR reduction and ARF development.…”
Get full text

The putative RNA helicase HELZ promotes cell proliferation, translation initiation and ribosomal protein S6 phosphorylation. by Philippe A Hasgall, David Hoogewijs, Marius B Faza, Vikram G Panse, Roland H Wenger, Gieri Camenisch

“…Although HELZ interacted with the poly(A)-binding protein (PABP) via its PAM2 motif, PABP was dispensable for HELZ function in protein translation. Importantly, downregulation of HELZ reduced translational initiation, resulting in the disassembly of polysomes, in a reduction of cell proliferation and hypophosphorylation of ribosomal protein S6.…”
Get full text

The Potential Role of miRNAs as New Biomarkers for Osteoporosis by Maria Materozzi, Daniela Merlotti, Luigi Gennari, Simone Bianciardi

“…Osteoporosis is the most common metabolic bone disorder affecting up to 40% of postmenopausal women, characterized by a reduction in bone mass and strength leading to bone fragility and fractures. …”
Get full text

Amylin in the Periphery by Peter J. Wookey, Loredanna Xuereb, Christos Tikellis, Mark E. Cooper

“…As a hormone, amylin acts to modify gastric motility, renal resorption, and has metabolic actions. It is postulated that the principal function of amylin as a hormone is the activation of physiological processes associated with feeding. …”
Get full text

Unveiling the therapeutic benefits of black chokeberry (Aronia melanocarpa) in alleviating hyperuricemia in mice by Chin-Yuan Liu, Wen-Yu Liu, Yeu-Ching Shi, She-Ching Wu

“…Black chokeberry effectively increased the glutathione levels in hyperuricemic mice and reduced malondialdehyde levels, as well as significantly inhibiting adenosine deaminase activity.ConclusionIts efficacy is comparable to that of the marketed drug allopurinol, underscoring the potential of black chokeberry as a functional product for uric acid reduction.…”
Get full text

The LysR family transcriptional regulator ORF-L16 regulates spinosad biosynthesis in Saccharopolyspora spinosa by Xin Mu, Ru Lei, Shuqing Yan, Zixin Deng, Ran Liu, Tiangang Liu

Get full text

Prenatal Hyperhomocysteinemia Leads to Synaptic Dysfunction and Structural Alterations in the CA1 Hippocampus of Rats by Tatyana Y. Postnikova, Alexandra V. Griflyuk, Natalia L. Tumanova, Nadezhda M. Dubrovskaya, Anastasia V. Mikhel, Dmitriy S. Vasilev, Aleksey V. Zaitsev

“…Our results highlight the importance of maternal homocysteine levels in shaping hippocampal function and could offer insights into neurodevelopmental disorders associated with metabolic disturbances.…”
Get full text

Exercise Prescription Training in Chronic Obstructive Pulmonary Disease: Benefits and Mechanisms by Liu S, Yang A, Yu Y, Xu B, Yu G, Wang H

“…Exercise-mediated rehabilitation attenuates COPD progression and mitigates acute exacerbation risks via multifactorial mechanisms such as mitigation of inflammatory responses, reduction of oxidative stress, and improvement of endothelial cell function. …”
Get full text

Reduced M3 muscarinic acetylcholine receptor expression in gestational diabetes mellitus: implications for placental dysfunction and vascular regulation by Süleyman Cemil Oğlak, Fırat Aşır, Tuğcan Korak, Ayşegül Aşır, Emine Zeynep Yılmaz, Elif Ağaçayak

“…Objectives Gestational diabetes mellitus (GDM) is a prevalent metabolic disorder affecting pregnancy, leading to significant maternal and fetal complications. …”
Get full text

Comparative Metagenomics Reveals Microbial Diversity and Biogeochemical Drivers in Deep-Sea Sediments of the Marcus-Wake and Magellan Seamounts by Chengcheng Li, Bailin Cong, Wenquan Zhang, Tong Lu, Ning Guo, Linlin Zhao, Zhaohui Zhang, Shenghao Liu

“…It also supports the view that microbial community structure and metabolic function across seamount regions are likely influenced by the geomorphological features of the seamounts.…”
Get full text

Cardiac Toxicity Under Concurrent Administration of Trastuzumab (Anti‐HER2 Therapy) and Radiotherapy: Systematic Review and Meta‐Analysis by Ali Jabbari, Elham Mousavi, Majid Nikoubin‐Boroujeni, Shabnam Tabasi, Nazila Arjmandi, Noura Ghelishli, Zahra Arab‐Bafrani

Get full text

Strength training and chromium picolinate supplementation do not reduce adiposity or improve muscle morphology in obese rats by Daniel da Silva, Lucas Domingos, Amanda Madureira, Suellem Torezani-Salles, Danilo Bocalini, Breno Nogueira, Ana Paula Lima-Leopoldo, André Leopoldo

“… Introduction: Obesity induces metabolic dysfunctions, such as insulin resistance and dyslipidemia, which negatively affect skeletal muscle remodeling and function. …”
Get full text

Semaglutide in MASLD Patients: Improved Survival and Liver Outcomes by Mohamad Suki, Johnny Amer, Yael Milgrom, Muhammad Massarwa, Wadi Hazou, Yariv Tiram, Ofer Perzon, Yousra Sharif, Joseph Sackran, Revital Alon, Nachum Emil Eliezer Lourie, Itamar Raz, Ashraf Imam, Abed Khalaileh, Rifaat Safadi

“…Assessed outcomes included survival, biochemical, hematologic, AFP, metabolic and cardiovascular parameters, advanced liver disease (ALD), synthetic function, and metabolic markers. …”
Get full text

Recent advances in gut microbiota and thyroid disease: pathogenesis and therapeutics in autoimmune, neoplastic, and nodular conditions by Lihua Fang, Jie Ning

“…A pronounced shift in the gut microbiota composition has been consistently observed, with a significant reduction in bacteria such as Bifidobacterium, Bacillaceae, Megamonas, and Clostridium, and a notable increase in bacteria, including Bacteroides, Proteobacteria, Actinobacteria, Desulfobacterota, and Klebsiella. …”
Get full text

Melatonin as a potential treatment option in diabetes complications by Raniah I. Alnaser, Raniah I. Alnaser, Fawaz A. Alassaf, Mohammed N. Abed

“…Recent research indicates that disrupted sleeping and eating patterns along with ageing can contribute to the development of diabetes mellitus (DM) via effects on circadian rhythms and metabolic control. The use of anti- -DM drugs alone is insufficient to achieve control of the reduction in β-cell function, insulin resistance, inflammatory mediation, oxidative stress and the DM-related complications. …”
Get full text

Hydroxysafflor yellow A alleviates oxidative stress and inflammatory damage in the livers of mice with nonalcoholic fatty liver disease and modulates gut microbiota by Liang Wu, Liang Wu, Xueyun Dong, Wen Sun, Tan Jiajun, Asmaa Ali, Jiayuan He, Pingping Wang

“…Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC), and triglycerides (TG) were quantified to evaluate liver function and lipid metabolism. Oxidative stress markers, including superoxide dismutase (SOD) activity and malondialdehyde (MDA) concentration, were also assessed. …”
Get full text

Prepregnancy Obesity Reprograms Offspring Skeletal Muscle Fibre Transition Through H3K9me3 by Yichi Wu, Sujuan Li, Jingyi Zhang, Anran Tian, Xiangyao Wang, Xi Yang, Fucheng Meng, Qing Li, Yuan Gao, Yingying Li, Furong Liang, Minglan Yao, Xiaoping Luo, Cai Zhang

“…Given that skeletal muscle plays a crucial role in systemic metabolism, we investigated how maternal prepregnancy high‐fat diet (HFD) influences muscle fibre composition and metabolic function in offspring. …”
Get full text

Polysome profiling in liver identifies dynamic regulation of endoplasmic reticulum translatome by obesity and fasting. by Suneng Fu, Jason Fan, Joshua Blanco, Alfredo Gimenez-Cassina, Nika N Danial, Steve M Watkins, Gökhan S Hotamisligil

“…The strongest examples of such regulations were the reduction in Cyp7b1 and Slco1a1, molecules involved in bile acid metabolism. …”
Get full text

Correction possibilities of drug-induced liver toxicity in the treatment of patients with blood system tumors by V. B. Larionova, A. V. Snegovoy

“…The treatment regimens for drug-induced hepatotoxicity included the Heptral, which was prescribed until stable normalization of liver function.Results. All patients with developed liver failure showed metabolic disorders. …”
Get full text