Glycolytic switch in response to betulinic acid in non-cancer cells. by Elke H Heiss, Matthias P Kramer, Atanas G Atanasov, Hortenzia Beres, Daniel Schachner, Verena M Dirsch

“…We demonstrate that BA elevates the rates of cellular glucose uptake and aerobic glycolysis in mouse embryonic fibroblasts with concomitant reduction of glucose oxidation. Without eliciting signs of obvious cell death BA leads to compromised mitochondrial function, increased expression of mitochondrial uncoupling proteins (UCP) 1 and 2, and liver kinase B1 (LKB1)-dependent activation AMP-activated protein kinase. …”
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Splenium of Corpus Callosum: Patterns of Interhemispheric Interaction in Children and Adults by Maria G. Knyazeva

“…Reshaping interactions between interhemispherically distributed networks under various perceptual contexts allows sparsification of responses to superfluous information from the visual environment, leading to a reduction of metabolic and structural redundancy in a child's brain.…”
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Sitagliptin, a dipeptidyl peptidase-4 inhibitor, in patients with short bowel syndrome and colon in continuity: an open-label pilot study by Bolette Hartmann, Jens Juul Holst, Rahim Mohammad Naimi, Mark Krogh Hvistendahl, Lise Margrete Thomassen, Hanna Johnsen, Charlotte Bayer Christiansen, Palle Bekker Jeppesen

“…To assess intestinal function, metabolic balance studies were done at baseline and following 8 weeks of treatment.Results Of the 10 patients planned for enrolment, 8 patients were included; 7 patients completed the study. …”
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The genetic association of the transcription factor NPAT with glycemic response to metformin involves regulation of fuel selection. by Changwei Chen, Jennifer R Gallagher, Jamie Tarlton, Lidy van Aalten, Susan E Bray, Michael L J Ashford, Rory J McCrimmon, Ewan R Pearson, Alison D McNeilly, Calum Sutherland

“…In contrast, metformin regulation of respiratory exchange ratio (RER) was completely lost in animals lacking one allele of npat. There was also a reduction in metformin correction of impaired glucose tolerance, however no other metabolic abnormalities, or response to metformin, were found in the npat heterozygous mice. …”
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Shotgun lipidomics identifies a paired rule for the presence of isomeric ether phospholipid molecular species. by Kui Yang, Zhongdan Zhao, Richard W Gross, Xianlin Han

“…The biochemical basis of this rule results from the fact that the enzymes which participate in either the sequential oxidation of aliphatic alcohols to fatty acids, or the reduction of long chain fatty acids to aliphatic alcohols (metabolic precursors of ether lipid synthesis), are not entirely selective with respect to acyl chain length or degree of unsaturation. …”
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Human cardiac tissues produce lower contractile stress and exhibit slower cross-bridge cycling in type 2 diabetes by J. H. Musgrave, J.-C. Han, M.-L. Ward, N. Kang, A. J. Taberner, K. Tran

“…While the clinical features of diabetic cardiomyopathy have been extensively studied, the effects of diabetes and associated changes in metabolic state on contractile cross-bridge function are less well understood. …”
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Supervised aerobic-strength exercise reduces postural sway and improves dual-task gait in Parkinson’s disease by Pavol Martiš, Diana Bzdúšková, Zuzana Košutzká, Lucia Slobodová, Igor Straka, Karin Marček Malenovská, Oksana Mytiai, Veronika Tirpáková, Patrik Konrády, Viera Litváková, Martin Turi Nagy, Zuzana Urbančík, Peter Valkovič, Jozef Ukropec, Barbara Ukropcová, Jana Kimijanová

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Geroderma Osteodysplastica With Concomitant Transposition of Great Vessels: A Case Report and Literature Review by Charbel Saad, Christine Aoun, Charbel Iskandar, Tony Hayek, Maroun Matar, Andre Megarbane

“…Geroderma Osteodysplastica (GO) is a rare autosomal recessive connective tissue disease characterized by wrinkled skin and osteoporosis, two distinct aging-related features. A loss of function mutation in GORAB results in the disease. …”
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Dietary Strategies to Mitigate Alzheimer’s Disease: Insights into Antioxidant Vitamin Intake and Supplementation with Microbiota–Gut–Brain Axis Cross-Talk by Wan Zurinah Wan Ngah, Hajar Fauzan Ahmad, Sheril June Ankasha, Suzana Makpol, Ikuo Tooyama

“…The changed gut microbiota affects brain function and behavior through several mechanisms, including tau phosphorylation and increased amyloid deposits, neuroinflammation, metabolic abnormalities, and persistent oxidative stress. …”
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The postbiotic ReFerm® versus standard nutritional support in advanced alcohol-related liver disease (GALA-POSTBIO): a randomized controlled phase 2 trial by Johanne K. Hansen, Mads Israelsen, Suguru Nishijima, Sara E. Stinson, Peter Andersen, Stine Johansen, Camilla D. Hansen, Maximilian Joseph Brol, Sabine Klein, Robert Schierwagen, Frank Erhard Uschner, Karolina Sulek, Ida F. Villesen, Katrine P. Lindvig, Katrine H. Thorhauge, Nikolaj Torp, Jane M. Jensen, Marisa Isabell Keller, Gitte H. Jensen, Sönke Detlefsen, Diana J. Leeming, Evelina Stankevic, Tommi Suvitaival, Andressa Zawadzki, Michael Kuhn, Lars Juhl Jensen, Morten Karsdal, Jonel Trebicka, Hans Israelsen, Cristina Legido-Quigley, Peer Bork, Manimozhiyan Arumugam, Torben Hansen, Maja Thiele, Aleksander Krag

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ANGIOTENSIN II RECEPTOR ANTAGONISTS AND ACE INHIBITORS: OPTIMIZATION OF CHOICE FOR TREATMENT OF CARDIOVASCULAR DISEASES by E. M. Khurs, A. V. Poddubnaya

“…Valsartan had priority in prevention of early cardiac remodeling (reduction in left ventricular (LV) hypertrophy and myocardial stress, improvement of functional heart parameters) at early CVC stage (HT, metabolic syndrome). …”
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The pulmoprotective effects of pirfenidone against paraquat-induced pulmonary toxicity: a systematic review by Sajjad Sadeghi, Hamid Madanchi, Mohammad Karami, Rezvan Yazdian-Robati, Mohammad Seyedabadi, Hamidreza Mohammadi

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Plant-derived polyphenolic compounds for managing schizophrenia: mechanisms and therapeutic potential by Xiaolin Ji, Jianbo Chai, Sihan Zhao, Yonghou Zhao

“…These compounds also help restore mitochondrial function by replenishing ATP levels and boosting systemic antioxidant capacity through the reduction of serum malondialdehyde (MDA) levels, while simultaneously enhancing the activity of antioxidant enzymes, including superoxide dismutase (SOD). …”
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Probiotics mitigate stress and inflammation in malnourished adults via gut microbiota modulation: a randomized controlled trial by Maryam Ahmadi-Khorram, Maryam Ahmadi-Khorram, Alireza Hatami, Alireza Hatami, Parastoo Asghari, Parastoo Asghari, Ali Jafarzadeh Esfehani, Asma Afshari, Fateme Javdan, Fateme Javdan, Mohsen Nematy, Mohsen Nematy

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EVALUATING THE CLINICAL AND HEMODYNAMICAL ACTION OF NEBIVOLOL IN CHRONIC HEART FAILURE by M. A. Gurevich, N. P. Sanina, T. F. Hohlova, V. I. Buvalcev

“…During 3 months’ observation examined patients had KDR and KSR distinctly lowered, speed of shortening of miocardium fibrem and the function of throw and MV grew, tension in a pulmonary artery decreased. …”
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Cardiac Obesity and Cardiac Cachexia: Is There a Pathophysiological Link? by K. Selthofer-Relatić, A. Kibel, D. Delić-Brkljačić, I. Bošnjak

“…Progressive heart failure with misbalanced metabolic and catabolic processes will change muscle, bone, and fat mass and function, with possible changes in the cardiac fat state from excessive accumulation to reduction and cardiac cachexia with a worse prognosis. …”
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Regulatory effects of Xihu Longjing tea on the intestinal flora of mice fed with high-fat and high-fructose diet by HU Liquan, TU Linyue, ZHAO Yueling, XIE Hengtong, XU An’an, XU Ping, ZHOU Jihong, WANG Yuefei

“…An increasing number of studies have shown that the intestinal flora and microbial ecology mediated by the intestinal flora play key roles in metabolic disorders associated with high-fat and high-fructose diet. …”
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Integrated analysis of electrical stimulation effects on Pseudomonas aeruginosa PAO1 inoculated denitrifying community: targeted and untargeted metabolomic analysis of phenazine bi... by Li Wu, Li Wu, Yong Liu, Yong Liu, Jianping Deng, Jianping Deng, Shuanglin Gui, Shuanglin Gui, Hanbing Nie, Hanbing Nie

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Reduced IFN-γ-expressing SARS-CoV-2 specific CD4+ T cells and transient CD8 + T cell activation associate with higher HOMA-IR 1-year post COVID-19 in obese individuals by Rona Kartika, Dicky Levenus Tahapary, Farid Kurniawan, Syahidatul Wafa, Tika Pradnjaparamita, Simon P. Jochems, Heri Wibowo, Imam Subekti

“…This reduction, along with the decreased frequencies of both functional CD4⁺ within 12 months of convalescence, suggests a potential association between impaired SARS-CoV-2-specific T cell function and the development of insulin resistance following COVID-19. …”
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Cardiovascular effects of obstructive sleep apnoea and effects of continuous positive airway pressure therapy: evidence from different study models by Matteo Bradicich, Martino F. Pengo, Joerg Steier, Esther Irene Schwarz

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