Glutathione in Cerebral Microvascular Endothelial Biology and Pathobiology: Implications for Brain Homeostasis by Wei Li, Carmina Busu, Magdalena L. Circu, Tak Yee Aw

“…The integrity of the vascular endothelium of the blood-brain barrier (BBB) is central to cerebrovascular homeostasis. Given the function of the BBB as a physical and metabolic barrier that buffers the systemic environment, oxidative damage to the endothelial monolayer will have significant deleterious impact on the metabolic, immunological, and neurological functions of the brain. …”
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Immunosenescence: Aging and Immune System Decline by Priyanka Goyani, Rafail Christodoulou, Evros Vassiliou

“…Inflammaging, characterized by chronic systemic inflammation, further impairs immune function. Cellular metabolic adaptations and hematopoietic changes alter immune cell function, contributing to a diminished immune response. …”
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Biomechanics of the tumor extracellular matrix and regulatory T cells: regulatory mechanisms and potential therapeutic targets by Wen-Bo Huang, Heng-zhou Lai, Jing Long, Zhuo-ling Dai, Qiong Ma, Chong Xiao, Feng-Ming You

“…Moreover, biomechanical signals derived from the ECM strengthen the oxidative phosphorylation (OXPHOS) metabolic phenotype and immunosuppressive function of Tregs by modulating mitochondrial dynamics. …”
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Regenerative activity of stomach epithelial cells at small-intestinal obstruction by V. Ye. Milyukov, K. K. Nguyen

“…Conclusions. Suppression of metabolic processes of epithelial cells of coating layer and cells of cervical and fundic parts of the glands at preservation of main cells metabolism causes reduction of mucosal preoperative activity and may cause suppression of regenerative capacity and decrease of protective function.…”
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Pharmacokinetics of drugs in cachectic patients: a systematic review. by Katja Trobec, Mojca Kerec Kos, Stephan von Haehling, Jochen Springer, Stefan D Anker, Mitja Lainscak

“…Changes in the expression and function of metabolic enzymes could influence the metabolism of drugs, and their renal excretion could be affected by possible reduction in kidney function. …”
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Neurofibromin 1 mediates sleep depth in Drosophila. by Elizabeth B Brown, Jiwei Zhang, Evan Lloyd, Elizabeth Lanzon, Valentina Botero, Seth Tomchik, Alex C Keene

“…Despite extensive epidemiological evidence linking sleep dysregulation with obesity, diabetes, and metabolic syndrome, little is known about the neural and molecular basis for the integration of sleep and metabolic function. …”
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Scutellarin prevents obesity-induced renal fibrosis via reduced activation of AP-1 by Haoan Yi, Yibing Jiang, Wei Li, Ling Shen, Wei Zhang, Shude Li, Yushan Xu, Fei Li

“…SCU was administered orally at doses of 25, 50, and 100 mg/kg/day during the last 8 weeks. Metabolic function was assessed by measuring serum triglycerides (TG), total cholesterol (TC), and glucose levels. …”
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Bioelectrical Impedance Analysis as a Helpful Tool in Pediatric Obesity Monitoring: A Case Report by Agata Przytula, Joanna Popiolek-Kalisz

“…<b>Case Presentation</b>: We present a case of a 10-year-old boy who was referred to a dietitian due to concerns about a diagnosis of obesity and metabolic complications including abnormal lipid profile and liver function. …”
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The suberin transporter StABCG1 is required for barrier formation in potato leaves by Elvio Henrique Benatto Perino, Ulrike Smolka, Karin Gorzolka, Ramona Grützner, Sylvestre Marillonnet, Khabat Vahabi, Sabine Rosahl

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Physical training influence on blood pressure dynamics and target organs status in arterial hypertension patients by N. I. Gromnatsky, V. A. Novikov, V. N. Shilenok

“…Target organ influence was assessed by echocardiography, transcranial duplex sonography of cerebral vessels, with functional metabolic and myogenic tests, as well as with ultrasound endothelial function assessment. …”
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Exploring the effects of Xinnaoning capsule in microcirculatory dysfunction model rats through laser speckle contrast imaging and metabolomics by Yuanfang Sun, Yuanfang Sun, Shasha Li, Lijing Du, Lijing Du, Xiaopeng Ren, Xiaopeng Ren, Huizi Jin, Shikai Yan, Shikai Yan, Xue Xiao

“…Xinnaoning capsule could recover the increased blood viscosity as well as the abnormal vasomotor and microcirculation function in model rats. Furthermore, Xinnaoning capsule intervention could alter metabolic state in model rats, which was characterized by the abnormality metabolites mainly in pathway of phospholipids and arachidonic acid metabolism.ConclusionThe macroscopic image and microscopic indicators elucidated that Xinnaoning capsule was highly effective against microcirculatory dysfunction. …”
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Low-Dose Bisphenol-A Impairs Adipogenesis and Generates Dysfunctional 3T3-L1 Adipocytes. by Fabiana Ariemma, Vittoria D'Esposito, Domenico Liguoro, Francesco Oriente, Serena Cabaro, Antonietta Liotti, Ilaria Cimmino, Michele Longo, Francesco Beguinot, Pietro Formisano, Rossella Valentino

“…Environmental endocrine disruptors (EDCs), including bisphenol-A (BPA), have been recently involved in obesity and diabetes by dysregulating adipose tissue function. Our aim was to examine whether prolonged exposure to low doses of BPA could affect adipogenesis and adipocyte metabolic functions. …”
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Dual role of Metrnl: exercise-induced benefits and potential cancer implications by Hamid Alizadeh

“…Metrnl (Meteorin-like), a protein elevated by exercise, supports metabolic regulation, inflammation reduction and glucose homeostasis. …”
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The heat of longevity: sex differences in lifespan and body temperature by Chiara Ruocco, Maurizio Ragni, Enzo Nisoli

“…Dietary restriction (DR) has long been recognized as a powerful intervention for extending lifespan and improving metabolic health across species. In laboratory animals, DR—typically a 30%–40% reduction in caloric intake—delays aging and enhances mitochondrial function, oxidative defense, and anti-inflammatory pathways. …”
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Exercise and tissue fibrosis: recent advances in therapeutic potential and molecular mechanisms by Zheng Zhao, Yongjia Zhu, Dongfeng Wan

“…Tissue fibrosis represents an aberrant repair process, occurring because of prolonged injury, sustained inflammatory response, or metabolic disorders. It is characterized by an excessive accumulation of extracellular matrix (ECM), resulting in tissue hardening, structural remodeling, and loss of function. …”
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The Hidden Burden: Gastrointestinal Involvement in Lysosomal Storage Disorders by Vincenza Gragnaniello, Chiara Cazzorla, Daniela Gueraldi, Andrea Puma, Christian Loro, Alberto B. Burlina

“…Background: Lysosomal storage disorders (LSDs) are rare inherited metabolic diseases characterized by defects in lysosomal enzyme function or membrane transport. …”
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Nanoencapsulated roselle anthocyanins extract extends lifespan in Western diet-fed male Drosophila via enhanced mitochondrial biogenesis by Qianhua Yuan, Wanhan Song, Ya Wang, Yutong Xie, Dazhang Deng, Nageena Qayyum, Huawen Li, Honghui Guo

“…This study evaluated nanoencapsulated roselle anthocyanins extract (Nano-RAE) in mitigating WD-induced metabolic disturbances and lifespan reduction in Drosophila melanogaster. …”
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B cell-derived nociceptin/orphanin FQ contributes to impaired glucose tolerance and insulin resistance in obesity by Stephanie C. Puente-Ruiz, Leona Ide, Julia Schuller, Adel Ben-Kraiem, Anne Hoffmann, Adhideb Ghosh, Falko Noé, Christian Wolfrum, Kerstin Krause, Martin Gericke, Nora Klöting, Jens C. Brüning, F. Thomas Wunderlich, Matthias Blüher, Alexander Jais

“…Here, we investigate the effects of nociceptin/orphanin FQ (N/OFQ) on metabolic function and inflammation in obesity. Selectively targeting N/OFQ, encoded by the Pnoc gene, in B cells mitigates the adverse metabolic effects of diet-induced obesity and enhances insulin sensitivity and glucose tolerance. …”
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Distinct gut microbiota and metabolomic profiles in HBV-related liver cirrhosis: insights into disease progression by Ke Shi, Lina Sun, Ying Feng, Xianbo Wang

“…Gut microbiota alterations at various stages of liver function were analyzed using 16S rRNA gene sequencing. …”
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Two strategies for arterial hypertension treatment in patients with secondary chronic pyelonephritis by M. E. Statsenko, M. V. Derevyanchenko

“…The combinations “enalapril + indapamide” and “enalapril + nifedipine SR” had similar effects in terms of BP lowering, MAU reduction, and improvement of proximal renal tubular function. …”
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