Biomarkers of residual risk and all-cause mortality after acute coronary syndrome. by Anna Toso, Mario Leoncini, Mauro Maioli, Simona Villani, Francesco Bellandi

“…Diversification of secondary preventive measures based on routine evaluations of inflammation and kidney function markers, not only LDL-C, could lead to better targeted reduction of residual risk after ACS.…”
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Innovative Mycotoxin Detoxifying Agents Decrease the Absorption Rate of Aflatoxin B1 and Counteract the Oxidative Stress in Broiler Chickens Exposed to Low Dietary Levels of the My... by Matteo Cuccato, Neenu Amminikutty, Veronica Spalenza, Vanessa Conte, Stefano Bagatella, Donato Greco, Vito D’Ascanio, Francesco Gai, Achille Schiavone, Giuseppina Avantaggiato, Carlo Nebbia, Flavia Girolami

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Impact of Poly(Lactic Acid) and Graphene Oxide Nanocomposite on Cellular Viability and Proliferation by Karina Torres Pomini, Júlia Carolina Ferreira, Laira Mireli Dias da Silva, Paulo Gabriel Friedrich Totti, Monique Gonçalves Alves, Eliana de Souza Bastos Mazuqueli Pereira, Marcelo Melo Soares, Durvanei Augusto Maria, Rose Eli Grassi Rici

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Efficacy of febuxostat on hyperuricemia and estimated glomerular filtration rate in patients with non-dialysis stage 3/4 chronic kidney disease and assessment of cardiac function:... by Yousuf Abdulkarim Waheed, Yousuf Abdulkarim Waheed, Fan Yang, Jie Liu, Shifaa Almayahe, Karthick Kumaran Munisamy Selvam, Disheng Wang, Disheng Wang, Disheng Wang, Dong Sun, Dong Sun, Dong Sun

“…Our aim is to investigate the efficacy of febuxostat on kidney function. In addition, the cardiac function will be assessed.MethodWe conducted a single-center, interventional, randomized, controlled, open-label study. …”
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Probiotics as Renal Guardians: Modulating Gut Microbiota to Combat Diabetes-Induced Kidney Damage by Saleh Bakheet Al-Ghamdi

“…Weekly assessments included fasting blood glucose, insulin, glycation markers, and kidney function tests. Glucose metabolism and insulin sensitivity were analyzed through oral glucose tolerance test (OGTT) and insulin sensitivity test (IST). …”
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Anterior insular cortex glutamate-glutamine (Glx) levels predict general psychopathology via heightened error sensitivity by Haeorum Park, Minchul Kim, Minchul Kim, Jaejoong Kim, Jaejoong Kim, Sunghwan Kim, Sunghwan Kim, Bumseok Jeong

“…Error sensitivity fully mediated the AIC-Glx/G-score link; associations were specific to Glx, not other metabolites.DiscussionHigher excitatory tone in the AIC appears to enlarge prediction-error weighting, which in turn amplifies a shared anxiety-depression dimension. Dynamic Glx reductions during reward learning suggest acute metabolic demand superimposed on a trait-like baseline that biaes cognition. …”
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<i>Gastrodia elata</i>, <i>Polygonatum sibiricum</i>, and <i>Poria cocos</i> as a Functional Food Formula: Cognitive Enhancement via Modulation of Hippocampal Neuroinflammation and... by Yiwen Zhang, Fang Chen, Xueyan Li, Yanfei Xu, Xinmin Liu, Muhammad Qasim Barkat, Muhammad Iqbal Choudhary, Qi Chang, Ning Jiang

“…These herbs are combined in the Compound Gastrodia elata Formula (CGEF), a functional food formulation. Amidst growing interest in functional foods, this study explores the cognitive-enhancing effects of CGEF, focusing on cognitive function improvement. …”
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Mitochondrial DNA depletion syndrome and its cardiac complication by Shengfang Bao, Shengfang Bao, Jiajun Ye, Jiaqi Zhou, Chen Zheng, Yuejuan Xu, Sun Chen

“…Mitochondrial depletion syndrome (MTDPS) is a heterogeneous group of genetic disorders characterized by a significant reduction in mitochondrial DNA (mtDNA) copy number, leading to the impaired mitochondrial function. …”
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Cross-Species Multi-Omics Analysis Reveals Myeloid-Driven Endothelial Oxidative Stress in Ischemic Stroke by Ziqi Cheng, Hua Zhu, Shi Feng, Yonggang Zhang, Xiaoxing Xiong

“…Endothelial scRNA-seq data showed reductions in the oxidative phosphorylation, glutathione, and nicotinate metabolic pathways, together with elevated pentose phosphate pathway activity, suggestive of oxidative stress and compromised antioxidant capacity. …”
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Effect of Roux-en-Y gastric bypass on patients with type 2 diabetes mellitus and body mass index of 27.5–35 kg/m2–a single center retrospective cohort study by Xiang Gao, Tao Wang, Jiahao Li, Weizheng Li, Liyong Zhu, Shaihong Zhu, Zhi Song, Pengzhou Li

“…Abstract Introduction While Roux-en-Y gastric bypass (RYGB) has been extensively studied in patients with type 2 diabetes mellitus (T2DM) and preserved islet function, the significance of insulin resistance in guiding RYGB treatment remains unclear. …”
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Renal phenotyping in a hypomorphic murine model of propionic aciduria reveals common pathomechanisms in organic acidurias by Anke Schumann, Ainhoa Martinez-Pizarro, Eva Richard, Christoph Schell, Anna Laura Kössinger, Karina A. Zeyer, Stefan Tholen, Oliver Schilling, Michael Barry, Björn Neubauer, Michael Köttgen, Luciana Hannibal, Lourdes R. Desviat, Ute Spiekerkötter

“…Our investigations revealed altered mitochondrial networks shifted towards fission and a marked reduction of mitophagy. We observed a steep reduction of PGC-1-α, the key mediator modulating mitochondrial functions and a counter actor of mitochondrial fission. …”
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Immunometabolic Effects of Ginger (<i>Zingiber officinale</i> Roscoe) Supplementation in Obesity: A Comprehensive Review by María Elizabeth Preciado-Ortiz, Gildardo Gembe-Olivarez, Erika Martínez-López, Juan José Rivera-Valdés

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Platinum Compound on Gold–Magnesia Hybrid Structure: A Theoretical Investigation on Adsorption, Hydrolysis, and Interaction with DNA Purine Bases by Zhenjun Song, Mingyue Liu, Aiguo Zhong, Meiding Yang, Zhicai He, Wenmin Wang, Hongdao Li

“…Cisplatin-based platinum compounds are important clinical chemotherapeutic agents that participate in most tumor chemotherapy regimens. Through density-functional theory calculations, the formation and stability of the inorganic oxide carrier, the mechanisms of the hydrolysis reaction of the activated platinum compound, and its binding mechanism with DNA bases can be studied. …”
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Investigating the Antibacterial, Antioxidant, and Cholesterol-lowering Properties of Yogurt Fortified with Postbiotic of Lactobacillus acidophilus and Lactiplantibacillus plantarum... by Sareh Davarzani, Mohammad Reza Sanjabi, Naheed Mojgani, Saeed Mirdamadi, Mostafa Soltani

“…Postbiotics have gained attention in the food industry due to their functional properties and ease of use compared to their live parent cells. …”
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Kefir Probiotic-Enriched Non-Alcoholic Beers: Microbial, Genetic, and Sensory-Chemical Assessment by Alessandra Souza Marques do Nascimento, Raquel Nunes Almeida da Silva, Pedro Paulo Lordelo Guimarães Tavares, Adriana Silva Borges, Marina Passos Soares Cardoso, Ana Katerine de Carvalho Lima Lobato, Rogéria Comastri de Castro Almeida, Karina Teixeira Magalhães-Guedes

“…Fermentation led to reductions in sucrose (~0.35 to ~0.22 g/L) and °Brix (~5.55 to ~3.80), with increases in lactic acid (~0.55 to ~1.25 g/L) and acetic acid (~0.08 to ~0.14 g/L), confirming active microbial metabolism. …”
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Antioxidant and <i>In Vitro</i> Hepatoprotective Activities of a Polyphenol-Rich Fraction from the Peel of <i>Citrus lumia</i> Risso (Rutaceae) by Vincenzo Musolino, Antonio Cardamone, Rosario Mare, Anna Rita Coppoletta, Francesca Lorenzo, Francesca Rita Noto, Angelo Galluccio, Luigi Tucci, Carmine Lupia, Cristina Carresi, Mariangela Marrelli, Samantha Maurotti, Micaela Gliozzi, Tiziana Montalcini, Arturo Pujia, Vincenzo Mollace

“…<i>Citrus</i> fruits are a rich source of bioactive compounds, particularly polyphenols, which have been linked to a reduction in the risk of several metabolic diseases. …”
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DPP-4 Inhibitor Sitagliptin Improves Cardiac Function and Glucose Homeostasis and Ameliorates β-Cell Dysfunction Together with Reducing S6K1 Activation and IRS-1 and IRS-2 Degradat... by Shigang Qiao, Guofang Mao, Hua Li, Zhimin Ma, Lei Hong, Huiling Zhang, Chen Wang, Jianzhong An

“…In this study, we explored whether DPP-4 inhibitor sitagliptin (SIT) is involved in the protection of cardiac function and β-cell function using an obesity female mouse model. …”
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Natural Language Understanding: Methodological Conceptualization by Vitalii Shymko

“…And the theoretical conclusion that emotions fulfill the function of the operator of the structural features of the information metabolism of NLU is substantiated. …”
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Exploiting moderate hypoxia to benefit patients with brain disease: Molecular mechanisms and translational research in progress by Hannelore Ehrenreich, Max Gassmann, Luise Poustka, Martin Burtscher, Peter Hammermann, Anna‐Leena Sirén, Klaus‐Armin Nave, Kamilla Miskowiak

“…We have coined the term “functional hypoxia” for this important demand‐responsive, relative reduction in O2 availability. …”
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Dissecting the Molecular Mechanism of 10-HDA Biosynthesis: Role of Acyl-CoA Delta(11) Desaturase and Transcriptional Regulators in Honeybee Mandibular Glands by Yunchang Li, Xiaojing Zhang, Zhenyu Xia, Yue Hao

“…A five-step biosynthetic pathway for 10-HDA was proposed, and cross-species analysis of <i>Apis mellifera</i> and <i>A. cerana</i> revealed the conserved expression patterns of 15 key enzymes involved. Functional validation via RNA interference (RNAi) demonstrated that knockdown of acyl-CoA Delta(11) desaturase (<i>d11ds</i>, LOC551527), a key enzyme in FA desaturation, led to a 50% reduction in 10-HDA levels. …”
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