Unraveling the interplay between mesenchymal stem cells, gut microbiota, and systemic sclerosis: therapeutic implications by Lili Zhang, Hui Wang, Lu Zhao, Jin Zhang, Wenchang Sun, Jinjin Chu, Haobin Zhao, Chunjuan Yang, Shushan Yan, Xiaohua Chen, Donghua Xu

“…In summary, the findings in the present study have suggested the close association between gut microbiota and metabolic dysbiosis in mice with SSc. The administration of MSCs has been shown to regulate the disrupted metabolic pathways in SSc mice, thus restoring the normal function of the gut microbiota. …”
Get full text

Effect of outpatient or home-based cardiac rehabilitation training on cardiopulmonary function and mental health after percutaneous coronary intervention in young and middle-aged p... by LI Jingyuan, LI Haiying, GUO Xiao, QU Fengxia, XIN Yue, ZHOU Yaqun

“…Objective To investigate the effect of outpatient or home-based cardiac rehabilitation training on cardiopulmonary function and mental health after percutaneous coronary intervention (PCI) in young and middle-aged patients with coronary heart disease. …”
Get full text

From Agricultural Waste to Functional Tea: Optimized Processing Enhances Bioactive Flavonoid Recovery and Antioxidant Capacity with Multifaceted Health Benefits in Loquat (<i>Eriob... by Mingzheng Duan, Xi Wang, Jinghan Feng, Xu Xiao, Lingying Zhang, Sijiu He, Liya Ma, Xue Wang, Shunqiang Yang, Muhammad Junaid Rao

“…This work provides a scientific foundation for upcycling loquat flowers into standardized nutraceutical ingredients, addressing both agricultural waste reduction and the growing demand for natural functional foods.…”
Get full text

Iron acquisition strategies in pathogenic fungi by Kathryn Takemura, Vanessa Kolasinski, Matteo Del Poeta, Nathalia Fidelis Vieira de Sa, Ashna Garg, Iwao Ojima, Maurizio Del Poeta, Nivea Pereira de Sa

“…ABSTRACT Iron plays a crucial role in various biological processes, including enzyme function, DNA replication, energy production, oxygen transport, lipid, and carbon metabolism. …”
Get full text

Yeast hydrolysate and exercise ameliorate high-fat diet-induced obesity in C57BL/6 mice by Nari Kim, Yejin Ahn, Eun-Jin Jung, Hyeon-Son Choi, Hyung Joo Suh, Yeok Boo Chang

Get full text

Effect of CFTR modulators on glucose homeostasis in children and young adults with cystic fibrosis-related diabetes: a systematic review by Paola Giordano, Giuseppina Leonetti, Vanja Granberg, Rosa Maria Pia Casolino, Giuseppe Lassandro, Maurizio Delvecchio, Giovanna Linguiti

“…The advent of CFTR modulators, including ivacaftor, lumacaftor/ivacaftor, and elexacaftor/tezacaftor/ivacaftor (ETI), has revolutionized CF management by improving pulmonary function, nutritional status, and overall survival. …”
Get full text

Characterization of rhizosphere bacterial communities in oilseed rape cultivars with different susceptibility to Plasmodiophora brassicae infection by Yue Deng, Yue Deng, Wenxian Wu, Xiaoqing Huang, Xiaoqing Huang, Xiaoxiang Yang, Xiaoxiang Yang, Yaoyin Yu, Yaoyin Yu, Zhongmei Zhang, Zhongmei Zhang, Zijin Hu, Xiquan Zhou, Kang Zhou, Kang Zhou, Yong Liu, Yong Liu, Lei Zhang, Lei Zhang

“…Functional analysis of the nitrogen cycle showed that genes related to nitrification (nxrB) were upregulated in susceptible cultivars, while genes related to assimilatory nitrate reduction (nasA, narB, and nirA) were upregulated in resistant cultivars that were infected with P. brassicae. …”
Get full text

甘油二酯的降血脂及控制体质量作用机制研究进展Research progress on the mechanism of diacylglycerol on reducing blood lipid and controlling body weight by 施丽娜1，王亚群2，王明星2，王月华2，程芳园2，金俊1，金青哲1，吴港城1，王兴国1SHI Lina1，WANG Yaqun2，WANG Mingxing2，WANG Yuehua2，CHENG Fangyuan2， JIN Jun1，JIN Qingzhe1，WU Gangcheng1，WANG Xingguo1

“…In order to provide a theoretical reference for the application of DAG oil as a functional blood lipid-lowering and weight-reducing oil, the blood lipid reduction and body weight control efficacy of DAG were introduced, and the mechanism of action was reviewed. …”
Get full text

Effect of sleeve gastrectomy on cardiac inflammatory markers and early postoperative outcomes: A systematic review by Abeer Majed Al Kusayer, Hadia Radwan, Dimitrios Papandreou, Haydar Hasan

Get full text

Association between serum high-density lipoprotein cholesterol and lung function in adults: three cross-sectional studies from US and Korea National Health and Nutrition Examinatio... by Young Sam Kim, Chanho Lee, Youngjae Cha, Soo Han Bae

“…Introduction Cholesterol is an irreplaceable nutrient in pulmonary metabolism; however, studies on high-density lipoprotein cholesterol (HDL-C) levels have shown conflicting results regarding lung function. …”
Get full text

The Potential of Pequi Oil as a Modulator of Chaperone Expression to Minimize Heat Stress in Laying Hens by Paola Aparecida Damázio Rodrigues, Joyce Andrade da Silva, José Cavalcante Souza Vieira, Gabrieli Andressa de Lima, Laís Garcia Cordeiro, Elis Omar Figueroa Castillo, Júlia de Lima Lopes, Marília Afonso Rabelo Buzalaf, Pedro de Magalhães Padilha, José Roberto Sartori

Get full text

Investigating the potential of dietary taurine supplementation to mitigate temperature stress in juvenile olive flounder (Paralichthys olivaceus) by Abayomi Oladimeji Ogun, Haham Kim, Sooa Yoon, Suhyun Lee, Hyuncheol Jeon, Deni Aulia, Junhyeok Hur, Seunghyung Lee

“…However, there was a significant reduction in whole-body crude lipid content, indicating taurine’s role in fat metabolism. …”
Get full text

Green Radish Polysaccharide Prevents Alcoholic Liver Injury by Interfering with Intestinal Bacteria and Short-Chain Fatty Acids in Mice by Xiong Geng, Miaomiao Zhuang, Weina Tian, Huayan Shang, Ziyi Gong, Yanfang Lv, Jianrong Li

“…Using biochemical analysis, high-throughput sequencing of gut microbiota, and gas chromatography–mass spectrometry to measure short-chain fatty acids (SCFAs) in feces, we found that GRP intervention significantly improved lipid metabolism and hepatic function in mice subjected to excessive alcohol intake. …”
Get full text

C-Phycocyanin Extract Modulates Thermogenic and Inflammatory Markers in Brown Adipose Tissue of High-Fat Diet-Fed Animals by Artur Francisco Silva-Neto, Julia Ferreira Rocha, Gustavo Oliveira Lima, Juliana Miki Oguma, Vivien Cayres Giarola Suannes Pucci, Yasmin Alaby Martins Ferreira, Maria Isabel Alonso-Vale, Claudia Maria Oller do Nascimento, Mônica Marques Telles, Anna Rafaela Cavalcante Braga, Luciana Chagas Caperuto, Lila Missae Oyama

Get full text

The complex phenotype and function of spinal cord microglia during ALS progression and the impact of metabotropic glutamate receptor type 5 down-regulation in SOD1G93A mice by Matilde Balbi, Carola Torazza, Tiziana Altosole, Silvia Ravera, Emanuele Farinini, Sara Tessitore, Francesca Bacchetti, Francesca Rosso, Ilaria Musante, Silvana Alfei, Maria Cerminara, Aldamaria Puliti, Gilberto Filaci, Daniela Fenoglio, Riccardo Leardi, Ernesto Fedele, Giambattista Bonanno, Marco Milanese, Tiziana Bonifacino

“…Overall, our results suggest that mGluR5 manipulation ameliorates microglia phenotype and function in ALS by both direct and indirect mechanisms. …”
Get full text

Severe Hypoglycemia and Pituitary Stalk Interruption Syndrome in a 5-Year-Old Boy with Coexistent Hyperprolinaemia: A Case Report and Literature Review by Aikaterini Theodosiadi, Ilektra Toulia, Maria G. Grammatikopoulou, Fotini Adamidou, Danai Chourmouzi, Charalampos Antachopoulos, Athanasios E. Evangeliou, Dimitrios G. Goulis, Kyriaki Tsiroukidou

Get full text

Integrated metabolomic-lipidomic profiling reveals novel biomarkers and therapeutic targets for alcohol use disorder with cognitive impairment by Li Shi, Li Shi, Li Shi, Xiaofang Chen, Bojie Zhou, Bojie Zhou, Shanghao Yang, Shanghao Yang, Qinglin Ou, Qinglin Ou, Xuhui Zhou, Xuhui Zhou

“…AUD-CI patients exhibited 49 unique lipid alterations, notably 70% reduction of phosphatidylcholine PC (42:4) versus HCs (p=0.002), strongly correlated with synaptic protein markers (r=0.82, p&lt;0.001).ConclusionOur findings characterize a dysregulated liver-gut-brain metabolic axis in AUD-CI pathogenesis, highlighting the mTORC1-sphingolipid pathway as a promising therapeutic target. …”
Get full text

Critical contributions of neuronal subtypes to pediatric drug-resistant focal dysplasia by Yujie Zhang, Lin Li, Fengjun Zhu, Xinyang Zhang, Dan Xia, Qiuling Miao, Cheng Zhong, Cheng Zhong, Shuli Liang, Dezhi Cao, Dezhi Cao, Huafang Zou, Jing Duan, Yousheng Shu, Yi Yao, Jianming Song, Songnian Hu, Jianxiang Liao, Jianxiang Liao, Qiang Zhou

“…Differentially expressed genes (DEGs) in the PVALB_RGS5 subtype were particularly enriched in pathways related to synaptic function. Recordings from fast-spiking (FS)/parvalbumin-containing neurons in brain sections from patients with FCD revealed a reduction in excitatory synaptic inputs, which indicates fewer synaptic inputs onto these neurons and lower activity. …”
Get full text

Effects of small sided football and date seed (Phoenix dactylifera) powder supplementation on liver enzymes in inactive college subjects: an interventional study by Mohammad Mehdi Khaleghi, Abdossaleh Zar, Hamid Reza Sadeghipour

Get full text

Exercise Interventions in Breast Cancer: Molecular Mechanisms, Physical Benefits, and Practical Recommendations by Vasiliki Michou, Stefanos Zervoudis, Panagiotis Eskitzis, Georgios Tsamos, Dimitra Vasdeki, Andriani Vouxinou, Anisa Markja, Georgios Iatrakis

“…Furthermore, we summarize findings from clinical trials evaluating the effects of exercise on cardiorespiratory fitness, functional capacity, and quality of life in breast cancer patients. …”
Get full text