GLP-1R/GCGR dual agonism dissipates hepatic steatosis to restore insulin sensitivity and rescue pancreatic β-cell function in obese male mice by Rhianna C. Laker, Shaun Egolf, Sarah Will, Louise Lantier, Owen P. McGuinness, Charles Brown, Nicholas Bhagroo, Stephanie Oldham, Kyle Kuszpit, Alex Alfaro, Xidan Li, Taewook Kang, Giovanni Pellegrini, Anne-Christine Andréasson, Sarina Kajani, Sadichha Sitaula, Martin R. Larsen, Christopher J. Rhodes

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Efficacy of novel activated bamboo charcoal in reducing uremic toxins and enhancing kidney function in chronic kidney disease patients: a pilot randomized controlled trial by Kuo-Chin Hung, Mei-Yueh Lee, Shih-Yuan Hung, Chiao-Yin Sun, Chau-Chung Wu, Cheng-Jui Lin

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THE WAYS OF SYMPATHETIC SYSTEM OVERACTIVITY BLOCKING: RILMENIDINE VERSUS ATENOLOL by Y. R. Kasherininov, E. K. Shavarova, A. A. Shavarov, N. V. Vachrameeva, A. N. Krutikov, E. V. Smirnova, A. O. Коnrady, E. V. Shlyakhto

“…To evaluate effects of long-term treatment with rilmenidine compared with atenolol on lipid and glucose metabolism and cardiovascular remodeling in hypertension. …”
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Post‐hoc analysis of the tofogliflozin post‐marketing surveillance study (J‐STEP/LT): Tofogliflozin improves liver function in type 2 diabetes patients regardless of BMI by Hiroyuki Uchinuma, Mitsunori Matsushita, Masaya Tanahashi, Hideki Suganami, Kazunori Utsunomiya, Kohei Kaku, Kyoichiro Tsuchiya

“…However, lean MASLD is more prevalent in Japan, necessitating alternative approaches to body weight reduction. Materials and Methods We used the J‐STEP/LT dataset including up to 3‐year treatment data to analyze the effects of the SGLT2 inhibitor tofogliflozin on liver function and treatment safety and conducted a subgroup analysis based on body mass index (BMI; kg/m2, <20, 20–<23, 23–<25, 25–<30, and ≥30). …”
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Exposome and Metabolome Analysis of Sugarcane Workers Reveals Predictors of Kidney Injury by Arthur D. Stem, Stephen Brindley, Keegan L. Rogers, Adil Salih, Carlos A. Roncal-Jimenez, Richard J. Johnson, Lee S. Newman, Jaime Butler-Dawson, Lyndsay Krisher, Jared M. Brown

“…Cross-harvest metabolomic analysis found trends of fatty acid accumulation, perturbed amino acid metabolism, presence of pesticides, and other known signs of impaired kidney function. …”
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Devising and Testing a Comprehensive Physiotherapy Protocol to Improve Muscle Strength, Mass, Function and Quality of Life in Type 2 Diabetic Postmenopausal Women: A Research Proto... by Sonali Guliya, Subhasish Chatterjee

“…Introduction: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic condition that can pose significant challenges for postmenopausal women, particularly in terms of their physical capabilities and overall wellbeing and they are at five times more risk of experiencing a reduction in muscle strength and mass comparison to non diabetic postmenopausal women. …”
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Ammonium-Generating Microbial Consortia in Paddy Soil Revealed by DNA-Stable Isotope Probing and Metatranscriptomics by Chao-Nan Wang, Yoko Masuda, Keishi Senoo

“…Many of these bacteria participate in key ecological processes typical of paddy environments, including iron or sulfate reduction and rice straw decomposition. This study revealed the ammonium-generating microbial consortia in paddy soil that contain several key bacterial drivers of multiple reductive nitrogen transformations and suggested their diverse functions in paddy soil metabolism.…”
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TGFβ1 Restores Energy Homeostasis of Human Trophoblast Cells Under Hyperglycemia In Vitro by Inducing PPARγ Expression, AMPK Activation, and HIF1α Degradation by Nihad Khiat, Julie Girouard, Emmanuelle Stella Kana Tsapi, Cathy Vaillancourt, Céline Van Themsche, Carlos Reyes-Moreno

“…The TGFβ1/SMAD2 signaling pathway and the transcription factors PPARγ, HIF1α, and AMPK are key regulators of cell metabolism and are known to play critical roles in extravillous trophoblast cell differentiation and function. …”
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Clinical Recommendations of the Northwest Society for Enteral and Parenteral Nutrition, Interregional Association for Emergency Surgery, Russian Gastroenterological Association, Un... by Yu. V. Averyanova, E. M. Batyrshin, A. E. Demko, G. E. Ivanova, V. T. Ivashkin, L. N. Kostyuchenko, A. V. Lapitsky, I. N. Leiderman, V. M. Luft, I. V. Maev, I. G. Nikitin, M. S. Novruzbekov, Е. A. Poluektova, A. L. Potapov, A. V. Sytov, A. S. Trukhmanov

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Effects of Dan Shen (Salvia miltiorrhiza) on blood pressure management in hypertensive patients: a randomized controlled trial by Pan Li, Zonghua Jiang, Linfei Dong, Shifeng Wang, Jiangli Qi, Longhong Zhu

“…QoL, assessed via SF-36, improved significantly, particularly in vitality (+20.9) and physical functioning (+18.6). Adverse events (AEs) were mild to moderate, mainly gastrointestinal discomfort and dizziness, and did not result in dropout. …”
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Cyanobacterial mats and their associated microbiomes in saline and freshwater lakes from the Bolivian Altiplano by Guilherme Scotta Hentschke, Miguel Semedo, Jimmy Ciancas, Claudia Hoepfner, Claudia Hoepfner, Daniel Guzmán, Daniela S. Rivera, Vitor M. Vasconcelos, Vitor M. Vasconcelos

“…The microbiome associated with these mats was dominated by Alphaproteobacteria, Bacteroidia, Gammaproteobacteria, Clostridia, Cyanophyceae, and Campylobacteria. Functional predictions based on 16S rRNA gene profiles indicated a predominance of phototrophic and chemoheterotrophic metabolisms, along with sulfur respiration, nitrogen fixation, nitrate and nitrite reduction, and fermentation pathways. …”
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Linoleic acid metabolite 13-Hydroxyoctadecadienoic acid as a biphasic ferroptosis modulator in granulosa cells: multi-omics analysis of ovine atretic follicles by Yukun Song, Erhan Hai, Lixia He, Ning Zhang, Nan Zhang, Junlan Wang, Yupeng Sun, Dengke Zeng, Jiaxin Zhang, Jiaxin Zhang

“…Cell viability, lipid peroxidation levels, ferroptosis-related markers, and ferroptosis-related genes were measured.ResultsThe metabolomic analysis identified 87 and 48 differentially expressed metabolites in healthy and atretic follicles, respectively. Functional enrichment of atretic follicle fluid highlighted pathways related to linoleic acid and purine metabolism. …”
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MXene-based materials for enhanced water quality: Advances in remediation strategies by Ali Mohammad Amani, Milad Abbasi, Atena Najdian, Farzaneh Mohamadpour, Seyed Reza Kasaee, Hesam Kamyab, Shreeshivadasan Chelliapan, Mostafa Shafiee, Lobat Tayebi, Ahmad Vaez, Atefeh Najafian, Ehsan Vafa, Sareh Mosleh-Shirazi

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Tissue-Specific RNA-Seq Analysis of Cotton Roots’ Response to Compound Saline-Alkali Stress and the Functional Validation of the Key Gene <i>GhERF2</i> by Aiming Zhang, Qiankun Liu, Xue Du, Baoguang Xing, Shaoliang Zhang, Yanfang Li, Liuan Hao, Yangyang Wei, Yuling Liu, Pengtao Li, Shoulin Hu, Renhai Peng

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Astrocytes Differentiated from LRRK2-I1371V Parkinson’s-Disease-Induced Pluripotent Stem Cells Exhibit Similar Yield but Cell-Intrinsic Dysfunction in Glutamate Uptake and Metaboli... by Roon Banerjee, Aishwarya Raj, Chandrakanta Potdar, Pramod Kumar Pal, Ravi Yadav, Nitish Kamble, Vikram Holla, Indrani Datta

“…Owing to the presence of multiple enzymatic domains, LRRK2 has been associated with a diverse set of cellular functions and signaling pathways. It also has several pathological mutant-variants, and their incidences show ethnicity biases and drug-response differences with expression in dopaminergic-neurons and astrocytes. …”
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Targeting Toll-like receptor 4 and microbiota dysregulation: a new frontier in nonalcoholic fatty liver disease management by K.B. Kvit

“…Microbiome-targeted therapy proved effective in reducing TLR4-driven inflammation, improving metabolic and liver function, and normalizing dysbiotic microbial profiles, supporting the use of microbiota-focused interventions in NAFLD management.…”
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A Very Low-Calorie Ketogenic Diet Approach for Post-Bariatric Weight Regain: A Pilot Study by Ilaria Ernesti, Mikiko Watanabe, Alfredo Genco

“…Metabolic markers, such as insulin resistance (HOMA-IR), also improved significantly (<i>p</i> = 0.041). …”
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Gut Microbiome Engineering for Diabetic Kidney Disease Prevention: A <i>Lactobacillus rhamnosus GG</i> Intervention Study by Alaa Talal Qumsani

“…Glycemic indices were monitored at bi-weekly intervals, inflammatory biomarkers, renal function indices, and urinary albumin excretion. The metabolic profile was evaluated through the determination of HOMA-IR and the computation of metabolic syndrome scores. …”
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Short-term consequences of daily consumption of the quinoa (Chenopodium quinoa Willd.) diet in normal and diabetic rats by Murali Adiga, S. D. Manjula, Dhiren Punja, Chakravarthy Marx Sadacharan, Dinesh Upadhya, K. Vasanthalaxmi, Nanda Acharya, Chinmay Suryavanshi

“…Results: Diabetic rats receiving 40% and 80% quinoa diets exhibited significant reductions in fasting blood glucose (p < 0.05) and alanine transaminase levels (p < 0.01), indicating improved glycemic and hepatic function. …”
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Insect–Antioxidants Symbiotic Nexus—Pathway for Sustainable and Resilient Aquaculture: A Case Study for Evaluating Koi Carp Growth and Oxidative Stress Status by Alina Antache, Ira-Adeline Simionov, Ștefan-Mihai Petrea, Aurelia Nica, Puiu-Lucian Georgescu, Lăcrămioara Oprică, Marius-Nicușor Grigore, Mircea Oroian, Daniela Jitaru, Andreea Liteanu, Alin-Stelian Ciobîcă, Vladimir Poroch

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