Action and therapeutic targets of folliculin interacting protein 1: a novel signaling mechanism in redox regulation by Qingzhi Ran, Aoshuang Li, Bo Yao, Chunrong Xiang, Chunyi Qu, Yongkang Zhang, Yongkang Zhang, Xuanhui He, Hengwen Chen

Get full text

Lipids and C-reactive protein predict anhedonia and reward circuit functional connectivity responses to anti-cytokine and dopaminergic therapies in patients with depression by Aditya Singh, Mandakh Bekhbat, David R. Goldsmith, Ngoc-Anh Le, Evanthia C. Wommack, Zhihao Li, Ebrahim Haroon, Jennifer C. Felger

“…Increased inflammation and associated metabolic disturbances have been shown to affect neurotransmitters and brain circuits, contributing to an immunometabolic phenotype of anhedonic depression. …”
Get full text

Palmitic acid reduces LDLR-dependent uptake of macrophage-derived extracellular vesicles by hepatoma cells by Bootsakorn Boonkaew, Nantawat Satthawiwat, Bianca C. Pachane, Lucy M. Brett, Pisit Tangkijvanich, Chaiyaboot Ariyachet

“…Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by a complicated interaction of lipotoxicity and inflammation in the liver, yet the mechanisms linking these phenomena remain incompletely understood. …”
Get full text

Therapeutic potential of Medical Nutrition Therapy (MNT) in Non-Alcoholic Fatty Liver Disease (NAFLD) by Abdul-Malik Bawah, Kasim Abdulai, Priscilla Cecilia Akpene Amenya

“…Results: The MNT intervention group showed significant improvements in liver function tests (ALT and AST decreased by 25 % on average, p < 0.01) and metabolic markers (BMI reduced by 3 %, p < 0.01). …”
Get full text

Depressive disorders in women of climacteric age (review of foreign literature for 2012–2016) by N. A. Bokhan, E. V. Lukiyanova, G. G. Simutkin

“…The association of CD with social-environmental factors (gender, education, profession, social position, financial wealth) is discussed, achievement of the woman is considered as a actor of reduction of CD risk. The authors are highly interested in search for genetic markers (heredity, suicides in relatives), impairment of neuromediator exchange (neurotransmitters serotonin, dopamine, adrenaline, and noradrenaline), neuromorphologic alterations in brain sensorimotor cortex (motor function, attention, perception, memory, and emotional-motivational response), hormonal disturbances (neuroendocrine and metabolic) and psychoneuroimmunological patterns of association with CD. …”
Get full text

Metagenomic insights into surface sediment microbial community and functional composition along a water-depth gradient in a subtropic deep lake by Peixuan Zhang, Peixuan Zhang, Minglei Ren, Yan Xu, Jianjun Wang

“…We further found the surface layer was enriched in genes mainly involved in aerobic metabolism and methanogenesis. In contrast, genes related to reduction reactions, including dissimilatory nitrate and sulfate reduction were more abundant in the thermocline and deep layer, reflecting lower redox potential in a deeper layer. …”
Get full text

Effect of trimetazidine on left ventricular functions and cardiac biomarkers in diabetic patients with left ventricular diastolic dysfunction: a randomized controlled trial by Heba Serag, Lamia El Wakeel, Viola William, Mona Abdelsalam, Ahmed Abdelsalam, Rana Sayed

Get full text

Bovine colostrum-derived extracellular vesicles protect against non-alcoholic steatohepatitis by modulating gut microbiota and enhancing gut barrier function by Daye Mun, Sangdon Ryu, Daniel Junpyo Lee, Min-Jin Kwak, Hyejin Choi, An Na Kang, Dong-Hyun Lim, Sangnam Oh, Younghoon Kim

“…Transcriptomic analyses demonstrated a notable reduction in lipid metabolism, bacterial response, and inflammatory pathways in the intestine, as well as reduced expression of inflammation- and fibrosis-related pathways in the liver. …”
Get full text

Effect of Daily <i>Lactococcus cremoris</i> spp. Consumption Immobilized on Oat Flakes on Blood and Urine Biomarkers: A Randomized Placebo-Controlled Clinical Trial by Panoraia Bousdouni, Aikaterini Kandyliari, Anastasia Kargadouri, Panagiota Potsaki, Olga I. Papagianni, Maria-Eleni Stylianou, Nikoletta Stathopoulou, Panagiota Andrianopoulou, Maria Kapsokefalou, Vasiliki Bountziouka, Anastasia Kolomvotsou, Ioanna Prapa, Gregoria Mitropoulou, Chrysoula Pavlatou, Andreas G. Tzakos, Panayiotis Panas, Yiannis Kourkoutas, Antonios E. Koutelidakis

Get full text

Diverse microbiome functions, limited temporal variation and substantial genomic conservation within sedimentary and granite rock deep underground research laboratories by Yuki Amano, Rohan Sachdeva, Daniel Gittins, Karthik Anantharaman, Shufei Lei, Luis E. Valentin-Alvarado, Spencer Diamond, Hikari Beppu, Teruki Iwatsuki, Akihito Mochizuki, Kazuya Miyakawa, Eiichi Ishii, Hiroaki Murakami, Alexander L. Jaffe, Cindy Castelle, Adi Lavy, Yohey Suzuki, Jillian F. Banfield

“…Despite this, hydrogen metabolism, rubisco-based CO2 fixation, reduction of nitrogen compounds and sulfate reduction are well represented functions in microbiomes from both URLs, although methane metabolism is more prevalent at the organic- and CO2-rich Horonobe URL. …”
Get full text

Analysis of Microbial Community Heterogeneity and Carbon Fixation Capabilities in Oil-Contaminated Soils in Chinese Onshore Oilfields by Jiayu Song, Yakui Chen, Yilei Han, Yunzhao Li, Zheng Liu, Xingchun Li, Diannan Lu, Chunmao Chen

“…These metabolic pathways highlight the functional diversity of microorganisms. …”
Get full text

L-Glutamine peptides as a means of accelerated rehydration under intense physical activity in athletes by T. Pushkina, T. Popova, A. Zholinsky, A. Dmitriev, E. Tokaev, M. Klyuchnikov, A. Shestopalov

“…Urgent effects of L-Glutamine dipeptides under conditions of physical stress and hydration stress, influence on motor and cognitive functions of athletes, positive influence on physical readiness of athletes for prolonged debilitating exercises, reduction of weight loss (rehydration) are described. …”
Get full text

Intermittent Fasting and Its Health Implications: A Systematic Review of Existing Research by Jagoda Kubicka, Martyna Grabowska, Karolina Grabowska, Aleksandra Wiśniewska, Jakub Dąbek, Wiktoria Kosucka, Dominik Balik, Joanna Lara, Anna Kwasniewska, Karolina Kaszyńska

“…This review investigates the influence of IF on human health, focusing on metabolic effects, cardiometabolic health, neurocognitive functions, and hormonal changes. …”
Get full text

Still a dilemma! Are vonoprazan and esomeprazole attenuating the antiplatelet function of clopidogrel when taken concomitantly? A systematic review and meta-analysis by Eman Youssef, Aliaa Gamal, Hagar Youssef

“…Esomeprazole did not significantly reduce IPA% in the poor-metabolizer genotype of CYP2C19. Further RCTs are needed for conclusive evidence on the effect of vonoprazan and esomeprazole on clopidogrel’s function. …”
Get full text

Plant Growth-Promoting Effect and Complete Genomic Sequence Analysis of the Beneficial Rhizosphere <i>Streptomyces</i> sp. GD-4 Isolated from <i>Leymus secalinus</i> by Wanru Xu, Yimeng Liu, Yiping Cheng, Jie Zhang

Get full text

Hypoxia-inducible factors: details create a picture. Part I. HIF-1 by G. A. Ignatenko, N. N. Bondarenko, S. V. Tumanova, T. S. Ignatenko, A. A. Kaluga, Ya. S. Valigun

“…The review presents a comparative analysis of scientific data on the structural and functional characteristics of subunits (HIF-1α and HIF-1β) of hypoxia-inducible transcription factor-1 (HIF-1). …”
Get full text

High (≥6.5) Spontaneous and Persistent Urinary pH Is Protective of Renal Function at Baseline and during Disease Course in Idiopathic Membranous Nephropathy by Claudio Bazzi, Elena Tagliabue, Sara Raimondi, Virginia Rizza, Daniela Casellato, Masaomi Nangaku

“…Metabolic acidosis correction in advanced renal failure slows renal function decline attributed to tubulointerstitial damage (TID) reduction. …”
Get full text

Effects of combined metformin and semaglutide therapy on body weight, metabolic parameters, and reproductive outcomes in overweight/obese women with polycystic ovary syndrome: a pr... by Haiyan Chen, Xiaohui Lei, Zhuoran Yang, Yuxin Xu, Dongfang Liu, Cong Wang, Hu Du

“…Abstract Objective This study aimed to assess the effects of metformin (MET) monotherapy versus a combination of semaglutide and MET on weight, metabolism, reproductive function, and inflammatory markers in women with polycystic ovary syndrome (PCOS). …”
Get full text

Partial IGF-1 deficiency is sufficient to reduce heart contractibility, angiotensin II sensibility, and alter gene expression of structural and functional cardiac proteins. by José Luis González-Guerra, Inma Castilla-Cortazar, Gabriel A Aguirre, Úrsula Muñoz, Irene Martín-Estal, Elena Ávila-Gallego, Miriam Granado, Juan E Puche, Ángel Luis García-Villalón

“…Circulating levels of IGF-1 may decrease under several circumstances like ageing, metabolic syndrome, and advanced cirrhosis. This reduction is associated with insulin resistance, dyslipidemia, progression to type 2 diabetes, and increased risk for cardiovascular diseases. …”
Get full text

Mitigating enteric methane emissions: An overview of methanogenesis, inhibitors and future prospects by Xin Xie, Yurong Cao, Qiushuang Li, Qi Li, Xingze Yang, Rong Wang, Xiumin Zhang, Zhiliang Tan, Bo Lin, Min Wang

“…This review compiles data from 78 peer-reviewed in vivo studies conducted over the past 5 years, focusing on 10 inhibitors, which demonstrates 5% to 75% in daily methane emission reduction, 2% to 70% in methane yield reduction, and 11% to 74% in methane intensity reduction. …”
Get full text