Dynamics of endothelial function violation in patients with arterial hypertension with moderate cardiovascular risk and antihypertensive therapy treatment influence by T. S. Turlyun

“…Cardiovascular events risk reduction is caused by stabilization of blood pressure, indices of lipid profile lowering, the tendency to endothelial function improvement, especially with losartan potassium therapy.…”
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Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice by Ali Yousefian-Jazi, Suhyun Kim, Jiyeon Chu, Seung-Hye Choi, Phuong Thi Thanh Nguyen, Uiyeol Park, Min-gyeong Kim, Hongik Hwang, Kyungeun Lee, Yeyun Kim, Seung Jae Hyeon, Hyewhon Rhim, Hannah L. Ryu, Grewo Lim, Thor D. Stein, Kayeong Lim, Hoon Ryu, Junghee Lee

“…Moreover, MEF2C mutant cells show reduction of mitochondrial membrane potential, ATP level but elevation of oxidative stress. …”
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Effect of probiotics on cognitive function and cardiovascular risk factors in mild cognitive impairment and Alzheimer’s disease: an umbrella meta-analysis by Bin Xiao, Lina Fu, Zhe Yang, Guran Yu

“…Conclusion Probiotic supplementation appears to enhance cognitive function and metabolic parameters in individuals with MCI and AD, likely through mechanisms involving inflammation reduction, oxidative stress modulation, and improved insulin sensitivity. …”
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RNA-Seq Identification of Peanut Callus-Specific Promoters and Evaluation of Base-Editing Efficiency by Lulu Xue, Han Liu, Huanhuan Zhao, Pengyu Qu, Xiaona Li, Xiaobo Wang, Bingyan Huang, Ziqi Sun, Suoyi Han, Xiaodong Dai, Wenzhao Dong, Lei Shi, Xinyou Zhang

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Effect of Supplementation Lipogenic and Lipolytic Sources on Dry Matter Intake, Milk Composition and Blood Parameters of Lactating Cows by Mohammad Hassan Mortazavi, Mahdi Ganjkhanlou, Aboalfazl Zali, Kamran Reza Yazdi

“…On the other hand, conjugated linoleic acid supplement has a negative effect on the function of enzymes that produce milk de novo fatty acids, it causes a reduction of milk fatty acids and prevents releasing of energy through milk, which can help reduce the negative energy balance during early lactation. …”
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Microbial fermentation of soybeans: synergistic enhancement of bioactivity and sensory properties by Ruizhen Gong, Zsolt Zalán, Jiajia Song, Huayi Suo

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Mechanistic insights into nitrogen removal performance and electron competition with mixed electron donor supply in a biofilm electrode reactor by Xin Yuan, Chunfang Chao, Jiaojiao Niu, Jinxin Song, Yiwen Liu, Siyuan Zhai, Yingxin Zhao

“…Notably, nitrite reductase (Nir) emerged as the weakest competitor, resulting in a constrained NO2- reduction capacity. Based on the analysis of the electron competition characteristic, the potential NO3- metabolic pathway in the BER system was primarily driven by heterotrophic denitrification processes. …”
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Loss of Cdkn1a protects against MASLD alone or with alcohol intake by preserving lipid homeostasis by Arantza Lamas-Paz, Alejandro Hionides-Gutiérrez, Feifei Guo, Gonzalo Jorquera, Laura Morán-Blanco, Raquel Benedé-Ubieto, Mariana Mesquita, Olga Estévez-Vázquez, Kang Zheng, Marina Mazariegos, Elena Vázquez-Ogando, Elena Blázquez-López, Iris Asensio, Beste Mutlu, Beatriz Gomez-Santos, María Isabel Peligros, Javier Vaquero, Rafael Bañares, Teresa C. Delgado, María Luz Martínez-Chantar, Eduardo Martínez-Naves, Carlos Sanz-García, Mohamed Ramadan Mohamed, Sofía Tesolato, Pilar Iniesta, Rocío Gallego-Durán, Douglas Maya-Miles, Javier Ampuero, Manuel Romero-Gómez, Ana Martínez-Alcocer, David Sanfeliu-Redondo, Anabel Fernández-Iglesias, Jordi Gracia-Sancho, Mar Coll, Isabel Graupera, Pere Ginès, Andrea Ciudin, Jesús Rivera-Esteban, Juan M. Pericàs, Matías A. Ávila, Maria Dolores Frutos, Carlos Manuel Martínez-Cáceres, Bruno Ramos-Molina, Patricia Aspichueta, Pere Puigserver, Yulia A. Nevzorova, Francisco Javier Cubero

“…In the present study, we investigated the function of CDKN1A in SLD. Methods: CDKN1A expression levels were evaluated in different patient cohorts with SLD, fibrosis, and advanced chronic liver disease (ACLD). …”
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Comparative transcriptomics of two petal variants reveals key functional genes underlying petal shape development in lotus (Nelumbo) by Jiaxin He, Jiaxin He, Yini Ma, Qingqing Liu, Rui Zhang, Guohong Huang, Dasheng Zhang, Fengluan Liu, Caixia Yang

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Association of cardiovascular-kidney-metabolic index with all-cause mortality during hospitalization in critically ill patients: a retrospective cohort study from MIMIC IV2.2 by Xiaolong Qu, Yuping Liu, Peng Nie, Lei Huang

“…BackgroundThe cardiovascular-kidney-metabolic index (CKMI), a novel functional indicator proposed in this study, aims to accurately reflect the functional status of the heart, kidneys, and metabolism. …”
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Functions of Smartphone Apps and Wearable Devices Promoting Physical Activity: Six-Month Longitudinal Study on Japanese-Speaking Adults by Naoki Konishi, Takeyuki Oba, Keisuke Takano, Kentaro Katahira, Kenta Kimura

“…The secondary objective was to explore which functions and features of PA apps predict changes in PA levels. …”
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Hepcidin as a Therapeutic Target in Liver Cirrhosis: A Cohort Study on Iron Dysregulation by Arsalan Ahmed Uqaili, Adil Hassan Chang, Muhammad Amjad Kalhoro, Osama Ahmed, Mashooque Ali Samejo, Muhammad Sadik Memon, Ejaz Ahmed

“…The intervention group achieved notable liver function improvement through their Child-Pugh score drop from 8.2 to 6.5 (p=0.003) and their MELD score reduction from 18.2 to 14.9 (p=0.002). …”
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Exercise Intolerance in Type 2 Diabetes: A Systematic Review and Meta‐Analysis by Kara C. Anderson, Nathan R. Weeldreyer, Zachary S. Leicht, Siddhartha S. Angadi, Zhenqi Liu

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Effects of probiotics and synbiotics oral supplementation on thyroid function in adults: a grade-assessed systematic review and meta-analysis by Mehdi Karimi, Reyhane Rabiei, Kimia Kazemi, Reyhaneh Bagheri Motlagh, Omid Asbaghi

“…Abstract Background and aim Evidence suggests that the gut microbiota may have a potential impact on thyroid function, given the gut-thyroid axis and the microbiome’s involvement in nutrient absorption, immune modulation, and hormone metabolism. …”
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Evolution in a plant matrix: adaptive reshaping of kefir grains microbiota and function during long-term soymilk culture by Zhina Chen, Qingqing Li, Fanqi Li, Linlin Yin, La Wang, Tao Ye, Yi Wang, Shengju Fu, Weiming Wang, Xiaochen Huang

“…To explore the adaptability of kefir grains in long-term subculture in soymilk, this study tracked the succession and functional changes of its microbial community over 4 months. …”
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Ribonuclease activity of Dis3 is required for mitotic progression and provides a possible link between heterochromatin and kinetochore function. by Hiroaki Murakami, Derek B Goto, Takashi Toda, Ee Sin Chen, Shiv I Grewal, Robert A Martienssen, Mitsuhiro Yanagida

“…<h4>Background</h4>Cellular RNA metabolism has a broad range of functional aspects in cell growth and division, but its role in chromosome segregation during mitosis is only poorly understood. …”
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Relationship Between Resting-State Functional Magnetic Resonance Imaging and Different Time in Target Glucose Range in Elderly Patients with Type 2 Diabetes Mellitus by Yang P, Liu S, Li L

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Taurine ameliorates blood pressure and vascular function in patients with type 2 diabetes: Randomized, double-blind, placebo-controlled trial by Yingsha Li, Qianran Wang, Yi Liu, Qiang Li, Weijie Xia, Shaoyang Lin, Qian Yang, Alexandra Scholze, Zhigang Zhao, Hongbo He, Hexuan Zhang, Zhencheng Yan, Martin Tepel, Huaming Mu, Zhiming Zhu, Daoyan Liu

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Effects of the fixed-dose combination therapy with indapamide and valsartan on renal function in patients with Type 2 diabetes mellitus and arterial hypertension by T. V. Malykh, A. P. Babkin

“…The treatment was associated with a substantial reduction in BP levels, improved circadian BP profiles, and metabolic neutrality. …”
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The effects of melatonin on differentiated C2C12 myotubes in the absence of pathology: An oxygen-sparing action and enhancement of pro-survival signalling pathways by Garth Wentley, Russel J. Reiter, Yong-Xiao Wang, Gerald Maarman

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