Impaired cognitive function and decreased monoamine neurotransmitters in the DNAJC12 gene knockout mouse model by Shunan Wang, Ming Shen, Bo Pang, Bo Zhou, Yuan Yuan, Mei Lu, Xiangling Deng, Min Yang, Shufang Liu, Qiong Wang, Mei Xue, Qisheng Xia, Zhixin Zhang

“…The Morris water maze test was administered to evaluate the cognitive functions of the mice. Additionally, we utilized High-Performance Liquid Chromatography (HPLC) to measure serum aromatic amino acids and brain monoamines, facilitating an investigation into the metabolism of phenylalanine and tyrosine. …”
Get full text

Blocking the SIRPα-CD47 axis promotes macrophage phagocytosis of exosomes derived from visceral adipose tissue and improves inflammation and metabolism in mice by Yun-kai Lin, Yu-fei Pan, Tian-yi Jiang, Yi-bin Chen, Tai-yu Shang, Meng-you Xu, Hui-bo Feng, Yun-han Ma, Ye-xiong Tan, Hong-yang Wang, Li-wei Dong

“…In obesity, the lipidome profile of AT-Exos was significantly altered, and diet can modify the miRNA content and function within these exosomes, influencing lipid metabolism and inflammatory pathways that contribute to metabolic dysregulation. …”
Get full text

High-altitude hypoxia exacerbates chemotherapy-induced myelosuppression by lowering serum G-CSF/GM-CSF and regulating apoptosis and proliferation by Jing Shi, Fuxing Zhao, Tianlei Qiu, Dengfeng Ren, Zitao Li, Junli Ma, Jiuda Zhao

“…Transcriptomic analysis of BMNCs demonstrated that high-altitude hypoxia might modulate the hematopoietic function in CTX-induced myelosuppression mice through pathways related to hematopoiesis, such as porphyrin metabolism, hematopoietic cell lineage, ECM-receptor interaction, and PI3K-Akt signaling pathway. …”
Get full text

Сhronic hepatitis C in patients with мetabolic syndrome by T. V. Antonova, M. A. Romanova, E. G. Sergeeva

“…The study included 115 patients with chronic hepatitis C with compensated and subcompensated liver functions. Metabolic syndrome had been diagnosed in 13,0%, abdominal obesity – in 46,1%, reduction of high density lipoprotein cholesterol – in 51,3%, increase in blood pressure – in 22,6%, high triglycerides – in 8,8% and insulin resistance – in 28,7% of patients. …”
Get full text

Beta-hydroxy-beta-methylbutyrate (HMB) improves daily activity and whole-body protein metabolism in Duchenne muscular dystrophy dogs: a pilot study by Peter P. Nghiem, Alexis M. Rutledge, Kyle Tehas, Corine Kaderli, Meredith Poling, Sidney Arnim, Vitaliy Dernov, Celine van Sas, Macie L. Mackey, Gabriella A. M. ten Have, Mariëlle P. K. J. Engelen, Nicolaas E. P. Deutz

“…Daily HMB supplementation in DMD dogs can safely and positively influence protein and amino acid metabolism and improve overall daily activity.…”
Get full text

Allelic variation of the Tas1r3 taste receptor gene affects sweet taste responsiveness and metabolism of glucose in F1 mouse hybrids. by Vladimir O Murovets, Ekaterina A Lukina, Egor A Sozontov, Julia V Andreeva, Raisa P Khropycheva, Vasiliy A Zolotarev

“…Hemizygosity of Tas1r3 did not influence these behavioral and metabolic traits. However, the loss of the functional Tas1r3 allele was associated with a small decline in the long-term intake and preference for sweeteners and reduction of plasma insulin and body, liver, and fat mass.…”
Get full text

Differential effects of inulin and fructooligosaccharides on gut microbiota composition and glycemic metabolism in overweight/obese and healthy individuals: a randomized, double-bl... by Jie Li, Feitong Liu, Yuemei Luo, Anisha Wijeyesekera, Shan Wang, Xiaojiao Chen, Yamei Lv, Jing Jin, Huafang Sheng, Guopan Wang, Yuanan Wei, Zhuang Li, Muxuan Chen, Hongwei Zhou

“…Propionate levels decreased significantly in both overweight/obese (Cohen’s d = 0.89, p = 0.014) and healthy participants (Cohen’s d = 1.19, p = 0.020) following inulin. Functional prediction of gut microbiota revealed upregulation of microbial folate and glutathione metabolism with inulin, and purine metabolism with FOS. …”
Get full text

Effects of cryptotanshinone in treatment of polycystic ovary syndrome in rats: a systematic review and meta-analysis by Pingping Su, Xv Wang, Ruoqian Cai, Chang Yan, Yun Sun

“…Cryptotanshinone appears to restore both reproductive and metabolic functions, including the regulation of body weight, ovarian morphology, hormone levels, and gene expression. …”
Get full text

Acute Responses of Low-Load Resistance Exercise with Blood Flow Restriction by Andrew R. Jagim, Jordan Schuler, Elijah Szymanski, Chinguun Khurelbaatar, Makenna Carpenter, Jennifer B. Fields, Margaret T. Jones

Get full text

Misregulation of PPAR Functioning and Its Pathogenic Consequences Associated with Nonalcoholic Fatty Liver Disease in Human Obesity by Luis A. Videla, Paulina Pettinelli

Get full text

Clinical and Functional Characterization of Novel AGL Variants in Two Families with Glycogen Storage Disease Type III by Tingting Yu, Hao Fu, Aoyu Yang, Yan Liang

“…The purpose of this study was to elucidate the clinical and functional features of two novel variants in two families with GSDIIIa. …”
Get full text

Alterations and resilience of intestinal microbiota to increased water temperature are accompanied by the recovery of immune function in Nile tilapia by Zhenbing Wu, Qianqian Zhang, Xiehao Wang, Aihua Li

“…Notably, along with compromised immune function, short-term warming (7 days) drove a significant increase in the microbial richness and diversity of fish intestinal mucosae, in which the overgrowth of opportunistic pathogens such as Romboutsia ilealis, Escherichia–Shigella, Fusobacterium, Streptococcus, Acinetobacter, and Enterobacter inhibited the colonization of potential probiotics such as Cetobacterium, ultimately resulting in a significant reduction in metabolic pathways and a significant increase in the potentially pathogenic phenotype. …”
Get full text

Soil Bacterial Community Characteristics and Functional Analysis of Estuarine Wetlands and Nearshore Estuarine Wetlands in Qinghai Lake by Wei Ji, Zhiyun Zhou, Jianpeng Yang, Ni Zhang, Ziwei Yang, Kelong Chen, Yangong Du

“…In contrast, nearshore wetlands showed greater nitrogen fixation and organic matter degradation, facilitated by Rhizobium, Azotobacter, Clostridium, and nitrogen-fixing Cyanobacteria (e.g., Anabaena, Nostoc). Microbial metabolic functions varied by depth: surface soils (0–10 cm) favored environmental adaptation and organic degradation, whereas deeper soils (10–20 cm) exhibited lipid metabolism and DNA repair strategies for low-oxygen adaptation. …”
Get full text

The effect of arsenic on mitochondrial fatty acid metabolism via inhibition of carnitine palmitoyltransferase 1B and choline kinase beta in C2C12 cells. by Fu-Lin Yu, Ming-Yan Zhang, Gang-Wei Song, Yang-Shan Ning, Xian Wu, Yan Gao

“…These findings suggest that arsenic-induced pathological changes in skeletal muscle are associated with impaired mitochondrial membrane function, disrupted fatty acid metabolism, and reduced mitochondrial DNA content in muscle cells.…”
Get full text

Bacterial community composition and function in different habitats in Antarctic Fildes region revealed by high-throughput sequencing by Yi-He Zhang, Yi-He Zhang, Yong-Qiang Hu, Yin-Xin Zeng, Yin-Xin Zeng, Yin-Xin Zeng, Yin-Xin Zeng, Yin-Xin Zeng, Ting Hu, Wei Han, Yu Du, Zhong Hu, Shan-Shan Meng

“…More abundant genes related to methane metabolism (e.g., pmoA), nitrification (e.g., amoA and hao), reductive citrate cycle pathway (e.g., frdA), repair of DNA damage (e.g., lexA and uvrB), salt and osmotic stress tolerance (e.g., betB, gltB, and treS), and aromatic hydrocarbon degradation (e.g., bcrC and bssA) were detected in pristine and/or ornithogenic soils, whereas genes related to sulfur metabolism (e.g., soxY, fccB, dsrAB, and sat), nitrogen fixation (e.g., nifH), acetyl-CoA metabolism (e.g., acsB, cdhD, and cdhE), carbohydrate degradation (e.g., amyA and chiA), and cold adaptation (e.g., cspA, deaD and recQ) were in higher abundance in marine and/or intertidal sediments. …”
Get full text

Systematic review and meta-analysis of current guidelines, and their evidence base, on risk of renal function after administration of contrast medium for diabetic patients receivin... by Qinhui Xu, Weixing Huang, Weixing Huang, Qianyun Li, Tongan Bao, Hua Luo, Xiao Luo

“…Sensitivity analysis excluding one study revealed a significant reduction in creatinine with metformin. Logistic regression meta-analysis showed that metformin use was not significantly associated with CI-AKI or metabolic acidosis, while contrast volume was the only consistent predictor of CI-AKI. …”
Get full text

The impact of low energy availability risk on pre-competition physiological function in Chinese female combat athletes by Yiheng Liang, Yuxuan Li, Yan Chen, Kun Meng, Fanyang Zhou, Yiran Pei, Yong Liu, Junqiang Qiu

“…Additionally, athletes in the LEA group experienced significant reductions in VO2 and resting metabolic rate at 0 week of the competition compared to 4 weeks prior (p < 0.05). …”
Get full text

Effects of dietary fiber on Chinese children with functional constipation and targeted modification of gut microbiota and related metabolites by Pei Xiao, Ting Song, Xiao Lu Li, Yong Mei Xiao, Rui Xue Wang, Fei Fei Song, Dan Li, Ai Hua Zhang, Ying Wang, Ting Zhang, Ting Zhang

“…BackgroundAlthough dietary fiber is widely recommended for preventing and treating functional constipation (FC), clinical trial evidence remains limited and the efficacy has not been sufficiently tested in children.PurposeThis study aimed to evaluate the effects of dietary fiber on FC symptoms, while identifying modulations in gut microbiota and associated metabolic changes.ResultsBetween January 1, 2024, and June 1, 2024, a total of 60 patients diagnosed with FC were enrolled in the study across three centers; however, 54 children completed the study. …”
Get full text

Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells by Affiong Ika Oqua, Kin Chao, Liliane El Eid, Lisa Casteller, Billy P Baxter, Alba Miguéns-Gómez, Sebastian Barg, Ben Jones, Jorge Bernardino de la Serna, Sarah L Rouse, Alejandra Tomas

Get full text

Place of imidazoline receptor agonists in the treatment of hypertension by D. V. Nebieridze, A. S. Safaryan

“…An analysis of Russian and foreign studies is presented, the results of which indicate that this drug class not only provides adequate and long-term control of blood pressure, but also has a number of favorable metabolic effects. Therefore, it contributes to reducing insulin resistance (weight loss) and has organ protective properties (endothelial function improvement, left ventricular hypertrophy regression, microalbuminuria reduction). …”
Get full text