Deficiency of the mitochondrial transporter SLC25A47 minimally impacts hepatic lipid metabolism in fasted and diet-induced obese mice by Brecht Attema, Montserrat A. de la Rosa Rodriguez, Evert M. van Schothorst, Sander Grefte, Guido JEJ. Hooiveld, Sander Kersten

“…Depending on the nutritional status, metabolomic analysis showed modest alterations in plasma, liver, and hepatic mitochondrial levels of various metabolites related to amino acid metabolism, TCA cycle, and fatty acid metabolism. No major and consistent alterations in levels of specific metabolites were found that establish the substrate for and function of SLC25A47. …”
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Polystyrene Microplastics‐Induced Thyroid Dysfunction in Mice: A Study of Gene Expression, Oxidative Stress, and Histopathological Changes by Md. Sadequl Islam, Md. Kamruzzaman, Umme Kulsum Rima

“…MPs may disrupt endocrine function, particularly affecting the thyroid gland, which is essential for metabolism and development. …”
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Melatonin and blood pressure: a narrative review by О.О. Serhiyenko, V.B. Sehin, V.О. Kuznets, V.О. Serhiyenko

“…It has the ability to decrease adrenergic system activity and indirectly enhance endothelial function. Melatonin can provide antihypertensive effects by stimu­lating own receptors in the central nervous system and peripheral arteries. …”
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Sex-stratified osteochondral organ-on-chip model reveals sex-specific responses to inflammatory stimulation by Francisco Conceição, João Meneses, Filipa Lebre, Malin Becker, Nuno Araújo-Gomes, Rianne Vos, Ana R. Ribeiro, Ernesto Alfaro-Moreno, Jeroen Leijten, Liliana Moreira Teixeira

“…Osteoarthritis (OA) is a musculoskeletal degenerative disease characterized by alterations in cartilage and subchondral bone leading to impaired joint function. OA disproportionally affects females more than males, yet the molecular mechanisms underlying these biological sex differences remain elusive. …”
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Brassinosteroid Enhances Cucumber Stress Tolerance to NaHCO₃ by Modulating Nitrogen Metabolism, Ionic Balance and Phytohormonal Response by Wenjing Nie, Biao Gong, Dan Wen, Peng Qiao, Hongen Guo, Qinghua Shi

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Dose-dependent therapeutic effects of gum acacia on kidney and metabolic dysfunction in adenine-induced chronic kidney disease in rats: involvement of antioxidant pathways by Hadeer Badry, Nadia M. El-Beih, Aya M. Hussein, Hanaa F. Abd El-Kareem, Wael M. El-Sayed

“…Results AD treatment led to significant reductions in body weight, increased relative kidney weight, and disrupted kidney and liver function markers, including elevated urea, creatinine, ALT, GGT, and glucose levels. …”
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Kaempferia parviflora Extract (SIRTMAX®) reduces body fat in adults who are overweight: a 12-week randomized, double-blind, placebo-controlled trial by Hyun Kyung Sung, Jinhak Kim, Dongchan Oh, Sang Won Eun, Jin Tatsuzaki, Seon Mi Shin, Su Hyeon Jeong

“…Additionally, the intervention food was determined to be safe.ConclusionThis study suggests that health functional foods are effective in reducing body fat, thereby preventing various obesity-related diseases and metabolic syndromes.…”
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In vitro comparison of naturally bioactive plant extracts, essential oils, and marine algae targeting different modes of action for mitigation of enteric methane emissions in rumin... by Ian Hodge, Ian Hodge, Patrick Quille, Manimaran Ayyachamy, Shane O'Connell, Shane O'Connell

“…Total gas, CH4, and volatile fatty acid (VFA) outputs were recorded after in vitro batch fermentations simulating rumen 24 h metabolic events. The CMA.MgO rumen buffer displayed significant reductions (P=0.02) in both CH4 emissions relative to the control (Rel % CH4; 40.1%) and total gas production relative to the control (Rel % Total gas; 22.9%). …”
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Effects of Difenoconazole and Imidacloprid Seed Coatings on Soil Microbial Community Diversity and Ecological Function by Dunfeng Feng, Jiabin Chen, Guo Li, Xiaoying Yang, Yujie Xiong, An Lao, Suzhen Huang, Zheng Zheng

“…Through field experiments, this study systematically evaluated and compared the effects of difenoconazole and imidacloprid seed coatings on wheat rhizosphere soil microbial communities and ecological functions by measuring soil enzyme activities, employing 16S rRNA and ITS high-throughput sequencing technologies and predicting KEGG functional pathways. …”
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Association between estimated glucose disposal rate and preserved ratio impaired spirometry in adults by Tong Lin, Shaofeng Jin, Xingkai Shen, Shanshan Huang, Haiyan Mao

“…BackgroundPreserved ratio impaired spirometry (PRISm) is a newly defined phenotype of lung function impairment, characterized by a normal FEV1/FVC ratio alongside an FEV1/0.8 < FEV1 predicted value. …”
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Recycling of Lycium barbarum by-products and bioactive substance application in silage—Insight into antioxidant activity and the regulation mechanism of anaerobic fermentation by Yajun Zhang, Jiale Liao, Yongxiang Pan, Qing Zhang, Qiang Lu, Xiaodong Chen, Wencan Ke, Guijie Zhang

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Permafrost thawing by soil transplantation alters the functional genetic potential of the alpine permafrost microbiome by Maomao Feng, Gilda Varliero, Carla Perez-Mon, Serina Robinson, Weihong Qi, Beat Stierli, Beat Frey

“…Transplanted soils exhibited an enhanced functional genetic potential, particularly for genes related to “Information storage and processing”, “Cellular processes and signaling” and “Metabolism” functions, which suggests increased cellular processes and metabolism. …”
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The signaling function of IDO1 incites the malignant progression of mouse B16 melanoma by E Orecchini, ML Belladonna, MT Pallotta, C Volpi, L Zizi, E Panfili, M Gargaro, F Fallarino, S Rossini, C Suvieri, A Macchiarulo, S Bicciato, G Mondanelli, C Orabona

“…Our data, therefore, suggest that the IDO1 signaling function can also occur in tumor cells and that alternative therapeutic approach strategies should be undertaken to effectively tackle this important immune checkpoint molecule.…”
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Serum Tsukushi level is negatively associated with cholesterol efflux capacity in metabolic dysfunction-associated steatotic liver disease: a cross-sectional study by Sum Lam, David T. W. Lui, Carol H. Y. Fong, Ying Wong, Sammy W. M. Shiu, Karen S. L. Lam, Lung-Yi Mak, Man-Fung Yuen, Chi-Ho Lee, Kathryn Choon-Beng Tan

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Chagas disease induces gut microbial metabolic stress: Disruption of energy and nucleotide pathways and partial reversal by antiparasitic therapy (TRIPOBIOME-2 study) by José A. Pérez-Molina, Elena Moreno, Clara Crespillo-Andújar, Sandra Chamorro-Tojeiro, Marta Arsuaga, Leticia Olavarrieta, Oihane Martín, Begoña Monge-Maillo, Francesca Norman, Val F. Lanza, Sergio Serrano-Villar

“…Nevertheless, chronic CD produced a distinctive functional signature marked by depletion of energy-yielding pathways (reductive and canonical tricarboxylic-acid cycles, fatty-acid β-oxidation, haem and 2-methylcitrate metabolism) and modest enrichment of purine and pyrimidine biosynthetic routes. …”
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The Impact of Kefir Consumption on Inflammation, Oxidative Stress Status, and Metabolic-Syndrome-Related Parameters in Animal Models: A Systematic Review and Meta-Analysis by Zahid Naeem Qaisrani, Wai Phyo Lin, Bo Bo Lay, Khin Yadanar Phyo, Myat Mon San, Nurulhusna Awaeloh, Sasithon Aunsorn, Rinrada Pattanayaiying, Susakul Palakawong Na Ayudthaya, Choosit Hongkulsup, Nirunya Buntin, Sasitorn Chusri

“…Kefir, a fermented beverage rich in probiotics and beneficial compounds, has emerged as a functional food that may offer metabolic advantages. …”
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Exploring the disconnect: mechanisms underpinning the absence of physical function improvement with SGLT2 inhibitors by Cian Sutcliffe, Cian Sutcliffe, Jack A. Sargeant, Jack A. Sargeant, Thomas Yates, Thomas Yates, Melanie J. Davies, Melanie J. Davies, Luke A. Baker, Luke A. Baker

“…Current evidence suggests sodium-glucose cotransporter 2 inhibitors (SGLT2i) do not consistently improve patient physical function, despite improvements in clinical symptoms and reductions in both adiposity and body weight. …”
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The symbiont Wolbachia increases resistance to bifenthrin in Ectropis grisescens by regulating the host detoxification function by Tian Gao, Yong Zhang, Wanpeng Sun, Qiangkun Li, Xueyu Huang, Dian Zhi, Huabin Zi, Ruijie Ji, Yanhua Long, Chunmei Gong, Yunqiu Yang

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Dual roles of crayfish shell biochar on the fate of arsenic in acid and alkaline aerobic soils: insights from dissolved organic matter and metabolism genes by Tao Sun, Yuebing Sun, Penggang Pei, Qingqing Huang, Chao Wang, Shihang Wu, Xiaojia Zhou, Yingming Xu, Changbo Zhang, Gilles Mailhot, Davide Vione

“…Additionally, CSBC application stimulated microbial membrane transport and signal transport function in acid soil. Furthermore, it increased the relative abundance of Bradyrhizobium, Sphingomonas, Streptomyces, and Ktedonobacter, which harbor As(V) reduction (arsC and arrB) and As(III) efflux (ACR3) genes, thereby promoting As mobility in acid soil. …”
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Validation of Clinical-Grade Electroporation Systems for CRISPR-Cas9-Mediated Gene Therapy in Primary Hepatocytes for the Correction of Inherited Metabolic Liver Disease by Justin Gibson, Abishek Dhungana, Menam Pokhrel, Benjamin Arthur, Pramita Suresh, Olumide Adebayo, Renee N. Cottle

“…Recipients transplanted with GTx-electroporated cells showed a smaller weight reduction than controls transplanted with untransfected cells (7.9% and 13.8%, respectively). …”
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