IFLUENCE OF FUNCTIONAL FOOD PRODUCT ON SERUM FATTY ACID COMPOSITION IN HYPERLIPIDEMIC RATS by I. M. Chernukha, E. A. Kotenkova

“…A special area in the rapidly growing range of food products is occupied by specialized and functional products, especially for certain categories of citizens. …”
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Effect of nutritional intervention combined with vitamin D on glucose metabolism, sex hormones and inflammatory factors in patients with polycystic ovary syndrome by Kang Xinqin, Liu Lin

“…Conclusions: In this study, we intervened obese polycystic ovary syndrome patients with nutritional or conventional intervention and found that compared with conventional treatment, the posture, blood glucose metabolism, and lipid function of the patients who received nutritional intervention were more significantly metabolised, and the levels of inflammatory factors were more effectively inhibited, indicating the high clinical application value of nutritional intervention in obese polycystic ovary syndrome.…”
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Gut microbial metabolism of bile acids modifies the effect of Mediterranean diet interventions on cardiometabolic risk in a randomized controlled trial by Peipei Gao, Ehud Rinott, Danyue Dong, Zhendong Mei, Fenglei Wang, Yuxi Liu, Omer Kamer, Anat Yaskolka Meir, Kieran M. Tuohy, Matthias Blüher, Michael Stumvoll, Meir J. Stampfer, Iris Shai, Dong D. Wang

“…Bile acids (BAs) undergo extensive microbial metabolism in the gut and exert hormone-like functions on physiological processes underlying metabolic risk. …”
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Microbiome-producing SCFAs are associated with preterm birth via trophoblast function modulation by Lulu Meng, Meng Meng, Ruonan Zhang, Ayinisa Wubulikasimu, Hao Peng, Lu Zhang, Xinwen Chang, Guihai Ai, Gang Zou, Qizhi He, Kai Wang, Ming Liu, Tao Duan

“…Our study reveals that certain bacteria and their metabolic byproducts in the cervicovaginal environment, specifically short-chain fatty acids (SCFAs), are linked to the risk of preterm birth. …”
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GPD1L downregulation in colorectal cancer: a novel obesity-related biomarker linking metabolic dysregulation to tumor progression by Feng Zhu, Feng Zhu, Huiyuan Li, Huiyuan Li, Hongzhang Liu, Hongzhang Liu, Yusheng Wang, Yusheng Wang

“…ObjectiveTo delineate the expression profile and tumor-suppressive function of the metabolism-associated gene GPD1L in colorectal carcinogenesis. …”
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A legume-enriched diet improves metabolic health in prediabetes mediated through gut microbiome: a randomized controlled trial by Xiaorong Wu, Alvin Surya Tjahyo, Vera Sergeyevna Brok Volchanskaya, Long Hui Wong, Xianning Lai, Yi Ning Yong, Farhana Osman, Shia Lyn Tay, Priya Govindharajulu, Shalini Ponnalagu, Rachel Tso, Hwee Sze Teo, Kaijie Khoo, Huan Fan, Chew Chan Goh, Clara Poh Lian Yap, Melvin Khee-Shing Leow, Christiani Jeyakumar Henry, Sumanto Haldar, Kevin Junliang Lim

“…A legume-enriched, multicomponent intervention diet can improve metabolic health in a prediabetes population, in addition to benefits obtained from calorie restriction alone, partially mediated through changes in gut microbial composition and function. …”
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Psoriasis, chronic eczema and atopic dermatitis in males: functioning of sympathoadrenal and vagoinsular systems by N. Yu. Reznichenko

“…The high tension of glucocorticoid function of adrenal glands and increased activity of autonomic system; the intensive violations of autonomic homeostasis; the reduction of activity of compensatory organism reactions were found in male patients with chronic dermatoses. …”
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Effects of Iodixanol on Respiratory Functions during Coronary Angiography and the Role of Body Composition by Derya Guzel, Mustafa Gokhan Vural, Ramazan Akdemir

“…Our data suggested that diagnostic CA using iodixanol, an iso-osmolar contrast media, leads significant impairment in respiratory functions. Due to the persistence of these reductions even 2 hours after CA, ventilatory functions should be considered especially in patients whose body compositions or hydration levels are not within the desired physiological range.…”
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Impaired liver function: effect on paclitaxel toxicity, dose modifications and overall survival by Marieke Schmidt, Robin Vernooij, Merel van Nuland, Erin Smeijsters, Lot Devriese, Nadia Haj Mohammad, Thom Hermens, Julian Stammers, Christina Swart, Toine Egberts, Saskia Haitjema, Laureen Lammers

“…Abstract Background The anticancer drug paclitaxel is primarily metabolized in the liver. Previous studies have indicated a correlation between impaired liver function and paclitaxel toxicity, which may indicate dose reduction. …”
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PTEN deficiency in postnatally developing Purkinje cells disrupts metabolic signaling, leading to dendritic abnormalities and sex-specific behavioral deficits by Lindsay J. Walsh, Izabella M. Espinal-San Miguel, Ana V. Rodriguez, Ursula M. Peña, Kiley E. Flynn, Will C. Remillard, Siena R. Brazier, Natalia I. Anderson, Aidan J. Clark, Tiffany A. De Varona, Ileana Soto

“…These findings suggest that PTEN is critical for maintaining metabolic balance during postnatal dendritic maturation, and its loss leads to structural and functional impairments in PCs that contribute to behavioral phenotypes in a sex- and age-dependent manner.…”
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Construction and functional identification of overexpression vector of the peach PpCLH1 gene by LIU Xin, ZHANG Xiaoyu, MENG Junren, LI Ang, DUAN Wenyi, SUN Shihang, PAN Lei, ZENG Wenfang, WANG Zhiqiang, NIU Liang

“…An overexpression construct for PpCLH1 was engineered through homologous recombination techniques and transiently introduced into tobacco leaves to assess functional implications. The phenotypic evaluation of transfected tobacco leaves displayed a lighter green phenotype relative to the dark green control leaves, accompanied by a substantial reduction in chlorophyll content. …”
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Vascular endothelium state in different types of antihypertensive treatment by N. V. Kucherenko, O. V. Nastradin, E. V. Eliseeva, E. S. Potapova, V. A. Nevzorova

“…Ozone therapy facilitates normalization of vascular endothelium NO-producing function, decrease in LP activity, and AOP restoration.…”
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Effects of Sodium–Glucose Cotransporter 2 Inhibitors on Stage 4 Cardiovascular–Kidney–Metabolic Syndrome: A Propensity Score–Matched Study by Tao Liu, Zeyuan Fan, Yuntao Li, Bing Xiao, Chang He

“…SGLT2i use reduced the hazard for MAKEs by 11.5%, primarily due to a 19.7% reduction in the hazard for worsen kidney function. …”
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Thiazolopyridines Improve Adipocyte Function by Inhibiting 11 Beta-HSD1 Oxoreductase Activity by Thirumurugan Rathinasabapathy, Kimberly Marie Palatini Jackson, Yiwen Thor, Ayuba Sunday Buru, Debora Esposito, Xu Li, Mallikarjuna Rao Pichika, Ahmad Sazali Hamzah, Slavko Komarnytsky

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Neutrophil granulocyte functional status and expression of apoptosis markers in children with type 1 diabetes by Lyudmila Yur'evna Barycheva, Natalya Eduardovna Erdni-Goryaeva, Galina Alekseevna Alexandrovich

“…Results. A reduction in the bactericidal activity of NGs with deficiencies in phagocytosis, secretion of active oxygen radicals and functional reserve was found. …”
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Upstream therapy of reperfusion disorders of hemodynamics, rhythm and conduction in patients with acute myocardial infarction with diabetes mellitus and metabolic syndrome (second... by M.I. Shved, I.O. Yastremska, R.M. Ovsiychuk, L.P. Martyniuk, O.A. Prokopovych, Ya.M. Kitsak

“…Compensation of carbohydrate metabolism in patients with myocardial infarction combined with T2DM and MS using dapagliflozin was accompanied by a significant reduction in the incidence of life-threatening complications: the incidence of rhythm disturbances in patients of the study group decreased from 87.5 to 50.0 %, heart failure (Killip class II–III) — from 70.0 to 12.5 %, which was signi­ficant compared with the control group. …”
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Comprehensive analysis of faecal metagenomic and serum metabolism revealed the role of gut microbes and related metabolites in detecting colorectal lateral spreading tumours by Hao Lin, Yudai Chen, Ming Zhou, Hongli Wang, Lichun Chen, Li Zheng, Zhixin Wang, Xiaoling Zheng, Shiyun Lu

“…Colorectal lateral spreading tumours (LST), early-stage lesions of colorectal cancer (CRC), are associated with gut microbiota dysbiosis. However, the functional alterations in gut microbiota and their metabolic pathways remain inadequately understood. …”
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Clinical approaches to osteoporosis in patients with chronic kidney disease: A comprehensive review by Yasuo Imanishi, Taku Furukubo, Shigeichi Shoji

“…Reduced kidney function is complicated by secondary hyperparathyroidism, which exacerbates bone fragility. …”
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CONVENTIONAL APPROACHES TO THE THERAPY OF HEREDITARY MYOPATHIES by M. V. Pokrovsky, M. V. Korokin, A. M. Krayushkina, N. S. Zhunusov, K. N. Lapin, M. O. Soldatova, E. A. Kuzmin, O. S. Gudyrev, I. S. Kochkarova, A. V. Deikin

“…Based on a number of clinical and pathogenetic features, hereditary myopathies are divided into: 1) congenital myopathies; 2) muscular dystrophy; 3) mitochondrial and 4) metabolic myopathies. At the same time, treatment approaches vary significantly depending on the type of myopathy and can be based on 1) substitution of the mutant protein; 2) an increase in its expression; 3) stimulation of the internal compensatory pathways expression; 4) restoration of the compounds balance associated with the mutant protein function (for enzymes); 5) impact on the mitochondrial function (with metabolic and mitochondrial myopathies); 6) reduction of inflammation and fibrosis (with muscular dystrophies); as well as 7) an increase in muscle mass and strength. …”
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TSPAN4+ fibroblasts coordinate metastatic niche assembly through migrasome-driven metabolic reprogramming and stromal-immune crosstalk in pancreatic adenocarcinoma by Qingwen Hu, Qingwen Hu, Jiali Chen, Yang Liu, Yang Liu, Haiqing Chen, Haotian Lai, Lai Jiang, Xuancheng Zhou, Shengke Zhang, Jinbang Huang, Hao Chi, Bo Li, Xiaolin Zhong

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