Beyond Bone Remodeling: Denosumab’s Multisystemic Benefits in Musculoskeletal Health, Metabolism, and Age-Related Diseases—A Narrative Review by Yi-Ting Hung, Wen-Tien Wu, Ru-Ping Lee, Ting-Kuo Yao, Kuang-Ting Yeh

“…The drug showed potential cardiovascular benefits through its effects on cardiac and smooth muscle function. Notably, denosumab use was associated with reduced Type II diabetes mellitus risk through improved glucose metabolism. …”
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Choroid plexus-mediated CSF secretion remains stable in aging rats via high and age-resistant metabolic activity by Sara D. Lolansen, Eszter O. Révész, Søren N. Andreassen, Marleen Trapp, Chiara Salio, Marco Sassoé-Pognetto, Jens Velde Andersen, Emil W. Westi, Trine L. Toft-Bertelsen, Jonathan H. Wardman, Anne-Kristine Meinild Lundby, Flemming Dela, Annarita Patrizi, Blanca I. Aldana, Nanna MacAulay

“…Here, we resolve age-dependent modulation of CSF dynamics and choroid plexus function by complementary in vivo determinations of intracranial pressure (ICP) and CSF secretion/absorption rates, combined with transcriptomic, morphological, and metabolic analysis of choroid plexus in aging male rats. …”
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Are weight loss and metabolic outcomes of bariatric surgery influenced by candidate glucocorticoid receptor gene polymorphisms? A prospective study by Zohaib Iqbal, Senthil Kandaswamy Vasan, Helene Fachim, John Warner-Levy, Rachelle P. Donn, Basil J. Ammori, Adrian H. Heald, Handrean Soran, Akheel A. Syed

“…There was significant weight reduction after bariatric surgery with a postoperative BMI of 34.1 (6.8) kg/m2 at 24 months (p < 0.001).Conclusion While GRL polymorphisms with a known deleterious effect on adipose tissue mass and function may have a small, additive effect on the prevalence of obesity and related metabolic disorders in the population, we suggest that the relatively weak biological influence of these SNPs is readily overcome by bariatric surgery.…”
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Hormonal and metabolic characteristic of androgen deficiency and its correction by testosterone in men with type 1 diabetes mellitusundergoing programmed hemodialysis by Alexander Evgen'evich Lepetukhin, Nikolay Petrovich Goncharov, Anatoliy Ivanovich Mordik, Natalya Yur'evna Biskaeva

“…Requirement for EPO-b in subgroups A and C decreased by 32.1% (p=0.007) and 41.1% (p=0.001) respectively but remained unalteredin both control subgroups. Conclusion. Reduction of the TT level in men with DM1 on PHD is a function of age and constitutes an independent risk factor of anemia. …”
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Herbivore functions in the hot-seat: Resilience of Acanthurus triostegus to marine heatwaves. by Taylor Souza, Jeroen Brijs, Leon Tran, Larry Crowder, Jacob L Johansen

“…However, as thermally sensitive ectotherms, rising thermal stress may also pose a serious threat to these fishes and the critical ecosystem functions they deliver. Here we evaluate the consequences of thermal stress on the capacity of a common herbivorous coral reef fish (Acanthurus triostegus) to control finely filamentous matrices of Caulerpa sertularioides and C. verticillata algae in Hawai'i, by characterizing in-vivo changes in metabolic demands, diurnal foraging rates, activity patterns and individual condition in a laboratory setting during winter (24.0±0.1°C), summer (27.5±0.1°C), and at the peak of a representative marine heatwave, (31.0±0.1°C). …”
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Probiotics as a therapeutic strategy for metabolic dysfunction-associated steatotic liver disease: A systematic review and meta-analysis by Jing Lu, Xiaoxiao Dong, Ziqi Gao, Huizhen Yan, Dilireba Shataer, Liang Wang, Yanan Qin, Minwei Zhang, Jiayi Wang, Jie Cui, Shengyang Zhou

“…This systematic review and meta-analysis encompassed 12 randomized controlled trials including 657 participants to quantify the effects of probiotic supplementation on liver function indicators, lipid metabolism, and inflammatory markers in MASLD patients. …”
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The Concentration-dependent Investigation of the Toxic Effects of the Anorectic Agent Sibutramine on the Electrical Activity of the Cardiomyocytes in Metabolic Syndrome Rat Heart by Yusuf Olgar, Feyza Alyu, Yusuf Öztürk, Belma Turan

“…In addition to the known mode of its action through brown adipose tissue thermogenesis, systemic actions reveal some side effects including alterations in cardiac function. Despite various clinical findings, the effect of SBT on cellular levels remains elusive. …”
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TMAO is involved in sleep deprivation-induced cognitive dysfunction through regulating astrocytic cholesterol metabolism via SREBP2 by Shan Zhu, Yue Wang, Yansong Li, Na Li, Yige Zheng, Qiao Li, Hongyan Guo, Jianyu Sun, Qian Zhai, Yaomin Zhu

“…Astrocytic cholesterol biosynthesis is crucial for brain cholesterol homeostasis and cognitive function. However, the underlying mechanism of astrocytic cholesterol metabolism in SD-induced cognitive impairment has not been fully explored. …”
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Structural and Metabolic Changes in Pregnant Rat Uterine and Adipose Tissue Induced by a High-Fat High-Sugar Diet by Dina Šišljagić, Senka Blažetić, Milorad Zjalić, Irena Labak, Vedrana Ivić, Kálmán Ferenc Szűcs, Róbert Gáspár, Eszter Ducza, Sandor G. Vari, Andrijana Muller, Marija Heffer

“…Further research is needed to understand the functional consequences of these alterations on reproductive and metabolic health.…”
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An orally-administered nanotherapeutics with gold nanospheres supplying for rheumatoid arthritis therapy by re-shaping gut microbial tryptophan metabolism by Chuan Yang, Langlang Xie, Zihan Deng, Hongbo Ai, Tingwen Xiang, Xiaojing Yan, Zhiguo Ling, Shiyu Xiao, Yong Tang, Gang Huang, Fei Luo, Yueqi Chen

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Gut microbiota modulation by Traditional Chinese Medicine: a translational strategy for metabolic dysfunction-associated steatotic liver disease by Ting Zhou, Ting Zhou, Ziwen Jin, Ziwen Jin, Rilei Jiang, Weiwei Li

“…Growing evidence highlights gut microbiota dysbiosis as a pivotal contributor to MASLD pathogenesis, characterized by disrupted intestinal barrier function, endotoxin translocation, and dysregulated bile acid (BA) and short-chain fatty acid (SCFA) metabolism. …”
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Roux-en-Y gastric bypass and sleeve gastrectomy induce substantial and persistent changes in microbial communities and metabolic pathways by Jerry T. Dang, Valentin Mocanu, Heekuk Park, Michael Laffin, Naomi Hotte, Shahzeer Karmali, Daniel W. Birch, Karen L. Madsen

“…A multi-omics approach was used to perform integrated microbial-metabolomic analysis to identify functional pathways in which weight loss and metabolic changes occur after surgery. …”
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Irisin regulates cardiac myocyte energy metabolic remodeling involved the ADRA1A-AMPK signaling pathwayng pathway by Han Zhe, Jing Li, Yuan Bei, Feng Gao, Qingliang Chen

“…Its efficacy in enhancing cardiac function and energy metabolism in vivo further underscores its promise as a prospective treatment for cardiac conditions characterized by hypoxia.…”
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A central role for GRB10 in regulation of islet function in man. by Inga Prokopenko, Wenny Poon, Reedik Mägi, Rashmi Prasad B, S Albert Salehi, Peter Almgren, Peter Osmark, Nabila Bouatia-Naji, Nils Wierup, Tove Fall, Alena Stančáková, Adam Barker, Vasiliki Lagou, Clive Osmond, Weijia Xie, Jari Lahti, Anne U Jackson, Yu-Ching Cheng, Jie Liu, Jeffrey R O'Connell, Paul A Blomstedt, Joao Fadista, Joao Fadista, Sami Alkayyali, Tasnim Dayeh, Emma Ahlqvist, Jalal Taneera, Cecile Lecoeur, Ashish Kumar, Ola Hansson, Karin Hansson, Benjamin F Voight, Hyun Min Kang, Claire Levy-Marchal, Vincent Vatin, Aarno Palotie, Ann-Christine Syvänen, Andrea Mari, Michael N Weedon, Ruth J F Loos, Ken K Ong, Peter Nilsson, Bo Isomaa, Tiinamaija Tuomi, Nicholas J Wareham, Michael Stumvoll, Elisabeth Widen, Timo A Lakka, Claudia Langenberg, Anke Tönjes, Rainer Rauramaa, Johanna Kuusisto, Timothy M Frayling, Philippe Froguel, Mark Walker, Johan G Eriksson, Charlotte Ling, Peter Kovacs, Erik Ingelsson, Mark I McCarthy, Alan R Shuldiner, Kristi D Silver, Markku Laakso, Leif Groop, Valeriya Lyssenko

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Impact of graphene oxide disturbance on the structure and function of arbuscular mycorrhizal networks by Lian Duo, Hang Su, Jiayi Li, Qi Wang, Shulan Zhao

“…The differential expressed genes (DEGs) were notably enriched in processes such as the spliceosome and endocytosis, the pentose phosphate pathway, glycolysis and secondary metabolism, and amino acid metabolism. These findings strongly indicate that GO has a significant effect on the structure and functionality of CMNs.…”
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Administration of heat killed Fructobacillus fructosus OS-1010 attenuates metabolic disease induced by high fat diet in mice by Yoshiyuki Nakano, Ryosuke Nakamura, Hina Tanaka, Yuji Tokimoto, Yuna Masuda, Noriaki Emoto, Kouji Nishikawa, Hideaki Idogaki

“…The findings of this study suggest that heat-killed F. fructosus OS-1010 functions as an anti-obesity postbiotic, potentially benefiting both NAFLD and muscle weakness associated with obesity.…”
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Impact of Coenzyme Q10 on Mitochondrial Metabolism: A Complementary Study Using Fluorescence Lifetime Imaging and Electron Microscopy by Johannes Georg Wieland, Nilanjon Naskar, Kirsten Reess, Daniela Nobre Sarmento dos Santos, Julia M. Weise, Thomas Blatt, Sebastian Kordes, Paul Walther, Angelika Rück

“…Background: Coenzyme Q10 (CoQ10), also known as ubiquinone-10, is an important molecule of the mitochondrial respiratory chain that acts as an electron carrier between complexes I, II, and III and additionally functions as an antioxidant. Due to its bioenergetic properties, CoQ10 is of high interest for therapeutic and cosmetic use. …”
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Genomic characterisation of novel extremophile lineages from the thalassohaline lake Dziani Dzaha expands the metabolic repertoire of the PVC superphylum by Adrien Vigneron, Lilian A. Cloarec, Céline Brochier-Armanet, Jean Pierre Flandrois, Marc Troussellier, Cécile Bernard, Hélène Agogué, Philippe M. Oger, Mylène Hugoni

“…However, their evolutionary history and roles in ecosystem functioning and microbiome assemblage are poorly understood. …”
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Hormonal-metabolic markers and their relationships in patients with coronary heart disease after suffering from the COVID-19 coronavirus disease by S. M. Manuilov, N. S. Mykhailovska

“…The obtained results confirm common mechanisms between the development of hormonal and metabolic disorders and the occurrence of anxiety-depressive, cognitive disorders, vegetative imbalance against the background of overstrain of functional adaptation processes in patients with coronary heart disease in the long-COVID period.…”
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DHCR24 overexpression is involved in lipid metabolic reprogramming to drive cervical cancer malignant progression and is associated with immune microenvironment by Lin Cheng, Yuance Xu, Zhuo Li, Danting Sun, Yan Xu, Junqi He, Yulong Chen, Qin Yao

“…Abstract Objective Lipid metabolic reprogramming enables tumor cells to acquire malignant phenotypes, including enhanced proliferative capacity, migratory potential, and invasive properties. …”
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