CD44 modulates metabolic pathways and altered ROS-mediated Akt signal promoting cholangiocarcinoma progression. by Malinee Thanee, Hasaya Dokduang, Yingpinyapat Kittirat, Jutarop Phetcharaburanin, Poramate Klanrit, Attapol Titapun, Nisana Namwat, Narong Khuntikeo, Arporn Wangwiwatsin, Hideyuki Saya, Watcharin Loilome

“…Interestingly, a depletion of CD44 leads to metabolic pathway changes resulting in redox status modification and Trolox (anti-oxidant) led to the recovery of the cancer cell functions. …”
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A Proposed New Path for Management of Health in Inherited Metabolic Disorders Using Engineered Probiotic Bacteria by Kurtz CB, Calvo MS

“…Synthetic biology has emerged in the last decade, allowing scientists to specifically engineer probiotic bacteria to perform functions in the GI tract, such as the elimination or reduction of specific nutrients from ingested food sources. …”
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Short‐term dietary methionine restriction with high fat diet counteracts metabolic dysfunction in male mice by Marissa I. McGilvrey, Bethany Fortier, Diana Cooke, Maryam A. Mahdi, Benjamin Tero, Christian M. Potts, Abigail Kaija, Larisa Ryzhova, Carolina Cora, Adam Richardson, Douglas Guzior, Ilka Pinz, Calvin Vary, Robert A. Koza, Gene Ables, Lucy Liaw

“…Multi‐organ molecular changes in lipid metabolism, mitochondrial function, and bioenergetics are predicted to impact adipose tissue and liver function and cardiovascular health. …”
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A murine model of gestational diabetes reveals MASLD risk and alterations in markers of hepatic mitochondrial metabolism by Grace E. Shryack, Grace E. Shryack, Grace E. Shryack, Alexa A. Krause, Alexa A. Krause, Alexa A. Krause, Simone Hernandez Ruano, Laura C. Schulz, Kathleen A. Pennington, R. Scott Rector, R. Scott Rector, R. Scott Rector

“…IntroductionGestational Diabetes Mellitus (GDM) impacts roughly 1 in 7 pregnancies and results in metabolic dysfunction-associated steatotic liver disease (MASLD) in 30% of these women. …”
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PO90 | Acquired hemophilia A with high-titer inhibitor in a patient with cardiovascular and metabolic comorbidities

“…Prompt initiation of immunosuppressive therapy was crucial, allowing for hematologic recovery without significant infectious or metabolic complications. …”
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Elucidating a novel metabolic pathway for enhanced antimicrobial glycolipid biosurfactant production in the yeast Meyerozyma guilliermondii by Pattanan Songdech, L. A. Channa Bhathiya Jayasekara, Kwanrutai Watchaputi, Chutikarn Butkinaree, Yodying Yingchutrakul, Nitnipa Soontorngun

“…The objective was to elucidate metabolic pathways related to production of glycolipids and its functional properties. …”
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The Interplay Between Social Factors and Metabolic Bariatric Surgery Outcomes—A 5‐Year Prospective Study by Uta Sailer, Fatemeh Asgari, Jon A. Kristinsson, Ingela Lundin Kvalem

“…Methods Patients reported about structural and functional aspects of their social relations before surgery and at 1‐, 3‐ and 5‐year post‐surgery. …”
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Metagenomics-assembled genomes reveal microbial metabolic adaptation to athalassohaline environment, the case Lake Barkol, China by Maripat Xamxidin, Xuanqi Zhang, Gang Zheng, Can Chen, Min Wu

“…In this study, we employed high-throughput metagenomic sequencing to characterize the taxonomic composition, metabolic potential, and ecological functions of microbial communities in both water and sediment samples from Lake Barkol. …”
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Prediction of Metabolic Parameters of Diabetic Patients Depending on Body Weight Variation Using Machine Learning Techniques by Oana Vîrgolici, Daniela Lixandru, Andrada Mihai, Diana Simona Ștefan, Cristian Guja, Horia Vîrgolici, Bogdana Virgolici

“…<b>Background/Objectives</b>: Obesity is a major risk factor for diabetes mellitus, a metabolic disease characterized by elevated fasting blood glucose and glycosylated hemoglobin levels. …”
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FIELD STUDIES OF THE EFFECTIVENESS OF DIETARY SUPPLEMENTS WITH AIMED FUNCTIONAL PROPERTIES by Vekovcev A.A., Podzorova G.A., Kaz'mina A.Y., Poznyakovskiy V.M.

“…The developed product proves to contribute to the correction of metabolic abnormalities of people suffering from the above diseases. …”
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Evaluating the effect of antiepileptic drugs on the function of the thyroid gland of children by Mohamad Hasan Mohamadi, Afsaneh Mirshekari

“…Negative effects on lipid profile, metabolic functions and hypothyroidism are among the side effects of using these drugs. …”
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Doxycycline: An antibiotic with brain protective function in vanadium-intoxicated rats by Negia Emtawel Mohamed, Ezeddin Gassar, Sara Abdulla, Mustafa Elfakhri, Ayyub Patel, Syed Haider

“…Results: The results revealed that vanadium produced significant reduction in body and absolute brain weight, with neurological function deficits. …”
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Structural and Functional Characterization of N-Glycanase-1 Pathogenic Variants by Antje Banning, Lukas Hoeren, Isis Atallah, Ralph Orczyk, David Jacquier, Diana Ballhausen, Ritva Tikkanen

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Metabolic reset purification program improves antioxidant balance and gut microbiome in individuals transitioning to a healthier diet by Chinmayee Panda, Ralph Kruse, Kaya Williams, Brea Nance, Maruti Gudavalli, Shirin Pourafshar, Brandon Metzger, Slavko Komarnytsky, Slavko Komarnytsky

“…Whole food supplements rich in polyphenols, glucosinolates, and prebiotic fibers were included to support metabolic and gastrointestinal function. The intervention group exhibited 9% (p &lt; 0.0001) reduction in ROS-associated oxidative stress compared to diet alone, suggesting enhanced redox balance. …”
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Diversity of Bioactive Compounds in Microalgae: Key Classes and Functional Applications by Maslin Osathanunkul, Suebsuya Thanaporn, Lefkothea Karapetsi, Georgia Maria Nteve, Emmanouil Pratsinakis, Eleni Stefanidou, Giorgos Lagiotis, Eleni Avramidou, Lydia Zorxzobokou, Georgia Tsintzou, Artemis Athanasiou, Sofia Mpelai, Constantinos Constandinidis, Panagiota Pantiora, Marián Merino, José Luis Mullor, Luka Dobrovic, Leonardo Cerasino, Tomohisa Ogawa, Meropi Tsaousi, Alexandre M. C. Rodrigues, Helena Cardoso, Rita Pires, Daniel Figueiredo, Inês F. Costa, Catarina Anjos, Nikolaos E. Labrou, Panagiotis Madesis

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Long‐term p110α PI3K inactivation exerts a beneficial effect on metabolism by Lazaros C. Foukas, Benoit Bilanges, Lucia Bettedi, Wayne Pearce, Khaled Ali, Sara Sancho, Dominic J. Withers, Bart Vanhaesebroeck

“…Abstract The insulin/insulin‐like growth factor‐1 signalling (IIS) pathway regulates cellular and organismal metabolism and controls the rate of aging. Gain‐of‐function mutations in p110α, the principal mammalian IIS‐responsive isoform of PI 3‐kinase (PI3K), promote cancer. …”
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Identification of Subclinical Myocardial Dysfunction in Breast Cancer Patients with Metabolic Syndrome after Cancer-Related Comprehensive Therapy by Feng Zhang, Siyuan Wang, Siying Liang, Chao Yu, Sufang Li, Hong Chen, Shu Wang, Tiangang Zhu

“…Breast cancer patients with metabolic syndrome have an increased risk of cardiovascular disease. …”
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Intrinsic STING of CD8 + T cells regulates self-metabolic reprogramming and memory to exert anti-tumor effects by Qiuli Xu, Xin Hua, Bingbing Li, Bei Jiang, Jiajia Jin, Ranpu Wu, Yanli Gu, Hao Xu, Qinpei Cheng, Suhua Zhu, Fang Zhang, Tangfeng Lv, Yong Song

“…Moreover, we found that the loss of the STING gene results in a reduction in the number of mitochondria and a change in the metabolic pathway selection, thereby inducing excessive glycolysis in CD8 + T cells. …”
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Pathogenic aspects of fructose consumption in metabolic dysfunction-associated steatotic liver disease (MASLD): A narrative review by Katharina Burger, Michael Trauner, Ina Bergheim

“…Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly referred to non-alcoholic fatty liver disease (NAFLD), has become a global health concern with a still increasing prevalence. …”
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Genome-wide identification, evolution, and expression and metabolic regulation of the maize CHS gene family under abiotic stress by Xiaofang Wang, Jing Wu, Huangai Li, Lei Zhu, Yan Long

“…The knockout of ZmCHS25 disrupted the phenylpropanoid metabolic pathway and impaired the osmotic regulation ability of plant cells, ultimately leading to a significant reduction under salt stress conditions. …”
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