KDDC: a new framework that integrates kmers, dataset filtering, dimension reduction and classification algorithms to achieve immune cell heterogeneity classification by Nan Zhang, Nan Zhang, Shishun Zhao, Runze Wu, Xizi Luo, Ming Yang, Zecheng Chang, Jianting Xu

“…We also observed that 11 distinct cell subpopulations exhibited differences in cell proportions, inflammatory factorexpression, cell communication, and metabolic pathways, with notable activity in metabolic pathways. …”
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Features of hormonal function in pregnant women - displaced persons. by I. A. Zhabchenko, N. G. Korniets, S. V. Tertychna-Telyuk

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Study on the function of TTG1 gene in Camellia oleifera by Chengcheng Xiang, Chengcheng Xiang, Lizhi Xiao, Lizhi Xiao, Hongmei Tao, Hongmei Tao, Jie Cao, Jie Cao, Jun Yuan, Jun Yuan, Weihao Wang, Yao Jiang, Yao Jiang

“…Although the WD40-repeat transcription factor TTG1 is known to regulate plant secondary metabolism and development, its specific functions in C. oleifera remain uncharacterized. …”
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Novel use of proton magnetic resonance spectroscopy (1HMRS) to non-invasively assess placental metabolism. by Fiona C Denison, Scott I Semple, Sarah J Stock, Jane Walker, Ian Marshall, Jane E Norman

“…Proton magnetic resonance spectroscopy ((1)H MRS) can be used to assess the metabolic profile of tissue in-vivo. In FGR pregnancies, a reduction in N-acetylaspartate (NAA)/choline ratio and detection of lactate methyl are emerging as biomarkers of impaired neuronal metabolism and fetal hypoxia, respectively. …”
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Therapeutic effects of metabolic cardioprotector containing L-arginine and inosine in elderly patients with ischemic heart disease by O. A. Vorobjova

“…Recovery of endothelium-depended vasodilatation, improvement of indexes of nitric oxide metabolism, oxidative stress reduction, decrease of duration and expressiveness of episodes of myocardial ischemia during treatment by metabolic cardioprotector as a part of complex therapy throughout 3 months in these patients were shown.…”
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Reduced removal of waste products from energy metabolism takes center stage in human brain aging by Silvia Mangia, Mauro DiNuzzo, Sara Ponticorvo, Gerald A. Dienel, Kevin L. Behar, Helene Benveniste, Fahmeed Hyder, Federico Giove, Suzana Herculano-Houzel, Ognen A. Petroff, Lynn E. Eberly, Pavel Filip, Shalom Michaeli, Douglas L. Rothman

“…However, CBF is required also to clear the byproducts of energy metabolism, namely CO2 and protons. With the goal of determining whether age-associated reduction in regional CBF may lead to abnormal brain partial pressure of carbon dioxide (pCO2) and pH levels that are sufficient to alter brain activity and cognitive function, we applied a recently introduced homeostatic modeling of nutrients and waste products to human neuroimaging PET data acquired in young and older adults (Goyal et al. in Cell Metab 26(2):353–360, 2017). …”
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Lipocalin prostaglandin D synthase and PPARγ2 coordinate to regulate carbohydrate and lipid metabolism in vivo. by Sam Virtue, Mojgan Masoodi, Vidya Velagapudi, Chong Yew Tan, Martin Dale, Tapani Suorti, Marc Slawik, Margaret Blount, Keith Burling, Mark Campbell, Naomi Eguchi, Gema Medina-Gomez, Jaswinder K Sethi, Matej Orešič, Yoshihiro Urade, Julian L Griffin, Antonio Vidal-Puig

“…Despite the reduction in markers of lipolysis in scWAT, DKO mice had a normal metabolic rate and elevated serum FFA levels compared to L-PGDS KO alone. …”
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ROLE OF GENETIC VARIABILITY IN METABOLIC PATHWAYS ON CISPLATIN-INDUCED KIDNEY INJURY IN HEAD AND NECK CANCER PATIENTS by Ericka Francislaine Dias Costa, Ana Maria Castro Ferreira, Marilda Mazzali, Gustavo Jacob Lourenço, Carmen Silvia Passos Lima

“…Patients with the GSTP1 c.313AG or GG and ERCC1 c.354CT or TTC>T (17.57%), MLH1 c.93GA or A (12.49%), or MSH3 c.3133AG or GG (12.19%) combined genotypes showed a reduction in renal function after CDDP treatment. Renal function declines of 18.85% and 13.38% were observed in patients with ERCC1 c.354CT or TT and MLH1 c.93GA or AA or MSH3 c.3133AG or GG combined genotypes, respectively. …”
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Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells by Elizabeth Haythorne, Matthew Lloyd, John Walsby-Tickle, Andrei I. Tarasov, Jonas Sandbrink, Idoia Portillo, Raul Terron Exposito, Gregor Sachse, Malgorzata Cyranka, Maria Rohm, Patrik Rorsman, James McCullagh, Frances M. Ashcroft

“…Abstract Chronic hyperglycaemia causes a dramatic decrease in mitochondrial metabolism and insulin content in pancreatic β-cells. …”
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Effects and mechanisms of phytochemicals on skeletal muscle atrophy in glucolipid metabolic disorders: current evidence and future perspectives by Mengjie Li, Yige Qin, Ruixuan Geng, Jingjing Fang, Seong-Gook Kang, Kunlun Huang, Tao Tong

“…Several studies demonstrated an inverse relationship between dietary phytochemical supplementation and the onset of skeletal muscle atrophy caused by glucolipid metabolic disorders, as evidenced by improved muscle quality and function. …”
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The Hepatoprotective Properties of Gentiopicroside, Sweroside, and Swertiamarin Against Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) by Anthony O. Boateng, Vinood B. Patel, S. W. Annie Bligh

“…Metabolic dysfunction-associated steatotic liver disease (MASLD) is a metabolic disease characterised by the accumulation of fat in the liver. …”
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Reprogramming of liver metabolism during West Nile virus infection unveils novel aspects of disease pathophysiology by Patricia Mingo-Casas, Ana-Belén Blázquez, Josefina Casas, Ana Esteban, Estela Escribano-Romero, Pedro J. Sánchez-Cordón, Nereida Jiménez de Oya, Juan-Carlos Saiz, Miguel A. Martín-Acebes

“…Conclusions The discovery of these underestimated metabolic aspects of the infection repurposes the impact of WNV on liver function. …”
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Hypoxia Dependent Inhibition of Glioblastoma Cell Proliferation, Invasion, and Metabolism by the Choline-Kinase Inhibitor JAS239 by Claire Louise Kelly, Martyna Wydrzynska, Marie M. Phelan, Sofya Osharovich, Edward J. Delikatny, Violaine Sée, Harish Poptani

“…In addition, cell proliferation, cell cycle progression, and cell invasion parameters were measured in 2D cell monolayers as well as in 3D cell spheroids, with or without JAS239 treatment, in normoxic or hypoxic cells to assess the effect of hypoxia on JAS239 function. <b>Results:</b> Hypoxia and JAS239 treatment led to significant changes in the cellular metabolic pathways, specifically the phospholipid and glycolytic pathways, associated with a reduction in cell proliferation via induced cell cycle arrest. …”
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Mechanisms of Cisplatin-Induced Acute Kidney Injury: The Role of NRF2 in Mitochondrial Dysfunction and Metabolic Reprogramming by Jihan Liu, Yiming Wang, Panshuang Qiao, Yi Ying, Simei Lin, Feng Lu, Cai Gao, Min Li, Baoxue Yang, Hong Zhou

“…<i>Nfe2l2</i> knockout mice showed aggravated kidney injury, characterized by worsened kidney function and histopathological damage. Mechanistically, <i>Nfe2l2</i> knockout resulted in redox imbalance, reduced ATP synthesis, mitochondrial dysfunction and metabolic dysregulation. …”
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CNOT6L regulates energy metabolism in the ovarian granulosa cells associated with polycystic ovary syndrome by Shan Han, Shan Han, Yanqiu Xie, Jiale Lv, Xuedong Sun, Yuhua Shi, Yuhua Shi, Yuhua Shi

“…Subsequently, we conducted the Cnot6l-overexpressed granulosa cells to explore the alterations by which CNOT6L regulates ovarian granulosa cell function. The overexpression of CNOT6L in granulosa cells significantly inhibited the glycolytic pathway, activated the mitochondrial oxidative phosphorylation pathway, led to a reduction in the generation of the intermediate product lactate, and resulted in impaired energy supply to the oocyte. …”
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Slow virologic control but strong immune and metabolic recovery with dolutegravir-anchored therapy in an HIV cohort in Ghana by Mark Appeaning, Edwin Magomere, Alberta Mawulawoe Abotsi, Nana Ama Yeboaa Amoako, Kirk Elorm Kouffie, Becky Ewurama Tetteh, Bridget Nana Darkoa Quist, Christèle Nguepou Tchopba, Gloria Akosua Ansa, Evelyn Yayra Bonney, Peter Kojo Quashie

“…This report evaluates viral load dynamics, immune responses, and organ-level metabolic changes following antiretroviral therapy (ART) initiation. …”
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A Comparison Study of Olmesartan and Valsartan Effects on Myocardial Metabolism in Patients With Dilated Cardiomyopathy: the OVOID Trial by Sangyong Jo, Kyungil Park, Jae Hyuk Choi, Chang‐Bae Sohn, Jeonghwan Kim, Yong‐Seop Kwon, Su Hong Kim, Tae‐ho Park

“…Background Myocardial metabolism plays an important role in maintaining cardiac function. …”
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Dietary macronutrients modulate the proteome of brown adipose tissue in males and their female offspring by Erin L. Macartney, Alistair M. Senior, Angela J. Crean, Lewin Small, Lou Ruffino, Tamara J. Pulpitel, Marcelo A. Nobrega, Romain Barrès, Stephen J. Simpson

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Testosterone Deficiency and Lipid Dysregulation in Individuals with Coexisting Hypothyroidism and Type 2 Diabetes: Clinical and Metabolic Implications by Mandayal Jamatia, Mohammad N Khan, Ashok Kumar

“…Aim and background: This study aims to evaluate the biochemical and endocrine changes in individuals with diabetes, hypothyroidism, and their coexistence, focusing on glycemic control, lipid metabolism, and hormonal balance. Understanding their interplay is crucial for optimizing disease management, enabling early intervention, and improving patient outcomes through personalized therapeutic strategies and risk reduction approaches. …”
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The effects of HAPA theory-based case management in patients with metabolic dysfunction-associated steatotic liver disease by Jia Mei, Yuncai Xie, Pingping Huang, Yudi Jin, Xia Wang, Ying Chen

“…Introduction and Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common liver disease affecting people's health, with its incidence increasing year by year. …”
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