DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells by Ignacio Melero, Ruth Conde-Garrosa, David Sancho, Santos Mañes, Alfonso R Sanchez-Paulete, Francisco J Cueto, Carlos del Fresno, Paola Brandi, Alexis J. Combes, Elena Hernández-García, Michel Enamorado, Christian P Bromley, Manuel J Gomez, Santiago Zelenay, Salvador Iborra, Matthew F. Krummel

Get full text

Overview of preclinical and phase II clinical studies on Pegmolesatide’s long-term erythropoiesis stimulating effect via EPOR-mediated signal transduction by Xiaoying Ma, Zhen Li, Lu Zhang, Hui Qian, Qinkai Chen, Ye Tao, Yunfan Li, Dandan Wang, Zhizhen Hu, Weili Luo, Ping Li, Hai Yu, Changlin Mei, Xueqing Yu, Yuanfeng Zhou

Get full text

GP73-mediated secretion of PKM2 and GP73 promotes angiogenesis and M2-like macrophage polarization in hepatocellular carcinoma by Shujie Wang, Tongjia Zhang, Yue Zhou, Zitao Jiao, Kejia Lu, Xinyi Liu, Wei Jiang, Zhe Yang, Hui Li, Xiaowei Zhang

Get full text

Does Brand Awareness Influences Purchase Intention? The Mediation Role of Brand Equity Dimensions by Vitor Azzari, Anderson Pelissari

“…This effect is only observed when it is mediated by the three dimensions of CBBE - perceived quality, brand associations, and brand loyalty. …”
Get full text

The mediating role of social support in self-management and quality of life in patients with liver cirrhosis by Ying Zhang, LeYao Xiao, Qian Liu, XinYi Zhang, MingDan Li, YaLi Xu, Mei Dai, Fei Zhao, YouShu Shen, Jordan Tovera Salvador, Ping Yang

Subjects: Get full text

Family cohesion, children’s thoughts, and children’s cognitive assessments: Mediating role of sport anxiety by Юмна Али, Сайед М. И. Шах

“…Hayes’ PROCESS Macro further demonstrated that sport anxiety has a significant mediating effect between thoughts and cognitive outcomes, including negative self-evaluations, off-task evaluations, positive self-evaluations, and on-task thoughts. …”
Get full text

Knowledge, attitude, and practice toward vitiligo among vitiligo patients: a mediation analysis by Hua Feng, Xiulian Xu, Shuzhen Qi, Kun Chen, Mei Ju, Xiaofang Li, Shuxian Shang

“…The mean knowledge, attitude, and practice scores were 5.45 ± 2.74 (possible range: 0–10), 23.15 ± 6.78 (possible range: 8–40), and 37.13 ± 6.78 (possible range: 10–50), respectively. Mediation analysis indicated that knowledge (β = 0.24, P = 0.023), attitude (β=-0.28, P < 0.001), disease duration (β=-1.49, P < 0.001), and negative emotions (β=-1.54, P = 0.008) had direct effects on practice. …”
Get full text

The effect of leadership styles on employee’s performance in Ethiopian sports organizations with mediating and moderating roles by Yifan Liu, Abyot Abdela Ali, Jiawen Pan, Yi Xiao

“…It specifically examined the mediating effects of job satisfaction and the moderating impact of education level. …”
Get full text

RETRACTED: Post COVID green intellectual capital management with the mediation of organizational learning capability by Elena Rostislavovna Schislyaeva, Inna Petrovna Krasovskaya, Kristina Sergeevna Plis

“…Organizational learning capability was a mediator, while firm performance was the independent variable. …”
Get full text

Future anxiety and the motives for postponing parenthood: generational time perspective and life satisfaction as mediators by Małgorzata Szcześniak, Celina Timoszyk-Tomczak, Julia Łoś, Monika Grzeczka

“…The aim of our study was to verify how anxiety about the future relates to the motives for deferred parenthood and how this relationship is mediated by generational time perspective and life satisfaction.MethodsA total of 203 Polish adults between 18 and 40 years of age participated in the study. …”
Get full text

Fear of hypoglycemia in Italian mothers of children with type 1 diabetes: the mediating role of resilience by Paola Cardinali, Elisa Rapetti, Laura Migliorini

“… # Results The analysis of the mediation model shows that resilience assumes a mediational role in the relationships between the parental role and preoccupation with hypoglycemia. …”
Get full text

Retraction: Post COVID green intellectual capital management with the mediation of organizational learning capability by Frontiers Editorial Office

Get full text

The association between visceral fat metabolic score and stroke: mediation by declining kidney function by Yue Cao, Weixing Wen, Hao Zhang, Weiwen Li, Guolin Huang, Yuli Huang

“…A non-linear relationship was observed, with stroke risk sharply increasing when METS-VF exceeded 7.00. Mediation analysis revealed that declining eGFR mediated 26.72% of the METS-VF-stroke association. …”
Get full text

Control del estrés, ira y ansiedad en pacientes con hipertensión arterial mediante TREC by Federico Holst-Schumacher, Diego Quirós-Morales

Get full text

LA INDUSTRIA FARMACÉUTICA ESPAÑOLA: ANÁLISIS MEDIANTE LA PERSPECTIVA DE GRUPOS ESTRATÉGICOS 2000-2003 by Enzo Piña

Get full text

Professor, dividir não diminui? Relativizando possíveis verdades matemáticas mediante o uso da calculadora by Wagner da Silveira Marques

Get full text

LRP11 promotes stem-like T cells via MAPK13-mediated TCF1 phosphorylation, enhancing anti-PD1 immunotherapy by Zhishui Chen, Gang Chen, Li Chen, Xiangli Zhao, Lingjuan Sun, Zhibo Ma, Xiaosheng Tan, Yuhao Tu, Jingzeng Wang, Peixiang Lan

“…LRP11 activation enhanced TCF1+PD1+CD8+ T-cell-mediated antitumor immunity, consistent with LRP11 blocking impaired T-cell function. …”
Get full text

Chemo-proteomics reveals dihydrocaffeic acid exhibits anti-inflammation effects via Transaldolase 1 mediated PERK-NF-κB pathway by Guanjun Li, Huiying Li, Peili Wang, Xinzhou Zhang, Wenhua Kuang, Ling Huang, Ying Zhang, Wei Xiao, Qingfeng Du, Huan Tang, Jigang Wang

“…Also we demonstrated that DA reveals anti-inflammation effect through TALDO1 mediated PERK-IκBα-NF-κB pathway in RAW 264.7 cells. …”
Get full text

Gut microbiota derived DCA enhances FOLFOX efficacy via Ugt1a6b mediated enterohepatic circulation in colon cancer by Qian Fang, Xiaoying Hou, Limei Fan, Yufei Deng, Xiaoxuan Li, Hongyun Zhang, Haiping Wang, Zhengqi Fu, Binlian Sun, Xiji Shu, Hongzhi Du, Yuchen Liu

“…In conclusion, our findings establish that gut microbiota-derived DCA enhances the efficacy of FOLFOX potentially via Ugt1a6b mediated enterohepatic circulation, providing novel insights into a synergistic therapeutic strategy for improving colon cancer treatment.…”
Get full text

Single-cell transcriptome-wide Mendelian randomization and colocalization reveals immune-mediated regulatory mechanisms and drug targets for COVID-19Research in context by Hui Ying, Xueyan Wu, Xiaojing Jia, Qianqian Yang, Haoyu Liu, Huiling Zhao, Zhihe Chen, Min Xu, Tiange Wang, Mian Li, Zhiyun Zhao, Ruizhi Zheng, Shuangyuan Wang, Hong Lin, Yu Xu, Jieli Lu, Weiqing Wang, Guang Ning, Jie Zheng, Yufang Bi

“…Interpretation: Our study showcased the central role of immune-mediated regulatory mechanisms for COVID-19 and prioritized drug targets that might inform interventions for viral infectious diseases. …”
Get full text