Carvacrol attenuated haloperidol-induced Parkinson’s disease via TNF/NFκβ-NLRP3-mediated pyroptosis by Faisal Albaqami, Khawaja Waqas Ahmad, Fawad Ali Shah

“…Carvacrol was administered at a dose of 25 and 50 mg / kg once daily for fifteen days before haloperidol administration. …”
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Manganese Inhalation as a Parkinson Disease Model by José Luis Ordoñez-Librado, Verónica Anaya-Martínez, Ana Luisa Gutierrez-Valdez, Laura Colín-Barenque, Enrique Montiel-Flores, Maria Rosa Avila-Costa

“…By the end of Mn exposure, 10 mice were orally treated with 7.5 mg/kg L-DOPA. After 5 months of Mn mixture inhalation, striatal dopamine content decreased 71%, the SNc showed important reduction in the number of TH-immunopositive neurons, mice developed akinesia, postural instability, and action tremor; these motor alterations were reverted with L-DOPA treatment. …”
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Combining Ultrasound-Guided Popliteal Sciatic and Adductor Canal Block as a Lifesaver for High-Risk Patients Scheduled for Emergency Below Knee Surgery: A Case Series by Vijayalaxmi Biradar, Shweta Konnur, Abhay Sancheti

“…Adequate sensory and motor blockade required for surgery was achieved, with stable haemodynamic parameters throughout the procedure. …”
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<i>Eugenia uniflora</i> Effects on the Depressive-like Behavior of MPTP-Exposed Female Rats: Apoptosis and α-Synuclein Modulation by Anne Suély Pinto Savall, Jhuly Dorneles De Mello, Eduarda Monteiro Fidelis, Vandreza Cardoso Bortolotto, Mustafa Munir Mustafa Dahleh, Gustavo Petri Guerra, Marina Prigol, Robson Puntel, Jean Ramos Boldori, Cristiane Casagrande Denardin, Tuane Bazanella Sampaio, Simone Pinton

“…<b>Methods:</b> Rats received intranasal administration of MPTP or vehicle, followed by 14 days of oral administration of PFEU (300 or 2000 mg/kg, administered once daily) or vehicle. Depressive-like behavior was assessed using the splash and forced swimming tests, while motor ability was evaluated using the rotarod and open field tests. …”
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Rosa moschata ameliorates haloperidol-induced Parkinson's disease via reduction of neurodegeneration and oxidative stress by Badriyah S. Alotaibi, Uzma Saleem, Maryam Farrukh, Zunera Chaudhary, Nabia Anwar, Ifat Alsharif, Abdullah R. Alanzi, Tasahil S. Albishi, Fatima A. Jaber, Wedad Saeed Al-Qahtani, Muhammad Ajmal Shah

“…Methods: Haloperidol (1 mg/kg) was given to rats intraperitoneally for 3 weeks for induction of PD. …”
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Chronic Exposure to Arsenic in Drinking Water Causes Alterations in Locomotor Activity and Decreases Striatal mRNA for the D2 Dopamine Receptor in CD1 Male Mice by Claudia Leticia Moreno Ávila, Jorge H. Limón-Pacheco, Magda Giordano, Verónica M. Rodríguez

“…Arsenic exposure has been associated with sensory, motor, memory, and learning alterations in humans and alterations in locomotor activity, behavioral tasks, and neurotransmitters systems in rodents. …”
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Mimosapudica L. aqueous extract protects mice against pilocarpine–picrotoxin kindling-induced temporal lobe epilepsy, oxidative stress, and alteration in GABAergic/cholinergic path... by Hart Mann Alain Youbi Mambou, Simon Pale, Orelien Sylvain Mtopi Bopda, Vanessa Tita Jugha, Nji Seraphin Ombel Musa, Tambong Ako Ojongnkpot, Bertrand Yuwong Wanyu, Raymond Bess Bila, Rashed N. Herqash, Abdelaaty A. Shahat, Germain Sotoing Taiwe

“…Mimosa pudica extracts (160 mg/kg) significantly increased the latency time to status epilepticus by 70.91%. …”
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Analysis of Connectivity in Electromyography Signals to Examine Neural Correlations in the Activation of Lower Leg Muscles for Postural Stability: A Pilot Study by Gordon Alderink, Diana McCrumb, David Zeitler, Samhita Rhodes

“…Changes in connectivity in the beta and gamma bands were found to be most significant in the muscle pairs of the back leg during a tandem stance regardless of dominant foot placement. MSC identified the MG:S muscle pair as significant for the right and left leg. …”
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Antidepressant Effects of Probucol on Early-Symptomatic YAC128 Transgenic Mice for Huntington’s Disease by Cristine de Paula Nascimento-Castro, Ana Claudia Wink, Victor Silva da Fônseca, Claudia Daniele Bianco, Elisa C. Winkelmann-Duarte, Marcelo Farina, Ana Lúcia S. Rodrigues, Joana Gil-Mohapel, Andreza Fabro de Bem, Patricia S. Brocardo

“…The motor performance and affective symptoms were monitored using well-validated behavioral tests in YAC128 mice and age-matched wild-type littermates at 2, 4, and 6 months of age, after 1, 3, or 5 months of treatment with probucol (30 mg/kg/day via water supplementation, starting on postnatal day 30). …”
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Follow-Up of Advanced Parkinson’s Disease Patients after Clinical or Surgical Emergencies: A Practical Approach by Hélio A. G. Teive, Matheus Gomes Ferreira, Carlos Henrique F. Camargo, Renato P. Munhoz

“…Patients with advanced stage Parkinson’s disease (PD) typically present with a myriad of motor and nonmotor symptoms in addition to comorbidities and, as a consequence, polypharmacy. …”
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Valproate Treatment in an ALS Patient Carrying a c.194G>A Spastin Mutation and SMN2 Homozygous Deletion by Lucio Tremolizzo, Gessica Sala, Elisa Conti, Virginia Rodriguez-Menendez, Antonella Fogli, Angela Michelucci, Paolo Simi, Silvana Penco, Christian Lunetta, Massimo Corbo, Carlo Ferrarese

“…The patient was started on valproic acid (VPA, 600 mg/die per os) considering the capacity of this drug of increasing survival motor neuron through an epigenetic mechanism. …”
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Administration of Sex Hormone Preparations as a Risk Factor in the Development of Intrahepatic Cholestasis of Pregnancy and Biliary Sludge in Pregnant Women by Yu. B. Uspenskaya, I. V. Kuznetsova, A. A. Sheptulin, N. V. Goncharenko, A. N. Gerasimov, M. M. Amiraslanova

“…Patients with BS received treatment with ursodeoxycholic acid (UDCA) in a dose of 250–750 mg and choleretic herbal preparation (artichoke extract) for 2 months. …”
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Dexmedetomidine versus Dexamethasone as Perineural Adjuvants in Supraclavicular Brachial Plexus Block: An Interventional Study by Charmi Hitenbhai Shah, Jinesh Pareshbhai Kothari, Nilesh Vrajmohan Shah, Rajsi Rajan Shah, Sara Mary Thomas

“…Group 2 received the same local anaesthetic mixture with dexamethasone 8 mg (2 mL). The onset and duration of sensory and motor blocks, haemodynamic changes {variations in pulse, blood pressure, and oxygen saturation (SpO2)}, duration of rescue analgesia, side-effects, and complications were evaluated. …”
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Anxiolytic-Like Actions of Fatty Acids Identified in Human Amniotic Fluid by Rosa Isela García-Ríos, Juan Francisco Rodríguez-Landa, Carlos M. Contreras

“…Although a trend toward a dose-response effect was observed, only an amount of fatty acids that was similar to amniotic fluid fully mimicked the effect of diazepam (2 mg/kg, i.p.) in the defensive burying test, an action devoid of effects on locomotor activity and motor coordination. …”
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Deciphering In Vitro and In Vivo Pharmacological Properties of Seed and Fruit Extracts of Flacourtia jangomas (Lour.) Raeusch by Farhana Alam Ripa, Fowzia Alam, Fahmida Haque Riya, Yesmin Begum, Sharmin Akter Eti, Nusratun Nahar, Zebunnesa Ahmed, Sabrina Sharmin

“…In both in vivo analgesic tests, SFJC demonstrated substantial (p<0.01) pain inhibition percentages (tail immersion: 49.46%; acetic acid writhing: 66.43%) at a dose of 600 mg/kg. During neuropharmacological screening, all extracts significantly (p<0.01; p<0.05) and dose-dependently decreased the mice’s locomotion activity and motor balance. …”
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Semi-in-situ cutting force measurement of a jigsaw by Sándor Apáti, György Hegedűs, Sándor Hajdu

“…The method uses Fast Fourier Transform (FFT) analysis to determine the motor speeds, which helps calculate dynamic cutting parameters correctly. …”
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Efficacy and Safety of Pramipexole Sustained Release versus Immediate Release Formulation for Nocturnal Symptoms in Chinese Patients with Advanced Parkinson’s Disease: A Pilot Stud... by Haiyan Zhou, Shuhua Li, Hongmei Yu, Shenggang Sun, Xinhua Wan, Xiaodong Zhu, Chun-Feng Liu, Ling Chen, Wei Xiang, Yaqing Sun, Haibo Chen, Shengdi Chen

“…Other endpoints included motor complications (MDS-UPDRS part IV) score. Adverse events were evaluated for each group. …”
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Alpha-synuclein pathology enhances peripheral and CNS immune responses to bacterial endotoxins by Anna-Sophia Hartke, Cara S. Schreiber, Kristina Lau, Ivo Wiesweg, Inken Waltl, Ulrich Kalinke, Franziska Richter, Christopher Käufer

“…At this early time point, motor behavior is not yet robustly impacted by the observed pathological alterations. …”
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Psychometric Properties of the Apathy Scale in Advanced Parkinson’s Disease by John B. Wetmore, José Matías Arbelo, María José Catalán, Francesc Valldeoriola, Carmen Rodriguez-Blazquez, Pablo Martinez-Martin

“…AS total score was moderately correlated with Beck Depression Inventory (0.34) and with Non-Motor Symptoms Scale domains 2 (sleep/fatigue, 0.35), 3 (mood/apathy, 0.56), and 5 (attention/memory, 0.41). …”
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Comparison of PM2.5 Chemical Compositions during Haze and Non-haze Days in a Heavy Industrial City in North China by Menghui Li, Liping Wu, Xiangyan Zhang, Xinwu Wang, Wenyu Bai, Jing Ming, Chunmei Geng, Wen Yang

“…Additionally, an elevated TE concentration was observed during the episode (exceeding the pre- and post-haze values by 54.70% and 31.98%, respectively), with crustal elements (K, Al, Ca, Si, Na, Fe and Mg), the most abundant elemental components, accounting for 88.64%. …”
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