Expression of MTA1 in preeclamptic placental tissue and its effects on trophoblast function by GENG Yao, ZHANG Yang, ZHAO Jie, LI Wei, CAI Guoqing

“…Immunofluorescent double staining showed that MTA1 was mainly localized in the nuclei of trophoblast cells. The wound healing assay demonstrated that HTR8/SVneo with stable MTA1 knockdown exhibited weaker cell migration ability compared to the control group (P=0.002). …”
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NRF2 maintains redox balance via ME1 and NRF2 inhibitor synergizes with venetoclax in NPM1-mutated acute myeloid leukemia by Jiayuan Hu, Zihao Yuan, Yan Shu, Jun Ren, Jing Yang, Lisha Tang, Xingyu Wei, Yongcan Liu, Fangfang Jin, Qiaoling Xiao, Xinyi Chen, Nan Wu, Wen Zhao, Ziwei Li, Ling Zhang

“…Meanwhile, elevated NRF2 expression and its nuclear localization were observed in NPM1-mutated AML cells. …”
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Endothelial cell activation is attenuated by everolimus via transcriptional and post-transcriptional regulatory mechanisms after drug-eluting coronary stenting. by Zsolt Fejes, Zsolt Czimmerer, Tibor Szük, Szilárd Póliska, Attila Horváth, Enikő Balogh, Viktória Jeney, Judit Váradi, Ferenc Fenyvesi, György Balla, István Édes, József Balla, János Kappelmayer, Béla Nagy

“…We studied the effect of everolimus on E-selectin (SELE) and VCAM1 mRNA levels when human coronary artery (HCAECs) and human umbilical vein ECs were challenged with recombinant TNF-α (100 ng/mL) for 1-24 hours in the presence or absence of everolimus using 0.5 μM concentration locally maintained by DES. EC activation was evaluated via the levels of IL-1β and IL-6 mRNAs with miR-155 expression by RT-qPCR as well as the nuclear translocation of nuclear factor kappa beta (NF-κB) detected by fluorescence microscopy. …”
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The anticancer properties, cell-cycle cytotoxicity and apoptosis of cissus rotundifolia, trema orientalis, and buddleja polystachya with ocular applications by Ali Hendi Alghamdi, Aimun A.E. Ahmed, Mahadi bashir, Haidar abdalgadir, Asaad khalid, Ashraf N. Abdalla, Mohamed E. elzubier, Riyad almaimani, Bassem refaat, Khalid alzahrani, Saleh MS. alghamdi, Sheraz gul

“…Background: Buddleja polystachya, Trema orientalis, and Cissus rotundifolia were applied locally for various ocular purposes, while receiving few scientific evaluations. …”
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Causal relationships and predictability of the summer East Atlantic teleconnection by J. Carvalho-Oliveira, J. Carvalho-Oliveira, J. Carvalho-Oliveira, J. Carvalho-Oliveira, G. Di Capua, G. Di Capua, L. F. Borchert, R. V. Donner, R. V. Donner, J. Baehr

“…Our results suggest that while the overall impact may be limited, leveraging these causal links locally could help to constrain and improve the seasonal prediction skill of European summer climate.…”
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The Knob Domain of the Fiber-1 Protein Affects the Replication of Fowl Adenovirus Serotype 4 by Xiaofeng Li, Zhixun Xie, You Wei, Zhiqin Xie, Aiqiong Wu, Sisi Luo, Liji Xie, Meng Li, Yanfang Zhang

“…The fiber-1-Δ1 and fiber-1-Δ2 proteins were mainly localized in the cytoplasm of LMH cells. Fiber-1-Δ2 has a greater ability to inhibit FAdV-4 replication than fiber-1-Δ1, and 933 differentially expressed genes (DEGs) were detected between the fiber-1-Δ1 and fiber-1-Δ2 groups. …”
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Current <i>Streptococcus Pneumoniae</i> Serotypes in Sverdlovsk Region in 2020–2021 by E. V. Bolgarova, Yu. A. Zakharova, I. S. Mukhachev, I. A. Korotkova, I. A. Ivashchenko, А. V. Ostapchuk, O. I. Mamontov

“…In the individuals of the studied groups of observation, in 27.0% and 28.1% of the cases the study detected the S. pneumoniae in the biological material with circulation of 12 «vaccine» (19F – 2,6%, 6ABCD – 2,6%, 4 – 2,0%, 23F – 2,0%, 9AV – 1,3%, 9LN – 0,6%, 11AD – 1,3%, 18ABCF – 2,0%) and «nonvaccine» (15AF – 0.7%, 16F – 0.6%) serotypes. …”
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Programmed death-1 inhibition increases vaccine-induced T-cell infiltration in patients with prostate cancer by Colin Pritchard, Renee N Donahue, Jeffrey Schlom, James L Gulley, Ravi A Madan, Fatima Karzai, Amy Hankin, Jennifer L Marté, Ismail Baris Turkbey, Yo-Ting Tsai, Manuk Manukyan, Moniquea Williams, William Dahut, Shania Bailey, Wiem Lassoued, Michell Manu, Peter Pinto, Daniel Burnett, Elisabetta Xue, Kenneth D Canubas, Antonios Papanicolau-Sengo, Zhigang Kang, Sam Sater

“…The lead-in cohort had 12 patients with metastatic castration-resistant PC (mCRPC); the neoadjuvant cohort included 12 patients with localized PC who were candidates for radical prostatectomy (RP). …”
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Characterization of Novel WFS1 Variants in Three Diabetes Pedigrees by ChangQing Liu, HangYu Fang, Dong Wang, YiPing Cheng, Ping Shi, ChunXiao Yu, XiaoHong Li, Hui Zhao, Wei Hou, ZhenKui Guo, Chao Xu, QingBo Guan

“…Methods High‐throughput sequencing was employed to detect WFS1 gene mutations, followed by pathogenicity and conservation analysis using bioinformatics software. …”
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Long noncoding RNA LINC00339 promotes osteoporosis development via modulating of regulator CDC42 by binding PARP1 by Dong-Li Zhu, Yan Zhang, Xiao-Yu Zhang, Zi-Han Qiu, Ke Li, Xiao-Rong Zhou, Zhen-Zhen He, Xiao-Feng Chen, Shan-Shan Dong, Wen Tian, Ya-Kang Wang, Tie-Lin Yang, Bo Yang, Yan Guo

“…Functional analyses revealed that LINC00339 dysregulation exhibited an inverse correlation with osteogenic differentiation capacity across multiple osteoblast cell models. Subcellular localization analysis via FISH confirmed the predominant cytoplasmic distribution of LINC00339 in bone cells. …”
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Are treatment plans optimized on the basis of acuros XB dose calculation robust against anatomic changes during online adaptive radiotherapy for lung cancer regarding dose homogene... by Khouya Aymane, Santiago Alina, Ringbaek Toke, Guberina Nika, Guberina Maja, Gauler Thomas, Lübcke Wolfgang, Zylka Waldemar, Pöttgen Christoph, Stuschke Martin

“…Plan sensitivity to anatomic changes can be detected and controlled on the planning CT by the WOR of air in CBALPTV.…”
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ALKBH5, an m6A demethylase, attenuates tumor growth and inhibits metastasis in papillary thyroid carcinoma by Yong Zhuang, Qingyan Cai, Xin Hu, Huibin Huang

“…Immunofluorescence staining was used to localize the high accumulation of ALKBH5 in cells. …”
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Development and study of mucoadhesive microcapsules for the nasal levodopa delivery by D. S. Gordeeva, V. V. Khutoryanskiy, R. I. Moustafine

“…The drug in the microparticles acts locally, thereby ensuring the release of the drug in the required amount in the target organ. …”
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Glucose metabolism disorders associated with COVID-19: clinical and morphological study by T. L. Karonova, A. A. Mikhailova, D. I. Lagutina, O. M. Vorobeva, D. O. Grigoreva, K. A. Sterkhova, V. A. Malko, A. G. Mikheeva, A. T. Chernikova, L. B. Mitrofanova, E. V. Shlyakhto

“…Glucose metabolism disorders (GMD) were detected both in acute and in post-COVID, however, its pathogenic aspects remain unclear.AIM. …”
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Myofibrillogenesis Regulator-1 in Smooth Muscle Cells Modulates Inflammation Signaling Pathways via Regulating ROCK1 Ubiquitination and Degradation to Impact Aortic Dissection [Cor... by Yin H, Li X, Lu D, Zhao X, Yang Z, Wang Z, Xu F, Chen Y, Li C

“…Figure 5 MR-1 Affects AD Progression by Regulating the ROCK1-NF-kappaB p65 Signaling Pathway. (A and B) Co-localization of MR-1 (green) with ROCK1 (red) in human vSMCs induced by angiotensinII for 24&amp;#x00A0;hours. …”
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A rare case of multiple brain abscesses caused by Nocardia abscessus co-infection with tuberculous meningitis in an immunocompetent patient by Xiuri Wang, Lingyan Liang, Yunxiao Liang, Liuyang Hu

“…Case presentation A 34-year-old male patient initially presented with a week-long history of headaches, predominantly localized in the bilateral frontal region. Additionally, the patient experienced fever, and due to the recurrence of these symptoms, he was admitted to the hospital. …”
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Comorbidity in patients with lobular panniculitis-lipodermatosclerosis by O. N. Egorova, B. S. Belov, E. G. Sazhina

“…During clinical examination, the localization, prevalence, color and number of affected skin areas and sub cutaneous fat were determined. …”
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Characterization of dynamic stall of a wind turbine airfoil with a high Reynolds number by H. R. Kim, J. A. Printezis, J. D. Ahrens, J. R. Seume, L. Wein

“…The MCSP exhibits a breakdown in magnitude at the onset of the dynamic-stall formation stage and full stall, while the TESP supports indicating the emergence of a full stall by detecting the trailing-edge vortex.</p>…”
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Comparative analysis of the diagnostyc value of CT and MRI in the assessment of peritoneal carcinomatosis in ovarian cancer by Yu. A. Soloveva, N. A. Rubtsova, E. G. Novikova, D. O. Kabanov, S. A. Skugarev

“…The use of mmMRI at the preoperative stage made it possible to obtain a higher diagnostic efficiency in assessment of the operitoneal carcinomatosis prevalence, compared with CT data, especially with locuses of 5 mm or less localized at the level of the right dome of the diaphragm, along the peritoneum in the small intestine and its mesentery. …”
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Changes in concentrations of cytokines and markers of bone turnover in dairy cows during different stages of a production cycle by Aisha Tarar, Reza Sanaei, Babatunde A. Ayodele, Kristy DiGiacomo, Brian J. Leury, Eleanor J. Mackie, Andrew P. Woodward, Charles N. Pagel

“…These changes are regulated locally and systemically by a variety of factors, including hormones, cytokines, chemokines, and growth factors. …”
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