Prosthetic valve thrombosis in a patient secondary to COVID-19: a case report by L. V. Rasputina, D. V. Didenko

“…A well-known and dangerous complication of COVID-19 infection is the development of hypercoagulation, which leads to thrombosis of various localization. Therefore, the problem of anticoagulant therapy was widely discussed during the first months of the pandemic and continues to be relevant. …”
Get full text

Investigating the molecular mechanisms associated with ulcerative colitis through the application of single-cell combined spatial transcriptome sequencing by Hua Huang, Jiaze Ma, An Kang, Tianwei Guo, Wei Sun, Yan Xu, Lijiang Ji

“…Furthermore, immunofluorescence staining indicated co-localization of TIMP1 with the macrophage marker F4/80 in monocytes.ConclusionOur research delineated distinct monocyte subtypes correlated with UC and identified two pivotal genes, GNG5 and TIMP1, that contribute to the disease’s pathogenesis. …”
Get full text

Efficiency evaluation on case finding strategy for COVID-19 outbreak control under China’s “dynamic zero-case policy”: a retrospective field epidemiology study by Zhibei Zheng, Wanwan Sun, Qiuyao Duan, Shelan Liu, Enfu Chen, Jinren Pan

“…On average, 2.2, 7.4, and 106.5 cases were detected per million tests by low-, medium-, and high-risk area residents, respectively.ConclusionRapid and stringent comprehensive public health and social measures can contain the spread of SARS-CoV-2 in a localized area within weeks. …”
Get full text

Hylotelephium mingjinianum Extract Attenuates Oxidative Stress and Inflammation in Experimental Periodontitis by Yuan L, Kong C, Shi N, Chen J, Zhang T, Wang X

“…However, its role in the treatment of Periodontal disease has not been elaborated in detail.Purpose: This study aimed to elucidate the dual-target anti-inflammatory and antioxidant mechanisms of Hylotelephium mingjinianum extract (HME) in periodontitis treatment, focusing on its modulation of the Nrf2/NF-κB crosstalk.Methods: The periodontitis animal model of SD rats was established by ligation combined with Porphyromonas gingivalis (Pg) stimulation. The rats were locally administered HME (0.25%, 0.5%, and 1%, 0.5 mL/twice/day) for 14 days. …”
Get full text

Which сlinical, laboratory, and instrumental factors are associated with the development of the no-reflow phenomenon in patients with acute coronary syndrome? by E. V. Konstantinova, Yu. S. Ilin, A. A. Velikotskiy, A. O. Chernikov, M. S. Zhdanova, E. V. Ploshchenkov

“…Electrocardiographic changes in the anterior wall of the left ventricle were detected in 59% of Group 1 patients and 50% of Group 2 patients, p=0.018. …”
Get full text

GENDER DIFFERENCES OF CORONARY HEART DISEASE PATIENTS WITH POSTINFARCTION CARDIOSCLEROSIS AND CHRONIC MITRAL REGURGITATION BY THE DATA OF CORONARY ANGIOGRAPHY REGISTRY by E. I. Yaroslavskaya, V. A. Kuznetsov, G. S. Pushkarev, D. V. Krinochkin, G. V. Kolunin, E. A. Gorbatenko

“…They had higher indexes of left atrium size (25,1±2,9 vs 23,7±3,2 mm/m2, р=0,008), left ventricular (LV) posterior wall thickness (6.0±0.7 vs 5,2±0,8 mm/m2, р<0,001), lower extent of LV wall motion abnormalities (28,7±14,7 vs 33,5±14,9%, р=0,036) and higher LV ejection fraction (47,3±8,2 vs 43,9±9,2%, р=0,013). The localization of myocardial scars and coronary stenosis did not differ between men and women. …”
Get full text

Elucidation of the Active Agents in a West African Ground Herbal Medicine Formulation That Elicit Antimalarial Activities in In Vitro and In Vivo Models by Solomon Owumi, John O. Olanlokun, Bocheng Wu, Abiola Marian Duro-Ladipo, Sophia E. Oyelere, Shabana I. Khan, Adegboyega K. Oyelere

“…The goal of this study is to evaluate a formulation of Agunmu made from <i>M. indica</i>, <i>A. repens</i>, <i>E. chlorantha</i>, <i>A. boonei</i>, and <i>B. ferruginea</i>, sold in the open market and commonly used for the treatment of malaria by the locals, for its antimalarial effects and to determine the active principles that may contribute to the antimalarial effect. …”
Get full text

Identification and characterization of Trichoderma species aggressive to Pleurotus in Italy by Woo S L, Di Benedetto P, Senatore M, Abadi K, Gigante S, Soriente I, Ferraioli S, Scala F, Lorito M

“…Samples were obtained from different phases of compost preparation at the locality of a major producer and supplier of compost to the mushroom industry in Southern Italy, and microbial counts were conducted. …”
Get full text

Differential Expression of LncRNA MIAT and Its Clinical Significance in Intracranial Aneurysms by Fuquan Liu, Shuai Hao, Jingliyu Wang, Lei Chen, Ning Jiang, Laixing Liu, Xiangyi Wang

“…ABSTRACT Purpose: Intracranial aneurysm (IA) is characterized by localized dilation or ballooning of a blood vessel in the brain with life‐threatening consequences. …”
Get full text

Spleen Involvement at Diagnosis of Multiple Myeloma: A Case Report and Literature Review by Alessia Fiorini, Maria Gabriela Chavez, Valentina Panichi, Marco Dell'Aquila, Valentina Ranucci, Daniele Remotti, Michela Tarnani, Marco Montanaro, Roberto Latagliata, Alessandro Andriani

“…At physical examination, spleen enlargement was detected, with anemia (Hb 10.5 g/dL) and thrombocytopenia (48 × 109/L). …”
Get full text

Gastroesophageal circulating tumor cell crosstalk with peripheral immune system guides CTC survival and proliferation by Tania Rossi, Martina Valgiusti, Maurizio Puccetti, Giacomo Miserocchi, Michele Zanoni, Davide Angeli, Chiara Arienti, Ilaria Pace, Cristian Bassi, Ivan Vannini, Mattia Melloni, Erika Bandini, Milena Urbini, Massimo Negrini, Massimiliano Bonafè, Manuela Ferracin, Giulia Gallerani

Get full text

Interleukin-32 positive immune and resident cells in kidney samples from lupus patients: a pilot study by Simona Truglia, Simona Truglia, Francesco Ciccia, Silvia Mancuso, Antonella Capozzi, Aroldo Rizzo, Francesca Romana Spinelli, Fulvia Ceccarelli, Tania Colasanti, Cristina Garufi, Francesca Miranda, Maurizio Sorice, Cristiano Alessandri, Fabrizio Conti

Get full text

Clinical Presentation, Renal Histopathological Findings, and Outcome in Patients with Monoclonal Gammopathy and Kidney Disease by Gaetano Alfano, Alice Delrio, Francesco Fontana, Giacomo Mori, Silvia Cazzato, Annachiara Ferrari, Rossella Perrone, Silvia Giovanella, Giulia Ligabue, Riccardo Magistroni, Gianni Cappelli

Get full text

Identification of WRKY gene family and analysis of drought stress expression in Poncirus polyandra by ZHANG Shanshan, RUAN Sunmei, YANG Wenzhong

“…Comprehensive analyses were systematically performed using bioinformatics methods, including the physicochemical properties, sequence characteristics, phylogenetic relationships, chromosome localization, collinearity, gene structure and cis-acting elements of the PpWRKY family members. …”
Get full text

Functional omics of ORP7 in primary endothelial cells by Juuso H. Taskinen, Minna Holopainen, Hanna Ruhanen, Miesje van der Stoel, Reijo Käkelä, Elina Ikonen, Salla Keskitalo, Markku Varjosalo, Vesa M. Olkkonen

“…What is known about ORP7 points toward an endoplasmic reticulum and plasma membrane-localized protein, which also interacts with GABA type A receptor-associated protein like 2 (GABARAPL2) and unlipidated Microtubule-associated proteins 1A/1B light chain 3B (LC3B), suggesting a further autophagosomal/lysosomal association. …”
Get full text

Identification and Expression Analysis of the Phospholipase D Gene Family in Rice by Huasheng CAO, Tang LI, Liang XIONG, Fujun WANG, Shuguang LI, Haiyong GU, Gao HE, Shihu LIANG, Wenyong LUO

“…According to the phylogenetic tree, the PLD gene family was divided into four subfamilies, and there were significant differences in the number of exons among the members of different subfamilies. Chromosome localization analysis revealed that 17 PLD genes were located on 9 chromosomes. …”
Get full text

Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility. by Jian Zhao, Hui Wu, Melanie Khosravi, Huijuan Cui, Xiaoxia Qian, Jennifer A Kelly, Kenneth M Kaufman, Carl D Langefeld, Adrienne H Williams, Mary E Comeau, Julie T Ziegler, Miranda C Marion, Adam Adler, Stuart B Glenn, Marta E Alarcón-Riquelme, BIOLUPUS Network, GENLES Network, Bernardo A Pons-Estel, John B Harley, Sang-Cheol Bae, So-Young Bang, Soo-Kyung Cho, Chaim O Jacob, Timothy J Vyse, Timothy B Niewold, Patrick M Gaffney, Kathy L Moser, Robert P Kimberly, Jeffrey C Edberg, Elizabeth E Brown, Graciela S Alarcon, Michelle A Petri, Rosalind Ramsey-Goldman, Luis M Vilá, John D Reveille, Judith A James, Gary S Gilkeson, Diane L Kamen, Barry I Freedman, Juan-Manuel Anaya, Joan T Merrill, Lindsey A Criswell, R Hal Scofield, Anne M Stevens, Joel M Guthridge, Deh-Ming Chang, Yeong Wook Song, Ji Ah Park, Eun Young Lee, Susan A Boackle, Jennifer M Grossman, Bevra H Hahn, Timothy H J Goodship, Rita M Cantor, Chack-Yung Yu, Nan Shen, Betty P Tsao

“…Haplotype analysis revealed that the underlying causal variant, tagged by rs6677604 and rs16840639, was localized to a ~146 kb block extending from intron 9 of CFH to downstream of CFHR1. …”
Get full text

Clinical utility of the FilmArray® meningitis/encephalitis panel in children with suspected central nervous system infection in a low-resource setting – a prospective study in Sout... by Reza Rasti, Elias Kumbakumba, Deborah Nanjebe, Phuthumani Mlotshwa, Milly Nassejje, John Mzee, Stephen Businge, Gilbert Akankwasa, Dan Nyehangane, Jesper Gantelius, Yap Boum, Andreas Mårtensson, Juliet Mwanga-Amumpaire, Tobias Alfvén, Giulia Gaudenzi

“…More epidemiologically customized pathogen panels may increase FA-ME utility locally, although its use in similar settings would require major cost reductions. …”
Get full text

Pesticide Residues in Fruits and Vegetables from Cape Verde: A Multi-Year Monitoring and Dietary Risk Assessment Study by Andrea Acosta-Dacal, Ricardo Díaz-Díaz, Pablo Alonso-González, María del Mar Bernal-Suárez, Eva Parga-Dans, Lluis Serra-Majem, Adriana Ortiz-Andrellucchi, Manuel Zumbado, Edson Santos, Verena Furtado, Miriam Livramento, Dalila Silva, Octavio P. Luzardo

“…Residues were detected in 63.9% of fruits and 13.2% of vegetables, with imported fruits showing the highest contamination levels and diversity of compounds. …”
Get full text

Brain glucose metabolism in patients with traumatic brain injury undergoing rehabilitation: a longitudinal 18F-FDG PET study by Valeria Pingue, Valeria Pingue, Irene Bossert, Daniela D’Ambrosio, Antonio Nardone, Antonio Nardone, Giuseppe Trifirò, Nicola Canessa, Nicola Canessa, Diego Franciotta

“…Notably, such changes preferentially involve definite frontal brain areas regardless of TBI localization and entity. These findings pave the way for further studies with translational purposes.…”
Get full text