Improved CAR internalization and recycling through transmembrane domain optimization reduces CAR-T cytokine release and exhaustion by Shufeng Xie, Shufeng Xie, Jinlan Long, Ruiheng Wang, Ruiheng Wang, Rufang Xiang, Rufang Xiang, Huajian Xian, Yixin Wang, Weiyu Dou, Wenjie Zhang, Dan Li, Ting Kang, Zhihong Chen, Zhihong Chen, Chunjun Zhao, Zhenshu Xu, Han Liu

“…Furthermore, immunofluorescence microscopy analysis is performed to reveal the localization of internalized CAR molecules. RNA sequencing is used to detect the transcriptome of activated CAR-T cells. …”
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Can the Position of the Impacted Third Molars Be an Early Risk Indicator of Pathological Conditions? A Retrospective Cone-Beam Computed Tomography Study by Melda Pelin Akkitap, Birsay Gumru

“…Results: Distal caries was mostly detected in relation to Class A (20.4%) and contact point at (12.5%) and above (10.5%) the cementoenamel junction (CEJ) (P = 0.000; P < 0.05). …”
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Cytogenomic evaluation of regenerated Aralia elata using PLOP-FISH and flow cytometry by Eliazar Alumbro Peniton, Hong Thi Nguyen, Nomar Espinosa Waminal, Tae-Jin Yang, Hyun Hee Kim

“…Six repeat probes were detected using FISH. Tandem repeat AeTR49 was identified as an excellent cytogenetic marker for homologous chromosomes, and AeTR161 and AeTR178 were localized in the centromeric and telomeric sections, respectively. …”
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A Systems Hypothesis of Lipopolysaccharide-Induced Vitamin Transport Suppression and Metabolic Reprogramming in Autism Spectrum Disorders: An Open Call for Validation and Therapeut... by Albion Dervishi

“…By incorporating cofactor dependency and subcellular localization, PM³ identified a coordinated suppression of multivitamin transporters (e.g., −4.5% in SLC5A6, −3.5% in SLC19A2), potentially limiting cofactor availability and compounding energy deficits in ASD brains. …”
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Clinical and Functional Characterization of Novel AGL Variants in Two Families with Glycogen Storage Disease Type III by Tingting Yu, Hao Fu, Aoyu Yang, Yan Liang

“…Based on the ACMG criteria, both variants were considered likely pathogenic, in accordance with the functional analysis results, which demonstrated that the mutated protein was still localized in the cytoplasm and that the glycogen content of cells transfected with the mutated AGL was increased compared to cells transfected with the wild-type one. …”
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Recurrent secondary hyperparathyroidism due to a gradually increasing intrathyroidal parathyroid adenoma in a fifth parathyroid gland of a patient undergoing long-term haemodialysi... by Jun Yang, Ninghu Liu, Jili Wang, Xinhui Su

“…An IPA is often difficult to localize preoperatively, making diagnosis and treatment challenging. …”
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ASSOCIATION OF LETHAL OUTCOMES IN SURGICAL SEPSIS WITH ALLELIC VARIANTS OF TNF Α AND HEAT SHOCK PROTEIN (HSP70-2) GENES by A. V. Shevchenko, O. V. Golovanova, V. I. Konenkov, E. I. Streltsova

“…Taking into account close localization of genes encoding HSP70-2 and TNFα and mutual influence of their products upon development of septic process, we investigated allelic polymorphism in the coding region of HSP70-2 gene at position 1267, and a promoter polymorphism of TNFα gene (–308 position) in sixty-one patients with surgical sepsis, as compared with 100 healthy donors, assuming that certain genomic variants can be associated with susceptibility for sepsis and/or fatal outcomes in severe sepsis. …”
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Precision Targeting in Metastatic Prostate Cancer: Molecular Insights to Therapeutic Frontiers by Whi-An Kwon, Jae Young Joung

“…Parallel efforts have refined imaging—particularly prostate-specific membrane antigen (PSMA) positron emission tomography-computed tomography—to detect and localize metastatic lesions with high sensitivity, thereby guiding patient selection for PSMA-targeted radioligand therapies. …”
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Enhancing depression recognition through a mixed expert model by integrating speaker-related and emotion-related features by Weitong Guo, Qian He, Ziyu Lin, Xiaolong Bu, Ziyang Wang, Dong Li, Hongwu Yang

“…Experimental results demonstrate that our method achieves 74.3% accuracy on a self-built Chinese localized depression dataset and an MAE of 6.32 on the AVEC2014 dataset. …”
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Bionomics of Comadia redtenbacheri (Hammerschmidt, 1847) (Lepidoptera: Cossidae) by C. Llanderal-Cázares, R. Castro-Torres, K. Miranda-Perkins

“… Boring insects feed on the internal tissues of their hosts, and their activity is detected only after a severe damage to the host has occurred; therefore, studying their biology in the wild is difficult. …”
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Brain perfusion alterations in patients and survivors of COVID‐19 infection using arterial spin labeling: A systematic review by Sana Mohammadi, Sadegh Ghaderi, Farzad Fatehi

“…Additionally, some investigations reported hyperperfusion localized to the leptomeninges. These results may reflect underlying mechanisms such as hypoxic–ischemic injury, inflammation, vascular dysfunction, and neuronal damage attributable to COVID‐19. …”
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MEDIUM-TERM PROGNOSIS OF CANCER MORTALITY AMONG THE POPULATION OF RUSSIA by V. M. Merabishvili

“…Cancer remains a difficult disease to prevent, detect, treat or manage it. The mortality rate is one of the most important criteria for assessing the health of the population. …”
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Assessment of Type and Concentration of Pesticide Residues in Fluted Pumpkin (Telfairia occidentalis) and Green Amaranth (Amaranthus hybridus) Sold in Akure, Ondo State, Nigeria by B. O. Akinyanmi, B. M. Macaulay, O. D. Ibigbemi, O. A. Gbaye

“…This study has brought to the fore the need for more attention to be paid to pesticide contamination of locally-consumed agricultural products against the high incidence of health challenges (such as cancer, birth defect, impaired immune function, and neurobehavioral disorder) linked to pesticide contamination. …”
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Pancreatic transcription factors containing protein transduction domains drive mouse embryonic stem cells towards endocrine pancreas. by Maria João Lima, Hilary M Docherty, Yuanxiao Chen, Ludovic Vallier, Kevin Docherty

“…The results demonstrate that each transcription factor was efficiently taken up by the cells, where they were localized in the nuclei. RT-qPCR was used to measure the expression levels of pancreatic markers. …”
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P86 | THE EFFECTS OF NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITION ON THE EXPRESSION OF BRAIN DERIVED NEUROTROPHIC FACTOR IN THE OLFACTORY BULB ORGANOTYPIC SLICE CULTURES

“…Impaired olfactory function appears to be one of the earliest detectable functional alterations in Alzheimer disease1,2. …”
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Significance of magnetic resonance imaging for early rheumatoid arthritis activity by E Y Pogozeva

“…X-ray examination revealed erosions in only 20,8% of pts. Localization of erosions revealed by X-ray and MRI coincided in 36,4% of cases and in 61,8% of pts erosions were detected only by MRI. …”
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Landmark PALOMA and MARIPOSA Studies Reveal the Impact of Amivantamab Alone and Combined with Lazertinib in Advanced NSCLC by Hiba Mechahougui, Laure Smekens, Alfredo Addeo

“…Mutations in the epidermal growth factor receptor (*EGFR*) gene are frequently detected in non-small cell lung cancer (NSCLC). The most common *EGFR* mutations include deletions in exon 19 (Ex19del) and point L858R mutations in exon 21. …”
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Edible Macrofungi of Çorum Province by Sinan Alkan, Gıyasettin Kaşık, Celâleddin Öztürk, Sinan Aktaş

“…These 56 taxa were represented by two divisio, four ordo and 14 families. The localities of identified species in the provincial boundaries are given. …”
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Vegetative innervation of the human vocal larynx by A. Yu. Yurkov, T. I. Shustova, N. S. Alekseeva, V. I. Popadyuk, P. V. Nacharov

“…Adrenergic nerve fibers were detected by the Bjerklund method modified by V.N. Shvalev and N.I. …”
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Spread of Quarantine Plant Diseases and Phytonematodes in Ukraine by Y. Holiachuk, H. Kosylovych

“…Between 2015 and 2023, six locally presented quarantine pathogens and one phytonematode species (list A-2 of the List of regulated harmful organisms) were detected in Ukraine, as well as three pathogens with status of absent in Ukraine (list A-1). …”
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