Case Report: Two instances of lung metastasis in low-grade endometrial stromal sarcoma by Anying Long, Xiaoxue Tian, Yao Li, Shuai Luo, Jinjing Wang

“…At the initial staging, no lung metastasis was detected. After surgery, she underwent EBRT radiotherapy. …”
Get full text

Cinobufagin inhibits hepatocellular carcinoma EMT-like stemness via VEGF/VEGFR2 autocrine signaling by Mingjun Ye, Shujun Chen, Chen Lu, Yangpei Wu, Jiaming Tian, Anqi Han, Jimin Zhu, Baikun Li, Qinglin Li

“…An immunofluorescence double staining method was used to detect the localization of VEGFa and VEGFR2. The effects of inhibiting the VEGFa/VEGFR2 autocrine pathway on Huh7 cell metastasis and the effects of the VEGFa/VEGFR2 autocrine pathway on the regulation of PI3K/AKT-dependent migration, invasion, and epithelial‒mesenchymal transition were examined through use of the VEGFR2 inhibitor apatinib and the PI3K inhibitor LY294002. …”
Get full text

Metastatic lesions of the uterus, fallopian tubes and ovaries in undifferentiated pleomorphic sarcoma of the left tibia (clinical case) by O. I. Kit, E. V. Verenikina, A. P. Menshenina, L. Yu. Vladimirova, E. A. Kalabanova, T. O. Lapteva, A. A. Barashev, K. S. Eremin, A. Yu. Ardzha

“…According to the results of follow-up examination, a voluminous, multinodular, solid mass of merging character was detected in the pelvis, with total dimensions of up to 11 cm, and a cavitary mass of up to 5 cm was detected in the posterior vault. …”
Get full text

Temporal lobe white matter pathways: clinical and anatomical examination related to surgery of drug-resistant structural focal epilepsy by A. A. Sufianov, I. S. Shelyagin, K. Simfukwe, E. S. Markin, S. Zh. Stefanov, Yu. A. Yakimov, P. O. Akimova, R. A. Sufianov

“…Background. Detected temporal lobe focal cortical dysplasia (FCD) often results in developing drug-resistant epilepsy requiring surgical treatment. …”
Get full text

Long-Term Administration of Anthraquinone Rhein on Induction of Constipation in Sprague-Dawley Rats via SCF/c-Kit Signaling Pathways by Bo Zhang, Mingdong Huo, Zhicheng Chen, Feng Gao, Yan Liu, Xingxin Zhou

“…After scarification, colonic tissues were freshly prepared for histological localization detected by immunohistochemical analysis and for the expression of stem cell factor (SCF) and c-kit proteins determined by western blot assay. …”
Get full text

Motion correction of simultaneous brain PET/MR images based on tracer uptake characteristics by Sheng-Chieh Chiu, Jose Angelo U. Perucho, Yu-Hua Dean Fang

“…Abstract Background Simultaneous PET/MR imaging enables precise anatomical localization and PET quantification by reducing PET-to-MR misalignments. …”
Get full text

Immunohistochemical evaluation of salivary gland tumors differentiation and proliferation by using calponin and telomerase by Srwsht Saeed Abdulrahman, Dena Nadhim Mohammad, Marwa Abdul–Salam Hamied, Mardin Othman Abdulqadir

“…The immunohistochemical staining and evaluation of subcellular localization, pattern, intensity, and distribution for calponin and immune scoring for telomerase were done. …”
Get full text

Positive selection at core genes may underlie niche adaptation in Fusobacterium animalis by Diego Forni, Audun Sivertsen, Rachele Cagliani, Alessandra Mozzi, Cristian Molteni, Øyvind Kommedal, Manuela Sironi

“…Results indicated that the coding sequences of these genes have been targeted by intense purifying selection, possibly as the result of their often-essential functions. However, localized signatures of positive selection were also detectable. …”
Get full text

LINC01013 reverses bisphosphonate-impaired osteogenic differentiation of JBMMSCs by regulating intracellular translocation of ILF3 by Jiaxin Song, Wanqing Wang, Xuanhe Feng, Haoqing Yang, Zhaochen Shan, Zhipeng Fan

“…We also further clarified that LINC01013 binding to ILF3 affects ILF3 nuclear localization to regulate JBMMSCs osteogenic differentiation and regulates NLRP3/Caspase-1 pathway to affect JBMMSCs function under BP stimulation.…”
Get full text

Impact of POU3F4 mutation on cochlear development and auditory function by Jiong Dang, Panpan Bian, Chao Chen, Chi Chen, Wenqi Shan, Luhang Cai, Yong Li, Huan Tan, Baicheng Xu, Minxin Guan, Yufen Guo

“…Alterations in expression and subcellular localization of POU3F4 were detected at the cellular level. …”
Get full text

Soil mycobiome structure across central and peripherial zones in a pecan nut agroecosystem [Carya illinoinensis (Wangenh.) K. Koch] by Sánchez-Ledesma Judith A., Águila Bernardo, Garibay-Orijel Roberto, Peña Cristina García-De la, Nava-Reyna Erika

“…A total of 4,443 fungal OTUs were detected at 97% similarity. Alpha diversity indices did not differ significantly between zones. …”
Get full text

Identifying Anthropogenic Versus Natural Submerged Prehistoric Landscapes: Two Case Studies from the Sicilian Channel by Ehud Galili, Liora Kolska Horwitz, Ilaria Patania, Amir Bar, Isaac Ogloblin Ramirez

“…Our examination has led us to conclude that both localities are not anthropogenic features. The Pantelleria Vecchia Bank features represent natural outcrops on a submerged paleo-landscape that were shaped by depositional and erosional processes during transgression and regression periods. …”
Get full text

Sepsis by Pasteurella multocida in an Elderly Immunocompetent Patient after a Cat Bite by Lara Caserza, Gabriella Piatti, Aldo Bonaventura, Luca Liberale, Federico Carbone, Franco Dallegri, Luciano Ottonello, Giulia Gustinetti, Valerio Del Bono, Fabrizio Montecucco

“…The cat bite was misdiagnosed at admission partly due to an underestimation of this event by the patient’s relatives. An inflamed area localized at perimalleolar skin of the right leg was detected. …”
Get full text

Cellular and biophysical barriers to lipid nanoparticle mediated delivery of RNA to the cytosol by Johanna M. Johansson, Hampus Du Rietz, Hampus Hedlund, Hanna C. Eriksson, Erik Oude Blenke, Aditya Pote, Said Harun, Pontus Nordenfelt, Lennart Lindfors, Anders Wittrup

“…Finally, we visualize localized ionizable lipid enrichment in endosomal membranes and membrane damage in direct proximity to siRNA-LNPs tethered to luminal vesicle membranes. …”
Get full text

PATHOLOGICAL RESPONSE OF GASTRIC CANCER TO NEOADJUVANT PROLONGED CHEMORADIOTHERAPY FOLLOWED BY D2 GASTRECTOMY by Е. F. Lushnikov, А. Yu. Abrosimov, B. А. Berdov, Yu. Т. Neborak, V. Yu. Skoropad

“…Pathological response of locally advanced gastric cancer to neoadjuvant prolonged chemoradiotherapy followed by D2 gastrectomy was analyzed considering clinical and morphological findings. …”
Get full text

TBC1D24 interacts with the v-ATPase and regulates intraorganellar pH in neurons by Sara Pepe, Davide Aprile, Enrico Castroflorio, Antonella Marte, Simone Giubbolini, Samir Hopestone, Anna Parsons, Tânia Soares, Fabio Benfenati, Peter L. Oliver, Anna Fassio

“…In Tbc1d24 knockout neurons, we detected V1 mis-localization with increased pH at endo-lysosomal compartments and autophagy impairment. …”
Get full text

Exo70 Enhances Exosome Secretion by Modulating Multivesicular Body Trafficking to Promote Pancreatic Cancer Metastasis by Wenqing ZHANG, Jingzhou XIANG, Tianhui HU

“…Changes in the expression of Exo70 and exosomal marker proteins were detected by Western blot. The localization of multivesicular bodies (MVBs) was examined by immunofluorescence. …”
Get full text

Review of models for estimating 3D human pose using deep learning by Sani Salisu, Kamaluddeen Usman Danyaro, Maged Nasser, Israa M. Hayder, Hussain A. Younis

“…Human pose estimation (HPE) is designed to detect and localize various parts of the human body and represent them as a kinematic structure based on input data like images and videos. …”
Get full text

Correlation between p53 Status, DNA Ploidy, Proliferation Rate and Nuclear Morphology in Breast Cancer. An Image Cytometric Study by Katrin Friedrich, Volker Dimmer, Gunter Haroske, Wolfdietrich Meyer, Franz Theissig, Klaus Dietmar Kunze

“…The study was designed to detect differences in the nuclear morphology of tumours and tumour cell populations with different p53 expression in correlation with DNA ploidy and proliferation rate. …”
Get full text

Long-Term Follow-Up of HLA-A2+ Patients with High-Risk, Hormone-Sensitive Prostate Cancer Vaccinated with the Prostate Specific Antigen Peptide Homologue (PSA146-154) by Supriya Perambakam, Hui Xie, Seby Edassery, David J. Peace

“…Twenty-eight HLA-A2+ patients with high-risk, locally advanced or metastatic, hormone-sensitive prostate cancer were immunized with a peptide homologue of prostate-specific antigen, PSA146-154, between July 2002 and September 2004 and monitored for clinical and immune responses. …”
Get full text