A strategy for cost-effective large language model use at health system-scale by Eyal Klang, Donald Apakama, Ethan E. Abbott, Akhil Vaid, Joshua Lampert, Ankit Sakhuja, Robert Freeman, Alexander W. Charney, David Reich, Monica Kraft, Girish N. Nadkarni, Benjamin S. Glicksberg

“…We evaluated how concatenating queries with multiple clinical notes and tasks simultaneously affects model performance under increasing computational loads. We assessed ten LLMs of different capacities and sizes utilizing real-world patient data. …”
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Advances in the effectiveness and safety of azvudine treatment: a comprehensive review by Jiayi Li, Jiayi Li, Bo Zhu, Bo Zhu, Jian Lu, Zheyi Dong, Ping Li, Wenge Li, Chunfu Zheng, Junbiao Chang, Shunlai Shang, Shunlai Shang

“…Clinical trials have demonstrated its ability to reduce the viral load, shorten the time to nucleic acid negativity, and improve clinical outcomes in patients. …”
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Three-arm polyrotaxanes with multidirectional molecular motions as the nanocarrier for nitric oxide-enhanced photodynamic therapy against bacterial biofilms in septic arthritis by Shixin Liu, Yuanfang Jiang, Yu Zhang, Kai Lv, Jiaxin Zhu, Mei Liu, Hao Xu, Genlong Jiao, Wanyong Yang, Guodong Sun, Dong Ma

“…Herein, we report a three-arm structure using the photosensitive core chlorin e6 to integrate three α-cyclodextrin (α-CD) polyrotaxane chains as the supramolecular nanocarrier of NO-enhanced PDT therapy, in which NO was loaded on the cationic rings (α-CDs). Beneficial from the enhanced permeability of the nanocarrier due to the collective act on biofilms by the molecular motions (slide and rotation of rings) of three chains in different directions, NO capable of inducing biofilm dispersal and reactive oxygen species were efficiently delivered deep inside biofilms under 660 nm laser irradiation, and reactive nitrogen species with stronger bactericidal ability was produced in-situ, further accomplishing bacteria elimination inside biofilms. …”
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Design, development, and testing of a cassava storage root-cutting robot utilizing a Stewart platform and mask R-CNN for precision agriculture by Thanaporn Singhpoo, Seree Wongpichet, Jetsada Posom, Kanda Runapongsa Saikaew, Arthit Phuphaphud, Poramate Banterng, Mahisorn Wongphati, Khwantri Saengprachatanarug

“…The specifications of these components, including dimensions, load capacity, and speed, were meticulously defined and calculated based on a physical survey of cassava plants. …”
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Solvent-free synthesis of highly dispersed zinc-doped porous carbons as efficient dibenzothiophene adsorbents by Ping Lu, Zhenhua Sun, Xinrong Ke, Changshen Ye, Zhixian Huang, Ting Qiu

“…The solvent-free synthesized highly dispersed Zn-doped carbon shows great potential for producing sulfur-free fuel oil and for designing metal-loaded carbon adsorbents.…”
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Advancing Dermatomycosis Diagnosis: Evaluating a Microarray-Based Platform for Rapid and Accurate Fungal Detection—A Pilot Study by Vittorio Ivagnes, Elena De Carolis, Carlotta Magrì, Riccardo Torelli, Brunella Posteraro, Maurizio Sanguinetti

“…In clinical samples, the assay showed good sensitivity (78.6%) and high specificity (91.7%), detecting additional positive cases missed by culture, which highlights the assay’s ability to identify non-viable fungi and low fungal loads. …”
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Functionalized and Theranostic Lipidic and Tocosomal Drug Delivery Systems: Potentials and Limitations in Cancer Photodynamic Therapy by Fahime Nasr Esfahani, Sahand Karimi, Zahra Jalilian, Mehran Alavi, Bushra Aziz, Enam Alhagh Charkhat Gorgich, M. R. Mozafari, Elham Taghavi, Sargol Aminnezhad, Sara Ataei

“…These carrier systems possess the ability to enhance the bioavailability, permeability, and solubility of the drug. …”
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Adhesive and injectable hydrogel microspheres for NRF2-mediated periodontal bone regeneration by Yu Wang, Shanshan Jin, Yaru Guo, Yilong Lu, Xuliang Deng

“…Here, inspired by the adhesive property of mussels, we have created adhesive and mineralized hydrogel microspheres loaded with traditional compound cordycepin (MMS-CY). …”
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Tailoring the Composition of HA/PEG Mixed Nano-Assemblies for Anticancer Drug Delivery by Beatrice Zurletti, Ilaria Andreana, Iris Chiara Salaroglio, Valeria Bincoletto, Maela Manzoli, Barbara Rolando, Paola Milla, Chiara Riganti, Barbara Stella, Silvia Arpicco

“…In this work, a polyethylene glycol-phospholipid conjugate was employed to form nanocarriers loaded with a lipophilic derivative of gemcitabine. …”
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Multi-Objective Improved Differential Evolution Algorithm-Based Smart Home Energy Management System Considering Energy Storage System, Photovoltaic, and Electric Vehicle by Mina GhasemiGarpachi, Moslem Dehghani, Mokhtar Aly, Jose Rodriguez

“…Home energy management systems (HEMSs) are becoming increasingly popular as smart homes become more prevalent, along with their ability to reduce peak network loads and generate and store green energy locally. …”
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Variation Characteristics of Sediment Transport for a Vertical Gauze Sand Barrier During Different Sampling Seasons by Yan Deren, Yang Zhiguo, Gao Haiyan, Huang Haiguang, Hu Xiaolong

“…As the size of the gauze sand barrier increased, its ability to reduce the amount of sediment transport decreased. …”
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Influence of Ballast and Sub-Ballast Thickness on Structural Behavior of Heavy-Haul Railway Platform Determined by Using Finite Element Modeling by Magdiel Acaz de Oliveira Teixeira, William Wilson dos Santos, Lisley Madeira Coelho, Lidiane Hellen dos Santos Santana, Fábio Grisolia de Ávila, Sergio Neves Monteiro, Antônio Carlos Rodrigues Guimarães

“…The results indicate that reducing ballast thickness increases deflection and vertical stresses, while excessive thickness elevates system stiffness, reducing its ability to dissipate stresses. This condition can intensify the transmission of dynamic loads to track components, accelerating rail and sleeper wear and requiring more frequent corrective interventions, thereby increasing maintenance costs. …”
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Municipal secondary-treated effluent data seem to be a suitable source of information for human viral trends by Elsa T. Rodrigues, Joana M. Oliveira, Anália Carmo, Miguel A. Pardal, Ana M. Matos

“…Employing a long-time series of municipal wastewater samples collected in 2020, the present study aims to confirm whether the appearance of SARS-CoV-2 influences the environmental load and behaviour of both JC Virus and Norovirus, determine the ability of the selected wastewater treatment plant (WWTP) to remove viral genomes, and assess if secondary-treated effluent data is somehow related to the incidence of the viral diseases reported by the local hospital. …”
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Evaluation of multimodal imaging guided multifunctional bio-targeted reactive oxygen species production synergists: a preliminary study by Xia Ou, Xia Ou, Yu Tang, Haiyan Yang, Haiyan Yang, Yan Du, Zhong Zhang, Li Lin, Qi Wang, Jianzhong Zou

“…The tumor-targeted ability of B.bifidum@PC-CLs was detected through electrostatic adsorption. …”
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Synergistic Antiviral Activity of Xanthan Gum and Camostat Against Influenza Virus Infection by Kyeunghwa Chun, Yujeong Na, Byeongyong Kim, Dongjin Lee, Jongseo Choi, Gwanyoung Kim, Sokho Kim, Min-Soo Kim

“…Additionally, we conducted in vitro combination treatment experiments to evaluate the antiviral ability of XG in conjunction with camostat, a previously known TMPRSS2 inhibitor. …”
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Real-time detection and identification of fish skin health in the underwater environment based on improved YOLOv10 model by Duanrui Wang, Meng Wu, Xingyue Zhu, Qiwei Qin, Shaowen Wang, Haibin Ye, Kaiyuan Guo, Chi Wu, Yi Shi

“…DCW-YOLO substitutes the CIoU loss function in YOLOv10 with the NWD loss function, thereby improving the model’s ability to detect densely packed targets. The C2f-D-LKA layer is employed in place of the C2f convolutional layer, improving the model’s capacity to capture irregularly shaped and sized objects while effectively reducing computational overhead and parameter load. …”
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The Antifungal Activity of a Polygalacturonic and Caprylic Acid Ointment in an In Vitro, Three-Dimensional Wound Biofilm Model by Bahgat Z. Gerges, Joel Rosenblatt, Y-Lan Truong, Ying Jiang, Issam I. Raad

“…The use of HOCl in <i>Candida</i>-colonized wounds should include consideration of the extracellular matrix load in the wound bed. PG + CAP warrants further study in wounds compromised by <i>Candida</i> biofilms.…”
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Genome and Pathogenicity Analysis of an NADC30-like PRRSV Strain in China’s Xinjiang Province by Honghuan Li, Wei Zhang, Yanjie Qiao, Wenxing Wang, Wenxiang Zhang, Yueli Wang, Jihai Yi, Huan Zhang, Zhongchen Ma, Chuangfu Chen

“…The porcine reproductive and respiratory syndrome virus (PRRSV) possesses an inherent ability to adapt to environmental transformations and undergo evolutionary changes, which has imposed significant economic pressure on the global pig industry. …”
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Estimation of Dynamic Stiffness and Analysis of Error Source of Spacer Grid for Pressurized Water Reactor Fuel Assembly by ZHOU Ding1, 2, HUANG Congcai2, LI Tianyong2, QIAO Hongwei2, CUI Yihang2, ZHAO Xiangji2, MA Jianzhong2, SUN Lei2

“…Fuel assemblies are core components in pressurized water reactor (PWR), in which spacer grids serve as essential structural elements to support fuel rods, maintain fuel rod spacing, mix coolant, and resist external loads. The mechanical reliability of spacer grids is of great significance to ensure the integrity and safety of nuclear fuels, particularly under low-speed impact loads that may occur during transportation, handling, or accident scenarios. …”
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Optimizing Ultrasound Probe Disinfection for Healthcare-Associated Infection Control: A Comparative Analysis of Disinfectant Efficacy by Gaetano Ferrara, Giovanni Cangelosi, Sara Morales Palomares, Stefano Mancin, Marianna Melina, Orejeta Diamanti, Marco Sguanci, Antonella Amendola, Fabio Petrelli

“…<b>Background/Aims:</b> Ultrasound is a key diagnostic tool in modern medicine due to its ability to provide real-time, high-resolution images of the internal structures of the human body. …”
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