Multifaceted Applications of Zerumbone-Loaded Metal–Organic Framework-5: Anticancer, Antibacterial, Antifungal, DNA-Binding, and Free Radical Scavenging Potentials by Sumeyya Deniz Aybek, Mucahit Secme, Hasan Ilhan, Leyla Acik, Suheyla Pinar Celik, Gonca Gulbay

“…In the present research, metal–organic framework-5 (MOF-5) was synthesized and loaded with zerumbone (ZER@MOF-5), followed by the evaluation of its anticancer, antibacterial, antifungal, DNA-binding, and free radical scavenging potentials. …”
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Development of an XGBoost-based prediction model for wound recurrence risk in diabetic foot ulcer patients treated with antibiotic-loaded bone cement by Yi Zhang, Yi Zhang, Xingyu Sun, Cheng Cheng, Nianzong Hou, Nianzong Hou, Shiliang Han, Xin Tang

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Cell-free osteoarthritis treatment with dual-engineered chondrocyte-targeted extracellular vesicles derived from mechanical loading primed mesenchymal stem cells by Peng Wang, Haiyue Zhao, Wei Chen, Yuhui Guo, Shuo Zhang, Xin Xing, Shuai Yang, Fengkun Wang, Juan Wang, Zengwu Shao, Yingze Zhang

“…CTP/miR OE -EVs exhibit excellent ability to specifically target cartilage and ameliorate OA pathology. …”
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Biomanufacturing and Curcumin-Loading of Human Choroid Plexus Organoid-Derived Extracellular Vesicles from a Vertical-Wheel Bioreactor to Alleviate Neuro-Inflammation by Justice Ene, Laureana Muok, Vanessa Gonzalez, Nicolas Sanchez, Aakash Nathani, Falak Syed, Zixiang Leonardo Liu, Mandip Singh, Tristan Driscoll, Yan Li

“…Additionally, this study loaded curcumin into ChP organoid-derived EVs, performed EV lyophilization, and determined the ability of the re-hydrated EVs to alleviate neuro-inflammation. …”
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Cumulative blood pressure load as a predictor of arterial stiffness progression and incident diabetic kidney disease: a multicenter longitudinal study by Cong Liu, Bangqun Ji, Yao Liang, Juan Shi, Yufan Wang, Tingyu Ke, Li Li, Dong Zhao, Yuancheng Dai, Qijuan Dong, Fengmei Xu, Ying Peng, Weiqing Wang, Qidong Zheng, Yifei Zhang

“…The primary outcomes were the progression of arterial stiffness, assessed by brachial-ankle pulse wave velocity (ba-PWV) changes, and the incidence of DKD, defined as an estimated glomerular filtration rate < 60 mL/min/1.73m2 or urine albumin-to-creatinine ratio ≥ 3.39 mg/mmol. The predictive ability of cumulative BP load calculated under different clinically recommended targets was compared using adjusted R squared (adjusted R2) for continuous outcomes and net reclassification improvement (NRI) for binary outcomes. …”
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Age dynamics of doctor's professional competencies by M. A. Yakushin, A. V. Vorobeva, S. Yu. Yarotsky, M. D. Vasiliev, O. Yu. Arseenkova, T. I. Yakushina

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Docosahexaenoic acid-acylated astaxanthin monoester enhances microglial autophagy for ameliorating amyloid-β load and cognitive deficits in models of Alzheimer’s disease by Xiaoxu Wang, Bo Dong, Yu Song, Zhigao Wang, Yuming Wang, Jie Xu, Changhu Xue

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Non-clinical studies of the effectiveness of specialized sports nutrition product for correction of physical efficiency and psycho-physiological condition during intensive loads by T. Pushkina, E. Tokaev, T. Popova, A. Murashev, N. Tropskaya, E. Kislyakova, I. Shashkova, A. Zherebtsov

“…At the first stage the animals were subjected to exercise stress in form of a tail suspension, followed by jogging on a treadmill prior to failure on the 1st, 10th and 20th days of the experiment. Before and after the load, an electrocardiogram and a pneumogram were recorded. …”
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Microgrid Power System Modeling Using the Multi-Agent Systems Concept and Stabilization by Lyapunov-Based Cooperative Controller During Disturbance and Load Shedding by Mohammad Tolou Askari, Z. Zandi

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Short-Term Load Forecasting Based on Pelican Optimization Algorithm and Dropout Long Short-Term Memories–Fully Convolutional Neural Network Optimization by Haonan Wang, Shan Huang, Yue Yin, Tingyun Gu

“…This method firstly uses DLSTMs to extract the time-series features of the load data, which can effectively capture the dynamic changes in the time series; subsequently, it combines the convolution operation of FCNs to obtain high-resolution information between the load data and the features, which enhances the expressive ability of the model. …”
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Parametrical Synthesis of Radio Devices with the Set Quantity of Identical Cascades for Inclusion Variants of Jet Two-port Networks between a Nonlinear Part and Loading by A. A. Golovkov, A. V. Fomin

“…It is shown that the frequency characteristics of the studied radio devices from the same stages are identical or similar to the frequency characteristics of radio devices from the same stage, but with the signal source and load resistances changed in a certain way. Such schemes are called equivalent. …”
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Inherent thermodynamic performance assessment of a variable refrigerant flow system under transient cooling load: A case study of an eco-villa by Muhammad Reshaeel, Mohamed I. Hassan Ali

“…Analysis of the system's intrinsic performance variables reveals its ability to dynamically adjust compressor speed in response to fluctuating cooling loads, enhancing isentropic efficiency. …”
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The inhibitor of apoptosis proteins antagonist Debio 1143 promotes the PD-1 blockade-mediated HIV load reduction in blood and tissues of humanized mice. by Michael Bobardt, Joseph Kuo, Udayan Chatterji, Norbert Wiedemann, Gregoire Vuagniaux, Philippe Gallay

“…Anti-PD-1 mAb administration reduced HIV load in blood by 94%, and addition of D1143 further enhanced this reduction from 94 to 97%. …”
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Acetazolamide-Loaded Poly(δ-Decalactone) Nanoemulsion for Topical Eye Delivery: Enhanced Corneal Permeation and Sustained Intraocular Pressure Reduction in Glaucoma Therapy by Ankita Kishore, Alok Kumar Mahor, Rishikesh Gupta, Prem Prakash Singh, Brajesh Kumar Lodhi, Priyanka Rathore, Jessica M. Rosenholm, Kuldeep K. Bansal

“…This investigation focused on developing an ACZ-loaded nanoemulsion (ACZ-NE) utilizing biodegradable oily polymer poly(δ-decalactone) (PDL) to enhance the drug’s solubility, permeability, and therapeutic efficacy. …”
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Curcumin-loaded nanoparticles for renal ischemia-reperfusion injuries: Triple-play of redox homeostasis accommodation, lipid metabolism regulation, and nuclear magnetic tracing by Ning Wang, Xuna Xue, Zhibo Zhang, Meng Gao, Lianhong Yin, Lina Xu, Xuerong Zhao, Jinyong Peng

“…By self-assembling PD and G while loading Cur, a nanoparticle was successfully prepared, PDG@Cur, which served three functions: regulation of lipid metabolism, maintenance of redox homeostasis, and function as a nuclear magnetic resonance (NMR) tracer. …”
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Relationship between breaking load and protein composition of acidic heat-induced gels prepared from the acidic precipitate of soy flour aqueous dispersions by Masahiko Samoto, Ryo Okuzono, Mako Igarashi, Sayuri Sakurada, Yasuki Matsumura, Akihiro Nakamura, Masayuki Shibata

“…The results of two experiments, that is, the addition of fractionated protein components (7S, 11S, polar lipid-associated protein (PLAP), and oil body-associated protein (OBAP)) to the original AP-SF gels and the examination of a correlation between the breaking load of AP-SF gels and the protein composition of soybean cultivars used for the AP-SF preparation suggested that 7S globulin has an ability to effectively increased the breaking load of AP-SF gels. …”
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Protective effects of bone marrow mesenchymal stem cell-derived exosomes loaded cerium dioxide nanoparticle against deoxynivalenol-induced liver damage by Zitong Meng, Mingmeng Tang, Shiyin Xu, Xiaolei Zhou, Zixuan Zhang, Liunan Yang, Andreas K. Nüssler, Liegang Liu, Wei Yang

“…Results We successfully loaded BMSC-exos with CeO2 NPs (BMSC-exos @ CeO2) using extrusion techniques, verified through electron microscopy and elemental mapping. …”
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Macrophage Membrane Coated Manganese Dioxide Nanoparticles Loaded with Rapamycin Alleviate Intestinal Ischemia-Reperfusion Injury by Reducing Oxidative Stress and Enhancing Autopha... by Sheng R, Wang W, Zeng W, Li B, Yu H, Li X, Liang Y, Wang Y, Liao Y, Liu D

“…In vitro OGD/R model in IEC-6 cells and in vivo mouse I/R injury models were used. Targeting ability was evaluated through in-vivo imaging system. …”
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Localized propranolol delivery from a copper-loaded hydrogel for enhancing infected burn wound healing via adrenergic β-receptor blockade by Wenzhe Sun, Hongwei Lu, Pengqin Zhang, Lian Zeng, Bing Ye, Yi Xu, Jianan Chen, Peiran Xue, Jialin Yu, Kaifang Chen, Bin Wu, Xiao Lv, Xiaodong Guo, Yanzhen Qu

“…To address these challenges, we pioneered the study of locally delivered propranolol for burn wound treatment, revealing its ability to antagonize norepinephrine (NE) and regulate the sympathetic nervous system. …”
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A Study on the Design of a Fault-Tolerant Consequent-Pole Hybrid Excited Machine for Electric Vehicles by Guangyu Qu, Jinyi Yu, Zhenghan Li, Wei Liu

“…Next, some electromagnetic properties, including the flux distribution, the no-load back-EMF, the electromagnetic torque, the cogging torque, and the fault-tolerant ability, are discussed in detail. …”
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