Constructed transferrin receptor-targeted liposome for the delivery of fluvoxamine to improve prognosis in a traumatic brain injury mouse model by Liang Mi, Jiangyuan Yuan, Yuxing Jiang, Yuqian Hu, Chuanxiang Lv, Yongqiang Xu, Mingqi Liu, Tao Liu, Xuanhui Liu, Jinhao Huang, Rongcai Jiang, Wei Quan

“…The TfR-targeted polypeptide liposome loaded with Flv (TPL-Flv) implements cell targeting ability on human umbilical vein endothelial cells (HUVECs) in vitro detected by flow cytometry, and drug safety was proved through cell viability analysis and blood routine and biochemistry analysis. …”
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Dominant follicle-targeted nanocarriers for GH delivery to alleviate premature ovarian insufficiency by Shao Yang, Yawei Sun, Wei Luo, Xiaofeng Zhou, Xiao Gu, Wenzhe Zhang, Huashan Zhu, Wenjia Wu, Xueying Wu, Mengru Yu, Shan Wang

“…Therefore, we constructed a GH-loaded complex zeolitic imidazolate frameworks-8 (ZIF8)-GH@ZP3Ab, which uses ZIF8 to load GH and ZP3 antibody (ZP3Ab) to specifically bind ZP3. …”
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Type I IFN induces long-chain acyl-CoA synthetase 1 to generate a phosphatidic acid reservoir for lipotoxic saturated fatty acids by Shelley Barnhart, Masami Shimizu-Albergine, Eyal Kedar, Vishal Kothari, Baohai Shao, Melissa Krueger, Cheng-Chieh Hsu, Jingjing Tang, Jenny E. Kanter, Farah Kramer, Danijel Djukovic, Vadim Pascua, Yueh-Ming Loo, Lucrezia Colonna, Sadie J. Van den Bogaerde, Jie An, Michael Gale, Jr., Karen Reue, Edward A. Fisher, Sina A. Gharib, Keith B. Elkon, Karin E. Bornfeldt

“…Conversely, ACSL1 induction is not needed for IFN-I’s ability to induce the prototypical IFN-stimulated protein signature or to suppress proliferation or macrophage metabolism. …”
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Engineering and Evaluation of a Live-Attenuated Vaccine Candidate with Enhanced Type 1 Fimbriae Expression to Optimize Protection Against <i>Salmonella</i> Typhimurium by Patricia García, Arianna Rodríguez-Coello, Andrea García-Pose, María Del Carmen Fernández-López, Andrea Muras, Miriam Moscoso, Alejandro Beceiro, Germán Bou

“…Safety and immunogenicity were assessed by clinical monitoring, bacterial load, fecal shedding, ELISA tests, and adhesion/blocking assays using fecal extracts. …”
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Comprehensive efficacy of nano-formulated mixed probiotics on broiler chickens’ performance and Salmonella Typhimurium challenge by Sherief M. Abdel-Raheem, Marwa I. Abd El-Hamid, Tarek Khamis, Heba A. Baz, Anaam E. Omar, Wafaa M. Gad, Mona M. El-Azzouny, Manal A.M. Habaka, Rania I. Mohamed, Mona E. Elkenawy, Rehab E. Dawod, Eman. A. Elalfy, Doaa Ibrahim

“…Upregulation of immmune related genes (IL-1β, IL-6, IL-8, MyD88, NF-kB, CCL20, CXCLi2, TLR-2, TLR-4 and SOCS1) was prominently subsided in BLB-NPsIII fed group. The strengthening ability of BLB-NPs for broilers' intestinal barriers was evidenced by augmented expression of JAM, MUC-2, occludin and FABP-2 genes, diminished S. …”
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Distinct roles of the two BRCA2 DNA-binding domains in DNA damage repair and replication fork preservation by Francisco E. Neal, Wenjing Li, Mollie E. Uhrig, Jeffrey N. Katz, Shahrez Syed, Neelam Sharma, Arijit Dutta, Sandeep Burma, Robert Hromas, Alexander V. Mazin, Eloise Dray, David S. Libich, Shaun K. Olsen, Elizabeth V. Wasmuth, Weixing Zhao, Claus S. Sørensen, Claudia Wiese, Youngho Kwon, Patrick Sung

“…We show that OB-DBD and CTRB-DBD confer single-strand DNA (ssDNA)- and dsDNA-binding capabilities, respectively, and that BRCA2 variants mutated in either domain are impaired in their ability to load the recombinase RAD51 onto ssDNA pre-occupied by RPA. …”
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Carcinogenic health risks and water quality assessment of groundwater around lead–zinc mining areas of Ebonyi state Nigeria: a data-driven machine learning approach by Obinna Chigoziem Akakuru, Moses Oghenenyoreme Eyankware, Godwin O. Aigbadon, Ayatu Ojonugwa Usman, Alexander Iheanyi Opara, Kizito Ojochenemi Musa, Micheal Akaninyene Okon, Okechukwu Pius Aghamelu, Gabriel Ehriga Odesa, Ifeyinwa Juliana Ofoh, Annabel U. Obinna-Akakuru

“…Machine learning was preferred over traditional methods for its ability to capture complex, non-linear relationships in the data, allowing for more accurate predictions of contamination levels and health risks, which is crucial for targeted monitoring and efficient groundwater management in mining-impacted areas. …”
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Myocarditis and neutrophil-mediated vascular leakage but not cytokine storm associated with fatal murine leptospirosisResearch in context by Stylianos Papadopoulos, David Hardy, Frédérique Vernel-Pauillac, Magali Tichit, Ivo G. Boneca, Catherine Werts

“…On day 3 post infection, the mice were humanely euthanised and blood and organs were collected. Bacterial load, biochemical parameters, cytokine production and leucocyte population were assessed by qPCR, ELISA, cytometry and immunohistochemistry. …”
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Breeding report of a native early-maturing apple variety Xialimeng in Xinjiang by GUO Jing, BAO Anming, LIU Yuxin, YANG Jing, LU Biao, HAN Zhengwei, WANG Yan, WANG Baoqing

“…This variety has medium budbreak rate and branching ability. It has strong adaptability and strong resistance to barren and cold, and can overwinter upright in northern Xinjiang. …”
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Integrative review of artificial intelligence applications in nursing: education, clinical practice, workload management, and professional perceptions by Rabie Adel El Arab, Omayma Abdulaziz Al Moosa, Mette Sagbakken, Ahmed Ghannam, Fuad H. Abuadas, Joel Somerville, Joel Somerville, Abbas Al Mutair, Abbas Al Mutair, Abbas Al Mutair, Abbas Al Mutair, Abbas Al Mutair

“…Learners also reported an increased cognitive load and heightened stress levels when navigating these more complex, AI-driven activities.Clinical decision support and monitoringAI-enabled alert algorithms and wearable sensors enabled nurses to detect subtle signs of patient deterioration and fever significantly earlier than conventional methods, supporting timelier clinical interventions. …”
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Targeting and reprogramming microglial phagocytosis of neutrophils by ginsenoside Rg1 nanovesicles promotes stroke recovery by Kaichao Hu, Junrui Ye, Pinglong Fan, Ruifang Zheng, Shasha Wang, Ye Peng, Yuan Ruan, Xu Yan, Zhao Zhang, Shifeng Chu, Naihong Chen

“…These biomimetic vesicles exploit the inherent targeting ability of neutrophil membranes to reach brain injury sites and are subsequently taken up by microglia. …”
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Bidirectional modulation of glycolysis using a multifunctional nanocomposite hydrogel promotes bone fracture healing in type 2 diabetes mellitus by Shengming Zhang, Weixian Hu, Yanzhi Zhao, Yuheng Liao, Kangkang Zha, Wenqian Zhang, Chenyan Yu, Jiewen Liao, Hui Li, Wu Zhou, Faqi Cao, Bobin Mi, Guohui Liu

“…Comprehensive in vitro and in vivo experiments in a T2D fracture mouse model confirmed the hydrogel's ability to improve the inflammatory microenvironment and accelerate bone healing. …”
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Surface display of Lys0859, a Streptococcus suis prophage lysin, on Bacillus subtilis spores and its antibacterial activity against Streptococcus suis by Linkang Wang, Linkang Wang, Linkang Wang, Xiaochao Duan, Xiaochao Duan, Xiaochao Duan, Xiaochao Duan, Mengyuan Zhu, Mengyuan Zhu, Mengyuan Zhu, Haiyan Wang, Haiyan Wang, Haiyan Wang, Haiyan Wang, Xinxin Li, Xinxin Li, Xinxin Li, Xinxin Li, Dayue Hu, Dayue Hu, Dayue Hu, Dayue Hu, Xiangmin Li, Xiangmin Li, Xiangmin Li, Xiangmin Li, Ping Qian, Ping Qian, Ping Qian, Ping Qian

“…Phage lysin is regarded as a promising substitute for antibiotics due to its ability to quickly and efficiently kill bacteria without easily developing resistance. …”
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Molecular classification of head and neck squamous cell carcinoma based on hypoxia-related genes and clinical significance of STC2 by ZHU Jianing, WANG Tiantian, ZHANG Rui, SONG Hongquan

“…CCK-8 assay and cell scratch assay were used to assess the effect of STC2 on cell proliferation and migration ability. Results Based on HRGs expression profiles, HNSCC was categorized into three subclasses (C1, C2, and C3). …”
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Identify the Challenges of Sustainable Agricultural Development in the South of Kerman Province by Omid Sharifi, Amir Afzali Gorouh, Mona Babaee

“…Establishing appropriate policies to support and support producers, they maintain the ability to produce high quality and quantity, which can focus on the production of healthy products for the sustainability of production units in each of the three, including the economic, social and environmental dimension. …”
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Deep Learning Based 3D Visualization Health Condition Monitoring Method for Anchor Digging Machines by YANG Xueqi, GAO Xinqin, ZHENG Haiyang, YANG Jun

“…They are subjected to high-intensity loads, resulting in frequent failures, and the challenge of effective health management becomes increasingly prominent. …”
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Micro-expression recognition based on self-supervised masked optical flow(基于自监督掩码光流的人脸微表情识别) by 刘晓宇(LIU Xiaoyu), 谢志华(XIE Zhihua), 周志武(ZHOU Zhiwu)

“…The pre-trained feature extractor is loaded into the ViT-Large model in the downstream task, achieving good performance in micro-expression recognition. …”
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HLA-Bw4 in association with KIR3DL1 favors natural killer cell-mediated protection against severe COVID-19 by Ruihua Wang, Ying Sun, Bo-Hua Kuang, Xiao Yan, Jinju Lei, Yu-Xin Lin, Jinxiu Tian, Yating Li, Xiaoduo Xie, Tao Chen, Hui Zhang, Yi-Xin Zeng, Jincun Zhao, Lin Feng

“…This suggests that HLA-Bw4 alleles that impair their ability to load SARS-CoV-2 peptides will become targets for NK-mediated destruction. …”
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Identifying and Validating Indicators of Ritualism in the Iranian Higher Education System: A Mixed-Methods Study by Seyed Hedayat Davarpanah, Reza Hoveida, Mostafa Bagherian Far

“…This phenomenon has led the higher education system in Iran away from its primary objectives, inhibiting its ability to fulfill its intended role. Consequently, addressing ritualism as a dysfunction within university performance is crucial. …”
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Unveiling the third dimension of glass by Faidra Oikonomopoulou

“…Its inherent transparency has given us the ability to create diaphanous barriers between the interior and the exterior that allow for space and light continuity. …”
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