Injured Cardiac Tissue-Targeted Delivery of TGFβ1 siRNA by FAP Aptamer-Functionalized Extracellular Vesicles Promotes Cardiac Repair by Kang JY, Mun D, Park M, Yoo G, Kim H, Yun N, Joung B

“…To treat cardiac injury, hEV@FAP were loaded with TGFβ 1 siRNA (siTGFβ 1), identified as a molecular target for cardiac repair. …”
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Optimal allocation of STATCOM for multi-objective ORPD problem on thermal wind solar hydro scheduling using driving training based optimization by Tushnik Sarkar, Sabyasachi Gupta, Chandan Paul, Susanta Dutta, Provas Kumar Roy, Anagha Bhattacharya, Ghanshyam G. Tejani, Seyed Jalaleddin Mousavirad

“…Appropriate probability density functions (PDF) are employed to estimate the uncertain WP, PV source, HP, and load demand. Uncertain scenarios with variable load demand, wind speed (WS), solar irradiance (SI), and water flow rate (WFR) are created using Monte Carlo simulations (MCS). …”
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Reliability and validity of the Clinical pHysical rEsilience assEssment Scale (CHEES) in community-dwelling older adults by Yiwen Xing, Pan Liu, Wenhua Yu, Yiwei Zhao, Zhibin Wang, Yue Wu, Xue Gao, Yu Wang, Yansu Guo, Yumin Wang, Yi Tang, Lina Ma

“…Background: Physical resilience is closely related to healthy aging and refers to the ability of an individual to recover or maintain function after a stressor. …”
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Fabrication of GDNF-Gel/HA-Mg nerve conduit and its role in repairing peripheral nerve defects by Yuanqing Cai, Yi Chen, Hongyan Li, Yanyu Wang, Guangyang Zhang, Jialin Liang, Leifeng Lv, Ying Huang, Wenming Zhang, Xiaoqian Dang, Xinyu Fang, Yong Wang

“…Methods: A hydroxyapatite (HA) coating was first applied to the pure Mg surface, followed by the formation of gelatin methacrylate (GelMA) loaded with glial cell-derived neurotrophic factor (GDNF) on the HA-coated Mg surface. …”
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The combination of Clostridium butyricum and Akkermansia muciniphila mitigates DSS-induced colitis and attenuates colitis-associated tumorigenesis by modulating gut microbiota and... by Dengxiong Hua, Qin Yang, Xiaowei Li, Xuexue Zhou, Yingqian Kang, Yan Zhao, Daoyan Wu, Zhengrong Zhang, Boyan Li, Xinxin Wang, Xiaolan Qi, Zhenghong Chen, Guzhen Cui, Wei Hong

“…Furthermore, fecal microbiota transplantation therapy showed that transplanting feces from CRC mice treated with the co-administration of CB and AKK into other CRC mice alleviated the tumor loads in the colon and significantly extended their survival rate. …”
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Mental fatigue and sleep restriction effects on perceptual-cognitive performance in trained beach volleyball athletes by Bruno Teixeira Barbosa, Bruno Teixeira Barbosa, Bruno Teixeira Barbosa, Dalton de Lima-Junior, Alexandre Moreira, Fábio Yuzo Nakamura, Gilmário Ricarte Batista, Gilmário Ricarte Batista, Heloiana Faro, Leonardo de Sousa Fortes, Leonardo de Sousa Fortes

“…This suggests that MF and SR conditions may impair athletes’ ability to respond quickly to visual stimuli in different scenarios.…”
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Right-sided hemicolectomy in 90-year-old patient with cecum cancer by A. M. Sidorenko, T. A. Semenova, V. V. Varvarov

“…The cardiovascular system in elderly people loses the ability to adapt to tachycardia, a sudden increase in load. …”
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MULTIMODAL APPROACH TO THE STUDY OF SPECIALIZED TEXTS IN TECHNICAL DISCOURSE by Yuliia V. Polycheva, Volodymyr I. Vetokhin

“…The image is the most important part of multimodal technical texts and carries a significant functional load, providing a more complete, comprehensive perception. …”
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Optimized biosynthesis and performance enhancement of γ-PGA from Bacillus licheniformis: a study on wettability, microstructure, and environmental performance by Mingming Cheng, Shuoshi Zhang, Jianbo Gao, Wenqing Liu, Gang Zhou, Tao Sui, Daoquan Cheng, Cheng Wang, Xiangchuan Wang, Xiaoyan Li, Yuxi Li

“…Due to the abundance of free carboxyl groups (a-COOH), amino groups (NH–), and carbonyl groups (CO) on the molecular chains of γ-PGA, along with numerous hydrogen bonds between the γ-PGA chains, γ-PGA has a strong ability to absorb and retain water, making its capacity to wet solids significantly stronger than that of plain water. …”
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Traffic environment perception algorithm based on multi-task feature fusion and orthogonal attention by Zhengfeng LI, Mingen ZHONG, Yihong ZHANG, Kang FAN, Zhiying DENG, Jiawei TAN

“…This mechanism minimizes computational load while amplifying significant spatial features within the input images. …”
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An Ensemble Learning-Based Predictive Parameterization Approach for Permanent Magnet Synchronous Machines by Sema Nur Ipek, Nur Bekiroglu, Murat Taskiran

“…Permanent Magnet Synchronous Machines (PMSMs) are extensively utilized for their ability to deliver accurate position control, and the equivalent circuit characteristics of these machines are essential in several applications, particularly in formulating the control strategy. …”
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Application of Artificial Neural Network for Predicting Shaft and Tip Resistances of Concrete Piles by Ehsan Momeni, Ramli Nazir, Danial Jahed Armaghani, Harnedi Maizir

“…Axial bearing capacity (ABC) of piles is usually determined by static load test (SLT). However, conducting SLT is costly and time-consuming. …”
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Dendritic cell membrane-based DCsLipo@MnO2@siCTLA4@PD-1α nanomedicine for the treatment of Lynch syndrome-related colorectal cancer by Wenjin Zhong, Pengcheng Wang, Jintian Wang, Yuejia Zhu, Liquan Chen, Yilong Qian, Xiang Huang, Kai Ye

“…Finally, the anti-cancer effect and immune activation ability of the nanomedicine against LS-CRC were verified by a mouse allograft model. …”
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Medical-psychological aspects of professional deformation of personality development among emergency medical staff by O. S. Lalymenko, І. V. Zavhorodnii, V. A. Kapustnyk, I. Boeckelmann, V. F. Zabashta, M. O. Stytsenko

“…A low level of resilience with successful coping strategies under low-load conditions was more pronounced in 14.3 % of emergency medical services staff over 40 years old and in 9.1 % of those under 29 years of age. …”
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Sequentially assembled co-delivery nanoplatform of SIRT1 protein and SOX9-expressing plasmid for multipronged therapy of intervertebral disc degeneration by Xiaoyu Zhang, Qianping Guo, Jiawei Fang, Qi Cheng, Zhuang Zhu, Qifan Yu, Huan Wang, Youzhi Hong, Chengyuan Liu, Huilin Yang, Caihong Zhu, Bin Li, Li Ni

“…In vitro, the nanoplatforms showed antioxidant capacity, and the ability to restore mitochondrial homeostasis and normal ECM metabolism, as well as to maintain cellular phenotypes. …”
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Dual-functional injectable adhesive hydrogel delivering ginger-derived doxorubicin vesicles for osteosarcoma recurrence suppression and post-resection wound healing by Qiang Zhang, Qiang Zhang, Qiang Zhang, Qiang Zhang, Yu Zhang, Yu Zhang, Yu Zhang, Yu Zhang, Hui Chen, Hui Chen, Hui Chen, Hui Chen, Lei-Na Sun, Lei-Na Sun, Lei-Na Sun, Lei-Na Sun, Bin Zhang, Bin Zhang, Bin Zhang, Bin Zhang, Dong-Sheng Yue, Dong-Sheng Yue, Dong-Sheng Yue, Dong-Sheng Yue, Chang-Li Wang, Chang-Li Wang, Chang-Li Wang, Chang-Li Wang, Zhen-Fa Zhang, Zhen-Fa Zhang, Zhen-Fa Zhang, Zhen-Fa Zhang

“…The hydrogel incorporates ginger vesicles (GVs) loaded with doxorubicin (DOX), offering a dual therapeutic approach. …”
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Licochalcone a: A promising antiparasitic drug against giardiasis by Yingying Zhang, Wenchao Zhao, Haili Du, Pitambar Dhakal, Xinyi Chen, Longfei Wu, Xiaoying Li, Rongjun Wang, Longxian Zhang, Sumei Zhang, Junqiang Li

“…We determined the 50% inhibitory concentration (IC50) of Lic A, analyzed the adhesive ability of G. duodenalis, and assessed intestinal morphology and various indicators in the gerbil model. …”
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High-throughput single-cell analysis reveals Omp38-specific monoclonal antibodies that protect against Acinetobacter baumannii infection by Yiwei Zhang, Hao Cheng, Peng Yu, Shufeng Wang, Hui Dong, Song Lu, Ruiqi Yang, Baiqing Li, Jie Luo, Ruihan Mao, Zhaohui Zhang, Yong Qi, Xiaohua Chen, Jinya Ding, Zemin He, Jingbo Zhang, Tingting Zhao, Xiangmei Chen, Rong Lin, Haibo Li, Yi Tian, Yuzhang Wu

“…Intravenous administration of the Omp38-specific mAbs significantly improved the survival rate and reduced the bacterial load in a mouse model of lethal A. baumannii infection. …”
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Bridge Deflection Separation Prediction Model Based on DWT-LSTM and Its Engineering Application by ZHENG Shuai, JIANG He, WANG Zhongchang, DING Jia, YANG Yi

“…Focusing on the Xiongshang High-Speed Railway Bridge over the Daguang Expressway, sensors installed on the bridge were used to monitor variations in deflection, dynamic load, and temperature. Secondly, considering the decoupling of different deflection components across time scales, wavelet-based optimization was applied to decompose historical monitoring data into trend deflection caused by prestress loss and noise deflection induced by external factors such as temperature and dynamic loads. …”
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A tailored phytosomes based nose-to-brain drug delivery strategy: Silver bullet for Alzheimer's disease by Xiao Yue, Haihua Guo, Guanlin Wang, Jieyun Li, Zizhao Zhai, Zeting Wang, Wenhao Wang, Ziyu Zhao, Xiao Xia, Chuangxin Chen, Yingtong Cui, Chuanbin Wu, Zhengwei Huang, Xuejuan Zhang

“…On the one hand, Ginseng RG3-based phytosomes loaded with RHT was designed for the co-delivery of GRg3 and RHT, achieving the multi-target pharmacology for AD treatment. …”
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