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Structural basis for RNA-guided DNA degradation by Cas5-HNH/Cascade complex
Published 2025-02-01Get full text
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1842
Vitrification affects the post-implantation development of mouse embryos by inducing DNA damage and epigenetic modifications
Published 2025-02-01“…However, vitrification significantly reduced blastocyst cell number and the live pup frequency. Vitrification induced ROS accumulation, DNA damage, and apoptosis in mouse blastocysts. …”
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Incidence and pathological features of IgA nephropathy before and during the COVID-19 pandemic
Published 2025-02-01Get full text
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Molecular self-assembly strategy tuning a dry crosslinking protein patch for biocompatible and biodegradable haemostatic sealing
Published 2025-02-01“…The protein patch enhances adhesion performance on the wet tissue through a dry cross-linking method and robust intra/inter-molecular interactions. …”
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Screening of soybean antifungal isoflavones based on targeted metabolomics analysis
Published 2025-01-01“…Soybean (Glycine max) is a key crop rich in bioactive compounds, particularly isoflavones, which play a significant role in plant defense against biotic stress like fungal infections. In this study, nine soybean varieties with varying susceptibility to mildew were evaluated. …”
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Effects of Dust Event Days on Influenza: Evidence from Arid Environments in Lanzhou
Published 2022-10-01“…Abstract Airborne aerosol is believed to be an important pathway for infectious disease transmissions like COVID-19 and influenza. However, the effects of dust event days on influenza have been rarely explored, particularly in arid environments. …”
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Network pharmacology and experimental verification to investigate the mechanism of isoliquiritigenin for the treatment of Alzheimer’s disease
Published 2025-02-01“…Subsequently, the receiver operating characteristic (ROC) curve analysis and the assessment of hub gene expression levels between AD and healthy individuals were used to estimate a possible link between target genes in AD. Finally, experiments were conducted to verify the therapeutic mechanism of ISL in lipopolysaccharide (LPS)-induced BV2 microglial cells. …”
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Geological characteristics and main enrichment controlling factors of coalbed methane in Nanchuan area, southeastern Sichuan Basin
Published 2025-01-01“…It is characterized by "high gas content, abundant free gas, and oversaturation", and its gas content increases with burial depth. (4) The in-situ stress in the study area is moderate (35 to 60 MPa), with a small two-way horizontal stress difference coefficient (< 0.1) and good roof and floor plates, forming effective stress shielding favorable for fracturing transformation. (5) The main controlling factors for CBM methane enrichment in the Nanchuan area include the sedimentary environment, which determines coal-bearing formations; the degree of coal evolution, which determines the intensity of hydrocarbon generation; and the preservation conditions, which govern CBM enrichment.…”
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Air Pollution Forecasting Using Artificial and Wavelet Neural Networks with Meteorological Conditions
Published 2020-05-01Get full text
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