Molecular characterization of a rare TP63 variant associated with split-hand/split-foot malformation 4 and incomplete penetrance: disruption of the p63-Dlx signaling pathway by Jianlong Zhuang, Yanqing Li, Yu’e Chen, Hegan Zhang, Shufen Liu, Manman Hu, Chunnuan Chen

“…This study reports a causative variant in the TP63 gene in a Chinese family exhibiting limb anomalies associated with SHFM4. Methods Enrolled in this study was a Chinese family with limb anomalies without any other clinical features. …”
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Role of exhaled hydrogen sulfide in the diagnosis of colorectal cancer by Jian Chen, Yujen Tseng, Peizhun Du, Pengcheng Liu, Huilu Zhang, Guangjian Huang, Cheng’en Hu

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Analysis of factors associated with intercostal neuralgia after osteoporotic thoracic spine fracture and construction of a prediction model by Zhen-Gang Liu, Fan Yang, Peng-fu Li, Qi Song, Gao Wang, Bo-Yin Zhang

“…Results This study included a total of 104 patients based on the presence or absence of intercostal neuralgia.The results of multifactorial logistic regression analysis showed that injured vertebral intervertebral foraminal area (P = 0.0008, regression coefficient estimate 0.0490, 95% confidence interval 0.0219–0.0798, OR = 1.0503), injured vertebral intervertebral foraminal volume (P = 0.0001, regression coefficient value − 0.0028, 95% confidence interval − 0.0044 to -0.0015, OR = 0.9972), and nerve root area (P = 0.0038, regression coefficient estimate=-0.0876, 95% confidence interval − 0.1506 to -0.0309, OR = 0.9161) were independent associated factors.The fatty degeneration ratio have a positive promotional effect on the probability of developing intercostal pain.The area under the ROC curve (AUC) of the prediction model was 0.851, which indicated that the line graph model had a certain degree of predictive validity. …”
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Social isolation in the young and middle-aged patients with stroke: role of social support, family resilience and hope by Xiao Jia Wu, Ke Ke, Hui Liu, Shao Ping Zhan, Lei Wang, Juan Feng He

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Phage vB_Kpn_HF0522: Isolation, Characterization, and Therapeutic Potential in Combatting K1 Klebsiella pneumoniae Infections by Yan T, Wang Q, Ma C, Teng X, Gong Z, Chu W, Zhou Q, Liu Z

“…Tao Yan,1,2 Qiuyan Wang,2 Chengcheng Ma,2 Xuan Teng,2 Zhen Gong,2 Wenwen Chu,2 Qiang Zhou,2 Zhou Liu1 1Department of Clinical Laboratory Center, Anhui Chest Hospital, Hefei, 230031, People’s Republic of China; 2Department of Clinical Laboratory, the Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, People’s Republic of ChinaCorrespondence: Zhou Liu, Department of Clinical Laboratory Center, Anhui Chest Hospital, Hefei, People’s Republic of China, Email liuzhou0112@ahmu.edu.cnPurpose: Klebsiella pneumoniae is a globally prevalent pathogen responsible for severe hospital- and community-acquired infections, and presents significant challenges for clinical management. …”
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Application of deep learning models on single-cell RNA sequencing analysis uncovers novel markers of double negative T cells by Tian Xu, Qin Xu, Ran Lu, David N. Oakland, Song Li, Liwu Li, Christopher M. Reilly, Xin M. Luo

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Hepatobiliary organoid research: the progress and applications by Rui-Qi Zou, Rui-Qi Zou, Yu-Shi Dai, Yu-Shi Dai, Fei Liu, Fei Liu, Si-Qi Yang, Si-Qi Yang, Hai-Jie Hu, Hai-Jie Hu, Fu-Yu Li, Fu-Yu Li

“…Organoid culture has emerged as a forefront technology in the life sciences field. As “in vitro micro-organs”, organoids can faithfully recapitulate the organogenesis process, and conserve the key structure, physiological function and pathological state of the original tissue or organ. …”
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East Asian Gene flow bridged by northern coastal populations over past 6000 years by Juncen Liu, Yichen Liu, Yongsheng Zhao, Chao Zhu, Tianyi Wang, Wen Zeng, Bo Sun, Fen Wang, Hui Han, Zhenguang Li, Xiaotian Feng, Peng Cao, Fengshi Luan, Feng Liu, Qingyan Dai, Junfeng Guo, Zimeng Wang, Chengmin Wei, Qiaowei Wei, Ruowei Yang, Weihong Hou, Wanjing Ping, Fan Bai, Bo Miao, Wenjun Wang, Melinda A. Yang, Qiaomei Fu

“…We found that ancestry related to ShanDong populations likely explains the mainland East Asian ancestry observed in post-Yayoi populations from the Japanese archipelago, particularly recent populations who lived in the Ryukyu Islands after ~2800 BP. …”
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Clinical and genetic analysis of methylmalonic aciduria in 60 patients from Southern China: a single center retrospective study by Hiba Abid, Areeba Abid, Sarah Sohail, Sara Jawaid

“…We highlight the variability in serum MMA levels due to dietary intake, renal function, and external factors, advocating for the integration of supplementary diagnostic tools, such as the 1–13 C-propionate oxidation breath test, alongside biomarkers like fibroblast growth factor 21, growth differentiation factor 15, and lipocalin-2, to improve diagnostic accuracy. …”
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STRUCTURAL CAPITAL MANAGEMENT AND PERFORMANCE OF PUBLIC UNIVERSITIES IN NIGERIA by Fatima Bisola MAHMOUD, Mubaraq Sanni, Ismaila Daudu ALIU

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Role of thermal and dynamical subdaily perturbations over the Tibetan Plateau in 30-day extended-range forecast of East Asian precipitation in early summer by Bian He, Xinyu He, Yimin Liu, Guoxiong Wu, Qing Bao, Wenting Hu, Chen Sheng, Shijian Feng

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Lactate/albumin ratio as a prognostic biomarker for in-hospital mortality in pediatric patients with necrotizing enterocolitis by Ban Li, Yuanzhi Chen, Zhen Yang, Xianglun Sun, Cheng Tian, Jingsi Liu, Lihua Yuan, Kanglin Dai

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IMF B y influence on fast earthward convection flows in the near-lunar magnetotail by T. C. Liu, T. Pitkänen, S. Nilsson, A. Kullen, J.-S. Park, M. Hamrin, W. S. Shang, H. Z. Wang, S. T. Yao

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ThyroNet-X4 genesis: an advanced deep learning model for auxiliary diagnosis of thyroid nodules’ malignancy by Xiaoxue Wang, Yupeng Niu, Hongli Liu, Fa Tian, Qiang Zhang, Yimeng Wang, Yeju Wang, Yijia Li

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Enhanced preoperative prediction of breast lesion pathology, prognostic biomarkers, and molecular subtypes using multiple models diffusion-weighted MR imaging by Litong He, Feng Li, Yanjin Qin, Yuling Li, Qilan Hu, Zhiqiang Liu, Yunfei Zhang, Tao Ai

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Rib suppression-based radiomics for diagnosis of neonatal respiratory distress syndrome in chest X-rays by Yudong Wang, Zongjin Qu, Zhengjun Dai, Yuhong Li, Yanyan Liu, Wei Wang, Lianxiang Xiao, Yi Zhang

“…The data was partitioned into training and validation subsets based on chronological order. We applied rib suppression to the CXR images and extracted and analyzed radiomic features from lung regions both before and after rib suppression. …”
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Research on Performance and Mechanism of the NH3-SCR Reaction over Fly Ash-derived Mn-Ce/Zeolite X by Weijia Ren, Qi Xin, Zhesheng Hua, Zhong Zheng, Lifeng Xiao, Shaojun Liu, Chenghang Zheng, Yang Yang

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Abnormal sagittal patellar tilt during active knee flexion and extension on 4DCT might be associated with patellofemoral pain by Yurou Chen, Xin Liu, Bo Sheng, Mao Yuan, Furong Lv, Fajin Lv, Fan Yu, Jia Li

“…Patella-patellar tendon angle (P-PTA), patella-lateral tibial plateau angle (P-LTPA), patella-screen horizontal line angle (P-SHLA), articular facet of the patella-lateral tibial plateau angle (PA-LTPA), articular facet of the patella-screen horizontal line angle (PA-SHLA), and upper margin of the patella-quadriceps tendon angle (PU-QTA) were used to evaluate the sagittal patellar tilt. …”
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Harmonious regulation flavor and lipid oxidation in dry-cured tenderloin through electrical stimulation: A study on lipase activity and sensory correlations by Lisha Lan, Li Chen, Xiaolin Zhong, Weiguo Cao, Ying Zhou, Jing Wan, Yuanyuan Liu, Qinjin Zhu

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Development and application of an efficient, accurate, and environmentally friendly liquid chromatography–tandem mass spectrometry method for the determination of five Alternaria t... by Huiyuan Lang, Zengwang Guo, Yu Wu, Li Li, Hongmei Liu, Lianzhou Jiang, Songxue Wang, Jin Ye

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